UniProtKB - O64823 (MCU2_ARATH)
Protein
Calcium uniporter protein 2, mitochondrial
Gene
At2g23790
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.By similarity
GO - Molecular functioni
- calcium channel activity Source: GO_Central
- uniporter activity Source: GO_Central
GO - Biological processi
- calcium import into the mitochondrion Source: GO_Central
- mitochondrial calcium ion homeostasis Source: GO_Central
Keywordsi
Molecular function | Calcium channel, Ion channel |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium uniporter protein 2, mitochondrial |
Gene namesi | Ordered Locus Names:At2g23790Imported ORF Names:F27L4.3Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G23790 |
TAIRi | locus:2049013, AT2G23790 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- integral component of mitochondrial inner membrane Source: GO_Central
- uniplex complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 231 – 251 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 257 – 277 | Helical; Name=2Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 69 | MitochondrionSequence analysisAdd BLAST | 69 | |
ChainiPRO_0000431371 | 70 – 336 | Calcium uniporter protein 2, mitochondrialAdd BLAST | 267 |
Proteomic databases
PaxDbi | O64823 |
PRIDEi | O64823 |
ProteomicsDBi | 238700 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 2263, 4 interactors |
IntActi | O64823, 4 interactors |
STRINGi | 3702.AT2G23790.1 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2966, Eukaryota |
HOGENOMi | CLU_066330_0_0_1 |
InParanoidi | O64823 |
OMAi | EIMQMPV |
OrthoDBi | 1076768at2759 |
PhylomeDBi | O64823 |
Family and domain databases
InterProi | View protein in InterPro IPR006769, MCU_C IPR039055, MCU_fam |
PANTHERi | PTHR13462, PTHR13462, 1 hit |
Pfami | View protein in Pfam PF04678, MCU, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O64823-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMRKLLSKK LFNITNVASQ SLMNCRISSS SLAVRTRVPN DSTDTTKIAP
60 70 80 90 100
EPGDLAMSRR FMHNSAMIRP AEIMQMPVGE SLIEKLREID GSKDRIRLDG
110 120 130 140 150
LSPPERETSL TVADTKKLLR AAQIEIVKSK LRETGRSWMP YKEFVSVCGE
160 170 180 190 200
ASSDPDLGSK IAKMLDDSAN VIVLGDSVCI RPDQVTKSIE GLLPLPKIHN
210 220 230 240 250
PNDPRRIEFK ELEAEKAVID VKAHTLVRKE LWAGLGYLIL QTAGFMRLTF
260 270 280 290 300
WELSWDVMEP ICFYVTSVYF MAGYAFFLRT SKEPSFEGFY QSRFEAKQRK
310 320 330
LMNEYEFDLE RYNELKKLFC SKPSDHVSKI LGAIKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004482 Genomic DNA Translation: AAC17084.1 CP002685 Genomic DNA Translation: AEC07491.1 AY145900 mRNA Translation: AAN59955.1 |
PIRi | A84629 |
RefSeqi | NP_179959.1, NM_127942.3 |
Genome annotation databases
EnsemblPlantsi | AT2G23790.1; AT2G23790.1; AT2G23790 |
GeneIDi | 816911 |
Gramenei | AT2G23790.1; AT2G23790.1; AT2G23790 |
KEGGi | ath:AT2G23790 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004482 Genomic DNA Translation: AAC17084.1 CP002685 Genomic DNA Translation: AEC07491.1 AY145900 mRNA Translation: AAN59955.1 |
PIRi | A84629 |
RefSeqi | NP_179959.1, NM_127942.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 2263, 4 interactors |
IntActi | O64823, 4 interactors |
STRINGi | 3702.AT2G23790.1 |
Proteomic databases
PaxDbi | O64823 |
PRIDEi | O64823 |
ProteomicsDBi | 238700 |
Genome annotation databases
EnsemblPlantsi | AT2G23790.1; AT2G23790.1; AT2G23790 |
GeneIDi | 816911 |
Gramenei | AT2G23790.1; AT2G23790.1; AT2G23790 |
KEGGi | ath:AT2G23790 |
Organism-specific databases
Araporti | AT2G23790 |
TAIRi | locus:2049013, AT2G23790 |
Phylogenomic databases
eggNOGi | KOG2966, Eukaryota |
HOGENOMi | CLU_066330_0_0_1 |
InParanoidi | O64823 |
OMAi | EIMQMPV |
OrthoDBi | 1076768at2759 |
PhylomeDBi | O64823 |
Miscellaneous databases
PROi | PR:O64823 |
Gene expression databases
ExpressionAtlasi | O64823, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR006769, MCU_C IPR039055, MCU_fam |
PANTHERi | PTHR13462, PTHR13462, 1 hit |
Pfami | View protein in Pfam PF04678, MCU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MCU2_ARATH | |
Accessioni | O64823Primary (citable) accession number: O64823 Secondary accession number(s): Q8H1L7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 26, 2014 |
Last sequence update: | August 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families