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Entry version 152 (16 Oct 2019)
Sequence version 1 (01 Aug 1998)
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Protein
Submitted name:

At2g34970

Gene

At2g34970

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factorImported
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
At2g34970Imported
Submitted name:
Putative translation initiation factor eIF-2B epsilon subunitImported
Submitted name:
Trimeric LpxA-like enzymeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At2g34970Imported
ORF Names:F19I3.20Imported, F19I3_20Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT2G34970

The Arabidopsis Information Resource

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TAIRi
locus:2044712 AT2G34970

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

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PRIDEi
O64760

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O64760

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O64760 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
O64760, 3 interactors

STRING: functional protein association networks

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STRINGi
3702.AT2G34970.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O64760

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini549 – 720W2InterPro annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni441 – 464DisorderedSequence analysisAdd BLAST24
Regioni518 – 542DisorderedSequence analysisAdd BLAST25
Regioni711 – 730DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi713 – 730AcidicSequence analysisAdd BLAST18

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1461 Eukaryota
COG1208 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000216610

KEGG Orthology (KO)

More...
KOi
K03240

Identification of Orthologs from Complete Genome Data

More...
OMAi
NVAMIDY

Database of Orthologous Groups

More...
OrthoDBi
369837at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04197 eIF-2B_epsilon_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 1 hit
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR035543 eIF-2B_epsilon_N
IPR001451 Hexapep
IPR016021 MIF4-like_sf
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
IPR003307 W2_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00132 Hexapep, 1 hit
PF00483 NTP_transferase, 1 hit
PF02020 W2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00515 eIF5C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51363 W2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O64760-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAQKKGGAA ARVSEDAEVQ SRHRLQAILL ADSFATKFRP VTLERPKVLL
60 70 80 90 100
PIVNVPMIDY TLAWLESAGI EEVFVFCCAH SMQVIEYLEK SEWYSHPNLL
110 120 130 140 150
VRTIESHKSI SAGDALRYMY EQQTETSQIQ GDFVLVSGDT VSNMPLADLI
160 170 180 190 200
QEHRERKKKD EKAIMTMVIK QSKSSPLTHQ SRLGTDQLFI AVDPLTKQLL
210 220 230 240 250
HYEEDKIDHP SGSVCLEKSL LDTNPSVLVC NDMQDCYIDI CSPEVLSLFE
260 270 280 290 300
DNFDYQHLRR HFVKGVLVDD IMGYKIFTHE IHSSYAGRID NFRSYDTVSK
310 320 330 340 350
DIIQRWTYPY VPDINFSGNR PLKLGRQGIY KASDVVQSRS ADVGASTVIG
360 370 380 390 400
YGTKIGHGDK IMNSVIGNGC SIGSNVVIEG SYIWNNVTIE DGCEIRNAIV
410 420 430 440 450
CDGVKIRAGA VLQPGVVLSF NVVVGRDFVV PAYSKVSLLQ QPTTEDSDEE
460 470 480 490 500
LEYADSSSGT ADHLSGLNLQ MESKASELGP DGAGYIWEVC EGAHDEEWKH
510 520 530 540 550
SVAPIPKDKL SEITQAIDDD DTDDESVVPT SGELKSDADS INTDVNDPND
560 570 580 590 600
DYYYFEKEVE GTVLRAVEEN IKVDLVTMEI NGLRLSFNME SADCAGATFF
610 620 630 640 650
SMIKLALDTP HNSGSELYKN AASIITKWKD LLGFYAKKID EQIEVIMKFE
660 670 680 690 700
EMCQESHKEL GPLFTQILHL LYDKDVLQED AILRWEEEKA GADEADKVYL
710 720 730
KQCDTFIQWL KEASEEEDED DEDEEEEEDN
Length:730
Mass (Da):81,864
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02CEDB9B35386194
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004238 Genomic DNA Translation: AAC12836.1
AY140053 mRNA Translation: AAM98194.1
BT010333 mRNA Translation: AAQ56776.1
CP002685 Genomic DNA Translation: AEC09044.1

Protein sequence database of the Protein Information Resource

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PIRi
T00478

NCBI Reference Sequences

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RefSeqi
NP_181042.1, NM_129049.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G34970.1; AT2G34970.1; AT2G34970

Database of genes from NCBI RefSeq genomes

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GeneIDi
818061

Gramene; a comparative resource for plants

More...
Gramenei
AT2G34970.1; AT2G34970.1; AT2G34970

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G34970

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004238 Genomic DNA Translation: AAC12836.1
AY140053 mRNA Translation: AAM98194.1
BT010333 mRNA Translation: AAQ56776.1
CP002685 Genomic DNA Translation: AEC09044.1
PIRiT00478
RefSeqiNP_181042.1, NM_129049.3

3D structure databases

SMRiO64760
ModBaseiSearch...

Protein-protein interaction databases

IntActiO64760, 3 interactors
STRINGi3702.AT2G34970.1

PTM databases

iPTMnetiO64760

Proteomic databases

PRIDEiO64760

Genome annotation databases

EnsemblPlantsiAT2G34970.1; AT2G34970.1; AT2G34970
GeneIDi818061
GrameneiAT2G34970.1; AT2G34970.1; AT2G34970
KEGGiath:AT2G34970

Organism-specific databases

AraportiAT2G34970
TAIRilocus:2044712 AT2G34970

Phylogenomic databases

eggNOGiKOG1461 Eukaryota
COG1208 LUCA
HOGENOMiHOG000216610
KOiK03240
OMAiNVAMIDY
OrthoDBi369837at2759

Gene expression databases

ExpressionAtlasiO64760 baseline and differential

Family and domain databases

CDDicd04197 eIF-2B_epsilon_N, 1 hit
Gene3Di1.25.40.180, 1 hit
3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035543 eIF-2B_epsilon_N
IPR001451 Hexapep
IPR016021 MIF4-like_sf
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
IPR003307 W2_domain
PfamiView protein in Pfam
PF00132 Hexapep, 1 hit
PF00483 NTP_transferase, 1 hit
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS51363 W2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO64760_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O64760
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: October 16, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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