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Entry version 124 (07 Oct 2020)
Sequence version 1 (01 Aug 1998)
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Protein

Cationic amino acid transporter 5

Gene

CAT5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High-affinity permease involved in the transport of the cationic amino acids (e.g. arginine, and, to a lower extent, citrulline and glutamate). Transport mostly basic amino acids, and, to a lower extent neutral and acidic amino acids.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=12.0 µM for arginine1 Publication

    pH dependencei

    Optimal transport of arginine at pH 5.1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAmino-acid transport, Transport

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.3.3.12, the amino acid-polyamine-organocation (apc) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cationic amino acid transporter 5
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CAT5
    Ordered Locus Names:At2g34960
    ORF Names:F19I3.19
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Arabidopsis Information Portal

    More...
    Araporti
    AT2G34960

    The Arabidopsis Information Resource

    More...
    TAIRi
    locus:2044682, AT2G34960

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 67CytoplasmicSequence analysisAdd BLAST67
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
    Topological domaini89 – 97ExtracellularSequence analysis9
    Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
    Topological domaini119 – 143CytoplasmicSequence analysisAdd BLAST25
    Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
    Topological domaini165 – 192ExtracellularSequence analysisAdd BLAST28
    Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
    Topological domaini214 – 222CytoplasmicSequence analysis9
    Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
    Topological domaini244 – 251ExtracellularSequence analysis8
    Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
    Topological domaini273 – 290CytoplasmicSequence analysisAdd BLAST18
    Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
    Topological domaini312 – 341ExtracellularSequence analysisAdd BLAST30
    Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
    Topological domaini363 – 389CytoplasmicSequence analysisAdd BLAST27
    Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
    Topological domaini411ExtracellularSequence analysis1
    Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
    Topological domaini433 – 450CytoplasmicSequence analysisAdd BLAST18
    Transmembranei451 – 471HelicalSequence analysisAdd BLAST21
    Topological domaini472 – 477ExtracellularSequence analysis6
    Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
    Topological domaini499 – 505CytoplasmicSequence analysis7
    Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
    Topological domaini527 – 537ExtracellularSequence analysisAdd BLAST11
    Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
    Topological domaini559 – 569CytoplasmicSequence analysisAdd BLAST11

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004157811 – 569Cationic amino acid transporter 5Add BLAST569

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O64759

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O64759

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    240538

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in roots, stems, flowers, seeds, and leaves. Mostly present in leaf rims and cotyledons of developing seedlings.1 Publication

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O64759, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O64759, AT

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    3406, 1 interactor

    Protein interaction database and analysis system

    More...
    IntActi
    O64759, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    3702.AT2G34960.1

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1286, Eukaryota

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_007946_15_9_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O64759

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    TYVAGCF

    Database of Orthologous Groups

    More...
    OrthoDBi
    439017at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O64759

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002293, AA/rel_permease1
    IPR029485, CAT_C

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13520, AA_permease_2, 1 hit
    PF13906, AA_permease_C, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    O64759-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MEGEERGYWR WSKRDFFPEE SFQSFGSYRA ALSQTCSRFK NRLVSRSDDE
    60 70 80 90 100
    NERFELKKQS EHEMKRCLTW WDLVWFGFGS VIGAGIFVLT GQEAHEQAGP
    110 120 130 140 150
    AIVLSYVVSG LSAMLSVFCY TEFAVEIPVA GGSFAYLRIE LGDFAAFITA
    160 170 180 190 200
    GNILLESIVG TAAVARAWTS YFATLLNRSP NALRIKTDLS SGFNLLDPIA
    210 220 230 240 250
    VVVIAASATI ASISTRKTSL LNWIASAINT LVIFFVIIAG FIHADTSNLT
    260 270 280 290 300
    PFLPFGPEGV FRAAAVVYFA YGGFDSIATM AEETKNPSRD IPIGLLGSMS
    310 320 330 340 350
    IITVIYCLMA LSLSMMQKYT DIDPNAAYSV AFQSVGMKWG KYLVALGALK
    360 370 380 390 400
    GMTTVLLVGA LGQARYVTHI ARTHMIPPIF ALVHPKTGTP INANLLVAIP
    410 420 430 440 450
    SALIAFFSGL DVLASLLSIS TLFIFTMMPI ALLVRRYYVR QDTPRVHLIK
    460 470 480 490 500
    LITCLLFVVV SSMGTSAYWG MQRKGSWIGY TVTVPFWFLG TLGIVFFVPQ
    510 520 530 540 550
    QRTPKVWGVP LVPWLPCLSI ATNIFLMGSL GAMAFVRFGV CTLAMLLYYF
    560
    LLGLHATFDM AHQQIVPRT
    Length:569
    Mass (Da):62,636
    Last modified:August 1, 1998 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3234EB8CD900A378
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAL91292 differs from that shown. Reason: Frameshift.Curated
    The sequence AAN18189 differs from that shown. Reason: Frameshift.Curated

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AC004238 Genomic DNA Translation: AAC12835.1
    CP002685 Genomic DNA Translation: AEC09043.1
    AY090448 mRNA Translation: AAL91292.1 Frameshift.
    BT000623 mRNA Translation: AAN18189.1 Frameshift.

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T00477

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_181041.1, NM_129048.3

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    AT2G34960.1; AT2G34960.1; AT2G34960

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    818060

    Gramene; a comparative resource for plants

    More...
    Gramenei
    AT2G34960.1; AT2G34960.1; AT2G34960

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ath:AT2G34960

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC004238 Genomic DNA Translation: AAC12835.1
    CP002685 Genomic DNA Translation: AEC09043.1
    AY090448 mRNA Translation: AAL91292.1 Frameshift.
    BT000623 mRNA Translation: AAN18189.1 Frameshift.
    PIRiT00477
    RefSeqiNP_181041.1, NM_129048.3

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi3406, 1 interactor
    IntActiO64759, 1 interactor
    STRINGi3702.AT2G34960.1

    Protein family/group databases

    TCDBi2.A.3.3.12, the amino acid-polyamine-organocation (apc) family

    Proteomic databases

    PaxDbiO64759
    PRIDEiO64759
    ProteomicsDBi240538

    Genome annotation databases

    EnsemblPlantsiAT2G34960.1; AT2G34960.1; AT2G34960
    GeneIDi818060
    GrameneiAT2G34960.1; AT2G34960.1; AT2G34960
    KEGGiath:AT2G34960

    Organism-specific databases

    AraportiAT2G34960
    TAIRilocus:2044682, AT2G34960

    Phylogenomic databases

    eggNOGiKOG1286, Eukaryota
    HOGENOMiCLU_007946_15_9_1
    InParanoidiO64759
    OMAiTYVAGCF
    OrthoDBi439017at2759
    PhylomeDBiO64759

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:O64759

    Gene expression databases

    ExpressionAtlasiO64759, baseline and differential
    GenevisibleiO64759, AT

    Family and domain databases

    InterProiView protein in InterPro
    IPR002293, AA/rel_permease1
    IPR029485, CAT_C
    PfamiView protein in Pfam
    PF13520, AA_permease_2, 1 hit
    PF13906, AA_permease_C, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAAT5_ARATH
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O64759
    Secondary accession number(s): Q8RX58
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: August 1, 1998
    Last modified: October 7, 2020
    This is version 124 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families
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