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Entry version 130 (16 Oct 2019)
Sequence version 2 (16 May 2006)
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Protein

Inositol-3-phosphate synthase 1

Gene

RINO1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in myo-inositol synthesis. Is a key enzyme in the phytic acid biosynthesis pathway in seeds.1 Publication

Miscellaneous

Plants silencing RINO1 show a low phytic acid phenotype in seeds, and high accumulation of inorganic phosphate (Pi) in seeds.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

NAD+Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: myo-inositol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.Curated
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase 1 (RINO2), Inositol-3-phosphate synthase 1 (RINO1)
  2. Inositol-1-monophosphatase (OSJNBa0010D22.28), Inositol-1-monophosphatase (Os02g0169900), Inositol-1-monophosphatase (LOC_Os03g39000), Inositol-1-monophosphatase (Os02g0169900)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processInositol biosynthesis, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
5.5.1.4 4460

Reactome - a knowledgebase of biological pathways and processes for plant species

More...
PlantReactomei
R-OSA-1119378 Myo-inositol biosynthesis
R-OSA-1119434 Phytic acid biosynthesis (lipid-independent)

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O64437

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00823;UER00787

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol-3-phosphate synthase 1Curated (EC:5.5.1.4Curated)
Short name:
MIP synthase 1Curated
Alternative name(s):
Myo-inositol 1-phosphate synthaseCurated
Short name:
IPSCurated
Short name:
MI-1-P synthaseCurated
OsINO1-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RINO11 Publication
Synonyms:INO1Curated, INO1-11 Publication
Ordered Locus Names:Os03g0192700Imported, LOC_Os03g09250Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. japonica (Rice)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39947 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000059680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001951951 – 510Inositol-3-phosphate synthase 1Add BLAST510

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O64437

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in embryos, but transcripts are undetectable in roots, leaves, flowers and anthers.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the apical region of globular-stage embryos 2 days after anthesis (DAA). Expressed in the scutellum and aleurone layer 4 DAA. Expression in these cells increases until 7 DAA, and then gradually decreases.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by sucrose and glucose (PubMed:11975732). Induced by abscisic acid (ABA) (PubMed:11975732, PubMed:24467907).2 Publications

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O64437 OS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4530.OS03T0192700-01

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O64437

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0693 Eukaryota
COG1260 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O64437

KEGG Orthology (KO)

More...
KOi
K01858

Identification of Orthologs from Complete Genome Data

More...
OMAi
EGWDNID

Database of Orthologous Groups

More...
OrthoDBi
451916at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002587 Myo-inos-1-P_Synthase
IPR013021 Myo-inos-1-P_Synthase_GAPDH
IPR036291 NAD(P)-bd_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11510 PTHR11510, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01658 Inos-1-P_synth, 1 hit
PF07994 NAD_binding_5, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF015578 Myoinos-ppht_syn, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O64437-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFIESFRVES PHVRYGAAEI ESDYQYDTTE LVHESHDGAS RWIVRPKSVR
60 70 80 90 100
YNFRTTTTVP KLGVMLVGWG GNNGSTLTAG VIANREGISW ATKDKVQQAN
110 120 130 140 150
YYGSLTQAST IRVGSYNGEE IYAPFKSLLP MVNPDDLVFG GWDISNMNLA
160 170 180 190 200
DAMTRAKVLD IDLQKQLRPY MESMVPLPGI YDPDFIAANQ GSRANNVIKG
210 220 230 240 250
TKKEQMEQII KDIREFKEKS KVDKVVVLWT ANTERYSNVC VGLNDTMENL
260 270 280 290 300
LASVDKNEAE ISPSTLYAIA CVMEGIPFIN GSPQNTFVPG LIDLAIKNNC
310 320 330 340 350
LIGGDDFKSG QTKMKSVLVD FLVGAGIKPT SIVSYNHLGN NDGMNLSAPQ
360 370 380 390 400
TFRSKEISKS NVVDDMVSSN AILYELGEHP DHVVVIKYVP YVGDSKRAMD
410 420 430 440 450
EYTSEIFMGG KSTIVLHNTC EDSLLAAPII LDLVLLAELS TRIQLKAEGE
460 470 480 490 500
EKFHSFHPVA TILSYLTKAP LVPPGTPVVN ALAKQRAMLE NIMRACVGLA
510
PENNMILEYK
Length:510
Mass (Da):56,264
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20DD8DFAD199F937
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti185F → V in BAA25729 (PubMed:9880347).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB012107 mRNA Translation: BAA25729.1
EU267961 mRNA Translation: ACA50483.1
AC116604 Genomic DNA No translation available.
DP000009 Genomic DNA Translation: ABF94419.1
AP008209 Genomic DNA Translation: BAF11156.1
AP014959 Genomic DNA Translation: BAS82735.1
CM000140 Genomic DNA Translation: EEE58482.1
AK058750 mRNA Translation: BAG86795.1
AK103501 mRNA Translation: BAG96116.1

NCBI Reference Sequences

More...
RefSeqi
XP_015632437.1, XM_015776951.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
Os03t0192700-01; Os03t0192700-01; Os03g0192700

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4331917

Gramene; a comparative resource for plants

More...
Gramenei
Os03t0192700-01; Os03t0192700-01; Os03g0192700

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
osa:4331917

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012107 mRNA Translation: BAA25729.1
EU267961 mRNA Translation: ACA50483.1
AC116604 Genomic DNA No translation available.
DP000009 Genomic DNA Translation: ABF94419.1
AP008209 Genomic DNA Translation: BAF11156.1
AP014959 Genomic DNA Translation: BAS82735.1
CM000140 Genomic DNA Translation: EEE58482.1
AK058750 mRNA Translation: BAG86795.1
AK103501 mRNA Translation: BAG96116.1
RefSeqiXP_015632437.1, XM_015776951.1

3D structure databases

SMRiO64437
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4530.OS03T0192700-01

Proteomic databases

PaxDbiO64437

Genome annotation databases

EnsemblPlantsiOs03t0192700-01; Os03t0192700-01; Os03g0192700
GeneIDi4331917
GrameneiOs03t0192700-01; Os03t0192700-01; Os03g0192700
KEGGiosa:4331917

Phylogenomic databases

eggNOGiKOG0693 Eukaryota
COG1260 LUCA
InParanoidiO64437
KOiK01858
OMAiEGWDNID
OrthoDBi451916at2759

Enzyme and pathway databases

UniPathwayiUPA00823;UER00787
BRENDAi5.5.1.4 4460
PlantReactomeiR-OSA-1119378 Myo-inositol biosynthesis
R-OSA-1119434 Phytic acid biosynthesis (lipid-independent)
SABIO-RKiO64437

Gene expression databases

GenevisibleiO64437 OS

Family and domain databases

InterProiView protein in InterPro
IPR002587 Myo-inos-1-P_Synthase
IPR013021 Myo-inos-1-P_Synthase_GAPDH
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR11510 PTHR11510, 1 hit
PfamiView protein in Pfam
PF01658 Inos-1-P_synth, 1 hit
PF07994 NAD_binding_5, 1 hit
PIRSFiPIRSF015578 Myoinos-ppht_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRINO1_ORYSJ
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O64437
Secondary accession number(s): Q10QK8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 16, 2006
Last modified: October 16, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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