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UniProtKB - O64404 (TPSD4_ABIGR)

Entry version 90 (23 Feb 2022)
Sequence version 1 (01 Aug 1998)
Previous versions | rss
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Protein

Delta-selinene synthase

Gene

ag4

Organism
Abies grandis (Grand fir) (Pinus grandis)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in defensive oleoresin formation in conifers in response to insect attack or other injury. Involved in 34 sesquiterpene (C15) olefins biosynthesis.

2 Publications

Miscellaneous

In sesquiterpene synthases utilizing farnesyl diphosphate as substrate, magnesium is more efficient as cofactor than is manganese.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.5 µM for farnesyl diphosphate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: oleoresin biosynthesis

This protein is involved in the pathway oleoresin biosynthesis, which is part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the pathway oleoresin biosynthesis and in Terpene metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi331Magnesium 1By similarity1
Metal bindingi331Magnesium 2By similarity1
Metal bindingi335Magnesium 1By similarity1
Metal bindingi335Magnesium 2By similarity1
Metal bindingi475Magnesium 3By similarity1
Metal bindingi483Magnesium 3By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		4.2.3.60, 2
4.2.3.71, 2
4.2.3.76, 2

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		O64404

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00924

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Delta-selinene synthase (EC:4.2.3.711 Publication, EC:4.2.3.761 Publication)
Alternative name(s):
Agfdsel1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ag4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAbies grandis (Grand fir) (Pinus grandis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri46611 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Pinopsida › Pinidae › Conifers I › Pinaceae › Abies

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001864471 – 581Delta-selinene synthaseAdd BLAST581

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Constitutive expression.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O64404

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi331 – 335DDXXD motif5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg2+.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the terpene synthase family. Tpsd subfamily.Curated

Family and domain databases

Conserved Domains Database

More...CDDi		cd00684, Terpene_cyclase_plant_C1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.600.10, 1 hit
1.50.10.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008949, Isoprenoid_synthase_dom_sf
IPR034741, Terpene_cyclase-like_1_C
IPR044814, Terpene_cyclase_plant_C1
IPR001906, Terpene_synth_N
IPR036965, Terpene_synth_N_sf
IPR005630, Terpene_synthase_metal-bd
IPR008930, Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01397, Terpene_synth, 1 hit
PF03936, Terpene_synth_C, 1 hit

Structure-Function Linkage Database

More...SFLDi		SFLDG01019, Terpene_Cyclase_Like_1_C_Termi, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48239, SSF48239, 1 hit
SSF48576, SSF48576, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O64404-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEISESSIP RRTGNHHGNV WDDDLIHSLN SPYGAPAYYE LLQKLIQEIK 
        60         70         80         90        100
HLLLTEMEMD DGDHDLIKRL QIVDTLECLG IDRHFEHEIQ TAALDYVYRW 
       110        120        130        140        150
WNEKGIGEGS RDSFSKDLNA TALGFRALRL HRYNVSSGVL KNFKDENGKF 
       160        170        180        190        200
FCNFTGEEGR GDKQVRSMLS LLRASEISFP GEKVMEEAKA FTREYLNQVL 
       210        220        230        240        250
AGHGDVTDVD QSLLREVKYA LEFPWHCSVP RWEARSFLEI YGHNHSWLKS 
       260        270        280        290        300
NINQKMLKLA KLDFNILQCK HHKEIQFITR WWRDSGISQL NFYRKRHVEY 
       310        320        330        340        350
YSWVVMCIFE PEFSESRIAF AKTAILCTVL DDLYDTHATL HEIKIMTEGV 
       360        370        380        390        400
RRWDLSLTDD LPDYIKIAFQ FFFNTVNELI VEIVKRQGRD MTTIVKDCWK 
       410        420        430        440        450
RYIESYLQEA EWIATGHIPT FNEYIKNGMA SSGMCILNLN PLLLLDKLLP 
       460        470        480        490        500
DNILEQIHSP SKILDLLELT GRIADDLKDF EDEKERGEMA SSLQCYMKEN 
       510        520        530        540        550
PESTVENALN HIKGILNRSL EEFNWEFMKQ DSVPMCCKKF TFNIGRGLQF 
       560        570        580 
IYKYRDGLYI SDKEVKDQIF KILVHQVPME E
Length:581
Mass (Da):67,968
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i864622AE8BCC32C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41L → I in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti54 – 62LTEMEMDDG → SIEMEDS in AAK83561 (PubMed:11404343).Curated9
Sequence conflicti75T → S in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti90 – 92QTA → ETT in AAK83561 (PubMed:11404343).Curated3
Sequence conflicti105G → D in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti155T → S in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti164Q → R in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti197N → T in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti201 – 203AGH → TGR in AAK83561 (PubMed:11404343).Curated3
Sequence conflicti209 – 211VDQ → LDE in AAK83561 (PubMed:11404343).Curated3
Sequence conflicti238L → I in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti272H → Q in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti289Q → D in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti295K → N in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti302 – 307SWVVMC → FWAVIG in AAK83561 (PubMed:11404343).Curated6
Sequence conflicti325 – 326IL → TV in AAK83561 (PubMed:11404343).Curated2
Sequence conflicti329V → I in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti341 – 343HEI → DEL in AAK83561 (PubMed:11404343).Curated3
Sequence conflicti358 – 359TD → IH in AAK83561 (PubMed:11404343).Curated2
Sequence conflicti375 – 377TVN → IAD in AAK83561 (PubMed:11404343).Curated3
Sequence conflicti381V → F in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti386R → Q in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti393T → A in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti415T → S in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti418I → M in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti429M → L in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti434M → L in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti437L → V in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti446D → G in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti464 – 467LDLL → QELS in AAK83561 (PubMed:11404343).Curated4
Sequence conflicti474A → T in AAK83561 (PubMed:11404343).Curated1
Sequence conflicti551I → L in AAK83561 (PubMed:11404343).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U92266 mRNA Translation: AAC05727.1
AF326513 Genomic DNA Translation: AAK83561.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ag:AAC05727

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92266 mRNA Translation: AAC05727.1
AF326513 Genomic DNA Translation: AAK83561.1

3D structure databases

SMRiO64404
ModBaseiSearch...

Genome annotation databases

KEGGiag:AAC05727

Enzyme and pathway databases

UniPathwayiUPA00924
BRENDAi4.2.3.60, 2
4.2.3.71, 2
4.2.3.76, 2
SABIO-RKiO64404

Family and domain databases

CDDicd00684, Terpene_cyclase_plant_C1, 1 hit
Gene3Di1.10.600.10, 1 hit
1.50.10.130, 1 hit
InterProiView protein in InterPro
IPR008949, Isoprenoid_synthase_dom_sf
IPR034741, Terpene_cyclase-like_1_C
IPR044814, Terpene_cyclase_plant_C1
IPR001906, Terpene_synth_N
IPR036965, Terpene_synth_N_sf
IPR005630, Terpene_synthase_metal-bd
IPR008930, Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF01397, Terpene_synth, 1 hit
PF03936, Terpene_synth_C, 1 hit
SFLDiSFLDG01019, Terpene_Cyclase_Like_1_C_Termi, 1 hit
SUPFAMiSSF48239, SSF48239, 1 hit
SSF48576, SSF48576, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPSD4_ABIGR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O64404
Secondary accession number(s): Q94FW3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: August 1, 1998
Last modified: February 23, 2022
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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