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Entry version 140 (07 Apr 2021)
Sequence version 2 (03 Oct 2006)
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Protein

Zinc finger X-chromosomal protein

Gene

ZFX

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcriptional activator.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri420 – 442C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 537C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri543 – 565C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 594C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri600 – 622C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 651C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri657 – 679C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri685 – 708C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri714 – 736C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri742 – 765C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri771 – 794C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger X-chromosomal protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFX
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000472571 – 800Zinc finger X-chromosomal proteinAdd BLAST800

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei269PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O62836

PRoteomics IDEntifications database

More...
PRIDEi
O62836

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000007730, Expressed in longissimus thoracis muscle and 19 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O62836, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000010165

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O62836

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 442C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 537C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri543 – 565C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 594C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri600 – 622C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 651C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri657 – 679C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri685 – 708C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri714 – 736C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri742 – 765C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri771 – 794C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158684

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021097_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O62836

Identification of Orthologs from Complete Genome Data

More...
OMAi
CKVDGIC

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

TreeFam database of animal gene trees

More...
TreeFami
TF335557

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006794, Transcrp_activ_Zfx/Zfy-dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 7 hits
PF04704, Zfx_Zfy_act, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O62836-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEDGLELQP QEPNSFFDTT GADATHMDGD QIVVEVQETV FVSDVVDSDI
60 70 80 90 100
TVHNFVPDDP DSVVIQDVIE DVVIEDVQCP DIMEEADVSE TVIIPEQVLD
110 120 130 140 150
SDVTEEVSLA HCTVPDDVLA SDITSASMSM PEHVLTSESI HVSDIGHVEH
160 170 180 190 200
VVHDSVVEAE IVTDPLTADV VSEEVLVADC ASEAVIDANG IPVDQQEDDK
210 220 230 240 250
GNCEDYLMIS LDDAGKIEHD GSSGMTMDAE SEIDPCKVDG TCPEVIKVYI
260 270 280 290 300
FKADPGEDDL GGTVDIVESE PENDHGVELL DQNNSIRVPR EKMVYMTVND
310 320 330 340 350
SQQEDEDLNV AEIADEVYME VIVGEEDAAA AAAAAAAHEQ QMDDNEIKTF
360 370 380 390 400
MPIAWAAAYG NNSDGIENRN GTASALLHID ESAGLGRLAK QKPKKRRRPD
410 420 430 440 450
SRQYQTAIII GPDGHPLTVY PCMICGKKFK SRGFLKRHMK NHPEHLTKKK
460 470 480 490 500
YRCTDCDYTT NKKISLHNHL ESHKLTSKAE KAIECDECGK HFSHAGALFT
510 520 530 540 550
HKMVHKEKGA NKMHKCKFCE YETAEQGLLN RHLLAVHSKN FPHICVECGK
560 570 580 590 600
GFRHPSELKK HMRIHTGEKP YQCQYCEYRS ADSSNLKTHV KTKHSKEMPF
610 620 630 640 650
KCDICLLTFS DTKEVQQHAL IHQESKTHQC LHCDHKSSNS SDLKRHIISV
660 670 680 690 700
HTKDYPHKCD MCDKGFHRPS ELKKHVAAHK GKKMHQCRHC DFKIADPFVL
710 720 730 740 750
SRHILSVHTK DLPFRCKRCR KGFRQQNELK KHMKTHSGRK VYQCEYCEYS
760 770 780 790 800
TTDASGFKRH VISIHTKDYP HRCEYCKKGF RRPSEKNQHI MRHHKEVGLP
Length:800
Mass (Da):90,175
Last modified:October 3, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C785B739A0ABE0A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1LN80A0A3Q1LN80_BOVIN
Zinc finger X-chromosomal protein
ZFX
753Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti329 – 339AAAAAAAAAHE → VPLQQPLPPMK in BAA28278 (PubMed:9457673).CuratedAdd BLAST11
Sequence conflicti363S → Y in BAA28278 (PubMed:9457673).Curated1
Sequence conflicti376L → F in BAA28278 (PubMed:9457673).Curated1
Sequence conflicti531R → P in AAL18260 (Ref. 2) Curated1
Sequence conflicti557E → K in AAL18260 (Ref. 2) Curated1
Sequence conflicti582D → N in AAL18260 (Ref. 2) Curated1
Sequence conflicti619 – 620AL → VF in AAL18260 (Ref. 2) Curated2
Sequence conflicti712L → F in AAL18260 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D84097 mRNA Translation: BAA28278.1
AF032866 mRNA Translation: AAL18260.1

NCBI Reference Sequences

More...
RefSeqi
NP_803456.1, NM_177490.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000010165; ENSBTAP00000010165; ENSBTAG00000007730
ENSBTAT00000034353; ENSBTAP00000034250; ENSBTAG00000007730

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
280961

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:280961

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84097 mRNA Translation: BAA28278.1
AF032866 mRNA Translation: AAL18260.1
RefSeqiNP_803456.1, NM_177490.1

3D structure databases

SMRiO62836
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010165

Proteomic databases

PaxDbiO62836
PRIDEiO62836

Genome annotation databases

EnsembliENSBTAT00000010165; ENSBTAP00000010165; ENSBTAG00000007730
ENSBTAT00000034353; ENSBTAP00000034250; ENSBTAG00000007730
GeneIDi280961
KEGGibta:280961

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7543

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000158684
HOGENOMiCLU_021097_0_0_1
InParanoidiO62836
OMAiCKVDGIC
OrthoDBi1318335at2759
TreeFamiTF335557

Gene expression databases

BgeeiENSBTAG00000007730, Expressed in longissimus thoracis muscle and 19 other tissues
ExpressionAtlasiO62836, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR006794, Transcrp_activ_Zfx/Zfy-dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 7 hits
PF04704, Zfx_Zfy_act, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 13 hits
SUPFAMiSSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFX_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O62836
Secondary accession number(s): Q95LI4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2006
Last modified: April 7, 2021
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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