UniProtKB - O62743 (CCR5_CERAT)
C-C chemokine receptor type 5
CCR5
Functioni
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
By similarityGO - Molecular functioni
- C-C chemokine receptor activity Source: UniProtKB
GO - Biological processi
- chemotaxis Source: InterPro
- immune response Source: InterPro
- inflammatory response Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: C-C chemokine receptor type 5Short name: C-C CKR-5 Short name: CC-CKR-5 Short name: CCR-5 Short name: CCR5 Alternative name(s): CD_antigen: CD195 |
Gene namesi | Name:CCR5 Synonyms:CMKBR5 |
Organismi | Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) |
Taxonomic identifieri | 9531 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercocebus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- external side of plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 30 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 31 – 58 | Helical; Name=1Sequence analysisAdd BLAST | 28 | |
Topological domaini | 59 – 68 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 69 – 89 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 90 – 102 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 103 – 124 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 125 – 141 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 142 – 166 | Helical; Name=4Sequence analysisAdd BLAST | 25 | |
Topological domaini | 167 – 198 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 199 – 218 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 219 – 235 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 236 – 260 | Helical; Name=6Sequence analysisAdd BLAST | 25 | |
Topological domaini | 261 – 277 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 278 – 301 | Helical; Name=7Sequence analysisAdd BLAST | 24 | |
Topological domaini | 302 – 352 | CytoplasmicSequence analysisAdd BLAST | 51 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069253 | 1 – 352 | C-C chemokine receptor type 5Add BLAST | 352 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 3 | SulfotyrosineBy similarity | 1 | |
Glycosylationi | 6 | O-linked (GalNAc...) serineBy similarity | 1 | |
Glycosylationi | 7 | O-linked (GalNAc...) serineCurated | 1 | |
Modified residuei | 10 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 14 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 15 | SulfotyrosineSequence analysis | 1 | |
Glycosylationi | 16 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 17 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Disulfide bondi | 20 ↔ 269 | By similarity | ||
Disulfide bondi | 101 ↔ 178 | PROSITE-ProRule annotation | ||
Lipidationi | 321 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 323 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 324 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 336 | Phosphoserine; by BARK1By similarity | 1 | |
Modified residuei | 337 | Phosphoserine; by BARK1By similarity | 1 | |
Modified residuei | 342 | Phosphoserine; by BARK1By similarity | 1 | |
Modified residuei | 349 | Phosphoserine; by BARK1By similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, SulfationInteractioni
Subunit structurei
Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4.
Interacts with GRK2.
Interacts with ARRB1 and ARRB2.
Interacts with CNIH4.
Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis.
By similarityProtein-protein interaction databases
STRINGi | 9531.ENSCATP00000036258 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
InterProi | View protein in InterPro IPR002240, Chemokine_CCR5 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01110, CHEMOKINER5 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MDYQVSSPTY DIDYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNIL
60 70 80 90 100
VVLILINCKR LKSMTDIYLL NLAISDLLFL LTVPFWAHYA AAQWDFGNTM
110 120 130 140 150
CQLLTGLYFI GFFSGIFFII LLTIDRYLAI VHAVFALKAR TVTFGVVTSV
160 170 180 190 200
ITWVVAVFAS LPGIIFTRSQ REGLHYTCSP HFPYSQYQFW KNFQTLKIVI
210 220 230 240 250
LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI MIVYFLFWAP
260 270 280 290 300
YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV
310 320 330 340 350
GEKFRNYLLV FFQKHIAKRF CKCCSIFQQE ASERASSVYT RSTGEQEISV
GL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 2 | D → E in strain: Isolate 087. | 1 | |
Natural varianti | 3 | Y → D in strain: Isolate 079. | 1 | |
Natural varianti | 25 | V → G in strain: Isolate 087. | 1 | |
Natural varianti | 100 | M → K in strain: Isolate 079. | 1 | |
Natural varianti | 107 | L → V in strain: Isolate 089. | 1 | |
Natural varianti | 134 | V → G in strain: Isolate 079. | 1 | |
Natural varianti | 146 | V → L in strain: Isolate 085 and Isolate 089. | 1 | |
Natural varianti | 340 | T → I in strain: Isolate 079. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF051902 Genomic DNA Translation: AAC39830.1 AF051903 Genomic DNA Translation: AAC39831.1 AF051904 Genomic DNA Translation: AAC39832.1 AF051905 Genomic DNA Translation: AAC39833.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF051902 Genomic DNA Translation: AAC39830.1 AF051903 Genomic DNA Translation: AAC39831.1 AF051904 Genomic DNA Translation: AAC39832.1 AF051905 Genomic DNA Translation: AAC39833.1 |
3D structure databases
SMRi | O62743 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9531.ENSCATP00000036258 |
Protein family/group databases
GPCRDBi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR002240, Chemokine_CCR5 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01110, CHEMOKINER5 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCR5_CERAT | |
Accessioni | O62743Primary (citable) accession number: O62743 Secondary accession number(s): O62744, O62745, O62746 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | December 15, 1998 | |
Last modified: | February 23, 2022 | |
This is version 93 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families