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Entry version 104 (25 May 2022)
Sequence version 1 (01 Aug 1998)
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Protein

Sodium/nucleoside cotransporter 1

Gene

SLC28A1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium-dependent and pyrimidine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). Transports uridine, cytidine, thymidine, and nucleoside-derived drugs.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/nucleoside cotransporter 1
Alternative name(s):
Concentrative nucleoside transporter 1
Short name:
CNT 1
Na(+)/nucleoside cotransporter 1
Sodium-coupled nucleoside transporter 1
Solute carrier family 28 member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC28A1
Synonyms:CNT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced
  • UP000008227 Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 79CytoplasmicSequence analysisAdd BLAST79
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei80 – 103HelicalSequence analysisAdd BLAST24
Topological domaini104 – 108ExtracellularSequence analysis5
Transmembranei109 – 127HelicalSequence analysisAdd BLAST19
Topological domaini128 – 146CytoplasmicSequence analysisAdd BLAST19
Transmembranei147 – 166HelicalSequence analysisAdd BLAST20
Topological domaini167 – 177ExtracellularSequence analysisAdd BLAST11
Transmembranei178 – 194HelicalSequence analysisAdd BLAST17
Topological domaini195 – 200CytoplasmicSequence analysis6
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 260ExtracellularSequence analysisAdd BLAST39
Transmembranei261 – 282HelicalSequence analysisAdd BLAST22
Topological domaini283 – 293CytoplasmicSequence analysisAdd BLAST11
Transmembranei294 – 317HelicalSequence analysisAdd BLAST24
Topological domaini318 – 336ExtracellularSequence analysisAdd BLAST19
Transmembranei337 – 359HelicalSequence analysisAdd BLAST23
Topological domaini360 – 365CytoplasmicSequence analysis6
Transmembranei366 – 385HelicalSequence analysisAdd BLAST20
Topological domaini386 – 422ExtracellularSequence analysisAdd BLAST37
Transmembranei423 – 445HelicalSequence analysisAdd BLAST23
Topological domaini446 – 456CytoplasmicSequence analysisAdd BLAST11
Transmembranei457 – 478HelicalSequence analysisAdd BLAST22
Topological domaini479 – 533ExtracellularSequence analysisAdd BLAST55
Transmembranei534 – 557HelicalSequence analysisAdd BLAST24
Topological domaini558 – 568CytoplasmicSequence analysisAdd BLAST11
Transmembranei569 – 591HelicalSequence analysisAdd BLAST23
Topological domaini592 – 647ExtracellularSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000704471 – 647Sodium/nucleoside cotransporter 1Add BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi604N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi642N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O62667

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000002842

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
O62667

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O62667

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni34 – 58DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3747, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O62667

Database of Orthologous Groups

More...
OrthoDBi
471043at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008276, C_nuclsd_transpt
IPR018270, C_nuclsd_transpt_met_bac
IPR030212, CNT1/CNT2
IPR011657, CNT_C_dom
IPR002668, CNT_N_dom
IPR011642, Gate_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10590, PTHR10590, 1 hit
PTHR10590:SF16, PTHR10590:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07670, Gate, 1 hit
PF07662, Nucleos_tra2_C, 1 hit
PF01773, Nucleos_tra2_N, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00804, nupC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O62667-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDNTPRQRD PISLTSVANG LENMGAELLE SLEEGRAPGS DSSPAEVGGG
60 70 80 90 100
WSKAGPEHLG RRSLQPALRV RRFCREHTQL FRWICTGLLC TAFAAFLLIA
110 120 130 140 150
CLLDFQRALA LFVLFCVVLF FLAHSLLKRL LGPKLLRCVK PLRHPCLNLW
160 170 180 190 200
FKRGLALAAF LGLVLWLVLD TAQRPEQLVS FGGICVFILL LFAGSKHHRA
210 220 230 240 250
VSWRAVSWGL GLQFALGLFV IRTEPGFIAF QWLGDQIQIF LSYTEAGSSF
260 270 280 290 300
VFGEALVKDV FAFQVLPIIV FFSCAMSVLY YVGLMQWVIL KISWLMQATM
310 320 330 340 350
GTTATETLSV AGNIFVSQTE APLLIRPYLA DMTLSEIHVV MTGGYATIAG
360 370 380 390 400
SLLGAYISFG IDAASLIAAS VMAAPCALAL SKLVYPEVEE SKFKREEGVK
410 420 430 440 450
LTYGDAQNLL EAASSGAAMS VRVVTNIAAN LIAFLAVLAF INAALSWLGD
460 470 480 490 500
MVDVQGLSFQ LICSYVLRPV AFLMGVAWED CPVVAELLGM KLFLNEFVAY
510 520 530 540 550
QELSGYKQRR LAGAEEWVGS RKQWISVRAE ILTTYALCGF ANFSSIGIML
560 570 580 590 600
GGLTSMVPQR KGDFSQIVLR ALCTGACVSL VNACVAGILY VPRGAEVDCV
610 620 630 640
SFLNTTLSSS SFEVYQCCRQ FFQSTSLEFS PEALDNCCRF YNHTICV
Length:647
Mass (Da):70,823
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB93804706FAFD63
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF009673 mRNA Translation: AAC17947.1

NCBI Reference Sequences

More...
RefSeqi
NP_999277.1, NM_214112.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397200

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:397200

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009673 mRNA Translation: AAC17947.1
RefSeqiNP_999277.1, NM_214112.1

3D structure databases

AlphaFoldDBiO62667
SMRiO62667
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000002842

Proteomic databases

PaxDbiO62667

Genome annotation databases

GeneIDi397200
KEGGissc:397200

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9154

Phylogenomic databases

eggNOGiKOG3747, Eukaryota
InParanoidiO62667
OrthoDBi471043at2759

Family and domain databases

InterProiView protein in InterPro
IPR008276, C_nuclsd_transpt
IPR018270, C_nuclsd_transpt_met_bac
IPR030212, CNT1/CNT2
IPR011657, CNT_C_dom
IPR002668, CNT_N_dom
IPR011642, Gate_dom
PANTHERiPTHR10590, PTHR10590, 1 hit
PTHR10590:SF16, PTHR10590:SF16, 1 hit
PfamiView protein in Pfam
PF07670, Gate, 1 hit
PF07662, Nucleos_tra2_C, 1 hit
PF01773, Nucleos_tra2_N, 1 hit
TIGRFAMsiTIGR00804, nupC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS28A1_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O62667
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: August 1, 1998
Last modified: May 25, 2022
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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