UniProtKB - O62666 (IL16_PANTR)
Pro-interleukin-16
IL16
Functioni
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4 (By similarity).
By similarityPro-interleukin-16 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells (By similarity).
By similarityGO - Molecular functioni
- CD4 receptor binding Source: GO_Central
- cytokine activity Source: GO_Central
GO - Biological processi
- induction of positive chemotaxis Source: GO_Central
- leukocyte chemotaxis Source: GO_Central
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Pro-interleukin-16Cleaved into the following chain: Alternative name(s): Lymphocyte chemoattractant factor Short name: LCF |
Gene namesi | Name:IL16 |
Organismi | Pan troglodytes (Chimpanzee) |
Taxonomic identifieri | 9598 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Nucleus, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000377547 | 1 – 631 | Pro-interleukin-16Add BLAST | 631 | |
ChainiPRO_0000015420 | 511 – 631 | Interleukin-16By similarityAdd BLAST | 121 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 221 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | O62666 |
Interactioni
Subunit structurei
Homotetramer (Probable). Pro-interleukin-16 interacts (via PDZ 2 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Pro-interleukin-16 interacts with GRIN2A. Pro-interleukin-16 interacts with GABPB1. Pro-interleukin-16 interacts (via PDZ 3 domain) with HDAC3 (By similarity).
By similarityCuratedGO - Molecular functioni
- CD4 receptor binding Source: GO_Central
- cytokine activity Source: GO_Central
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000012595 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 411 – 496 | PDZ 1PROSITE-ProRule annotationAdd BLAST | 86 | |
Domaini | 533 – 618 | PDZ 2PROSITE-ProRule annotationAdd BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 31 – 271 | DisorderedSequence analysisAdd BLAST | 241 | |
Regioni | 318 – 340 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 405 – 501 | Interaction with PPP1R12A, PPP1R12B and PPP1R12CBy similarityAdd BLAST | 97 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 35 – 49 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 127 – 166 | Polar residuesSequence analysisAdd BLAST | 40 | |
Compositional biasi | 221 – 235 | Pro residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3528, Eukaryota |
InParanoidi | O62666 |
Family and domain databases
Gene3Di | 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR020450, IL-16 IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 2 hits |
PRINTSi | PR01931, INTRLEUKIN16 |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MDYSFDTTAE DPWVRISDCI KNLFSPIMSE SHGHMPLQPN ASLNEEDGTQ
60 70 80 90 100
GHPDGTPPKL DTANGTPKVY KSADSSTVKK GPPVAPKPAW FRQSLKGLRN
110 120 130 140 150
RASDPRGLPD PALSTQPAPA SREHLGSHIR ASSSSSSIRQ RISSFETFGS
160 170 180 190 200
SQLPDKGAQR LSLQPSSGEA AKPLGKHEEG RFSGLLGRGA APTLVPQQPE
210 220 230 240 250
QVLSSGSPAA SEARDPGVSE SPPPGRQPNQ KTLPPGPDPL LRLLSTQTEE
260 270 280 290 300
SQGPVLKMPS QRARSFPLTR SQSCETKLLD EKTSKLYSIS SQVSSAVMKS
310 320 330 340 350
LLCLPSSISC AQTPCIPKEG ASPTSSSNED SAANGSAETS ALDTGFSLNL
360 370 380 390 400
SELREYTEGL TEAKEDDDGD HSSLQSGQSV ISLLSSEELK KLIEEVKVLD
410 420 430 440 450
EATLKQLDSI HVTILHKEEG AGLGFSLAGG ADLENKVITV HRVFPNGLAS
460 470 480 490 500
QEGTIQKGNE VLSINGKSLK GTTHNDALAI LRQAREPRQA VIVTRKLTPE
510 520 530 540 550
AMPDLNSSTD SAASASAASD VSVESTAEAT VCTVTLEKMS AGLGFSLEGG
560 570 580 590 600
KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLAGTA MQGLTRFEAW
610 620 630
NIIKALPDGP VTIVIRRKSL QSKETTAAGD S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007879 mRNA Translation: AAC16030.1 |
RefSeqi | NP_001009028.1, NM_001009028.1 XP_009427855.1, XM_009429580.2 |
Genome annotation databases
GeneIDi | 449644 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007879 mRNA Translation: AAC16030.1 |
RefSeqi | NP_001009028.1, NM_001009028.1 XP_009427855.1, XM_009429580.2 |
3D structure databases
AlphaFoldDBi | O62666 |
SMRi | O62666 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000012595 |
Proteomic databases
PaxDbi | O62666 |
Genome annotation databases
GeneIDi | 449644 |
Organism-specific databases
CTDi | 3603 |
Phylogenomic databases
eggNOGi | KOG3528, Eukaryota |
InParanoidi | O62666 |
Family and domain databases
Gene3Di | 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR020450, IL-16 IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 2 hits |
PRINTSi | PR01931, INTRLEUKIN16 |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | IL16_PANTR | |
Accessioni | O62666Primary (citable) accession number: O62666 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 7, 2003 |
Last sequence update: | August 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |