Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leukocyte cell-derived chemotaxin-2

Gene

LECT2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a neutrophil chemotactic activity (PubMed:9524238). Also a positive regulator of chondrocyte proliferation (PubMed:10050029, PubMed:8798437).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53ZincBy similarity1
Metal bindingi57ZincBy similarity1
Metal bindingi138ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processChemotaxis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte cell-derived chemotaxin-2
Short name:
LECT-2
Short name:
bLECT2
Alternative name(s):
Chondromodulin II
Short name:
ChM-II
Short name:
bChM-II
Gene namesi
Name:LECT2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:30832 LECT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001736319 – 151Leukocyte cell-derived chemotaxin-2Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 60By similarity
Disulfide bondi36 ↔ 41By similarity
Disulfide bondi99 ↔ 142By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO62644
PRIDEiO62644

Expressioni

Gene expression databases

BgeeiENSBTAG00000001247 Expressed in 4 organ(s), highest expression level in liver

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001648

Structurei

3D structure databases

SMRiO62644
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LECT2/MIM-1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ84 Eukaryota
ENOG410XVAU LUCA
GeneTreeiENSGT00390000015484
HOGENOMiHOG000113312
HOVERGENiHBG052320
InParanoidiO62644
OMAiSHGCGQY
OrthoDBiEOG091G0B4B
TreeFamiTF331097

Family and domain databases

Gene3Di2.70.70.10, 1 hit
InterProiView protein in InterPro
IPR011055 Dup_hybrid_motif
IPR008663 LECT2
IPR017381 LECT2_chordata
IPR016047 Peptidase_M23
PANTHERiPTHR11329 PTHR11329, 1 hit
PfamiView protein in Pfam
PF01551 Peptidase_M23, 1 hit
PIRSFiPIRSF038085 LECT3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O62644-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSTGTLLLA ALISPALAGP WAIICAGKSS NEIRTCDGHG CGQYTAQRNQ
60 70 80 90 100
KLHQGVDVLC SDGSTVYAPF TGKIMGQEKP YKNKNAINNG VRISGGGFCI
110 120 130 140 150
KMFYIKPIKY KGSIKKGEKL GTLLPLQKVY PGIQSHIHIE NCDLSDPTVY

L
Length:151
Mass (Da):16,320
Last modified:August 1, 1998 - v1
Checksum:i2A1DE8FF5B28A3D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001350 mRNA Translation: BAA25302.1
D89011 mRNA Translation: BAB18616.1
BC103166 mRNA Translation: AAI03167.1
PIRiJH0270
RefSeqiNP_776805.1, NM_174380.2
UniGeneiBt.33536

Genome annotation databases

EnsembliENSBTAT00000001648; ENSBTAP00000001648; ENSBTAG00000001247
GeneIDi281899
KEGGibta:281899

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001350 mRNA Translation: BAA25302.1
D89011 mRNA Translation: BAB18616.1
BC103166 mRNA Translation: AAI03167.1
PIRiJH0270
RefSeqiNP_776805.1, NM_174380.2
UniGeneiBt.33536

3D structure databases

SMRiO62644
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001648

Proteomic databases

PaxDbiO62644
PRIDEiO62644

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001648; ENSBTAP00000001648; ENSBTAG00000001247
GeneIDi281899
KEGGibta:281899

Organism-specific databases

CTDi3950
VGNCiVGNC:30832 LECT2

Phylogenomic databases

eggNOGiENOG410IJ84 Eukaryota
ENOG410XVAU LUCA
GeneTreeiENSGT00390000015484
HOGENOMiHOG000113312
HOVERGENiHBG052320
InParanoidiO62644
OMAiSHGCGQY
OrthoDBiEOG091G0B4B
TreeFamiTF331097

Gene expression databases

BgeeiENSBTAG00000001247 Expressed in 4 organ(s), highest expression level in liver

Family and domain databases

Gene3Di2.70.70.10, 1 hit
InterProiView protein in InterPro
IPR011055 Dup_hybrid_motif
IPR008663 LECT2
IPR017381 LECT2_chordata
IPR016047 Peptidase_M23
PANTHERiPTHR11329 PTHR11329, 1 hit
PfamiView protein in Pfam
PF01551 Peptidase_M23, 1 hit
PIRSFiPIRSF038085 LECT3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLECT2_BOVIN
AccessioniPrimary (citable) accession number: O62644
Secondary accession number(s): Q3ZBQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again