Licorne

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: InterPro
• MAP kinase kinase activity Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development."
    Suzanne M., Irie K., Glise B., Agnes F., Mori E., Matsumoto K., Noselli S.
    Genes Dev 13:1464-1474(1999) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of Hippo signalling by p38 signalling."
    Huang D., Li X., Sun L., Huang P., Ying H., Wang H., Wu J., Song H.
    J Mol Cell Biol 8:328-337(2016) [PubMed] [Europe PMC] [Abstract]
  • Ref.2

    "A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression."
    Han Z.S., Enslen H., Hu X., Meng X., Wu I.-H., Barrett T., Davis R.J., Ip Y.T.
    Mol. Cell. Biol. 18:3527-3539(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• mitogen-activated protein kinase kinase kinase binding Source: FlyBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK."
    Inoue H., Tateno M., Fujimura-Kamada K., Takaesu G., Adachi-Yamada T., Ninomiya-Tsuji J., Irie K., Nishida Y., Matsumoto K.
    EMBO J 20:5421-5430(2001) [PubMed] [Europe PMC] [Abstract]
• protein kinase activity Source: FlyBaseInferred from direct assayⁱ
  • "The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development."
    Suzanne M., Irie K., Glise B., Agnes F., Mori E., Matsumoto K., Noselli S.
    Genes Dev 13:1464-1474(1999) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activation of MAPK activity Source: FlyBaseInferred from direct assayⁱ
  • "The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development."
    Suzanne M., Irie K., Glise B., Agnes F., Mori E., Matsumoto K., Noselli S.
    Genes Dev 13:1464-1474(1999) [PubMed] [Europe PMC] [Abstract]
  • Ref.2

    "A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression."
    Han Z.S., Enslen H., Hu X., Meng X., Wu I.-H., Barrett T., Davis R.J., Ip Y.T.
    Mol. Cell. Biol. 18:3527-3539(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• JNK cascade Source: FlyBaseInferred from direct assayⁱ
  • "Lic regulates JNK-mediated cell death in Drosophila."
    Sun Y., Zhang D., Li C., Huang J., Li W., Qiu Y., Mao A., Zhou M., Xue L.
    Cell Prolif 52:e12593-e12593(2019) [PubMed] [Europe PMC] [Abstract]
• MAPK cascade Source: FlyBaseInferred from direct assayⁱ
  • Ref.2

    "A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression."
    Han Z.S., Enslen H., Hu X., Meng X., Wu I.-H., Barrett T., Davis R.J., Ip Y.T.
    Mol. Cell. Biol. 18:3527-3539(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• mucosal immune response Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut."
    Ha E.M., Lee K.A., Seo Y.Y., Kim S.H., Lim J.H., Oh B.H., Kim J., Lee W.J.
    Nat Immunol 10:949-957(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of canonical Wnt signaling pathway Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Systematic screening of a Drosophila ORF library in vivo uncovers Wnt/Wg pathway components."
    Schertel C., Huang D., Bjorklund M., Bischof J., Yin D., Li R., Wu Y., Zeng R., Wu J., Taipale J., Song H., Basler K.
    Dev Cell 25:207-219(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of hippo signaling Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Regulation of Hippo signalling by p38 signalling."
    Huang D., Li X., Sun L., Huang P., Ying H., Wang H., Wu J., Song H.
    J Mol Cell Biol 8:328-337(2016) [PubMed] [Europe PMC] [Abstract]
• oocyte anterior/posterior axis specification Source: FlyBase <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "p38 MAPK signalling cascades: ancient roles and new functions."
    Martin-Blanco E.
    Bioessays 22:637-645(2000) [PubMed] [Europe PMC] [Abstract]
• oocyte axis specification Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development."
    Suzanne M., Irie K., Glise B., Agnes F., Mori E., Matsumoto K., Noselli S.
    Genes Dev 13:1464-1474(1999) [PubMed] [Europe PMC] [Abstract]
• p38MAPK cascade Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine."
    Chakrabarti S., Poidevin M., Lemaitre B.
    PLoS Genet 10:e1004659-e1004659(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell death Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Lic regulates JNK-mediated cell death in Drosophila."
    Sun Y., Zhang D., Li C., Huang J., Li W., Qiu Y., Mao A., Zhou M., Xue L.
    Cell Prolif 52:e12593-e12593(2019) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell size Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1."
    Cully M., Genevet A., Warne P., Treins C., Liu T., Bastien J., Baum B., Tapon N., Leevers S.J., Downward J.
    Mol Cell Biol 30:481-495(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of multicellular organism growth Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1."
    Cully M., Genevet A., Warne P., Treins C., Liu T., Bastien J., Baum B., Tapon N., Leevers S.J., Downward J.
    Mol Cell Biol 30:481-495(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: FlyBaseInferred from genetic interactionⁱ
  • "A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1."
    Cully M., Genevet A., Warne P., Treins C., Liu T., Bastien J., Baum B., Tapon N., Leevers S.J., Downward J.
    Mol Cell Biol 30:481-495(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of adult chitin-containing cuticle pigmentation Source: FlyBaseInferred from genetic interactionⁱ
  • "p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors."
    Sekine Y., Takagahara S., Hatanaka R., Watanabe T., Oguchi H., Noguchi T., Naguro I., Kobayashi K., Tsunoda M., Funatsu T., Nomura H., Toyoda T., Matsuki N., Kuranaga E., Miura M., Takeda K., Ichijo H.
    J Cell Sci 124:3006-3016(2011) [PubMed] [Europe PMC] [Abstract]
• tumor necrosis factor-mediated signaling pathway Source: FlyBaseInferred from genetic interactionⁱ
  • "MKK3 modulates JNK-dependent cell migration and invasion."
    Sun Y., Zhang D., Guo X., Li W., Li C., Luo J., Zhou M., Xue L.
    Cell Death Dis 10:149-149(2019) [PubMed] [Europe PMC] [Abstract]
  • "Lic regulates JNK-mediated cell death in Drosophila."
    Sun Y., Zhang D., Li C., Huang J., Li W., Qiu Y., Mao A., Zhou M., Xue L.
    Cell Prolif 52:e12593-e12593(2019) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• mitogen-activated protein kinase kinase kinase binding Source: FlyBaseInferred from physical interactionⁱ
  • "A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK."
    Inoue H., Tateno M., Fujimura-Kamada K., Takaesu G., Adachi-Yamada T., Ninomiya-Tsuji J., Irie K., Nishida Y., Matsumoto K.
    EMBO J 20:5421-5430(2001) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSKRHRLTPF TIAKEPEAAI VPPRNLDSRA TIQIGDRTFD IDADSLEKIC 
        60         70         80         90        100
DLGRGAYGIV DKMRHKQTDT VLAVKRIPMT VNIREQHRLV MDLDISMRSS 
       110        120        130        140        150
DCPYTVHFYG AMYREGDVWI CMEVMSTSLD KFYPKVFLHD LRMEESVLGK 
       160        170        180        190        200
IAMSVVSALH YLHAQLKVIH RDVKPSNILI NRAGQVKICD FGISGYLVDS 
       210        220        230        240        250
IAKTIDAGCK PYMAPERIDP QGNPAQYDIR SDVWSLGIGM IEMATGRYPY 
       260        270        280        290        300
DNWRTPFEQL RQVVEDSPPR LPEGTFSPEF EDFIAVCLQK EYMARPNYEQ 
       310        320        330 
LLKHSFIVEH LQRNTDISEF VARILDLPDA QPAQ                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ