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Protein

Calcium/calmodulin-dependent protein kinase type II

Gene

unc-43

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. Involved in activation of ADF neurons and increased tph-1 transcription following exposure to pathogenic bacteria which leads to learned olfactory aversion to the bacteria. Implicated in the muscle regulation of spicule protraction. In conjunction with egl-2 has a role in the suppression of mating behavior under food deprivation to encourage foraging. Involved in restricting str-2 expression to only one of the two AWC neurons. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.14 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Activity regulationi

Ca2+/calmodulin binding removes an autoinhibitory regulatory segment located C-terminal to the kinase domain. This releases the catalytic activity of the enzyme and makes accessible a regulatory residue Thr-284. Phosphorylation of Thr-284 by another kinase domain within the oligomeric holoenzyme keeps CaMKII active in the absence of Ca2+/calmodulin by preventing the rebinding of the regulatory segment to the kinase domain and by increasing the affinity of calmodulin for the enzyme. Can respond to high-frequency Ca2+ pulses to become Ca2+ independent.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41ATPPROSITE-ProRule annotation1 Publication1
Active sitei134Proton acceptorCurated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: GO_Central
  • calmodulin-dependent protein kinase activity Source: WormBase
  • identical protein binding Source: IntAct
  • ion channel binding Source: WormBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological processStress response
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.17 1045
SignaLinkiO62305

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type II1 Publication (EC:2.7.11.17)
Short name:
CaM kinase II1 Publication
Alternative name(s):
Uncoordinated protein 43
Gene namesi
Name:unc-43
ORF Names:K11E8.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK11E8.1a ; CE42693 ; WBGene00006779 ; unc-43
K11E8.1b ; CE28052 ; WBGene00006779 ; unc-43
K11E8.1d ; CE28054 ; WBGene00006779 ; unc-43
K11E8.1e ; CE28055 ; WBGene00006779 ; unc-43
K11E8.1f ; CE28056 ; WBGene00006779 ; unc-43
K11E8.1g ; CE28057 ; WBGene00006779 ; unc-43
K11E8.1h ; CE28058 ; WBGene00006779 ; unc-43
K11E8.1i ; CE28059 ; WBGene00006779 ; unc-43
K11E8.1k ; CE28060 ; WBGene00006779 ; unc-43
K11E8.1l ; CE28061 ; WBGene00006779 ; unc-43
K11E8.1m ; CE35590 ; WBGene00006779 ; unc-43
K11E8.1n ; CE40979 ; WBGene00006779 ; unc-43
K11E8.1o ; CE41430 ; WBGene00006779 ; unc-43
K11E8.1p ; CE42670 ; WBGene00006779 ; unc-43

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Increased frequency of defecation, typified by a weaker repetition of the defecation motor program, an echo, 10 s after the primary motor program. Abnormal spicule protraction. Lack of tph-1 transcriptional up-regulation during learned olfactory aversion to bacteria. Reduced brood size, body length and width. Lethargic movement. A gain-of function mutation reduces locomotory activity, alters excitation of three muscle types and lengthens the period of the motor output of a behavioral clock. Both classes of mutation inhibit neurotransmitter release.6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi41K → M: Loss of kinase activity. 1 Publication1
Mutagenesisi97F → E: Loss of cooperative activation of adjacent holoenzyme subunits. 2 Publications1
Mutagenesisi97F → K: Increase in calcium independent kinase activity, no effect on translocation to the neurite. 2 Publications1
Mutagenesisi100I → K: Loss of cooperative activation of adjacent holoenzyme subunits. 1 Publication1
Mutagenesisi108E → K in n498gf; slight increase in calcium independent kinase activity, no effect on translocation to the neurite. Nuclear translocation of daf-16 resulting in lifespan extension. 3 Publications1
Mutagenesisi134D → N: Loss of autoinhibition and increase in binding of Ca2+/calmodulin. 2 Publications1
Mutagenesisi147K → E: Slight increase in calcium independent kinase activity, no effect on translocation to the neurite. 1 Publication1
Mutagenesisi170G → E in sy574; abnormal spicule protraction; when associated with V-665. 1 Publication1
Mutagenesisi179S → L in e408; males display locomotor and muscle seizure defects and egg laying defects. 1 Publication1
Mutagenesisi200I → K: Loss of cooperative activation of adjacent holoenzyme subunits. 1 Publication1
Mutagenesisi236D → R: Increase in calcium independent kinase activity, loss of translocation to neurites and glr-1 trafficking. 1 Publication1
Mutagenesisi278 – 279AI → DD: Decrease in binding of Ca2+/calmodulin. 1 Publication2
Mutagenesisi280H → K: Increase in calcium independent kinase activity, no effect on translocation to the neurite. 1 Publication1
Mutagenesisi281R → E: Increase in calcium independent kinase activity and translocation to an unlocalized pool in the neurite. Small decrease in glr-1 trafficking. 1 Publication1
Mutagenesisi284T → D: Constitutively activate kinase activity, increase in translocation to the neurites. 1 Publication1
Mutagenesisi665A → V in sy574; abnormal spicule protraction; when associated with E-170. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003966451 – 720Calcium/calmodulin-dependent protein kinase type IIAdd BLAST720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284Phosphothreonine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO62305
PeptideAtlasiO62305
PRIDEiO62305

PTM databases

iPTMnetiO62305

Expressioni

Tissue specificityi

Expressed in the nervous system. Observed in the ADF and AWC neurons. Position in AWC neurons is regulated by microtubules. Localized to clusters in ventral cord neurites which appear to be required for glr-1 trafficking. Also present in oocytes.4 Publications

Interactioni

Subunit structurei

Dodecamer. Subunits are tightly packed around a central ring-shaped scaffold with extensive contacts between the regulatory segment of one kinase and the catalytic domain of another enabling cooperative activation of a subunit by the adjacent molecule (PubMed:16441656, PubMed:20139983). Interacts with and phosphorylates daf-16; the interaction promotes daf-16 nuclear localization. Interacts with egl-2 and tir-1 (PubMed:15625192, PubMed:21145946). Interacts with nsy-1 (PubMed:11336672).5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi43023, 8 interactors
DIPiDIP-25971N
DIP-58986N
IntActiO62305, 10 interactors
MINTiO62305

Structurei

Secondary structure

1720
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO62305
SMRiO62305
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO62305

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 269Protein kinasePROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000118944
InParanoidiO62305
PhylomeDBiO62305

Family and domain databases

InterProiView protein in InterPro
IPR013543 Ca/CaM-dep_prot_kinase-assoc
IPR039071 CAMK2
IPR011009 Kinase-like_dom_sf
IPR032710 NTF2-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR43940 PTHR43940, 1 hit
PfamiView protein in Pfam
PF08332 CaMKII_AD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (15+)i

Sequence statusi: Complete.

This entry describes 15 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 15 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform c1 Publication (identifier: O62305-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMNASTKFSD NYDVKEELGK GAFSVVRRCV HKTTGLEFAA KIINTKKLSA
60 70 80 90 100
RDFQKLEREA RICRKLQHPN IVRLHDSIQE ESFHYLVFDL VTGGELFEDI
110 120 130 140 150
VAREFYSEAD ASHCIQQILE SIAYCHSNGI VHRDLKPENL LLASKAKGAA
160 170 180 190 200
VKLADFGLAI EVNDSEAWHG FAGTPGYLSP EVLKKDPYSK PVDIWACGVI
210 220 230 240 250
LYILLVGYPP FWDEDQHRLY AQIKAGAYDY PSPEWDTVTP EAKSLIDSML
260 270 280 290 300
TVNPKKRITA DQALKVPWIC NRERVASAIH RQDTVDCLKK FNARRKLKAA
310 320 330 340 350
ISAVKMVTRM SGVLRTSDST GSVASNGSTT HDASQVAGTS SQPTSPAAEV
360 370 380 390 400
YPNVLLFNPQ KFPRNCVHPF TTHPYYSPKE SSKKKLFFTL LFEVCPHTSR
410 420 430 440 450
SHILLRDNTK NIYHPYHCFT NKMSNYERAA PSSHGSSTTK KIANAIADLV
460 470 480 490 500
IRRSSPSIRR KTEADVHNSN RNRKVSAPAN LQHALVPVID VVVATGALAS
510 520 530 540 550
SSVDNLSAST SSDLGRNLLN KKEQGPPSTI KESSESSQTI DDNDSEKGGG
560 570 580 590 600
QLKHENTVVR ADGATGIVSS SNSSTASKSS STNLSAQKQD IVRVTQTLLD
610 620 630 640 650
AISCKDFETY TRLCDTSMTC FEPEALGNLI EGIEFHRFYF DGNRKNQVHT
660 670 680 690 700
TMLNPNVHII GEDAACVAYV KLTQFLDRNG EAHTRQSQES RVWSKKQGRW
710 720
VCVHVHRSTQ PSTNTTVSEF
Note: No experimental confirmation available.Curated
Length:720
Mass (Da):79,927
Last modified:October 1, 2001 - v2
Checksum:i3231366FFF81A695
GO
Isoform a1 Publication (identifier: O62305-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-490: Missing.
     491-515: VVVATGALASSSVDNLSASTSSDLG → MKNIEYWQVLLNKIFATYKIKMKQC

Note: No experimental confirmation available.Curated
Show »
Length:230
Mass (Da):25,873
Checksum:i2EAD0E576BA0619A
GO
Isoform b1 Publication (identifier: O62305-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-138: HCIQQILESIAYCHSNGIVHRDLKPE → CCIMQILDGVNYCHQRGIVHRDMKV
     139-720: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:137
Mass (Da):15,801
Checksum:iDDF4E2AD6FC2A6F4
GO
Isoform d2 Publications (identifier: O62305-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-314: AAISAVKMVTRMSGVL → GAILTTMIATRNLSNL
     315-514: Missing.
     548-585: Missing.

Show »
Length:482
Mass (Da):54,589
Checksum:i3870201C3162C253
GO
Isoform e2 Publications (identifier: O62305-5) [UniParc]FASTAAdd to basket
Also known as: C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     350-364: VYPNVLLFNPQKFPR → GAILTTMIATRNLSN
     365-513: Missing.
     548-585: Missing.

Show »
Length:533
Mass (Da):59,537
Checksum:i0D8EF2D999E0B8AA
GO
Isoform f2 Publications (identifier: O62305-6) [UniParc]FASTAAdd to basket
Also known as: E1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-313: AAISAVKMVTRMSGV → GAILTTMIATRNLSS
     314-515: Missing.

Show »
Length:518
Mass (Da):58,067
Checksum:i14DA5EB06D2DAFF3
GO
Isoform g2 Publications (identifier: O62305-7) [UniParc]FASTAAdd to basket
Also known as: B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-314: AAISAVKMVTRMSGVL → GAILTTMIATRNLSNL
     315-514: Missing.

Show »
Length:520
Mass (Da):58,264
Checksum:i7D20BF318483E085
GO
Isoform h2 Publications (identifier: O62305-8) [UniParc]FASTAAdd to basket
Also known as: D1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     350-364: VYPNVLLFNPQKFPR → GAILTTMIATRNLSN
     365-513: Missing.

Show »
Length:571
Mass (Da):63,212
Checksum:i20C754B5BFE86D01
GO
Isoform i2 Publications (identifier: O62305-9) [UniParc]FASTAAdd to basket
Also known as: H1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-314: AAISAVKMVTRMSGVL → GAILTTMIATRNLSNL
     315-514: Missing.
     549-550: GG → NE
     551-720: Missing.

Show »
Length:350
Mass (Da):39,384
Checksum:iE300DB75FE74E9BC
GO
Isoform k2 Publications (identifier: O62305-10) [UniParc]FASTAAdd to basket
Also known as: F1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-302: AAIS → VVDS
     303-720: Missing.

Show »
Length:302
Mass (Da):34,198
Checksum:i5BCA124A7458DD9F
GO
Isoform l2 Publications (identifier: O62305-11) [UniParc]FASTAAdd to basket
Also known as: G1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-302: AAIS → VAIC
     303-720: Missing.

Show »
Length:302
Mass (Da):34,184
Checksum:i40C0FD5A7458DD9F
GO
Isoform m1 Publication (identifier: O62305-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-414: Missing.
     415-512: PYHCFTNKMS...VDNLSASTSS → MDGLLARLKL...KPEKLEVEAD

Note: No experimental confirmation available.Curated
Show »
Length:309
Mass (Da):34,103
Checksum:i13A93D058438BA8A
GO
Isoform n1 Publication (identifier: O62305-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-505: Missing.
     506-515: LSASTSSDLG → MNFLRFSGKC

Note: No experimental confirmation available.Curated
Show »
Length:215
Mass (Da):23,941
Checksum:i392E9298ABF7375D
GO
Isoform o1 Publication (identifier: O62305-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-416: Missing.
     417-514: HCFTNKMSNY...NLSASTSSDL → MDGLLARLKL...KPEKLEVEAD
     548-585: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:269
Mass (Da):30,200
Checksum:iD1B879B53DE0A973
GO
Isoform p1 Publication (identifier: O62305-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-504: Missing.
     505-513: NLSASTSSD → MIATRNLSN

Note: No experimental confirmation available.Curated
Show »
Length:216
Mass (Da):23,927
Checksum:i592578E5DE7DC6B4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EDZ5G5EDZ5_CAEEL
Calcium/calmodulin-dependent protei...
unc-43 CELE_K11E8.1, K11E8.1
681Annotation score:
E7EM33E7EM33_CAEEL
Calcium/calmodulin-dependent protei...
unc-43 CELE_K11E8.1, K11E8.1
103Annotation score:
F5GUA8F5GUA8_CAEEL
Calcium/calmodulin-dependent protei...
unc-43 CELE_K11E8.1, K11E8.1
266Annotation score:
F5GUA9F5GUA9_CAEEL
Calcium/calmodulin-dependent protei...
unc-43 CELE_K11E8.1, K11E8.1
298Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0395901 – 505Missing in isoform n. 1 PublicationAdd BLAST505
Alternative sequenceiVSP_0395911 – 504Missing in isoform p. 1 PublicationAdd BLAST504
Alternative sequenceiVSP_0395921 – 490Missing in isoform a. 1 PublicationAdd BLAST490
Alternative sequenceiVSP_0395931 – 416Missing in isoform o. 1 PublicationAdd BLAST416
Alternative sequenceiVSP_0395941 – 414Missing in isoform m. 1 PublicationAdd BLAST414
Alternative sequenceiVSP_039595113 – 138HCIQQ…DLKPE → CCIMQILDGVNYCHQRGIVH RDMKV in isoform b. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_039596139 – 720Missing in isoform b. 1 PublicationAdd BLAST582
Alternative sequenceiVSP_039597299 – 314AAISA…MSGVL → GAILTTMIATRNLSNL in isoform d, isoform g and isoform i. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_039598299 – 313AAISA…RMSGV → GAILTTMIATRNLSS in isoform f. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_039599299 – 302AAIS → VVDS in isoform k. 2 Publications4
Alternative sequenceiVSP_039600299 – 302AAIS → VAIC in isoform l. 2 Publications4
Alternative sequenceiVSP_039601303 – 720Missing in isoform k and isoform l. 2 PublicationsAdd BLAST418
Alternative sequenceiVSP_039602314 – 515Missing in isoform f. 2 PublicationsAdd BLAST202
Alternative sequenceiVSP_039603315 – 514Missing in isoform d, isoform g and isoform i. 3 PublicationsAdd BLAST200
Alternative sequenceiVSP_039604350 – 364VYPNV…QKFPR → GAILTTMIATRNLSN in isoform e and isoform h. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_039605365 – 513Missing in isoform e and isoform h. 3 PublicationsAdd BLAST149
Alternative sequenceiVSP_039606415 – 512PYHCF…ASTSS → MDGLLARLKLGSKRKKKTSS SVKRSSRPESARQAPRDTTG SLYSNLTASSSTVSACSAPE IVVLKKEQVVLAVDHKDQVD EQKKKNEQVVKKPEKLEVEA D in isoform m. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_039607417 – 514HCFTN…TSSDL → MDGLLARLKLGSKRKKKTSS SVKRSSRPESARQAPRDTTG SLYSNLTASSSTVSACSAPE IVVLKKEQVVLAVDHKDQVD EQKKKNEQVVKKPEKLEVEA D in isoform o. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_039608491 – 515VVVAT…SSDLG → MKNIEYWQVLLNKIFATYKI KMKQC in isoform a. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_039609505 – 513NLSASTSSD → MIATRNLSN in isoform p. 1 Publication9
Alternative sequenceiVSP_039610506 – 515LSASTSSDLG → MNFLRFSGKC in isoform n. 1 Publication10
Alternative sequenceiVSP_039611548 – 585Missing in isoform d, isoform e and isoform o. 3 PublicationsAdd BLAST38
Alternative sequenceiVSP_039612549 – 550GG → NE in isoform i. 2 Publications2
Alternative sequenceiVSP_039613551 – 720Missing in isoform i. 2 PublicationsAdd BLAST170

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180735 mRNA Translation: AAD53949.1
AF233262 mRNA Translation: AAF63320.1
AF233263 mRNA Translation: AAF63321.1
AF233264 mRNA Translation: AAF63322.1
AF233265 mRNA Translation: AAF63323.1
AF233266 mRNA Translation: AAF63324.1
AF233267 mRNA Translation: AAF63325.1
AF255956 mRNA Translation: AAF71543.1
Z70279 Genomic DNA Translation: CAA94242.3
Z70279, AL023841 Genomic DNA Translation: CAA94243.3
Z70279, AL023841 Genomic DNA Translation: CAC42322.1
Z70279, AL023841 Genomic DNA Translation: CAC42323.1
Z70279, AL023841 Genomic DNA Translation: CAC42324.1
Z70279, AL023841 Genomic DNA Translation: CAC42325.1
Z70279, AL023841 Genomic DNA Translation: CAC42326.1
Z70279, AL023841 Genomic DNA Translation: CAC42327.1
Z70279, AL023841 Genomic DNA Translation: CAC42328.1
Z70279, AL023841 Genomic DNA Translation: CAC42329.1
Z70279 Genomic DNA Translation: CAE46679.1
Z70279 Genomic DNA Translation: CAN86910.1
Z70279 Genomic DNA Translation: CAO82047.1
Z70279 Genomic DNA Translation: CAQ58116.1
PIRiB88809
T23616
RefSeqiNP_001023293.2, NM_001028122.4 [O62305-2]
NP_001023294.1, NM_001028123.3 [O62305-3]
NP_001023296.1, NM_001028125.3 [O62305-4]
NP_001023297.1, NM_001028126.3 [O62305-5]
NP_001023298.1, NM_001028127.3 [O62305-6]
NP_001023299.1, NM_001028128.3 [O62305-7]
NP_001023300.1, NM_001028129.3 [O62305-8]
NP_001023301.1, NM_001028130.3 [O62305-9]
NP_001023302.1, NM_001028131.3 [O62305-10]
NP_001023303.1, NM_001028132.3 [O62305-11]
NP_001023304.1, NM_001028133.4 [O62305-12]
NP_001122788.1, NM_001129316.2 [O62305-13]
NP_001122789.1, NM_001129317.2 [O62305-14]
NP_001129863.1, NM_001136391.2 [O62305-15]
UniGeneiCel.22903

Genome annotation databases

EnsemblMetazoaiK11E8.1a; K11E8.1a; WBGene00006779 [O62305-2]
K11E8.1b.1; K11E8.1b.1; WBGene00006779 [O62305-3]
K11E8.1b.2; K11E8.1b.2; WBGene00006779 [O62305-3]
K11E8.1b.3; K11E8.1b.3; WBGene00006779 [O62305-3]
K11E8.1d.1; K11E8.1d.1; WBGene00006779 [O62305-4]
K11E8.1d.2; K11E8.1d.2; WBGene00006779 [O62305-4]
K11E8.1d.3; K11E8.1d.3; WBGene00006779 [O62305-4]
K11E8.1e.1; K11E8.1e.1; WBGene00006779 [O62305-5]
K11E8.1e.2; K11E8.1e.2; WBGene00006779 [O62305-5]
K11E8.1e.3; K11E8.1e.3; WBGene00006779 [O62305-5]
K11E8.1f.1; K11E8.1f.1; WBGene00006779 [O62305-6]
K11E8.1f.2; K11E8.1f.2; WBGene00006779 [O62305-6]
K11E8.1f.3; K11E8.1f.3; WBGene00006779 [O62305-6]
K11E8.1g.1; K11E8.1g.1; WBGene00006779 [O62305-7]
K11E8.1g.2; K11E8.1g.2; WBGene00006779 [O62305-7]
K11E8.1g.3; K11E8.1g.3; WBGene00006779 [O62305-7]
K11E8.1h.1; K11E8.1h.1; WBGene00006779 [O62305-8]
K11E8.1h.2; K11E8.1h.2; WBGene00006779 [O62305-8]
K11E8.1h.3; K11E8.1h.3; WBGene00006779 [O62305-8]
K11E8.1i.1; K11E8.1i.1; WBGene00006779 [O62305-9]
K11E8.1i.2; K11E8.1i.2; WBGene00006779 [O62305-9]
K11E8.1i.3; K11E8.1i.3; WBGene00006779 [O62305-9]
K11E8.1k.1; K11E8.1k.1; WBGene00006779 [O62305-10]
K11E8.1k.2; K11E8.1k.2; WBGene00006779 [O62305-10]
K11E8.1k.3; K11E8.1k.3; WBGene00006779 [O62305-10]
K11E8.1l.1; K11E8.1l.1; WBGene00006779 [O62305-11]
K11E8.1l.2; K11E8.1l.2; WBGene00006779 [O62305-11]
K11E8.1l.3; K11E8.1l.3; WBGene00006779 [O62305-11]
K11E8.1m; K11E8.1m; WBGene00006779 [O62305-12]
K11E8.1n; K11E8.1n; WBGene00006779 [O62305-13]
K11E8.1o; K11E8.1o; WBGene00006779 [O62305-14]
K11E8.1p; K11E8.1p; WBGene00006779 [O62305-15]
GeneIDi177921
UCSCiK11E8.1a.1 c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180735 mRNA Translation: AAD53949.1
AF233262 mRNA Translation: AAF63320.1
AF233263 mRNA Translation: AAF63321.1
AF233264 mRNA Translation: AAF63322.1
AF233265 mRNA Translation: AAF63323.1
AF233266 mRNA Translation: AAF63324.1
AF233267 mRNA Translation: AAF63325.1
AF255956 mRNA Translation: AAF71543.1
Z70279 Genomic DNA Translation: CAA94242.3
Z70279, AL023841 Genomic DNA Translation: CAA94243.3
Z70279, AL023841 Genomic DNA Translation: CAC42322.1
Z70279, AL023841 Genomic DNA Translation: CAC42323.1
Z70279, AL023841 Genomic DNA Translation: CAC42324.1
Z70279, AL023841 Genomic DNA Translation: CAC42325.1
Z70279, AL023841 Genomic DNA Translation: CAC42326.1
Z70279, AL023841 Genomic DNA Translation: CAC42327.1
Z70279, AL023841 Genomic DNA Translation: CAC42328.1
Z70279, AL023841 Genomic DNA Translation: CAC42329.1
Z70279 Genomic DNA Translation: CAE46679.1
Z70279 Genomic DNA Translation: CAN86910.1
Z70279 Genomic DNA Translation: CAO82047.1
Z70279 Genomic DNA Translation: CAQ58116.1
PIRiB88809
T23616
RefSeqiNP_001023293.2, NM_001028122.4 [O62305-2]
NP_001023294.1, NM_001028123.3 [O62305-3]
NP_001023296.1, NM_001028125.3 [O62305-4]
NP_001023297.1, NM_001028126.3 [O62305-5]
NP_001023298.1, NM_001028127.3 [O62305-6]
NP_001023299.1, NM_001028128.3 [O62305-7]
NP_001023300.1, NM_001028129.3 [O62305-8]
NP_001023301.1, NM_001028130.3 [O62305-9]
NP_001023302.1, NM_001028131.3 [O62305-10]
NP_001023303.1, NM_001028132.3 [O62305-11]
NP_001023304.1, NM_001028133.4 [O62305-12]
NP_001122788.1, NM_001129316.2 [O62305-13]
NP_001122789.1, NM_001129317.2 [O62305-14]
NP_001129863.1, NM_001136391.2 [O62305-15]
UniGeneiCel.22903

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BDWX-ray1.80A/B1-543[»]
2F86X-ray2.64B/D/F/H/J/L/N540-720[»]
3KK8X-ray1.72A5-288[»]
3KK9X-ray3.21A6-287[»]
3KL8X-ray3.37A/C/E/G/I5-273[»]
ProteinModelPortaliO62305
SMRiO62305
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43023, 8 interactors
DIPiDIP-25971N
DIP-58986N
IntActiO62305, 10 interactors
MINTiO62305

PTM databases

iPTMnetiO62305

Proteomic databases

EPDiO62305
PeptideAtlasiO62305
PRIDEiO62305

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK11E8.1a; K11E8.1a; WBGene00006779 [O62305-2]
K11E8.1b.1; K11E8.1b.1; WBGene00006779 [O62305-3]
K11E8.1b.2; K11E8.1b.2; WBGene00006779 [O62305-3]
K11E8.1b.3; K11E8.1b.3; WBGene00006779 [O62305-3]
K11E8.1d.1; K11E8.1d.1; WBGene00006779 [O62305-4]
K11E8.1d.2; K11E8.1d.2; WBGene00006779 [O62305-4]
K11E8.1d.3; K11E8.1d.3; WBGene00006779 [O62305-4]
K11E8.1e.1; K11E8.1e.1; WBGene00006779 [O62305-5]
K11E8.1e.2; K11E8.1e.2; WBGene00006779 [O62305-5]
K11E8.1e.3; K11E8.1e.3; WBGene00006779 [O62305-5]
K11E8.1f.1; K11E8.1f.1; WBGene00006779 [O62305-6]
K11E8.1f.2; K11E8.1f.2; WBGene00006779 [O62305-6]
K11E8.1f.3; K11E8.1f.3; WBGene00006779 [O62305-6]
K11E8.1g.1; K11E8.1g.1; WBGene00006779 [O62305-7]
K11E8.1g.2; K11E8.1g.2; WBGene00006779 [O62305-7]
K11E8.1g.3; K11E8.1g.3; WBGene00006779 [O62305-7]
K11E8.1h.1; K11E8.1h.1; WBGene00006779 [O62305-8]
K11E8.1h.2; K11E8.1h.2; WBGene00006779 [O62305-8]
K11E8.1h.3; K11E8.1h.3; WBGene00006779 [O62305-8]
K11E8.1i.1; K11E8.1i.1; WBGene00006779 [O62305-9]
K11E8.1i.2; K11E8.1i.2; WBGene00006779 [O62305-9]
K11E8.1i.3; K11E8.1i.3; WBGene00006779 [O62305-9]
K11E8.1k.1; K11E8.1k.1; WBGene00006779 [O62305-10]
K11E8.1k.2; K11E8.1k.2; WBGene00006779 [O62305-10]
K11E8.1k.3; K11E8.1k.3; WBGene00006779 [O62305-10]
K11E8.1l.1; K11E8.1l.1; WBGene00006779 [O62305-11]
K11E8.1l.2; K11E8.1l.2; WBGene00006779 [O62305-11]
K11E8.1l.3; K11E8.1l.3; WBGene00006779 [O62305-11]
K11E8.1m; K11E8.1m; WBGene00006779 [O62305-12]
K11E8.1n; K11E8.1n; WBGene00006779 [O62305-13]
K11E8.1o; K11E8.1o; WBGene00006779 [O62305-14]
K11E8.1p; K11E8.1p; WBGene00006779 [O62305-15]
GeneIDi177921
UCSCiK11E8.1a.1 c. elegans

Organism-specific databases

CTDi177921
WormBaseiK11E8.1a ; CE42693 ; WBGene00006779 ; unc-43
K11E8.1b ; CE28052 ; WBGene00006779 ; unc-43
K11E8.1d ; CE28054 ; WBGene00006779 ; unc-43
K11E8.1e ; CE28055 ; WBGene00006779 ; unc-43
K11E8.1f ; CE28056 ; WBGene00006779 ; unc-43
K11E8.1g ; CE28057 ; WBGene00006779 ; unc-43
K11E8.1h ; CE28058 ; WBGene00006779 ; unc-43
K11E8.1i ; CE28059 ; WBGene00006779 ; unc-43
K11E8.1k ; CE28060 ; WBGene00006779 ; unc-43
K11E8.1l ; CE28061 ; WBGene00006779 ; unc-43
K11E8.1m ; CE35590 ; WBGene00006779 ; unc-43
K11E8.1n ; CE40979 ; WBGene00006779 ; unc-43
K11E8.1o ; CE41430 ; WBGene00006779 ; unc-43
K11E8.1p ; CE42670 ; WBGene00006779 ; unc-43

Phylogenomic databases

GeneTreeiENSGT00760000118944
InParanoidiO62305
PhylomeDBiO62305

Enzyme and pathway databases

BRENDAi2.7.11.17 1045
SignaLinkiO62305

Miscellaneous databases

EvolutionaryTraceiO62305
PROiPR:O62305

Family and domain databases

InterProiView protein in InterPro
IPR013543 Ca/CaM-dep_prot_kinase-assoc
IPR039071 CAMK2
IPR011009 Kinase-like_dom_sf
IPR032710 NTF2-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR43940 PTHR43940, 1 hit
PfamiView protein in Pfam
PF08332 CaMKII_AD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCC2D_CAEEL
AccessioniPrimary (citable) accession number: O62305
Secondary accession number(s): A5JYT0
, A7LPH2, B3GWC8, O62304, Q21431, Q7JLT8, Q9NG91, Q9NH55, Q9NH56, Q9NH57, Q9NH58, Q9NH59, Q9NH60, Q9U6Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2001
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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