Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O62305 (KCC2D_CAEEL)

Entry version 176 (07 Apr 2021)
Sequence version 2 (01 Oct 2001)
Previous versions | rss
Add a publicationFeedback
Protein

Calcium/calmodulin-dependent protein kinase type II

Gene

unc-43

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. Involved in activation of ADF neurons and increased tph-1 transcription following exposure to pathogenic bacteria which leads to learned olfactory aversion to the bacteria. Implicated in the muscle regulation of spicule protraction. In conjunction with egl-2 has a role in the suppression of mating behavior under food deprivation to encourage foraging. Involved in restricting str-2 expression to only one of the two AWC neurons. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.14 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Ca2+/calmodulin binding removes an autoinhibitory regulatory segment located C-terminal to the kinase domain. This releases the catalytic activity of the enzyme and makes accessible a regulatory residue Thr-284. Phosphorylation of Thr-284 by another kinase domain within the oligomeric holoenzyme keeps CaMKII active in the absence of Ca2+/calmodulin by preventing the rebinding of the regulatory segment to the kinase domain and by increasing the affinity of calmodulin for the enzyme. Can respond to high-frequency Ca2+ pulses to become Ca2+ independent.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei41ATPPROSITE-ProRule annotation1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei134Proton acceptorCurated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological processStress response
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.17, 1045

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CEL-3371571, HSF1-dependent transactivation
R-CEL-4086398, Ca2+ pathway
R-CEL-438066, Unblocking of NMDA receptors, glutamate binding and activation
R-CEL-5578775, Ion homeostasis
R-CEL-936837, Ion transport by P-type ATPases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O62305

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type II1 Publication (EC:2.7.11.17)
Short name:
CaM kinase II1 Publication
Alternative name(s):
Uncoordinated protein 43
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-43
ORF Names:K11E8.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...WormBasei		K11E8.1a ; CE42693 ; WBGene00006779 ; unc-43
K11E8.1b ; CE28052 ; WBGene00006779 ; unc-43
K11E8.1d ; CE28054 ; WBGene00006779 ; unc-43
K11E8.1e ; CE28055 ; WBGene00006779 ; unc-43
K11E8.1f ; CE28056 ; WBGene00006779 ; unc-43
K11E8.1g ; CE28057 ; WBGene00006779 ; unc-43
K11E8.1h ; CE28058 ; WBGene00006779 ; unc-43
K11E8.1i ; CE28059 ; WBGene00006779 ; unc-43
K11E8.1k ; CE28060 ; WBGene00006779 ; unc-43
K11E8.1l ; CE28061 ; WBGene00006779 ; unc-43
K11E8.1m ; CE35590 ; WBGene00006779 ; unc-43
K11E8.1n ; CE40979 ; WBGene00006779 ; unc-43
K11E8.1o ; CE41430 ; WBGene00006779 ; unc-43
K11E8.1p ; CE42670 ; WBGene00006779 ; unc-43

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Increased frequency of defecation, typified by a weaker repetition of the defecation motor program, an echo, 10 s after the primary motor program. Abnormal spicule protraction. Lack of tph-1 transcriptional up-regulation during learned olfactory aversion to bacteria. Reduced brood size, body length and width. Lethargic movement. A gain-of function mutation reduces locomotory activity, alters excitation of three muscle types and lengthens the period of the motor output of a behavioral clock. Both classes of mutation inhibit neurotransmitter release.6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi41K → M: Loss of kinase activity. 1 Publication1
Mutagenesisi97F → E: Loss of cooperative activation of adjacent holoenzyme subunits. 2 Publications1
Mutagenesisi97F → K: Increase in calcium independent kinase activity, no effect on translocation to the neurite. 2 Publications1
Mutagenesisi100I → K: Loss of cooperative activation of adjacent holoenzyme subunits. 1 Publication1
Mutagenesisi108E → K in n498gf; slight increase in calcium independent kinase activity, no effect on translocation to the neurite. Nuclear translocation of daf-16 resulting in lifespan extension. 3 Publications1
Mutagenesisi134D → N: Loss of autoinhibition and increase in binding of Ca2+/calmodulin. 2 Publications1
Mutagenesisi147K → E: Slight increase in calcium independent kinase activity, no effect on translocation to the neurite. 1 Publication1
Mutagenesisi170G → E in sy574; abnormal spicule protraction; when associated with V-665. 1 Publication1
Mutagenesisi179S → L in e408; males display locomotor and muscle seizure defects and egg laying defects. 1 Publication1
Mutagenesisi200I → K: Loss of cooperative activation of adjacent holoenzyme subunits. 1 Publication1
Mutagenesisi236D → R: Increase in calcium independent kinase activity, loss of translocation to neurites and glr-1 trafficking. 1 Publication1
Mutagenesisi278 – 279AI → DD: Decrease in binding of Ca2+/calmodulin. 1 Publication2
Mutagenesisi280H → K: Increase in calcium independent kinase activity, no effect on translocation to the neurite. 1 Publication1
Mutagenesisi281R → E: Increase in calcium independent kinase activity and translocation to an unlocalized pool in the neurite. Small decrease in glr-1 trafficking. 1 Publication1
Mutagenesisi284T → D: Constitutively activate kinase activity, increase in translocation to the neurites. 1 Publication1
Mutagenesisi665A → V in sy574; abnormal spicule protraction; when associated with E-170. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003966451 – 720Calcium/calmodulin-dependent protein kinase type IIAdd BLAST720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei284Phosphothreonine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O62305

PeptideAtlas

More...PeptideAtlasi		O62305

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O62305

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the nervous system. Observed in the ADF and AWC neurons. Position in AWC neurons is regulated by microtubules. Localized to clusters in ventral cord neurites which appear to be required for glr-1 trafficking. Also present in oocytes.4 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O62305, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dodecamer. Subunits are tightly packed around a central ring-shaped scaffold with extensive contacts between the regulatory segment of one kinase and the catalytic domain of another enabling cooperative activation of a subunit by the adjacent molecule (PubMed:16441656, PubMed:20139983).

Interacts with and phosphorylates daf-16; the interaction promotes daf-16 nuclear localization.

Interacts with egl-2 and tir-1 (PubMed:15625192, PubMed:21145946).

Interacts with nsy-1 (PubMed:11336672).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		43023, 21 interactors

Database of interacting proteins

More...DIPi		DIP-25971N
DIP-58986N

Protein interaction database and analysis system

More...IntActi		O62305, 10 interactors

Molecular INTeraction database

More...MINTi		O62305

STRING: functional protein association networks

More...STRINGi		6239.K11E8.1r

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1720
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O62305

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O62305

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 269Protein kinasePROSITE-ProRule annotationAdd BLAST258

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0033, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159769

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O62305

Database of Orthologous Groups

More...OrthoDBi		330091at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O62305

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013543, Ca/CaM-dep_prot_kinase-assoc
IPR011009, Kinase-like_dom_sf
IPR032710, NTF2-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08332, CaMKII_AD, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54427, SSF54427, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (15+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 15 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 15 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform c1 Publication (identifier: O62305-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMNASTKFSD NYDVKEELGK GAFSVVRRCV HKTTGLEFAA KIINTKKLSA 
        60         70         80         90        100
RDFQKLEREA RICRKLQHPN IVRLHDSIQE ESFHYLVFDL VTGGELFEDI 
       110        120        130        140        150
VAREFYSEAD ASHCIQQILE SIAYCHSNGI VHRDLKPENL LLASKAKGAA 
       160        170        180        190        200
VKLADFGLAI EVNDSEAWHG FAGTPGYLSP EVLKKDPYSK PVDIWACGVI 
       210        220        230        240        250
LYILLVGYPP FWDEDQHRLY AQIKAGAYDY PSPEWDTVTP EAKSLIDSML 
       260        270        280        290        300
TVNPKKRITA DQALKVPWIC NRERVASAIH RQDTVDCLKK FNARRKLKAA 
       310        320        330        340        350
ISAVKMVTRM SGVLRTSDST GSVASNGSTT HDASQVAGTS SQPTSPAAEV 
       360        370        380        390        400
YPNVLLFNPQ KFPRNCVHPF TTHPYYSPKE SSKKKLFFTL LFEVCPHTSR 
       410        420        430        440        450
SHILLRDNTK NIYHPYHCFT NKMSNYERAA PSSHGSSTTK KIANAIADLV 
       460        470        480        490        500
IRRSSPSIRR KTEADVHNSN RNRKVSAPAN LQHALVPVID VVVATGALAS 
       510        520        530        540        550
SSVDNLSAST SSDLGRNLLN KKEQGPPSTI KESSESSQTI DDNDSEKGGG 
       560        570        580        590        600
QLKHENTVVR ADGATGIVSS SNSSTASKSS STNLSAQKQD IVRVTQTLLD 
       610        620        630        640        650
AISCKDFETY TRLCDTSMTC FEPEALGNLI EGIEFHRFYF DGNRKNQVHT 
       660        670        680        690        700
TMLNPNVHII GEDAACVAYV KLTQFLDRNG EAHTRQSQES RVWSKKQGRW 
       710        720
VCVHVHRSTQ PSTNTTVSEF
Length:720
Mass (Da):79,927
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3231366FFF81A695
GO
Isoform a1 Publication (identifier: O62305-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-490: Missing.
     491-515: VVVATGALASSSVDNLSASTSSDLG → MKNIEYWQVLLNKIFATYKIKMKQC

Show »
Length:230
Mass (Da):25,873
Checksum:i2EAD0E576BA0619A
GO
Isoform b1 Publication (identifier: O62305-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-138: HCIQQILESIAYCHSNGIVHRDLKPE → CCIMQILDGVNYCHQRGIVHRDMKV
     139-720: Missing.

Show »
Length:137
Mass (Da):15,801
Checksum:iDDF4E2AD6FC2A6F4
GO
Isoform d2 Publications (identifier: O62305-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-314: AAISAVKMVTRMSGVL → GAILTTMIATRNLSNL
     315-514: Missing.
     548-585: Missing.

Show »
Length:482
Mass (Da):54,589
Checksum:i3870201C3162C253
GO
Isoform e2 Publications (identifier: O62305-5) [UniParc]FASTAAdd to basket
Also known as: C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     350-364: VYPNVLLFNPQKFPR → GAILTTMIATRNLSN
     365-513: Missing.
     548-585: Missing.

Show »
Length:533
Mass (Da):59,537
Checksum:i0D8EF2D999E0B8AA
GO
Isoform f2 Publications (identifier: O62305-6) [UniParc]FASTAAdd to basket
Also known as: E1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-313: AAISAVKMVTRMSGV → GAILTTMIATRNLSS
     314-515: Missing.

Show »
Length:518
Mass (Da):58,067
Checksum:i14DA5EB06D2DAFF3
GO
Isoform g2 Publications (identifier: O62305-7) [UniParc]FASTAAdd to basket
Also known as: B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-314: AAISAVKMVTRMSGVL → GAILTTMIATRNLSNL
     315-514: Missing.

Show »
Length:520
Mass (Da):58,264
Checksum:i7D20BF318483E085
GO
Isoform h2 Publications (identifier: O62305-8) [UniParc]FASTAAdd to basket
Also known as: D1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     350-364: VYPNVLLFNPQKFPR → GAILTTMIATRNLSN
     365-513: Missing.

Show »
Length:571
Mass (Da):63,212
Checksum:i20C754B5BFE86D01
GO
Isoform i2 Publications (identifier: O62305-9) [UniParc]FASTAAdd to basket
Also known as: H1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-314: AAISAVKMVTRMSGVL → GAILTTMIATRNLSNL
     315-514: Missing.
     549-550: GG → NE
     551-720: Missing.

Show »
Length:350
Mass (Da):39,384
Checksum:iE300DB75FE74E9BC
GO
Isoform k2 Publications (identifier: O62305-10) [UniParc]FASTAAdd to basket
Also known as: F1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-302: AAIS → VVDS
     303-720: Missing.

Show »
Length:302
Mass (Da):34,198
Checksum:i5BCA124A7458DD9F
GO
Isoform l2 Publications (identifier: O62305-11) [UniParc]FASTAAdd to basket
Also known as: G1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-302: AAIS → VAIC
     303-720: Missing.

Show »
Length:302
Mass (Da):34,184
Checksum:i40C0FD5A7458DD9F
GO
Isoform m1 Publication (identifier: O62305-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-414: Missing.
     415-512: PYHCFTNKMS...VDNLSASTSS → MDGLLARLKL...KPEKLEVEAD

Show »
Length:309
Mass (Da):34,103
Checksum:i13A93D058438BA8A
GO
Isoform n1 Publication (identifier: O62305-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-505: Missing.
     506-515: LSASTSSDLG → MNFLRFSGKC

Show »
Length:215
Mass (Da):23,941
Checksum:i392E9298ABF7375D
GO
Isoform o1 Publication (identifier: O62305-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-416: Missing.
     417-514: HCFTNKMSNY...NLSASTSSDL → MDGLLARLKL...KPEKLEVEAD
     548-585: Missing.

Show »
Length:269
Mass (Da):30,200
Checksum:iD1B879B53DE0A973
GO
Isoform p1 Publication (identifier: O62305-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-504: Missing.
     505-513: NLSASTSSD → MIATRNLSN

Show »
Length:216
Mass (Da):23,927
Checksum:i592578E5DE7DC6B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EDZ5G5EDZ5_CAEEL
Calcium/calmodulin-dependent protei...
unc-43 CELE_K11E8.1, K11E8.1
681Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GUA8F5GUA8_CAEEL
CaMKII_AD domain-containing protein
unc-43 CELE_K11E8.1, K11E8.1
266Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GUA9F5GUA9_CAEEL
CaMKII_AD domain-containing protein
unc-43 CELE_K11E8.1, K11E8.1
298Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EM33E7EM33_CAEEL
CaMKII_AD domain-containing protein
unc-43 CELE_K11E8.1, K11E8.1
103Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0395901 – 505Missing in isoform n. 1 PublicationAdd BLAST505
Alternative sequenceiVSP_0395911 – 504Missing in isoform p. 1 PublicationAdd BLAST504
Alternative sequenceiVSP_0395921 – 490Missing in isoform a. 1 PublicationAdd BLAST490
Alternative sequenceiVSP_0395931 – 416Missing in isoform o. 1 PublicationAdd BLAST416
Alternative sequenceiVSP_0395941 – 414Missing in isoform m. 1 PublicationAdd BLAST414
Alternative sequenceiVSP_039595113 – 138HCIQQ…DLKPE → CCIMQILDGVNYCHQRGIVH RDMKV in isoform b. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_039596139 – 720Missing in isoform b. 1 PublicationAdd BLAST582
Alternative sequenceiVSP_039597299 – 314AAISA…MSGVL → GAILTTMIATRNLSNL in isoform d, isoform g and isoform i. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_039598299 – 313AAISA…RMSGV → GAILTTMIATRNLSS in isoform f. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_039599299 – 302AAIS → VVDS in isoform k. 2 Publications4
Alternative sequenceiVSP_039600299 – 302AAIS → VAIC in isoform l. 2 Publications4
Alternative sequenceiVSP_039601303 – 720Missing in isoform k and isoform l. 2 PublicationsAdd BLAST418
Alternative sequenceiVSP_039602314 – 515Missing in isoform f. 2 PublicationsAdd BLAST202
Alternative sequenceiVSP_039603315 – 514Missing in isoform d, isoform g and isoform i. 3 PublicationsAdd BLAST200
Alternative sequenceiVSP_039604350 – 364VYPNV…QKFPR → GAILTTMIATRNLSN in isoform e and isoform h. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_039605365 – 513Missing in isoform e and isoform h. 3 PublicationsAdd BLAST149
Alternative sequenceiVSP_039606415 – 512PYHCF…ASTSS → MDGLLARLKLGSKRKKKTSS SVKRSSRPESARQAPRDTTG SLYSNLTASSSTVSACSAPE IVVLKKEQVVLAVDHKDQVD EQKKKNEQVVKKPEKLEVEA D in isoform m. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_039607417 – 514HCFTN…TSSDL → MDGLLARLKLGSKRKKKTSS SVKRSSRPESARQAPRDTTG SLYSNLTASSSTVSACSAPE IVVLKKEQVVLAVDHKDQVD EQKKKNEQVVKKPEKLEVEA D in isoform o. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_039608491 – 515VVVAT…SSDLG → MKNIEYWQVLLNKIFATYKI KMKQC in isoform a. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_039609505 – 513NLSASTSSD → MIATRNLSN in isoform p. 1 Publication9
Alternative sequenceiVSP_039610506 – 515LSASTSSDLG → MNFLRFSGKC in isoform n. 1 Publication10
Alternative sequenceiVSP_039611548 – 585Missing in isoform d, isoform e and isoform o. 3 PublicationsAdd BLAST38
Alternative sequenceiVSP_039612549 – 550GG → NE in isoform i. 2 Publications2
Alternative sequenceiVSP_039613551 – 720Missing in isoform i. 2 PublicationsAdd BLAST170

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF180735 mRNA Translation: AAD53949.1
AF233262 mRNA Translation: AAF63320.1
AF233263 mRNA Translation: AAF63321.1
AF233264 mRNA Translation: AAF63322.1
AF233265 mRNA Translation: AAF63323.1
AF233266 mRNA Translation: AAF63324.1
AF233267 mRNA Translation: AAF63325.1
AF255956 mRNA Translation: AAF71543.1
Z70279 Genomic DNA Translation: CAA94242.3
Z70279, AL023841 Genomic DNA Translation: CAA94243.3
Z70279, AL023841 Genomic DNA Translation: CAC42322.1
Z70279, AL023841 Genomic DNA Translation: CAC42323.1
Z70279, AL023841 Genomic DNA Translation: CAC42324.1
Z70279, AL023841 Genomic DNA Translation: CAC42325.1
Z70279, AL023841 Genomic DNA Translation: CAC42326.1
Z70279, AL023841 Genomic DNA Translation: CAC42327.1
Z70279, AL023841 Genomic DNA Translation: CAC42328.1
Z70279, AL023841 Genomic DNA Translation: CAC42329.1
Z70279 Genomic DNA Translation: CAE46679.1
Z70279 Genomic DNA Translation: CAN86910.1
Z70279 Genomic DNA Translation: CAO82047.1
Z70279 Genomic DNA Translation: CAQ58116.1

Protein sequence database of the Protein Information Resource

More...PIRi		B88809
T23616

NCBI Reference Sequences

More...RefSeqi		NP_001023293.2, NM_001028122.4 [O62305-2]
NP_001023294.1, NM_001028123.3
NP_001023296.1, NM_001028125.3
NP_001023297.1, NM_001028126.3
NP_001023298.1, NM_001028127.3 [O62305-6]
NP_001023299.1, NM_001028128.3
NP_001023300.1, NM_001028129.3
NP_001023301.1, NM_001028130.3
NP_001023302.1, NM_001028131.3
NP_001023303.1, NM_001028132.3
NP_001023304.1, NM_001028133.4 [O62305-12]
NP_001122788.1, NM_001129316.2 [O62305-13]
NP_001122789.1, NM_001129317.2 [O62305-14]
NP_001129863.1, NM_001136391.2 [O62305-15]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		K11E8.1a.1; K11E8.1a.1; WBGene00006779 [O62305-2]
K11E8.1b.1; K11E8.1b.1; WBGene00006779 [O62305-3]
K11E8.1b.2; K11E8.1b.2; WBGene00006779 [O62305-3]
K11E8.1b.3; K11E8.1b.3; WBGene00006779 [O62305-3]
K11E8.1d.1; K11E8.1d.1; WBGene00006779 [O62305-4]
K11E8.1d.2; K11E8.1d.2; WBGene00006779 [O62305-4]
K11E8.1d.3; K11E8.1d.3; WBGene00006779 [O62305-4]
K11E8.1e.1; K11E8.1e.1; WBGene00006779 [O62305-5]
K11E8.1e.2; K11E8.1e.2; WBGene00006779 [O62305-5]
K11E8.1e.3; K11E8.1e.3; WBGene00006779 [O62305-5]
K11E8.1f.1; K11E8.1f.1; WBGene00006779 [O62305-6]
K11E8.1f.2; K11E8.1f.2; WBGene00006779 [O62305-6]
K11E8.1f.3; K11E8.1f.3; WBGene00006779 [O62305-6]
K11E8.1g.1; K11E8.1g.1; WBGene00006779 [O62305-7]
K11E8.1g.2; K11E8.1g.2; WBGene00006779 [O62305-7]
K11E8.1g.3; K11E8.1g.3; WBGene00006779 [O62305-7]
K11E8.1h.1; K11E8.1h.1; WBGene00006779 [O62305-8]
K11E8.1h.2; K11E8.1h.2; WBGene00006779 [O62305-8]
K11E8.1h.3; K11E8.1h.3; WBGene00006779 [O62305-8]
K11E8.1i.1; K11E8.1i.1; WBGene00006779 [O62305-9]
K11E8.1i.2; K11E8.1i.2; WBGene00006779 [O62305-9]
K11E8.1i.3; K11E8.1i.3; WBGene00006779 [O62305-9]
K11E8.1k.1; K11E8.1k.1; WBGene00006779 [O62305-10]
K11E8.1k.2; K11E8.1k.2; WBGene00006779 [O62305-10]
K11E8.1k.3; K11E8.1k.3; WBGene00006779 [O62305-10]
K11E8.1l.1; K11E8.1l.1; WBGene00006779 [O62305-11]
K11E8.1l.2; K11E8.1l.2; WBGene00006779 [O62305-11]
K11E8.1l.3; K11E8.1l.3; WBGene00006779 [O62305-11]
K11E8.1m.1; K11E8.1m.1; WBGene00006779 [O62305-12]
K11E8.1n.1; K11E8.1n.1; WBGene00006779 [O62305-13]
K11E8.1o.1; K11E8.1o.1; WBGene00006779 [O62305-14]
K11E8.1p.1; K11E8.1p.1; WBGene00006779 [O62305-15]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		177921

UCSC genome browser

More...UCSCi		K11E8.1a.1, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180735 mRNA Translation: AAD53949.1
AF233262 mRNA Translation: AAF63320.1
AF233263 mRNA Translation: AAF63321.1
AF233264 mRNA Translation: AAF63322.1
AF233265 mRNA Translation: AAF63323.1
AF233266 mRNA Translation: AAF63324.1
AF233267 mRNA Translation: AAF63325.1
AF255956 mRNA Translation: AAF71543.1
Z70279 Genomic DNA Translation: CAA94242.3
Z70279, AL023841 Genomic DNA Translation: CAA94243.3
Z70279, AL023841 Genomic DNA Translation: CAC42322.1
Z70279, AL023841 Genomic DNA Translation: CAC42323.1
Z70279, AL023841 Genomic DNA Translation: CAC42324.1
Z70279, AL023841 Genomic DNA Translation: CAC42325.1
Z70279, AL023841 Genomic DNA Translation: CAC42326.1
Z70279, AL023841 Genomic DNA Translation: CAC42327.1
Z70279, AL023841 Genomic DNA Translation: CAC42328.1
Z70279, AL023841 Genomic DNA Translation: CAC42329.1
Z70279 Genomic DNA Translation: CAE46679.1
Z70279 Genomic DNA Translation: CAN86910.1
Z70279 Genomic DNA Translation: CAO82047.1
Z70279 Genomic DNA Translation: CAQ58116.1
PIRiB88809
T23616
RefSeqiNP_001023293.2, NM_001028122.4 [O62305-2]
NP_001023294.1, NM_001028123.3
NP_001023296.1, NM_001028125.3
NP_001023297.1, NM_001028126.3
NP_001023298.1, NM_001028127.3 [O62305-6]
NP_001023299.1, NM_001028128.3
NP_001023300.1, NM_001028129.3
NP_001023301.1, NM_001028130.3
NP_001023302.1, NM_001028131.3
NP_001023303.1, NM_001028132.3
NP_001023304.1, NM_001028133.4 [O62305-12]
NP_001122788.1, NM_001129316.2 [O62305-13]
NP_001122789.1, NM_001129317.2 [O62305-14]
NP_001129863.1, NM_001136391.2 [O62305-15]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BDWX-ray1.80A/B1-298[»]
A/B514-543[»]
2F86X-ray2.64B/D/F/H/J/L/N585-720[»]
3KK8X-ray1.72A5-288[»]
3KK9X-ray3.21A6-287[»]
3KL8X-ray3.37A/C/E/G/I5-273[»]
SMRiO62305
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi43023, 21 interactors
DIPiDIP-25971N
DIP-58986N
IntActiO62305, 10 interactors
MINTiO62305
STRINGi6239.K11E8.1r

PTM databases

iPTMnetiO62305

Proteomic databases

EPDiO62305
PeptideAtlasiO62305

Genome annotation databases

EnsemblMetazoaiK11E8.1a.1; K11E8.1a.1; WBGene00006779 [O62305-2]
K11E8.1b.1; K11E8.1b.1; WBGene00006779 [O62305-3]
K11E8.1b.2; K11E8.1b.2; WBGene00006779 [O62305-3]
K11E8.1b.3; K11E8.1b.3; WBGene00006779 [O62305-3]
K11E8.1d.1; K11E8.1d.1; WBGene00006779 [O62305-4]
K11E8.1d.2; K11E8.1d.2; WBGene00006779 [O62305-4]
K11E8.1d.3; K11E8.1d.3; WBGene00006779 [O62305-4]
K11E8.1e.1; K11E8.1e.1; WBGene00006779 [O62305-5]
K11E8.1e.2; K11E8.1e.2; WBGene00006779 [O62305-5]
K11E8.1e.3; K11E8.1e.3; WBGene00006779 [O62305-5]
K11E8.1f.1; K11E8.1f.1; WBGene00006779 [O62305-6]
K11E8.1f.2; K11E8.1f.2; WBGene00006779 [O62305-6]
K11E8.1f.3; K11E8.1f.3; WBGene00006779 [O62305-6]
K11E8.1g.1; K11E8.1g.1; WBGene00006779 [O62305-7]
K11E8.1g.2; K11E8.1g.2; WBGene00006779 [O62305-7]
K11E8.1g.3; K11E8.1g.3; WBGene00006779 [O62305-7]
K11E8.1h.1; K11E8.1h.1; WBGene00006779 [O62305-8]
K11E8.1h.2; K11E8.1h.2; WBGene00006779 [O62305-8]
K11E8.1h.3; K11E8.1h.3; WBGene00006779 [O62305-8]
K11E8.1i.1; K11E8.1i.1; WBGene00006779 [O62305-9]
K11E8.1i.2; K11E8.1i.2; WBGene00006779 [O62305-9]
K11E8.1i.3; K11E8.1i.3; WBGene00006779 [O62305-9]
K11E8.1k.1; K11E8.1k.1; WBGene00006779 [O62305-10]
K11E8.1k.2; K11E8.1k.2; WBGene00006779 [O62305-10]
K11E8.1k.3; K11E8.1k.3; WBGene00006779 [O62305-10]
K11E8.1l.1; K11E8.1l.1; WBGene00006779 [O62305-11]
K11E8.1l.2; K11E8.1l.2; WBGene00006779 [O62305-11]
K11E8.1l.3; K11E8.1l.3; WBGene00006779 [O62305-11]
K11E8.1m.1; K11E8.1m.1; WBGene00006779 [O62305-12]
K11E8.1n.1; K11E8.1n.1; WBGene00006779 [O62305-13]
K11E8.1o.1; K11E8.1o.1; WBGene00006779 [O62305-14]
K11E8.1p.1; K11E8.1p.1; WBGene00006779 [O62305-15]
GeneIDi177921
UCSCiK11E8.1a.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		177921
WormBaseiK11E8.1a ; CE42693 ; WBGene00006779 ; unc-43
K11E8.1b ; CE28052 ; WBGene00006779 ; unc-43
K11E8.1d ; CE28054 ; WBGene00006779 ; unc-43
K11E8.1e ; CE28055 ; WBGene00006779 ; unc-43
K11E8.1f ; CE28056 ; WBGene00006779 ; unc-43
K11E8.1g ; CE28057 ; WBGene00006779 ; unc-43
K11E8.1h ; CE28058 ; WBGene00006779 ; unc-43
K11E8.1i ; CE28059 ; WBGene00006779 ; unc-43
K11E8.1k ; CE28060 ; WBGene00006779 ; unc-43
K11E8.1l ; CE28061 ; WBGene00006779 ; unc-43
K11E8.1m ; CE35590 ; WBGene00006779 ; unc-43
K11E8.1n ; CE40979 ; WBGene00006779 ; unc-43
K11E8.1o ; CE41430 ; WBGene00006779 ; unc-43
K11E8.1p ; CE42670 ; WBGene00006779 ; unc-43

Phylogenomic databases

eggNOGiKOG0033, Eukaryota
GeneTreeiENSGT00940000159769
InParanoidiO62305
OrthoDBi330091at2759
PhylomeDBiO62305

Enzyme and pathway databases

BRENDAi2.7.11.17, 1045
ReactomeiR-CEL-3371571, HSF1-dependent transactivation
R-CEL-4086398, Ca2+ pathway
R-CEL-438066, Unblocking of NMDA receptors, glutamate binding and activation
R-CEL-5578775, Ion homeostasis
R-CEL-936837, Ion transport by P-type ATPases
SignaLinkiO62305

Miscellaneous databases

EvolutionaryTraceiO62305

Protein Ontology

More...PROi		PR:O62305

Gene expression databases

ExpressionAtlasiO62305, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013543, Ca/CaM-dep_prot_kinase-assoc
IPR011009, Kinase-like_dom_sf
IPR032710, NTF2-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF08332, CaMKII_AD, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF54427, SSF54427, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCC2D_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O62305
Secondary accession number(s): A5JYT0
, A7LPH2, B3GWC8, O62304, Q21431, Q7JLT8, Q9NG91, Q9NH55, Q9NH56, Q9NH57, Q9NH58, Q9NH59, Q9NH60, Q9U6Q0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2001
Last modified: April 7, 2021
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again