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Protein

Acyl-coenzyme A oxidase

Gene

acox-1.3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei431Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • ascaroside biosynthetic process Source: WormBase
  • fatty acid beta-oxidation using acyl-CoA dehydrogenase Source: GO_Central

Keywordsi

LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

ReactomeiR-CEL-2046106 alpha-linolenic acid (ALA) metabolism
R-CEL-390247 Beta-oxidation of very long chain fatty acids

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A oxidaseUniRule annotation
Gene namesi
Name:acox-1.3Imported
Synonyms:acox-3Imported
ORF Names:CELE_F08A8.3Imported, F08A8.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF08A8.3 ; CE17635 ; WBGene00008566 ; acox-1.3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiO62138
PeptideAtlasiO62138

Expressioni

Gene expression databases

BgeeiWBGene00008566 Expressed in 2 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

STRINGi6239.F08A8.3

Structurei

3D structure databases

ProteinModelPortaliO62138
SMRiO62138
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 143Acyl-CoA_ox_NInterPro annotationAdd BLAST122
Domaini145 – 254Acyl-CoA_dh_MInterPro annotationAdd BLAST110
Domaini479 – 656ACOXInterPro annotationAdd BLAST178

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0136 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00530000062919
HOGENOMiHOG000181256
InParanoidiO62138
KOiK00232
OMAiIAQAYAC
OrthoDBiEOG091G0A1P
PhylomeDBiO62138

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR029320 Acyl-CoA_ox_N
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF14749 Acyl-CoA_ox_N, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit

Sequencei

Sequence statusi: Complete.

O62138-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSICKGDNS DLTEERKNAT FDTDKMAAVI YGREEIASRR RQLTESISRI
60 70 80 90 100
HELAESKPLV FMTREEKIAE SCRKLEVLSR HWNQTPFNRD NEEDALHIYR
110 120 130 140 150
EVLGMEGHPL ALHDTMFIPT LVAQASQEQQ EKWLGRARRK EIIGCYAQTE
160 170 180 190 200
MGHGTNLRKL ETTATYSPDT QEFILNTPTI TALKWWPGAL GKSSNNAIVV
210 220 230 240 250
ANLLIKDQNY GPHPFMVQLR DEKTHIPLKG IVVGDIGPKM AFNGADNGYL
260 270 280 290 300
GFNNHRIPRT NLLMRHTKVE ANGTYIKPSH AKIGYSSMVK VRSRMAMDQG
310 320 330 340 350
LFLASALVIA VRYSAVRRQG FLEDKTQKVK VLDYQTQQHR LFPSLARAYA
360 370 380 390 400
FIFTGFETIH LYSQLLKDVD MGNTSGMADL HALTSGLKSV VTHQTGEGIE
410 420 430 440 450
QARMACGEHG YSMASYISEI YGVAIGGCTY EGENMVMLLQ LARYLVKSVE
460 470 480 490 500
LIKSGEEKKL GPMVSYLAAK GGHPDLSSLN GYVTAFEHMA RRQAWKATEK
510 520 530 540 550
FLKLMETGES REVAWNKSAV ELTRASRLHT RLFIIEAFMR RVSRIEDIPV
560 570 580 590 600
KEVLTDLLHL HVNYELLDVA TYALEFMSST QLDYIRDQLY LYLEKIRPSA
610 620 630 640 650
VSLVDSFQIS DMQLRSVLGR RDGNVYENLF KWAKSSPLNK SDVLPSVDKY
660
LKPMMEKAKL
Length:660
Mass (Da):74,781
Last modified:August 1, 1998 - v1
Checksum:i4E255D878FDB4234
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB16865.1
PIRiT20569
RefSeqiNP_493263.1, NM_060862.1
UniGeneiCel.30644

Genome annotation databases

EnsemblMetazoaiF08A8.3; F08A8.3; WBGene00008566
GeneIDi184167
KEGGicel:CELE_F08A8.3
UCSCiF08A8.3 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB16865.1
PIRiT20569
RefSeqiNP_493263.1, NM_060862.1
UniGeneiCel.30644

3D structure databases

ProteinModelPortaliO62138
SMRiO62138
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F08A8.3

Proteomic databases

PaxDbiO62138
PeptideAtlasiO62138

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF08A8.3; F08A8.3; WBGene00008566
GeneIDi184167
KEGGicel:CELE_F08A8.3
UCSCiF08A8.3 c. elegans

Organism-specific databases

CTDi184167
WormBaseiF08A8.3 ; CE17635 ; WBGene00008566 ; acox-1.3

Phylogenomic databases

eggNOGiKOG0136 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00530000062919
HOGENOMiHOG000181256
InParanoidiO62138
KOiK00232
OMAiIAQAYAC
OrthoDBiEOG091G0A1P
PhylomeDBiO62138

Enzyme and pathway databases

ReactomeiR-CEL-2046106 alpha-linolenic acid (ALA) metabolism
R-CEL-390247 Beta-oxidation of very long chain fatty acids

Gene expression databases

BgeeiWBGene00008566 Expressed in 2 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR029320 Acyl-CoA_ox_N
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF14749 Acyl-CoA_ox_N, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO62138_CAEEL
AccessioniPrimary (citable) accession number: O62138
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: October 10, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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