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Protein

Proteasome subunit beta type

Gene

pbs-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-6798695 Neutrophil degranulation
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.011

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta typeUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
Name:pbs-2Imported
ORF Names:C47B2.4Imported, CELE_C47B2.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC47B2.4 ; CE17564 ; WBGene00003948 ; pbs-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation, ProteasomeUniRule annotationImported

PTM / Processingi

Proteomic databases

EPDiO62102
PaxDbiO62102
PeptideAtlasiO62102

Expressioni

Gene expression databases

BgeeiWBGene00003948

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
pbs-3Q232375EBI-317386,EBI-314040

Protein-protein interaction databases

IntActiO62102, 2 interactors
STRINGi6239.C47B2.4

Structurei

3D structure databases

ProteinModelPortaliO62102
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0173 Eukaryota
COG0638 LUCA
GeneTreeiENSGT00510000046533
HOGENOMiHOG000182856
InParanoidiO62102
KOiK02739
OMAiMHGDNAS
OrthoDBiEOG091G0E5S
PhylomeDBiO62102

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR000243 Pept_T1A_subB
IPR035216 Proteasome_beta7
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF44 PTHR11599:SF44, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PRINTSiPR00141 PROTEASOME
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

O62102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATADVKSTV PHMDMDRGGA FDFSNCIRNQ AMCKMGGKAP KLTSTGTTIV
60 70 80 90 100
AVAFKGGLVM GADSRATAGN IIADKHCEKV HKLTESIYAC GAGTAADLDQ
110 120 130 140 150
VTKMLSGNLR LLELNTGRKA RVITALRQAK QHLFNYQGYI GAYLLIGGVD
160 170 180 190 200
PTGPHLYMCS ANGTTMAFPF TAQGSGSYAA ITILERDFKV DMTKDEAEKL
210 220 230 240 250
VQRALEAGMH GDNASGNSLN LVIIEPSETV FKGPIVPEFC KRPEPNDLVY
260 270
KFQAGATKVL KHKTYKYDVV ESMDITH
Length:277
Mass (Da):29,861
Last modified:August 1, 1998 - v1
Checksum:iA0FCD28F390DB551
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB16855.1
PIRiT19983
RefSeqiNP_493271.1, NM_060870.3
UniGeneiCel.23266

Genome annotation databases

EnsemblMetazoaiC47B2.4; C47B2.4; WBGene00003948
GeneIDi173168
KEGGicel:CELE_C47B2.4
UCSCiC47B2.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiO62102_CAEEL
AccessioniPrimary (citable) accession number: O62102
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: July 18, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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