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Protein

Axin-like protein pry-1

Gene

pry-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl-5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity.7 Publications

GO - Molecular functioni

  • armadillo repeat domain binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

SignaLinkiO62090

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-like protein pry-1
Alternative name(s):
Protein polyray1 Publication
Gene namesi
Name:pry-1Imported
ORF Names:C37A5.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC37A5.9 ; CE30125 ; WBGene00004202 ; pry-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Worms exhibit ectopic rays and lack alae in V cells of the male tail. Mutants appear scrawny, often herniated, uncoordinated, show defects in dorsal and ventral cord fasciculation, commissure guidance defects, and over activated Wnt signaling pathway. Phenotypes are more penetrant in the pry-1 and axl-1 double mutant, suggesting some functional overlaps.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003472541 – 586Axin-like protein pry-1Add BLAST586

Proteomic databases

EPDiO62090
PaxDbiO62090
PRIDEiO62090

Expressioni

Tissue specificityi

Expressed in hypodermal cells (seam cells) V5 and V6, Q neuroblasts, ventral hypodermal cells P7/8 to P11/12, body wall muscle cells and neurons in the head, the tail and the ventral nerve cord.1 Publication

Developmental stagei

Expressed throughout development.1 Publication

Gene expression databases

BgeeiWBGene00004202 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

Subunit structurei

Interacts (via N-terminus) with apr-1 (via C-terminus). Interacts with bar-1 (via ARM repeats), gsk-3, and mig-5.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi38675, 30 interactors
IntActiO62090, 14 interactors
STRINGi6239.C37A5.9

Structurei

3D structure databases

ProteinModelPortaliO62090
SMRiO62090
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 131RGSPROSITE-ProRule annotationAdd BLAST122
Domaini505 – 586DIXPROSITE-ProRule annotationAdd BLAST82

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 135Required for interaction with apr-11 PublicationAdd BLAST135

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi421 – 480Ser-richSequence analysisAdd BLAST60

Phylogenomic databases

eggNOGiENOG410K7XD Eukaryota
ENOG4110KZ2 LUCA
InParanoidiO62090
KOiK02157
OMAiCNATTSH
OrthoDBiEOG091G067M
PhylomeDBiO62090

Family and domain databases

Gene3Di3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00778 DIX, 1 hit
PF00615 RGS, 1 hit
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50841 DIX, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

O62090-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METHLGWARS LEAVLSDRSA LDAFQEWLIE YSSPQYLDLF FAIRAYERMA
60 70 80 90 100
LEGKPEKSQL SKSIYSKFLS SRTGNCEAIP KHFRAPIGEK LRHGTELEDR
110 120 130 140 150
VFSHCSNFVQ EFLRRQHEEF VGSEEFIEAF NKMSSTTADQ LPGGSAHHSS
160 170 180 190 200
HQNTMRRSSG TTSRKSAAQI ATQLTAEALL KSKHDRHSKL GETKLEKMYP
210 220 230 240 250
PTRQPYVCNA TTSHNDSAVS STFSGDTPEA HRMHSNRLRH IRDEQARENH
260 270 280 290 300
GTMTLPRVEK ASVDGQQWDH SSESGRRNFA MEITRKLLRH IDKVKLNDEM
310 320 330 340 350
EKRIDDIEEC RYTTIDMVNG TEPNDDLGKI DEDEELDDYL KMKMTDDSQK
360 370 380 390 400
GSTNRSPKGP AGEPNKSGEG SKNTTLSPTN RAPAQLHNTI RVPRRKDYPR
410 420 430 440 450
DTSASLKSHR HHQIDTNRMM SQSMCAPSYS SASSSYSRDS FAPAPTTRVN
460 470 480 490 500
FAPGSSKSSQ FYDSSGIGSM APSAFSATSS LDYKDRRQHR KAPTPKKHSK
510 520 530 540 550
IGKNLSNLIT ISYLGTDKIP VVTHVPNDGP MTLAEFKRHF ALPNGAHQLF
560 570 580
FKTECEDGSA PFQLLLIKDE HHLLPVFEGR IAAELR
Length:586
Mass (Da):66,002
Last modified:March 1, 2002 - v2
Checksum:i366D09FFC1568AE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF468834 mRNA Translation: AAL77082.1
Z92828 Genomic DNA Translation: CAB07332.2
PIRiT19802
RefSeqiNP_493474.2, NM_061073.5
UniGeneiCel.8800

Genome annotation databases

EnsemblMetazoaiC37A5.9; C37A5.9; WBGene00004202
GeneIDi173287
KEGGicel:CELE_C37A5.9
UCSCiC37A5.9.1 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF468834 mRNA Translation: AAL77082.1
Z92828 Genomic DNA Translation: CAB07332.2
PIRiT19802
RefSeqiNP_493474.2, NM_061073.5
UniGeneiCel.8800

3D structure databases

ProteinModelPortaliO62090
SMRiO62090
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38675, 30 interactors
IntActiO62090, 14 interactors
STRINGi6239.C37A5.9

Proteomic databases

EPDiO62090
PaxDbiO62090
PRIDEiO62090

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC37A5.9; C37A5.9; WBGene00004202
GeneIDi173287
KEGGicel:CELE_C37A5.9
UCSCiC37A5.9.1 c. elegans

Organism-specific databases

CTDi173287
WormBaseiC37A5.9 ; CE30125 ; WBGene00004202 ; pry-1

Phylogenomic databases

eggNOGiENOG410K7XD Eukaryota
ENOG4110KZ2 LUCA
InParanoidiO62090
KOiK02157
OMAiCNATTSH
OrthoDBiEOG091G067M
PhylomeDBiO62090

Enzyme and pathway databases

SignaLinkiO62090

Miscellaneous databases

PROiPR:O62090

Gene expression databases

BgeeiWBGene00004202 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00778 DIX, 1 hit
PF00615 RGS, 1 hit
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50841 DIX, 1 hit
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRY1_CAEEL
AccessioniPrimary (citable) accession number: O62090
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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