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Protein
Submitted name:

Proteasome Regulatory Particle, Non-ATPase-like

Gene

rpn-8

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-6798695 Neutrophil degranulation
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiM67.973

Names & Taxonomyi

Protein namesi
Submitted name:
Proteasome Regulatory Particle, Non-ATPase-likeImported
Gene namesi
Name:rpn-8Imported
ORF Names:CELE_R12E2.3Imported, R12E2.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiR12E2.3 ; CE18135 ; WBGene00004464 ; rpn-8

Subcellular locationi

Keywords - Cellular componenti

ProteasomeImported

PTM / Processingi

Proteomic databases

EPDiO61792
PaxDbiO61792
PeptideAtlasiO61792

Expressioni

Gene expression databases

BgeeiWBGene00004464

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiO61792, 3 interactors
MINTiO61792
STRINGi6239.R12E2.3.2

Structurei

3D structure databases

ProteinModelPortaliO61792
SMRiO61792
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 177MPNInterPro annotationAdd BLAST137

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili313 – 350Sequence analysisAdd BLAST38

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1556 Eukaryota
COG1310 LUCA
GeneTreeiENSGT00530000063075
HOGENOMiHOG000209236
InParanoidiO61792
KOiK03038
OMAiDAYFAVE
OrthoDBiEOG091G0DX6
PhylomeDBiO61792

Family and domain databases

CDDicd08062 MPN_RPN7_8, 1 hit
InterProiView protein in InterPro
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR033858 MPN_RPN7_8
IPR024969 Rpn11/EIF3F_C
PANTHERiPTHR10540:SF7 PTHR10540:SF7, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
PF13012 MitMem_reg, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

Sequencei

Sequence statusi: Complete.

O61792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTNKDGDV ATVKAVDVLK QKAGAHHCLG NVHANLPVNK VTVHPLVLLS
60 70 80 90 100
VVDHFNRVSK TQSVKRVVGV LLGSMKKDKT LDIGNSFAVP FDEDDKDKST
110 120 130 140 150
WFLDMDYLES MYGMFYKVAA KEKIVGWYHT GPKLHKNDIA INEQLKRFCP
160 170 180 190 200
NPVLVIIDAE PKNIGLPTEA YIEVQEVHDD GTPPIKTFEH VPSDIGAEEA
210 220 230 240 250
EEVGVEHLLR DIKDQTAGTL SQRITDQLMG LRGLQSQLES IEKYLHDIVR
260 270 280 290 300
GTLPVNHHVI YYVQEVLNLL PDVTHPDYIV SQNVQTNDQL MCVYMGSLVR
310 320 330 340 350
SVVALHNLID NKISLQKAEK EQETGEAEKK KDEKDKKDKK DEKKDEKKEK
360
DSKSSTPNTP KK
Length:362
Mass (Da):40,687
Last modified:August 1, 1998 - v1
Checksum:i5ABA83CD1CF85373
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD65169.1
PIRiT33096
RefSeqiNP_491319.1, NM_058918.5
UniGeneiCel.5686

Genome annotation databases

EnsemblMetazoaiR12E2.3; R12E2.3; WBGene00004464
GeneIDi172009
KEGGicel:CELE_R12E2.3
UCSCiR12E2.3.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiO61792_CAEEL
AccessioniPrimary (citable) accession number: O61792
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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