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UniProtKB - O61742 (PSMD4_CAEEL)

Entry version 141 (10 Feb 2021)
Sequence version 2 (01 Oct 2001)
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Protein

26S proteasome non-ATPase regulatory subunit 4

Gene

rpn-10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression (PubMed:20453865, PubMed:22105480, PubMed:26828939). Involvement in UBS might be cell type specific (PubMed:20453865). Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity (PubMed:26828939). Required for fertility, sperm production, and sex determination through regulation of tra-2 protein (PubMed:17050737). Plays a role in the elimination of paternal mitochondria in fertilized eggs (PubMed:22105480).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CEL-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-187577, SCF(Skp2)-mediated degradation of p27/p21
R-CEL-195253, Degradation of beta-catenin by the destruction complex
R-CEL-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-CEL-350562, Regulation of ornithine decarboxylase (ODC)
R-CEL-382556, ABC-family proteins mediated transport
R-CEL-4608870, Asymmetric localization of PCP proteins
R-CEL-4641258, Degradation of DVL
R-CEL-5632684, Hedgehog 'on' state
R-CEL-5687128, MAPK6/MAPK4 signaling
R-CEL-5689603, UCH proteinases
R-CEL-5689880, Ub-specific processing proteases
R-CEL-68949, Orc1 removal from chromatin
R-CEL-69017, CDK-mediated phosphorylation and removal of Cdc6
R-CEL-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-75815, Ubiquitin-dependent degradation of Cyclin D
R-CEL-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902, Regulation of RUNX2 expression and activity
R-CEL-8941858, Regulation of RUNX3 expression and activity
R-CEL-8948751, Regulation of PTEN stability and activity
R-CEL-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 4By similarity
Alternative name(s):
26S proteasome regulatory subunit rpn-10Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpn-10Imported
ORF Names:B0205.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...WormBasei		B0205.3 ; CE26355 ; WBGene00004466 ; rpn-10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Temperature-dependent increase in lifespan with a modest increase at 20 degrees Celsius and a 30% increase in mean lifespan at 25 degrees Celsius compared to wild-type animals (PubMed:26828939). Reduced fertility with no sperm produced in the spermatheca, accumulation of a sex-determination protein tra-2 in the intestine, no embryos in the uterus, and an increase in the development time to adulthood as evidenced by an expansion of the proximal oocytes at a young adult stage (PubMed:17050737, PubMed:26828939). Reduced ubiquitin-proteasome system function (UBS), particularly in dorsorectal neurons (PubMed:20453865, PubMed:26828939). Enhanced protein stability and increased resistance to protostasis in response to thermal stress and oxidative stress induced by tert-butyl hydroperoxide (PubMed:26828939). Irregular autophagy-lysosome pathway function with increased autophagy coupled with fewer intestinal lysosomes and reduced lysosomal function (PubMed:26828939). RNAi-mediated knockdown of skn-1 or elt-2 in the null mutant results in animals which are smaller and that developmentally arrest before adulthood (PubMed:26828939). RNAi-mediated knockdown results in reduced egg laying, abnormal gonad morphology with expansion of the proximal gonad greater than that of wild-type animals, and defective degradation of polyubiquitinated proteins and leads to an accumulation of these proteins (PubMed:17050737). Also results in delayed removal of paternal mitochondria until 4-fold stage of embryonic development (PubMed:22105480).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004367801 – 34626S proteasome non-ATPase regulatory subunit 4CuratedAdd BLAST346

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O61742

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O61742

PeptideAtlas

More...PeptideAtlasi		O61742

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed with high expression in the pharynx, intestine, hypodermis and spermatheca and weak expression in the excretory cell, body wall muscle, vulva and somatic gonad.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00004466, Expressed in material anatomical entity and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		O61742, 23 interactors

Molecular INTeraction database

More...MINTi		O61742

STRING: functional protein association networks

More...STRINGi		6239.B0205.3.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O61742

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 190VWFAPROSITE-ProRule annotationAdd BLAST186
Domaini216 – 235UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini273 – 292UIM 2PROSITE-ProRule annotationAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi234 – 261Ala-richPROSITE-ProRule annotationAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the proteasome subunit S5A family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2884, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000064050

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_033293_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O61742

Identification of Orthologs from Complete Genome Data

More...OMAi		IVFSCSP

Database of Orthologous Groups

More...OrthoDBi		1244685at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O61742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003903, UIM_dom
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02809, UIM, 2 hits
PF13519, VWA_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00726, UIM, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53300, SSF53300, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50330, UIM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O61742-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQESTMICV DNSEYMRNGD FQPTRLQSQQ DAVNLVTQCK LRANPENAVG 
        60         70         80         90        100
ILSMANSVQV LSSLSTEQGR LMMKNHSIEP FGKCNFIAGI KIAHLALKHR 
       110        120        130        140        150
QNRNHKMRVV LFIGSPLEEI EMNELVKIAK KMKKEKVLCD VIMFGENESD 
       160        170        180        190        200
GHEKFSTFVD TLNGKEGSGS SLIVVPQGSS LTDALLQSSV CKNEDGQAAF 
       210        220        230        240        250
GGGGNGMDNA FGMDVENDPD LALALRVSME EERARQAAAA AANGGAADSG 
       260        270        280        290        300
ADAEVAAAAA AVPLEEMDMG AMTEEQQLEW ALRLSMQENA PAEQPQVQHE 
       310        320        330        340 
QMDVDGAPAV GGDNLDDLMN NPELLQQIVD DLPAANAEKD DDKEKK
Length:346
Mass (Da):37,348
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADAFB35DE60BDE48
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD61298.1

NCBI Reference Sequences

More...RefSeqi		NP_492809.1, NM_060408.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		B0205.3.1; B0205.3.1; WBGene00004466
B0205.3.2; B0205.3.2; WBGene00004466

Database of genes from NCBI RefSeq genomes

More...GeneIDi		172977

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_B0205.3

UCSC genome browser

More...UCSCi		B0205.3.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD61298.1
RefSeqiNP_492809.1, NM_060408.4

3D structure databases

SMRiO61742
ModBaseiSearch...

Protein-protein interaction databases

IntActiO61742, 23 interactors
MINTiO61742
STRINGi6239.B0205.3.1

Proteomic databases

EPDiO61742
PaxDbiO61742
PeptideAtlasiO61742

Genome annotation databases

EnsemblMetazoaiB0205.3.1; B0205.3.1; WBGene00004466
B0205.3.2; B0205.3.2; WBGene00004466
GeneIDi172977
KEGGicel:CELE_B0205.3
UCSCiB0205.3.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		172977
WormBaseiB0205.3 ; CE26355 ; WBGene00004466 ; rpn-10

Phylogenomic databases

eggNOGiKOG2884, Eukaryota
GeneTreeiENSGT00530000064050
HOGENOMiCLU_033293_0_0_1
InParanoidiO61742
OMAiIVFSCSP
OrthoDBi1244685at2759
PhylomeDBiO61742

Enzyme and pathway databases

ReactomeiR-CEL-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-187577, SCF(Skp2)-mediated degradation of p27/p21
R-CEL-195253, Degradation of beta-catenin by the destruction complex
R-CEL-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-CEL-350562, Regulation of ornithine decarboxylase (ODC)
R-CEL-382556, ABC-family proteins mediated transport
R-CEL-4608870, Asymmetric localization of PCP proteins
R-CEL-4641258, Degradation of DVL
R-CEL-5632684, Hedgehog 'on' state
R-CEL-5687128, MAPK6/MAPK4 signaling
R-CEL-5689603, UCH proteinases
R-CEL-5689880, Ub-specific processing proteases
R-CEL-68949, Orc1 removal from chromatin
R-CEL-69017, CDK-mediated phosphorylation and removal of Cdc6
R-CEL-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-75815, Ubiquitin-dependent degradation of Cyclin D
R-CEL-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902, Regulation of RUNX2 expression and activity
R-CEL-8941858, Regulation of RUNX3 expression and activity
R-CEL-8948751, Regulation of PTEN stability and activity
R-CEL-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...PROi		PR:O61742

Gene expression databases

BgeeiWBGene00004466, Expressed in material anatomical entity and 5 other tissues

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR003903, UIM_dom
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF02809, UIM, 2 hits
PF13519, VWA_2, 1 hit
SMARTiView protein in SMART
SM00726, UIM, 2 hits
SUPFAMiSSF53300, SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50330, UIM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSMD4_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O61742
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: October 1, 2001
Last modified: February 10, 2021
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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