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UniProtKB - O61705 (SCXA_MESMA)
Protein
Neurotoxin BmK-M10
Gene
N/A
Organism
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Status
Functioni
Binds to voltage-dependent sodium channels (Nav) and voltage-dependent delayed rectifier potassium channels and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. Administration to mice at a dosage of 0.8 mg/kg produces an analgesic effect.
1 PublicationGO - Molecular functioni
- potassium channel inhibitor activity Source: UniProtKB
- sodium channel inhibitor activity Source: UniProtKB
- toxin activity Source: UniProtKB
GO - Biological processi
- defense response Source: InterPro
- modulation by symbiont of host nervous system process Source: InterPro
- negative regulation of voltage-gated sodium channel activity in another organism Source: UniProtKB
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Neurotoxin BmK-M10Alternative name(s): Alpha-neurotoxin TX9 BmK AngM11 Publication BmK-X Short name: BmKX BmK10 BmKalphaTx9 Bmk M10 Short name: BmkM10 Neurotoxin M10 |
Organismi | Mesobuthus martensii (Manchurian scorpion) (Buthus martensii) |
Taxonomic identifieri | 34649 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Mesobuthus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000035240 | 20 – 83 | Neurotoxin BmK-M101 PublicationAdd BLAST | 64 | |
PropeptideiPRO_0000035241 | 84 | Removed by a carboxypeptidase | 1 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 82 | Combined sources | ||
Disulfide bondi | 35 ↔ 55 | Combined sources | ||
Disulfide bondi | 41 ↔ 65 | Combined sources | ||
Disulfide bondi | 45 ↔ 67 | Combined sources |
Keywords - PTMi
Disulfide bondProteomic databases
PRIDEi | O61705 |
Expressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | O61705 |
SMRi | O61705 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O61705 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 83 | LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST | 63 |
Domaini
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).Curated
Sequence similaritiesi
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.Curated
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00107, Knot1, 1 hit |
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR044062, LCN-type_CS_alpha_beta_dom IPR003614, Scorpion_toxin-like IPR036574, Scorpion_toxin-like_sf IPR018218, Scorpion_toxinL IPR002061, Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537, Toxin_3, 1 hit |
PRINTSi | PR00285, SCORPNTOXIN |
SMARTi | View protein in SMART SM00505, Knot1, 1 hit |
SUPFAMi | SSF57095, SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863, LCN_CSAB, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O61705-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNYLVMISFA LLLMKGVESV RDAYIAKPEN CVYECGITQD CNKLCTENGA
60 70 80
ESGYCQWGGK YGNACWCIKL PDSVPIRVPG KCQR
Mass spectrometryi
Molecular mass is 7040.5 Da. Determined by ESI. 1 Publication
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF062563 Genomic DNA Translation: AAC16697.1 AF164203 mRNA Translation: AAK06898.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF062563 Genomic DNA Translation: AAC16697.1 AF164203 mRNA Translation: AAK06898.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KBK | NMR | - | A | 20-83 | [»] | |
AlphaFoldDBi | O61705 | |||||
SMRi | O61705 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PRIDEi | O61705 |
Miscellaneous databases
EvolutionaryTracei | O61705 |
Family and domain databases
CDDi | cd00107, Knot1, 1 hit |
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR044062, LCN-type_CS_alpha_beta_dom IPR003614, Scorpion_toxin-like IPR036574, Scorpion_toxin-like_sf IPR018218, Scorpion_toxinL IPR002061, Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537, Toxin_3, 1 hit |
PRINTSi | PR00285, SCORPNTOXIN |
SMARTi | View protein in SMART SM00505, Knot1, 1 hit |
SUPFAMi | SSF57095, SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863, LCN_CSAB, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCXA_MESMA | |
Accessioni | O61705Primary (citable) accession number: O61705 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | August 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families