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Protein

Programmed cell death activator egl-1

Gene

egl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in programmed cell death (PCD or apoptosis) by negatively regulating ced-9 (PubMed:9604928, PubMed:10688797, PubMed:15383288). Binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3 (PubMed:9604928, PubMed:10688797, PubMed:15383288). Required to activate programmed cell death in the sister cells of the serotonergic neurosecretory motor (NSM) neurons during embryogenesis (PubMed:12874127). Required to activate programmed cell death in the sister cells of the M4 motor neuron and I1 pharyngeal neuron during embryogenesis (PubMed:20713707). During larval development, required for the elimination of transient presynaptic components upstream of ced-9, ced-4 and ced-3 apoptotic pathway (PubMed:26074078). Together with ain-1, a component of the miRNA-induced-silencing complex (miRISC), and probably upstream of ced-3 and ced-4, regulates temporal cell fate patterning during larval development (PubMed:25432023).7 Publications

GO - Biological processi

  • actin filament depolymerization Source: UniProtKB
  • apoptotic mitochondrial changes Source: WormBase
  • apoptotic process Source: UniProtKB
  • apoptotic process involved in development Source: UniProtKB
  • defense response to Gram-negative bacterium Source: UniProtKB
  • negative regulation of protein binding Source: UniProtKB
  • oviposition Source: WormBase
  • positive regulation of apoptotic process Source: WormBase
  • positive regulation of apoptotic process involved in development Source: UniProtKB
  • positive regulation of programmed cell death Source: WormBase
  • positive regulation of synapse disassembly Source: UniProtKB
  • regulation of development, heterochronic Source: UniProtKB

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death activator egl-1
Alternative name(s):
Egg-laying defective protein 1
Gene namesi
Name:egl-1Imported
ORF Names:F23B12.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF23B12.9 ; CE35714 ; WBGene00001170 ; egl-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Synapse

Pathology & Biotechi

Disruption phenotypei

Mutants block programmed cell death (PubMed:9604928). In an ain-1 mutant background, enhances the proportion of animals arrested at the larval stage, with egg-laying defects and with a ruptured vulva (PubMed:25432023).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869441 – 106Programmed cell death activator egl-1Add BLAST106

Proteomic databases

PaxDbiO61667

Expressioni

Gene expression databases

BgeeiWBGene00001170

Interactioni

Subunit structurei

Interacts with ced-9; the interaction results in ced-4 release from the ced-4/ced-9 complex.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ced-9P419587EBI-495949,EBI-494110

Protein-protein interaction databases

BioGridi44947, 1 interactor
ComplexPortaliCPX-398 ced-9-egl-1 complex
ELMiO61667
IntActiO61667, 2 interactors
STRINGi6239.F23B12.9

Structurei

Secondary structure

1106
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi65 – 84Combined sources20
Helixi85 – 87Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TY4X-ray2.20C/D46-102[»]
ProteinModelPortaliO61667
SMRiO61667
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO61667

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410K9GF Eukaryota
ENOG4110JBC LUCA
HOGENOMiHOG000017551
InParanoidiO61667
KOiK20104
OMAiDAEMMSY
OrthoDBiEOG091G1CD6

Family and domain databases

InterProiView protein in InterPro
IPR021543 EGL-1
PfamiView protein in Pfam
PF11430 EGL-1, 1 hit

Sequencei

Sequence statusi: Complete.

O61667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMLTFASTS SDLLPMSNVF DVQSSVFYNE KNMFYSSSQD FSSCEDSSQF
60 70 80 90 100
ADDSGFFDDS EISSIGYEIG SKLAAMCDDF DAQMMSYSAH ASDRSLFHRL

LDFFAF
Length:106
Mass (Da):11,916
Last modified:March 29, 2005 - v2
Checksum:i2329D2DB0F019636
GO

Sequence cautioni

The sequence AAC39023 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057309 mRNA Translation: AAC39023.1 Different initiation.
BX284605 Genomic DNA Translation: CAB82213.2
PIRiT43032
RefSeqiNP_506575.2, NM_074174.3
UniGeneiCel.19641

Genome annotation databases

EnsemblMetazoaiF23B12.9; F23B12.9; WBGene00001170
GeneIDi179943
KEGGicel:CELE_F23B12.9
UCSCiF23B12.9 c. elegans

Similar proteinsi

Entry informationi

Entry nameiEGL1_CAEEL
AccessioniPrimary (citable) accession number: O61667
Secondary accession number(s): Q7JLC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: June 20, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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