UniProtKB - O61491 (FLOT1_DROME)
Protein
Flotillin-1
Gene
Flo1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.By similarity
GO - Molecular functioni
- structural molecule activity Source: UniProtKB
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- positive regulation of cell-cell adhesion mediated by cadherin Source: GO_Central
- positive regulation of cell junction assembly Source: GO_Central
- positive regulation of endocytosis Source: GO_Central
- protein kinase C signaling Source: GO_Central
- protein localization to plasma membrane Source: GO_Central
- regulation of receptor internalization Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
Reactomei | R-DME-8849932, Synaptic adhesion-like molecules |
Names & Taxonomyi
Protein namesi | Recommended name: Flotillin-1 |
Gene namesi | ORF Names:CG8200Imported |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0024754, Flo1 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Other locations
- caveola 1 Publication; Peripheral membrane protein 1 Publication
Note: Membrane-associated protein of caveolae.
Plasma Membrane
- flotillin complex Source: GO_Central
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: FlyBase
- cytoplasmic vesicle Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094054 | 1 – 426 | Flotillin-1Add BLAST | 426 |
Proteomic databases
PaxDbi | O61491 |
PRIDEi | O61491 |
PTM databases
SwissPalmi | O61491 |
Expressioni
Tissue specificityi
Expressed in brain and ventral nerve cord from stage 12-16 of embryogenesis.1 Publication
Gene expression databases
Bgeei | FBgn0024754, Expressed in oviduct (Drosophila) and 53 other tissues |
Genevisiblei | O61491, DM |
Interactioni
Subunit structurei
Heterooligomeric complex of flotillins 1 and 2 and caveolins 1 and 2.
By similarityProtein-protein interaction databases
BioGRIDi | 62460, 10 interactors |
DIPi | DIP-48829N |
IntActi | O61491, 4 interactors |
STRINGi | 7227.FBpp0086485 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2668, Eukaryota |
GeneTreei | ENSGT00560000077232 |
HOGENOMi | CLU_038134_1_0_1 |
InParanoidi | O61491 |
OMAi | QYDSEVK |
PhylomeDBi | O61491 |
Family and domain databases
InterProi | View protein in InterPro IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR031905, Flotillin_C IPR027705, Flotillin_fam |
PANTHERi | PTHR13806, PTHR13806, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit PF15975, Flot, 1 hit |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform Short (identifier: O61491-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTWGFVTCGP NEALVVSGCC YMKPLLVPGG RAFVWPVGQQ VQRISLNTMT
60 70 80 90 100
LQVESPCVYT SQGVPISVTG IAQVKVQGQN EDMLLTACEQ FLGKSEAEIN
110 120 130 140 150
HIALVTLEGH QRAIMGSMTV EEIYKDRKKF SKQVFEVASS DLANMGITVV
160 170 180 190 200
SYTIKDLRDE EGYLRSLGMA RTAEVKRDAR IGEAEARAEA HIKEAIAEEQ
210 220 230 240 250
RMAARFLNDT DIAKAQRDFE LKKAAYDVEV QTKKAEAEMA YELQAAKTKQ
260 270 280 290 300
RIKEEQMQVK VIERTQEIAV QEQEIMRRER ELEATIRRPA EAEKFRMEKL
310 320 330 340 350
AEANKQRVVM EAEAEAESIR IRGEAEAFAI AAKAKAEAEQ MAMKAEAYRE
360 370 380 390 400
YREAAMVEML LDTLPKVAAE VAAPLSQAKK ITMVSSGTGD IGAAKLTGEV
410 420
LSIVNKVPEL VKNITGVDIA RSVHAG
Isoform Long (identifier: O61491-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
162-162: G → GDSKG
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000506 | 162 | G → GDSKG in isoform Long. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF044734 mRNA Translation: AAC39012.1 AE013599 Genomic DNA Translation: AAF58120.1 AE013599 Genomic DNA Translation: AAF58121.1 AY058794 mRNA Translation: AAL14023.1 |
RefSeqi | NP_477358.1, NM_058010.4 [O61491-1] NP_725476.1, NM_166102.2 [O61491-2] |
Genome annotation databases
EnsemblMetazoai | FBtr0087351; FBpp0086484; FBgn0024754 [O61491-1] FBtr0087352; FBpp0086485; FBgn0024754 [O61491-2] |
GeneIDi | 36726 |
KEGGi | dme:Dmel_CG8200 |
UCSCi | CG8200-RA, d. melanogaster [O61491-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF044734 mRNA Translation: AAC39012.1 AE013599 Genomic DNA Translation: AAF58120.1 AE013599 Genomic DNA Translation: AAF58121.1 AY058794 mRNA Translation: AAL14023.1 |
RefSeqi | NP_477358.1, NM_058010.4 [O61491-1] NP_725476.1, NM_166102.2 [O61491-2] |
3D structure databases
SMRi | O61491 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 62460, 10 interactors |
DIPi | DIP-48829N |
IntActi | O61491, 4 interactors |
STRINGi | 7227.FBpp0086485 |
PTM databases
SwissPalmi | O61491 |
Proteomic databases
PaxDbi | O61491 |
PRIDEi | O61491 |
Genome annotation databases
EnsemblMetazoai | FBtr0087351; FBpp0086484; FBgn0024754 [O61491-1] FBtr0087352; FBpp0086485; FBgn0024754 [O61491-2] |
GeneIDi | 36726 |
KEGGi | dme:Dmel_CG8200 |
UCSCi | CG8200-RA, d. melanogaster [O61491-1] |
Organism-specific databases
CTDi | 36726 |
FlyBasei | FBgn0024754, Flo1 |
Phylogenomic databases
eggNOGi | KOG2668, Eukaryota |
GeneTreei | ENSGT00560000077232 |
HOGENOMi | CLU_038134_1_0_1 |
InParanoidi | O61491 |
OMAi | QYDSEVK |
PhylomeDBi | O61491 |
Enzyme and pathway databases
Reactomei | R-DME-8849932, Synaptic adhesion-like molecules |
Miscellaneous databases
BioGRID-ORCSi | 36726, 0 hits in 1 CRISPR screen |
ChiTaRSi | Flo1, fly |
GenomeRNAii | 36726 |
PROi | PR:O61491 |
Gene expression databases
Bgeei | FBgn0024754, Expressed in oviduct (Drosophila) and 53 other tissues |
Genevisiblei | O61491, DM |
Family and domain databases
InterProi | View protein in InterPro IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR031905, Flotillin_C IPR027705, Flotillin_fam |
PANTHERi | PTHR13806, PTHR13806, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit PF15975, Flot, 1 hit |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FLOT1_DROME | |
Accessioni | O61491Primary (citable) accession number: O61491 Secondary accession number(s): Q9V7D7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | August 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families