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Protein

Arginine kinase

Gene

ARGK

Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play an important role in the energy releasing mechanism in the visual system. By acting as an energy shuttle and/or as an energy reservoir, ARGK can provide both spatial and temporal buffering in delivering energy in sensory cells.

Catalytic activityi

ATP + L-arginine = ADP + N(omega)-phospho-L-arginine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei184ATPPROSITE-ProRule annotation1
Binding sitei224SubstrateBy similarity1
Binding sitei228ATPPROSITE-ProRule annotation1
Binding sitei270SubstrateBy similarity1
Binding sitei313SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi121 – 125ATPPROSITE-ProRule annotation5
Nucleotide bindingi279 – 283ATPPROSITE-ProRule annotation5
Nucleotide bindingi308 – 313ATPPROSITE-ProRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.3.3 387

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine kinase (EC:2.7.3.3)
Short name:
AK
Gene namesi
Name:ARGK
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis
Proteomesi
  • UP000005203 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002119911 – 355Arginine kinaseAdd BLAST355

Proteomic databases

PaxDbiO61367
PRIDEiO61367

Expressioni

Tissue specificityi

Highest level of expression in the compound eye. Relatively abundant in the brain, the thorax and the antennae. Lowest expression in the ovaries.

Interactioni

Protein-protein interaction databases

STRINGi7460.GB10973-PA

Structurei

3D structure databases

ProteinModelPortaliO61367
SMRiO61367
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 90Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd BLAST85
Domaini118 – 355Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni63 – 67Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3581 Eukaryota
COG3869 LUCA
InParanoidiO61367
KOiK00933
PhylomeDBiO61367

Family and domain databases

Gene3Di1.10.135.10, 1 hit
InterProiView protein in InterPro
IPR000749 ATP-guanido_PTrfase
IPR022415 ATP-guanido_PTrfase_AS
IPR022414 ATP-guanido_PTrfase_cat
IPR022413 ATP-guanido_PTrfase_N
IPR036802 ATP-guanido_PTrfase_N_sf
IPR014746 Gln_synth/guanido_kin_cat_dom
PANTHERiPTHR11547 PTHR11547, 1 hit
PfamiView protein in Pfam
PF00217 ATP-gua_Ptrans, 1 hit
PF02807 ATP-gua_PtransN, 1 hit
SUPFAMiSSF48034 SSF48034, 1 hit
SSF55931 SSF55931, 1 hit
PROSITEiView protein in PROSITE
PS00112 PHOSPHAGEN_KINASE, 1 hit
PS51510 PHOSPHAGEN_KINASE_C, 1 hit
PS51509 PHOSPHAGEN_KINASE_N, 1 hit

Sequencei

Sequence statusi: Complete.

O61367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDQAVLDKL ETGFSKLSSS DSKSLLKKYL SKDVFDQLKT KKTSFDSTLL
60 70 80 90 100
DCIQSGIENL DSGVGIYAPD AEAYTLFADL FDPIIEDYHG GFKKTDKHPP
110 120 130 140 150
KDFGDVDSLG NLDPANEFIV STRVRCGRSL EGYPFNPCLT EAQYKEMEEK
160 170 180 190 200
VSSTLSGLEG ELKGTFYPLT GMSKETQQKL IDDHFLFKEG DRFLQAANAC
210 220 230 240 250
RFWPTGRGIY HNDDKTFLVW CNEEDHLRII SMQMGGDLGQ VYRRLVHAVN
260 270 280 290 300
EIEKRLLFSH NDRLGFLTFC PTNLGTTVRA SVHIKLPKLA ANRAKLEEIA
310 320 330 340 350
GKFNLQVRGT RGEHTEAEGG IYDISNKRRL GLTEYQAVKE MHDGIAELIK

LEKEL
Length:355
Mass (Da):40,008
Last modified:August 1, 1998 - v1
Checksum:iE3BD2CA44BBDFFFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023619 mRNA Translation: AAC39040.1
PIRiPC6506
RefSeqiNP_001011603.1, NM_001011603.1
UniGeneiAme.1208

Genome annotation databases

GeneIDi550932
KEGGiame:550932

Similar proteinsi

Entry informationi

Entry nameiKARG_APIME
AccessioniPrimary (citable) accession number: O61367
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: August 1, 1998
Last modified: February 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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