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Entry version 144 (12 Aug 2020)
Sequence version 2 (06 Feb 2013)
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Protein

Teneurin-m

Gene

Ten-m

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with Ten-a to organize neuromuscular synapses. Functions in olfactory synaptic partner matching by promoting homophilic cell adhesion between pre-synaptic olfactory receptor neurons (ORN) axons and post-synaptic projection neurons (PN) dendrites partner in the developing antennal lobe to form stable connections. Also required for peripheral axon growth cone guidance and target recognition of motor neurons.4 Publications

Miscellaneous

The name odz (odd Oz) reflects the odd pair rule nature of the gene and Oz reflects the prominent expression of the gene in the brain, heart and neurons, corresponding to the three gifts that the Wizard of Oz bestowed.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion, Neurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Teneurin-m
Short name:
Tenm
Alternative name(s):
Odd Oz protein
Tenascin-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ten-m
Synonyms:odz
ORF Names:CG5723
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004449, Ten-m

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 229CytoplasmicSequence analysisAdd BLAST229
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 2731ExtracellularSequence analysisAdd BLAST2481

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Shows peripheral motor neuron axon guidance defects.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004210211 – 2731Teneurin-mAdd BLAST2731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi540 ↔ 549PROSITE-ProRule annotation
Disulfide bondi545 ↔ 560PROSITE-ProRule annotation
Disulfide bondi562 ↔ 571PROSITE-ProRule annotation
Disulfide bondi578 ↔ 589PROSITE-ProRule annotation
Disulfide bondi583 ↔ 594PROSITE-ProRule annotation
Disulfide bondi596 ↔ 605PROSITE-ProRule annotation
Disulfide bondi651 ↔ 664PROSITE-ProRule annotation
Disulfide bondi666 ↔ 675PROSITE-ProRule annotation
Disulfide bondi742 ↔ 752PROSITE-ProRule annotation
Disulfide bondi746 ↔ 762PROSITE-ProRule annotation
Disulfide bondi764 ↔ 773PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi857N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation occurs at tyrosine residues.1 Publication
Proteolytically cleaved.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O61307

PeptideAtlas

More...
PeptideAtlasi
O61307

PRoteomics IDEntifications database

More...
PRIDEi
O61307

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O61307

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in muscles and motor neurons (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the central nervous system and heart. Expressed in the developing antennal lobe. Expressed in subset of matching olfactory receptor neurons (ORN) and projection neurons (PN) in select glomeruli between 12 to 48 hours after puparium formation (apf) (at protein level). Expressed in odd-numbered blastoderm parasegments, the central nervous system, muscle attachment points and tracheal precursor cells. Expressed in the ventral nerve cord, the cardiac mesoderm and epidermis at late embryonic stages. Expressed in all imaginal disks.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004449, Expressed in embryonic/larval hemocyte (Drosophila) and 42 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O61307, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O61307, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterodimer with Ten-a.

Interacts with Ten-a; the interaction occurs at the neuromuscular junction.

Interacts with alpha-Spec and cher.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
65699, 9 interactors

Protein interaction database and analysis system

More...
IntActi
O61307, 705 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0297244

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O61307

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini536 – 572EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini574 – 606EGF-like 2PROSITE-ProRule annotationAdd BLAST33
Domaini643 – 676EGF-like 3PROSITE-ProRule annotationAdd BLAST34
Domaini738 – 774EGF-like 4PROSITE-ProRule annotationAdd BLAST37
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1160 – 1201NHL 1Add BLAST42
Repeati1202 – 1246NHL 2Add BLAST45
Repeati1391 – 1434NHL 3Add BLAST44
Repeati1459 – 1502NHL 4Add BLAST44
Repeati1618 – 1652YDSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi317 – 368Ser-richAdd BLAST52

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family. Teneurin subfamily.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1225, Eukaryota
KOG4659, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214453

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000229_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O61307

Identification of Orthologs from Complete Genome Data

More...
OMAi
AHYKYAY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 2 hits
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR008969, CarboxyPept-like_regulatory
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR008979, Galactose-bd-like_sf
IPR031325, RHS_repeat
IPR028916, Tox-GHH_dom
IPR006530, YD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05593, RHS_repeat, 1 hit
PF15636, Tox-GHH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49464, SSF49464, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01643, YD_repeat_2x, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform B (identifier: O61307-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPYEYESTL DCRDVGGGPT PAHAHPHAQG RTLPMSGHGR PTTDLGPVHG
60 70 80 90 100
SQTLQHQNQQ NLQAAQAAAQ SSHYDYEYQH LAHRPPDTAN NTAQRTHGRQ
110 120 130 140 150
GFLLEGVTPT APPDVPPRNP TMSRMQNGRL TVNNPNDADF EPSCLVRTPS
160 170 180 190 200
GNVYIPSGNL NINKGSPIDF KSGSACSTPT KDTLKGYERS TQGCMGPVLP
210 220 230 240 250
QRSVMNGLPA HHYSAPMNFR KDLVARCSSP WFGIGSISVL FAFVVMLILL
260 270 280 290 300
TTTGVIKWNQ SPPCSVLVGN EASEVTAAKS TNTDLSKLHN SSVRAKNGQG
310 320 330 340 350
IGLAQGQSGL GAAGVGSGGG SSAATVTTAT SNSGTAQGLQ STSASAEATS
360 370 380 390 400
SAATSSSQSS LTPSLSSSLA NANNGGARTF PARSFPPDGT TFGQITLGQK
410 420 430 440 450
LTKEIQPYSY WNMQFYQSEP AYVKFDYTIP RGASIGVYGR RNALPTHTQY
460 470 480 490 500
HFKEVLSGFS ASTRTARAAH LSITREVTRY MEPGHWFVSL YNDDGDVQEL
510 520 530 540 550
TFYAAVAEDM TQNCPNGCSG NGQCLLGHCQ CNPGFGGDDC SESVCPVLCS
560 570 580 590 600
QHGEYTNGEC ICNPGWKGKE CSLRHDECEV ADCSGHGHCV SGKCQCMRGY
610 620 630 640 650
KGKFCEEVDC PHPNCSGHGF CADGTCICKK GWKGPDCATM DQDALQCLPD
660 670 680 690 700
CSGHGTFDLD TQTCTCEAKW SGDDCSKELC DLDCGQHGRC EGDACACDPE
710 720 730 740 750
WGGEYCNTRL CDVRCNEHGQ CKNGTCLCVT GWNGKHCTIE GCPNSCAGHG
760 770 780 790 800
QCRVSGEGQW ECRCYEGWDG PDCGIALELN CGDSKDNDKD GLVDCEDPEC
810 820 830 840 850
CASHVCKTSQ LCVSAPKPID VLLRKQPPAI TASFFERMKF LIDESSLQNY
860 870 880 890 900
AKLETFNESR SAVIRGRVVT SLGMGLVGVR VSTTTLLEGF TLTRDDGWFD
910 920 930 940 950
LMVNGGGAVT LQFGRAPFRP QSRIVQVPWN EVVIIDLVVM SMSEEKGLAV
960 970 980 990 1000
TTTHTCFAHD YDLMKPVVLA SWKHGFQGAC PDRSAILAES QVIQESLQIP
1010 1020 1030 1040 1050
GTGLNLVYHS SRAAGYLSTI KLQLTPDVIP TSLHLIHLRI TIEGILFERI
1060 1070 1080 1090 1100
FEADPGIKFT YAWNRLNIYR QRVYGVTTAV VKVGYQYTDC TDIVWDIQTT
1110 1120 1130 1140 1150
KLSGHDMSIS EVGGWNLDIH HRYNFHEGIL QKGDGSNIYL RNKPRIILTT
1160 1170 1180 1190 1200
MGDGHQRPLE CPDCDGQATK QRLLAPVALA AAPDGSLFVG DFNYIRRIMT
1210 1220 1230 1240 1250
DGSIRTVVKL NATRVSYRYH MALSPLDGTL YVSDPESHQI IRVRDTNDYS
1260 1270 1280 1290 1300
QPELNWEAVV GSGERCLPGD EAHCGDGALA KDAKLAYPKG IAISSDNILY
1310 1320 1330 1340 1350
FADGTNIRMV DRDGIVSTLI GNHMHKSHWK PIPCEGTLKL EEMHLRWPTE
1360 1370 1380 1390 1400
LAVSPMDNTL HIIDDHMILR MTPDGRVRVI SGRPLHCATA STAYDTDLAT
1410 1420 1430 1440 1450
HATLVMPQSI AFGPLGELYV AESDSQRINR VRVIGTDGRI APFAGAESKC
1460 1470 1480 1490 1500
NCLERGCDCF EAEHYLATSA KFNTIAALAV TPDSHVHIAD QANYRIRSVM
1510 1520 1530 1540 1550
SSIPEASPSR EYEIYAPDMQ EIYIFNRFGQ HVSTRNILTG ETTYVFTYNV
1560 1570 1580 1590 1600
NTSNGKLSTV TDAAGNKVFL LRDYTSQVNS IENTKGQKCR LRMTRMKMLH
1610 1620 1630 1640 1650
ELSTPDNYNV TYEYHGPTGL LRTKLDSTGR SYVYNYDEFG RLTSAVTPTG
1660 1670 1680 1690 1700
RVIELSFDLS VKGAQVKVSE NAQKEMSLLI QGATVIVRNG AAESRTTVDM
1710 1720 1730 1740 1750
DGSTTSITPW GHNLQMEVAP YTILAEQSPL LGESYPVPAK QRTEIAGDLA
1760 1770 1780 1790 1800
NRFEWRYFVR RQQPLQAGKQ SKGPPRPVTE VGRKLRVNGD NVLTLEYDRE
1810 1820 1830 1840 1850
TQSVVVMVDD KQELLNVTYD RTSRPISFRP QSGDYADVDL EYDRFGRLVS
1860 1870 1880 1890 1900
WKWGVLQEAY SFDRNGRLNE IKYGDGSTMV YAFKDMFGSL PLKVTTPRRS
1910 1920 1930 1940 1950
DYLLQYDDAG ALQSLTTPRG HIHAFSLQTS LGFFKYQYYS PINRHPFEIL
1960 1970 1980 1990 2000
YNDEGQILAK IHPHQSGKVA FVHDTAGRLE TILAGLSSTH YTYQDTTSLV
2010 2020 2030 2040 2050
KSVEVQEPGF ELRREFKYHA GILKDEKLRF GSKNSLASAR YKYAYDGNAR
2060 2070 2080 2090 2100
LSGIEMAIDD KELPTTRYKY SQNLGQLEVV QDLKITRNAF NRTVIQDSAK
2110 2120 2130 2140 2150
QFFAIVDYDQ HGRVKSVLMN VKNIDVFRLE LDYDLRNRIK SQKTTFGRST
2160 2170 2180 2190 2200
AFDKINYNAD GHVVEVLGTN NWKYLFDENG NTVGVVDQGE KFNLGYDIGD
2210 2220 2230 2240 2250
RVIKVGDVEF NNYDARGFVV KRGEQKYRYN NRGQLIHSFE RERFQSWYYY
2260 2270 2280 2290 2300
DDRSRLVAWH DNKGNTTQYY YANPRTPHLV THVHFPKISR TMKLFYDDRD
2310 2320 2330 2340 2350
MLIALEHEDQ RYYVATDQNG SPLAFFDQNG SIVKEMKRTP FGRIIKDTKP
2360 2370 2380 2390 2400
EFFVPIDFHG GLIDPHTKLV YTEQRQYDPH VGQWMTPLWE TLATEMSHPT
2410 2420 2430 2440 2450
DVFIYRYHNN DPINPNKPQN YMIDLDSWLQ LFGYDLNNMQ SSRYTKLAQY
2460 2470 2480 2490 2500
TPQASIKSNT LAPDFGVISG LECIVEKTSE KFSDFDFVPK PLLKMEPKMR
2510 2520 2530 2540 2550
NLLPRVSYRR GVFGEGVLLS RIGGRALVSV VDGSNSVVQD VVSSVFNNSY
2560 2570 2580 2590 2600
FLDLHFSIHD QDVFYFVKDN VLKLRDDNEE LRRLGGMFNI STHEISDHGG
2610 2620 2630 2640 2650
SAAKELRLHG PDAVVIIKYG VDPEQERHRI LKHAHKRAVE RAWELEKQLV
2660 2670 2680 2690 2700
AAGFQGRGDW TEEEKEELVQ HGDVDGWNGI DIHSIHKYPQ LADDPGNVAF
2710 2720 2730
QRDAKRKRRK TGSSHRSASN RRQLKFGELS A
Length:2,731
Mass (Da):304,056
Last modified:February 6, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6718B77B8F62D482
GO
Isoform D (identifier: O61307-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     375-375: G → GGRAMSTRLS...PDVMPVLILE
     858-858: E → ESIFWNYFNA

Show »
Length:3,297
Mass (Da):366,082
Checksum:iBD302737C911F209
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PGF7M9PGF7_DROME
Tenascin major, isoform E
Ten-m 2017, 5301, BcDNA:AT25108, CG11452, CT16449
3,349Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA51678 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22A → G in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti22A → G in AAC05080 (PubMed:9373139).Curated1
Sequence conflicti37G → S in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti37G → S in AAC05080 (PubMed:9373139).Curated1
Sequence conflicti65A → V in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti89A → V in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti1837D → Y in CAA51678 (PubMed:8070401).Curated1
Sequence conflicti2099A → G in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti2099A → G in AAC05080 (PubMed:9373139).Curated1
Sequence conflicti2315A → T in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti2495M → T in CAA51678 (PubMed:8070401).Curated1
Sequence conflicti2710K → R in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti2710K → R in AAC05080 (PubMed:9373139).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054459375G → GGRAMSTRLSVRGAGERGRR HRRSLNEEQGEDDVATDGTF SDLITNESLNQQAAEKYLAT TLAKSPTDVHGSGNKTLPRM DGVYGTQRSEDTPDTSYDYV YEDEVEPETTPSLIRRTKTG QQFGKSLNSNLRSAAKTLVN KRRKYDHGTVEAEHIKHEEE EEEDEQKLERHEAIGMATEL TTESETSTLPAVIDDDNQSD NSSSGPTPETTVRSDTDDIV EINTPPSQTAQRTFAAVSHQ PAIEHDFQIKGTDAGGLQTE KPATDDINNERDLADNYEVD SKEPTSPGTPPQGKVSQQTG KASLQSLQSESDLMMNDASH YEDIDIVKLDGLTISHEEEI YKTADKENMAPKNQPSQHID RSQNEVLKGHQQGDEKQPQL EPLKPYVSERVDLPGKRIFL NLTIATDEGSDSVYTLHVEV PTGGGPHFIKEVLTHEKPTA QADSCVPEPPPRMPDCPCSC LPPPAPIYLDDTVDIDSAPP AKTVTTSTISAPINPFHSEE EDDEDGVRDEEQTPSSSTAT NLPSTEIDNHIAAFTEPAVG AGGVPFACPDVMPVLILE in isoform D. Curated1
Alternative sequenceiVSP_054460858E → ESIFWNYFNA in isoform D. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X73154 mRNA Translation: CAA51678.1 Different initiation.
AF008227, AF008224, AF008226 Genomic DNA Translation: AAC05080.1
AF008228 mRNA Translation: AAB88281.1
AE014296 Genomic DNA Translation: AAF51824.2
AE014296 Genomic DNA Translation: ABW08579.2

NCBI Reference Sequences

More...
RefSeqi
NP_001097661.2, NM_001104191.3 [O61307-2]
NP_524215.2, NM_079491.3 [O61307-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0078509; FBpp0078161; FBgn0004449 [O61307-1]
FBtr0306107; FBpp0297244; FBgn0004449 [O61307-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40464

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5723

UCSC genome browser

More...
UCSCi
CG5723-RB, d. melanogaster
CG5723-RC, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73154 mRNA Translation: CAA51678.1 Different initiation.
AF008227, AF008224, AF008226 Genomic DNA Translation: AAC05080.1
AF008228 mRNA Translation: AAB88281.1
AE014296 Genomic DNA Translation: AAF51824.2
AE014296 Genomic DNA Translation: ABW08579.2
RefSeqiNP_001097661.2, NM_001104191.3 [O61307-2]
NP_524215.2, NM_079491.3 [O61307-1]

3D structure databases

SMRiO61307
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi65699, 9 interactors
IntActiO61307, 705 interactors
STRINGi7227.FBpp0297244

PTM databases

iPTMnetiO61307

Proteomic databases

PaxDbiO61307
PeptideAtlasiO61307
PRIDEiO61307

Genome annotation databases

EnsemblMetazoaiFBtr0078509; FBpp0078161; FBgn0004449 [O61307-1]
FBtr0306107; FBpp0297244; FBgn0004449 [O61307-2]
GeneIDi40464
KEGGidme:Dmel_CG5723
UCSCiCG5723-RB, d. melanogaster
CG5723-RC, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
40464
FlyBaseiFBgn0004449, Ten-m

Phylogenomic databases

eggNOGiKOG1225, Eukaryota
KOG4659, Eukaryota
GeneTreeiENSGT01000000214453
HOGENOMiCLU_000229_1_0_1
InParanoidiO61307
OMAiAHYKYAY

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
40464, 0 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ten-m, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40464

Protein Ontology

More...
PROi
PR:O61307

Gene expression databases

BgeeiFBgn0004449, Expressed in embryonic/larval hemocyte (Drosophila) and 42 other tissues
ExpressionAtlasiO61307, baseline and differential
GenevisibleiO61307, DM

Family and domain databases

Gene3Di2.120.10.30, 2 hits
2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR008969, CarboxyPept-like_regulatory
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR008979, Galactose-bd-like_sf
IPR031325, RHS_repeat
IPR028916, Tox-GHH_dom
IPR006530, YD
PfamiView protein in Pfam
PF05593, RHS_repeat, 1 hit
PF15636, Tox-GHH, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 8 hits
SUPFAMiSSF49464, SSF49464, 1 hit
TIGRFAMsiTIGR01643, YD_repeat_2x, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTENM_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O61307
Secondary accession number(s): A8JNW8
, O18366, Q24551, Q9TX59, Q9VNU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: February 6, 2013
Last modified: August 12, 2020
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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