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UniProtKB - O61307 (TENM_DROME)

Entry version 144 (12 Aug 2020)
Sequence version 2 (06 Feb 2013)
Previous versions | rss
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Protein

Teneurin-m

Gene

Ten-m

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with Ten-a to organize neuromuscular synapses. Functions in olfactory synaptic partner matching by promoting homophilic cell adhesion between pre-synaptic olfactory receptor neurons (ORN) axons and post-synaptic projection neurons (PN) dendrites partner in the developing antennal lobe to form stable connections. Also required for peripheral axon growth cone guidance and target recognition of motor neurons.4 Publications

Miscellaneous

The name odz (odd Oz) reflects the odd pair rule nature of the gene and Oz reflects the prominent expression of the gene in the brain, heart and neurons, corresponding to the three gifts that the Wizard of Oz bestowed.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion, Neurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Teneurin-m
Short name:
Tenm
Alternative name(s):
Odd Oz protein
Tenascin-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ten-m
Synonyms:odz
ORF Names:CG5723
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0004449, Ten-m

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 229CytoplasmicSequence analysisAdd BLAST229
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 2731ExtracellularSequence analysisAdd BLAST2481

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Shows peripheral motor neuron axon guidance defects.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004210211 – 2731Teneurin-mAdd BLAST2731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi540 ↔ 549PROSITE-ProRule annotation
Disulfide bondi545 ↔ 560PROSITE-ProRule annotation
Disulfide bondi562 ↔ 571PROSITE-ProRule annotation
Disulfide bondi578 ↔ 589PROSITE-ProRule annotation
Disulfide bondi583 ↔ 594PROSITE-ProRule annotation
Disulfide bondi596 ↔ 605PROSITE-ProRule annotation
Disulfide bondi651 ↔ 664PROSITE-ProRule annotation
Disulfide bondi666 ↔ 675PROSITE-ProRule annotation
Disulfide bondi742 ↔ 752PROSITE-ProRule annotation
Disulfide bondi746 ↔ 762PROSITE-ProRule annotation
Disulfide bondi764 ↔ 773PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi857N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation occurs at tyrosine residues.1 Publication
Proteolytically cleaved.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O61307

PeptideAtlas

More...PeptideAtlasi		O61307

PRoteomics IDEntifications database

More...PRIDEi		O61307

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O61307

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in muscles and motor neurons (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the central nervous system and heart. Expressed in the developing antennal lobe. Expressed in subset of matching olfactory receptor neurons (ORN) and projection neurons (PN) in select glomeruli between 12 to 48 hours after puparium formation (apf) (at protein level). Expressed in odd-numbered blastoderm parasegments, the central nervous system, muscle attachment points and tracheal precursor cells. Expressed in the ventral nerve cord, the cardiac mesoderm and epidermis at late embryonic stages. Expressed in all imaginal disks.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0004449, Expressed in embryonic/larval hemocyte (Drosophila) and 42 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O61307, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O61307, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterodimer with Ten-a.

Interacts with Ten-a; the interaction occurs at the neuromuscular junction.

Interacts with alpha-Spec and cher.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		65699, 9 interactors

Protein interaction database and analysis system

More...IntActi		O61307, 705 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0297244

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O61307

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini536 – 572EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini574 – 606EGF-like 2PROSITE-ProRule annotationAdd BLAST33
Domaini643 – 676EGF-like 3PROSITE-ProRule annotationAdd BLAST34
Domaini738 – 774EGF-like 4PROSITE-ProRule annotationAdd BLAST37
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1160 – 1201NHL 1Add BLAST42
Repeati1202 – 1246NHL 2Add BLAST45
Repeati1391 – 1434NHL 3Add BLAST44
Repeati1459 – 1502NHL 4Add BLAST44
Repeati1618 – 1652YDSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi317 – 368Ser-richAdd BLAST52

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family. Teneurin subfamily.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1225, Eukaryota
KOG4659, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214453

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000229_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O61307

Identification of Orthologs from Complete Genome Data

More...OMAi		AHYKYAY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.120.10.30, 2 hits
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR008969, CarboxyPept-like_regulatory
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR008979, Galactose-bd-like_sf
IPR031325, RHS_repeat
IPR028916, Tox-GHH_dom
IPR006530, YD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05593, RHS_repeat, 1 hit
PF15636, Tox-GHH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 8 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49464, SSF49464, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01643, YD_repeat_2x, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform B (identifier: O61307-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPYEYESTL DCRDVGGGPT PAHAHPHAQG RTLPMSGHGR PTTDLGPVHG 
        60         70         80         90        100
SQTLQHQNQQ NLQAAQAAAQ SSHYDYEYQH LAHRPPDTAN NTAQRTHGRQ 
       110        120        130        140        150
GFLLEGVTPT APPDVPPRNP TMSRMQNGRL TVNNPNDADF EPSCLVRTPS 
       160        170        180        190        200
GNVYIPSGNL NINKGSPIDF KSGSACSTPT KDTLKGYERS TQGCMGPVLP 
       210        220        230        240        250
QRSVMNGLPA HHYSAPMNFR KDLVARCSSP WFGIGSISVL FAFVVMLILL 
       260        270        280        290        300
TTTGVIKWNQ SPPCSVLVGN EASEVTAAKS TNTDLSKLHN SSVRAKNGQG 
       310        320        330        340        350
IGLAQGQSGL GAAGVGSGGG SSAATVTTAT SNSGTAQGLQ STSASAEATS 
       360        370        380        390        400
SAATSSSQSS LTPSLSSSLA NANNGGARTF PARSFPPDGT TFGQITLGQK 
       410        420        430        440        450
LTKEIQPYSY WNMQFYQSEP AYVKFDYTIP RGASIGVYGR RNALPTHTQY 
       460        470        480        490        500
HFKEVLSGFS ASTRTARAAH LSITREVTRY MEPGHWFVSL YNDDGDVQEL 
       510        520        530        540        550
TFYAAVAEDM TQNCPNGCSG NGQCLLGHCQ CNPGFGGDDC SESVCPVLCS 
       560        570        580        590        600
QHGEYTNGEC ICNPGWKGKE CSLRHDECEV ADCSGHGHCV SGKCQCMRGY 
       610        620        630        640        650
KGKFCEEVDC PHPNCSGHGF CADGTCICKK GWKGPDCATM DQDALQCLPD 
       660        670        680        690        700
CSGHGTFDLD TQTCTCEAKW SGDDCSKELC DLDCGQHGRC EGDACACDPE 
       710        720        730        740        750
WGGEYCNTRL CDVRCNEHGQ CKNGTCLCVT GWNGKHCTIE GCPNSCAGHG 
       760        770        780        790        800
QCRVSGEGQW ECRCYEGWDG PDCGIALELN CGDSKDNDKD GLVDCEDPEC 
       810        820        830        840        850
CASHVCKTSQ LCVSAPKPID VLLRKQPPAI TASFFERMKF LIDESSLQNY 
       860        870        880        890        900
AKLETFNESR SAVIRGRVVT SLGMGLVGVR VSTTTLLEGF TLTRDDGWFD 
       910        920        930        940        950
LMVNGGGAVT LQFGRAPFRP QSRIVQVPWN EVVIIDLVVM SMSEEKGLAV 
       960        970        980        990       1000
TTTHTCFAHD YDLMKPVVLA SWKHGFQGAC PDRSAILAES QVIQESLQIP 
      1010       1020       1030       1040       1050
GTGLNLVYHS SRAAGYLSTI KLQLTPDVIP TSLHLIHLRI TIEGILFERI 
      1060       1070       1080       1090       1100
FEADPGIKFT YAWNRLNIYR QRVYGVTTAV VKVGYQYTDC TDIVWDIQTT 
      1110       1120       1130       1140       1150
KLSGHDMSIS EVGGWNLDIH HRYNFHEGIL QKGDGSNIYL RNKPRIILTT 
      1160       1170       1180       1190       1200
MGDGHQRPLE CPDCDGQATK QRLLAPVALA AAPDGSLFVG DFNYIRRIMT 
      1210       1220       1230       1240       1250
DGSIRTVVKL NATRVSYRYH MALSPLDGTL YVSDPESHQI IRVRDTNDYS 
      1260       1270       1280       1290       1300
QPELNWEAVV GSGERCLPGD EAHCGDGALA KDAKLAYPKG IAISSDNILY 
      1310       1320       1330       1340       1350
FADGTNIRMV DRDGIVSTLI GNHMHKSHWK PIPCEGTLKL EEMHLRWPTE 
      1360       1370       1380       1390       1400
LAVSPMDNTL HIIDDHMILR MTPDGRVRVI SGRPLHCATA STAYDTDLAT 
      1410       1420       1430       1440       1450
HATLVMPQSI AFGPLGELYV AESDSQRINR VRVIGTDGRI APFAGAESKC 
      1460       1470       1480       1490       1500
NCLERGCDCF EAEHYLATSA KFNTIAALAV TPDSHVHIAD QANYRIRSVM 
      1510       1520       1530       1540       1550
SSIPEASPSR EYEIYAPDMQ EIYIFNRFGQ HVSTRNILTG ETTYVFTYNV 
      1560       1570       1580       1590       1600
NTSNGKLSTV TDAAGNKVFL LRDYTSQVNS IENTKGQKCR LRMTRMKMLH 
      1610       1620       1630       1640       1650
ELSTPDNYNV TYEYHGPTGL LRTKLDSTGR SYVYNYDEFG RLTSAVTPTG 
      1660       1670       1680       1690       1700
RVIELSFDLS VKGAQVKVSE NAQKEMSLLI QGATVIVRNG AAESRTTVDM 
      1710       1720       1730       1740       1750
DGSTTSITPW GHNLQMEVAP YTILAEQSPL LGESYPVPAK QRTEIAGDLA 
      1760       1770       1780       1790       1800
NRFEWRYFVR RQQPLQAGKQ SKGPPRPVTE VGRKLRVNGD NVLTLEYDRE 
      1810       1820       1830       1840       1850
TQSVVVMVDD KQELLNVTYD RTSRPISFRP QSGDYADVDL EYDRFGRLVS 
      1860       1870       1880       1890       1900
WKWGVLQEAY SFDRNGRLNE IKYGDGSTMV YAFKDMFGSL PLKVTTPRRS 
      1910       1920       1930       1940       1950
DYLLQYDDAG ALQSLTTPRG HIHAFSLQTS LGFFKYQYYS PINRHPFEIL 
      1960       1970       1980       1990       2000
YNDEGQILAK IHPHQSGKVA FVHDTAGRLE TILAGLSSTH YTYQDTTSLV 
      2010       2020       2030       2040       2050
KSVEVQEPGF ELRREFKYHA GILKDEKLRF GSKNSLASAR YKYAYDGNAR 
      2060       2070       2080       2090       2100
LSGIEMAIDD KELPTTRYKY SQNLGQLEVV QDLKITRNAF NRTVIQDSAK 
      2110       2120       2130       2140       2150
QFFAIVDYDQ HGRVKSVLMN VKNIDVFRLE LDYDLRNRIK SQKTTFGRST 
      2160       2170       2180       2190       2200
AFDKINYNAD GHVVEVLGTN NWKYLFDENG NTVGVVDQGE KFNLGYDIGD 
      2210       2220       2230       2240       2250
RVIKVGDVEF NNYDARGFVV KRGEQKYRYN NRGQLIHSFE RERFQSWYYY 
      2260       2270       2280       2290       2300
DDRSRLVAWH DNKGNTTQYY YANPRTPHLV THVHFPKISR TMKLFYDDRD 
      2310       2320       2330       2340       2350
MLIALEHEDQ RYYVATDQNG SPLAFFDQNG SIVKEMKRTP FGRIIKDTKP 
      2360       2370       2380       2390       2400
EFFVPIDFHG GLIDPHTKLV YTEQRQYDPH VGQWMTPLWE TLATEMSHPT 
      2410       2420       2430       2440       2450
DVFIYRYHNN DPINPNKPQN YMIDLDSWLQ LFGYDLNNMQ SSRYTKLAQY 
      2460       2470       2480       2490       2500
TPQASIKSNT LAPDFGVISG LECIVEKTSE KFSDFDFVPK PLLKMEPKMR 
      2510       2520       2530       2540       2550
NLLPRVSYRR GVFGEGVLLS RIGGRALVSV VDGSNSVVQD VVSSVFNNSY 
      2560       2570       2580       2590       2600
FLDLHFSIHD QDVFYFVKDN VLKLRDDNEE LRRLGGMFNI STHEISDHGG 
      2610       2620       2630       2640       2650
SAAKELRLHG PDAVVIIKYG VDPEQERHRI LKHAHKRAVE RAWELEKQLV 
      2660       2670       2680       2690       2700
AAGFQGRGDW TEEEKEELVQ HGDVDGWNGI DIHSIHKYPQ LADDPGNVAF 
      2710       2720       2730 
QRDAKRKRRK TGSSHRSASN RRQLKFGELS A
Length:2,731
Mass (Da):304,056
Last modified:February 6, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6718B77B8F62D482
GO
Isoform D (identifier: O61307-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     375-375: G → GGRAMSTRLS...PDVMPVLILE
     858-858: E → ESIFWNYFNA

Show »
Length:3,297
Mass (Da):366,082
Checksum:iBD302737C911F209
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PGF7M9PGF7_DROME
Tenascin major, isoform E
Ten-m 2017, 5301, BcDNA:AT25108, CG11452, CT16449
3,349Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA51678 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22A → G in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti22A → G in AAC05080 (PubMed:9373139).Curated1
Sequence conflicti37G → S in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti37G → S in AAC05080 (PubMed:9373139).Curated1
Sequence conflicti65A → V in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti89A → V in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti1837D → Y in CAA51678 (PubMed:8070401).Curated1
Sequence conflicti2099A → G in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti2099A → G in AAC05080 (PubMed:9373139).Curated1
Sequence conflicti2315A → T in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti2495M → T in CAA51678 (PubMed:8070401).Curated1
Sequence conflicti2710K → R in AAB88281 (PubMed:9373139).Curated1
Sequence conflicti2710K → R in AAC05080 (PubMed:9373139).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054459375G → GGRAMSTRLSVRGAGERGRR HRRSLNEEQGEDDVATDGTF SDLITNESLNQQAAEKYLAT TLAKSPTDVHGSGNKTLPRM DGVYGTQRSEDTPDTSYDYV YEDEVEPETTPSLIRRTKTG QQFGKSLNSNLRSAAKTLVN KRRKYDHGTVEAEHIKHEEE EEEDEQKLERHEAIGMATEL TTESETSTLPAVIDDDNQSD NSSSGPTPETTVRSDTDDIV EINTPPSQTAQRTFAAVSHQ PAIEHDFQIKGTDAGGLQTE KPATDDINNERDLADNYEVD SKEPTSPGTPPQGKVSQQTG KASLQSLQSESDLMMNDASH YEDIDIVKLDGLTISHEEEI YKTADKENMAPKNQPSQHID RSQNEVLKGHQQGDEKQPQL EPLKPYVSERVDLPGKRIFL NLTIATDEGSDSVYTLHVEV PTGGGPHFIKEVLTHEKPTA QADSCVPEPPPRMPDCPCSC LPPPAPIYLDDTVDIDSAPP AKTVTTSTISAPINPFHSEE EDDEDGVRDEEQTPSSSTAT NLPSTEIDNHIAAFTEPAVG AGGVPFACPDVMPVLILE in isoform D. Curated1
Alternative sequenceiVSP_054460858E → ESIFWNYFNA in isoform D. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X73154 mRNA Translation: CAA51678.1 Different initiation.
AF008227, AF008224, AF008226 Genomic DNA Translation: AAC05080.1
AF008228 mRNA Translation: AAB88281.1
AE014296 Genomic DNA Translation: AAF51824.2
AE014296 Genomic DNA Translation: ABW08579.2

NCBI Reference Sequences

More...RefSeqi		NP_001097661.2, NM_001104191.3 [O61307-2]
NP_524215.2, NM_079491.3 [O61307-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0078509; FBpp0078161; FBgn0004449 [O61307-1]
FBtr0306107; FBpp0297244; FBgn0004449 [O61307-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		40464

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG5723

UCSC genome browser

More...UCSCi		CG5723-RB, d. melanogaster
CG5723-RC, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73154 mRNA Translation: CAA51678.1 Different initiation.
AF008227, AF008224, AF008226 Genomic DNA Translation: AAC05080.1
AF008228 mRNA Translation: AAB88281.1
AE014296 Genomic DNA Translation: AAF51824.2
AE014296 Genomic DNA Translation: ABW08579.2
RefSeqiNP_001097661.2, NM_001104191.3 [O61307-2]
NP_524215.2, NM_079491.3 [O61307-1]

3D structure databases

SMRiO61307
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi65699, 9 interactors
IntActiO61307, 705 interactors
STRINGi7227.FBpp0297244

PTM databases

iPTMnetiO61307

Proteomic databases

PaxDbiO61307
PeptideAtlasiO61307
PRIDEiO61307

Genome annotation databases

EnsemblMetazoaiFBtr0078509; FBpp0078161; FBgn0004449 [O61307-1]
FBtr0306107; FBpp0297244; FBgn0004449 [O61307-2]
GeneIDi40464
KEGGidme:Dmel_CG5723
UCSCiCG5723-RB, d. melanogaster
CG5723-RC, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		40464
FlyBaseiFBgn0004449, Ten-m

Phylogenomic databases

eggNOGiKOG1225, Eukaryota
KOG4659, Eukaryota
GeneTreeiENSGT01000000214453
HOGENOMiCLU_000229_1_0_1
InParanoidiO61307
OMAiAHYKYAY

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		40464, 0 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ten-m, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		40464

Protein Ontology

More...PROi		PR:O61307

Gene expression databases

BgeeiFBgn0004449, Expressed in embryonic/larval hemocyte (Drosophila) and 42 other tissues
ExpressionAtlasiO61307, baseline and differential
GenevisibleiO61307, DM

Family and domain databases

Gene3Di2.120.10.30, 2 hits
2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR008969, CarboxyPept-like_regulatory
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR008979, Galactose-bd-like_sf
IPR031325, RHS_repeat
IPR028916, Tox-GHH_dom
IPR006530, YD
PfamiView protein in Pfam
PF05593, RHS_repeat, 1 hit
PF15636, Tox-GHH, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 8 hits
SUPFAMiSSF49464, SSF49464, 1 hit
TIGRFAMsiTIGR01643, YD_repeat_2x, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTENM_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O61307
Secondary accession number(s): A8JNW8
, O18366, Q24551, Q9TX59, Q9VNU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: February 6, 2013
Last modified: August 12, 2020
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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