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Entry version 99 (25 May 2022)
Sequence version 1 (01 Aug 1998)
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Protein

Anion exchange protein

Gene
N/A
Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transportUniRule annotationARBA annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anion exchange proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei429 – 450HelicalUniRule annotationAdd BLAST22
Transmembranei471 – 494HelicalUniRule annotationAdd BLAST24
Transmembranei514 – 539HelicalUniRule annotationAdd BLAST26
Transmembranei546 – 564HelicalUniRule annotationAdd BLAST19
Transmembranei648 – 665HelicalUniRule annotationAdd BLAST18
Transmembranei685 – 703HelicalUniRule annotationAdd BLAST19
Transmembranei733 – 752HelicalUniRule annotationAdd BLAST20
Transmembranei773 – 799HelicalUniRule annotationAdd BLAST27
Transmembranei833 – 852HelicalUniRule annotationAdd BLAST20
Transmembranei859 – 878HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O61304

PeptideAtlas

More...
PeptideAtlasi
O61304

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00009920, Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini67 – 345Band_3_cytoInterPro annotationAdd BLAST279
Domaini400 – 910HCO3_cotranspInterPro annotationAdd BLAST511

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni179 – 223DisorderedSequence analysisAdd BLAST45
Regioni1051 – 1119DisorderedSequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi194 – 218Polar residuesSequence analysisAdd BLAST25
Compositional biasi1051 – 1067Polar residuesSequence analysisAdd BLAST17
Compositional biasi1087 – 1102Polar residuesSequence analysisAdd BLAST16
Compositional biasi1104 – 1119Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002289_5_1_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt-like_TM_dom
IPR003020, HCO3_transpt_euk
IPR003024, Na/HCO3_transpt
IPR016152, PTrfase/Anion_transptr

The PANTHER Classification System

More...
PANTHERi
PTHR11453, PTHR11453, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01231, HCO3TRNSPORT
PR01232, NAHCO3TRSPRT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55804, SSF55804, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00834, ae, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O61304-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHSVRRRMS KARRESQSIE LSSLAPGTRV MFLLKEKENT PALFTEMGEL
60 70 80 90 100
NNEEWRETAR WVKFEEDVEQ GGNRWSKPHV ATLSLHSLFQ LRSCIMNGHF
110 120 130 140 150
MNDLAETDIP SIFNAVIENL EKSGDLPSEN REELREILLR KHVHQYEQAK
160 170 180 190 200
KNGAGGEKGG FLSTVRSISD IGKSFSHGKN LSKIEEKPEG PVTSQTAGAP
210 220 230 240 250
SGSSNQLTLP TVESVPKDIS SEESSKGNLH FLKKLPAGVE ASNVLIGEVD
260 270 280 290 300
FLTRHICCFI RLKNANQLGD LTEVPVPTRF IFLLLGPTGH GQQYREIGRA
310 320 330 340 350
IATLMADEIF HDVAYGARDV DDLLDGIDEF LDQVTVLPPG EWDPNIRIEP
360 370 380 390 400
PSKLPSQEKR KQIGQELLVE PSSHKHVKKV VEEEEIHSHG DDPALKRTGK
410 420 430 440 450
LFGGLILDIK RKAPHFVSDF TDAFNLQCLA SICFMYFGLL APIVTFGGLL
460 470 480 490 500
EEATHQRMAA MENLFGGALW GVIYHFFAGQ PLTIVGSTGP VLVFETIVFD
510 520 530 540 550
FCHRLGMVYL SFRFWVHVWT AVIIFLMVVT DASALVSFIT RFTEESFATL
560 570 580 590 600
IAVIFIYEAI MKLVKIKGQL DMINYSRDFV EGGFCSCVPP IGKPSVSPDH
610 620 630 640 650
ARLVIKSTGL PIAFNDTFID YTAANLTDCR TIGGSFDGTT CFPLYDKLLM
660 670 680 690 700
SILLTVGTFF LATTLKKMRN SCYFPSSVRQ LLSDFAVMIA IASMTFVDIF
710 720 730 740 750
VGVNTPKLNV PSTFRPTWEG RGWFIPPFDA NEWWTAPLAI LPALLACILI
760 770 780 790 800
FMDQQITTVI VNRKENKLKK GCGYHLDLLV LSVSILMVGF LGLPIYVAAT
810 820 830 840 850
VLSINHINSL KVESECKAPG EVAQFVGVRE QRVTGIVTFL IIGLSVLATN
860 870 880 890 900
ILGRIPMPVL YGVFLYMGIS ALGGIQLFDR TLLLFMPMKY QPDTIYIRHV
910 920 930 940 950
PIRKIHLFTA FQIGCLALLW VIKSIKSTSI LFPIMLVVMV AIRKMMEKAF
960 970 980 990 1000
TTTDLKYLDD PMPDFHLRKK EDAKRRQSEG EAVEIEFDNE NQATTHAVKT
1010 1020 1030 1040 1050
EAHLHIPMAS GNVIKIPLAA IQEPSHSINL TKEVNNSGMW KHITSVDSKN
1060 1070 1080 1090 1100
SLVRDVPASS DPTSSRDAPI EQPEDDDDPI MIKVIRPSPH TSTSNLTTEN
1110
TPLLKDEEPP KTNPDEPKV
Length:1,119
Mass (Da):124,703
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CA9A9C0A1BC48DE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF004926 mRNA Translation: AAC16758.1

Protein sequence database of the Protein Information Resource

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PIRi
T37460

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004926 mRNA Translation: AAC16758.1
PIRiT37460

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiO61304
PeptideAtlasiO61304

Phylogenomic databases

HOGENOMiCLU_002289_5_1_1

Gene expression databases

BgeeiWBGene00009920, Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt-like_TM_dom
IPR003020, HCO3_transpt_euk
IPR003024, Na/HCO3_transpt
IPR016152, PTrfase/Anion_transptr
PANTHERiPTHR11453, PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit
PRINTSiPR01231, HCO3TRNSPORT
PR01232, NAHCO3TRSPRT
SUPFAMiSSF55804, SSF55804, 1 hit
TIGRFAMsiTIGR00834, ae, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO61304_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O61304
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 25, 2022
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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