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UniProtKB - O61199 (ODO1_CAEEL)

Entry version 145 (07 Apr 2021)
Sequence version 2 (01 Oct 2001)
Previous versions | rss
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Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

ogdh-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

thiamine diphosphateBy similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandThiamine pyrophosphate

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CEL-389661, Glyoxylate metabolism and glycine degradation
R-CEL-71064, Lysine catabolism
R-CEL-71403, Citric acid cycle (TCA cycle)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name:
OGDC-E1
Alpha-ketoglutarate dehydrogenase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ogdh-1
ORF Names:T22B11.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...WormBasei		T22B11.5a ; CE28486 ; WBGene00020679 ; ogdh-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000234100? – 10292-oxoglutarate dehydrogenase, mitochondrial

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O61199

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O61199

PeptideAtlas

More...PeptideAtlasi		O61199

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O61199

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00020679, Expressed in multi-cellular organism and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O61199, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		42364, 4 interactors

Protein interaction database and analysis system

More...IntActi		O61199, 1 interactor

STRING: functional protein association networks

More...STRINGi		6239.T22B11.5a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O61199

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0450, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183125

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004709_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O61199

Identification of Orthologs from Complete Genome Data

More...OMAi		RDSYCRT

Database of Orthologous Groups

More...OrthoDBi		134699at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O61199

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.11610, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032106, 2-oxogl_dehyd_N
IPR011603, 2oxoglutarate_DH_E1
IPR001017, DH_E1
IPR031717, KGD_C
IPR042179, KGD_C_sf
IPR029061, THDP-binding
IPR005475, Transketolase-like_Pyr-bd

The PANTHER Classification System

More...PANTHERi		PTHR23152, PTHR23152, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16078, 2-oxogl_dehyd_N, 1 hit
PF00676, E1_dh, 1 hit
PF16870, OxoGdeHyase_C, 1 hit
PF02779, Transket_pyr, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000157, Oxoglu_dh_E1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00861, Transket_pyr, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52518, SSF52518, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00239, 2oxo_dh_E1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O61199-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHRASLICRL ASPSRINAIR NASSGKSHIS ASTLVQHRNQ SVAAAVKHEP 
        60         70         80         90        100
FLNGSSSIYI EQMYEAWLQD PSSVHTSWDA YFRNVEAGAG PGQAFQAPPA 
       110        120        130        140        150
TAYAGALGVS PAAAQVTTSS APATRLDTNA SVQSISDHLK IQLLIRSYQT 
       160        170        180        190        200
RGHNIADLDP LGINSADLDD TIPPELELSF YGLGERDLDR EFLLPPTTFI 
       210        220        230        240        250
SEKKSLTLRE ILQRLKDIYC TSTGVEYMHL NNLEQQDWIR RRFEAPRVTE 
       260        270        280        290        300
LSHDQKKVLF KRLIRSTKFE EFLAKKWPSE KRFGLEGCEV LIPAMKQVID 
       310        320        330        340        350
SSSTLGVDSF VIGMPHRGRL NVLANVCRQP LATILSQFST LEPADEGSGD 
       360        370        380        390        400
VKYHLGVCIE RLNRQSQKNV KIAVVANPSH LEAVDPVVMG KVRAEAFYAG 
       410        420        430        440        450
DEKCDRTMAI LLHGDAAFAG QGVVLETFNL DDLPSYTTHG AIHIVVNNQI 
       460        470        480        490        500
GFTTDPRSSR SSPYCTDVGR VVGCPIFHVN VDDPEAVMHV CNVAADWRKT 
       510        520        530        540        550
FKKDVIVDLV CYRRHGHNEL DEPMFTQPLM YQRIKQTKTA LEKYQEKILN 
       560        570        580        590        600
EGVANEQYVK EELTKYGSIL EDAYENAQKV TYVRNRDWLD SPWDDFFKKR 
       610        620        630        640        650
DPLKLPSTGI EQENIEQIIG KFSQYPEGFN LHRGLERTLK GRQQMLKDNS 
       660        670        680        690        700
LDWACGEALA FGSLLKEGIH VRLSGQDVQR GTFSHRHHVL HDQKVDQKIY 
       710        720        730        740        750
NPLNDLSEGQ GEYTVCNSSL SEYAVLGFEL GYSMVDPNSL VIWEAQFGDF 
       760        770        780        790        800
SNTAQCIIDQ FISSGQSKWI RQSGLVMLLP HGYEGMGPEH SSARPERFLQ 
       810        820        830        840        850
MCNEDDEIDL EKIAFEGTFE AQQLHDTNWI VANCTTPANI YHLLRRQVTM 
       860        870        880        890        900
PFRKPAVVFS PKSLLRHPMA RSPVEDFQSG SNFQRVIPET GAPSQNPPDV 
       910        920        930        940        950
KRVVFCTGKV YYDMVAARKH VGKENDVALV RVEQLSPFPY DLVQQECRKY 
       960        970        980        990       1000
QGAEILWAQE EHKNMGAWSF VQPRINSLLS IDGRATKYAG RLPSSSPATG 
      1010       1020 
NKFTHMQEQK EMMSKVFGVP KSKLEGFKA
Length:1,029
Mass (Da):115,661
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71ECB0F4236135F4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U4PC51U4PC51_CAEEL
Oxoglutarate dehydrogenase (succiny...
ogdh-1 CELE_T22B11.5, T22B11.5
802Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FO081256 Genomic DNA Translation: CCD70240.1

Protein sequence database of the Protein Information Resource

More...PIRi		T15098

NCBI Reference Sequences

More...RefSeqi		NP_500617.1, NM_068216.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		T22B11.5a.1; T22B11.5a.1; WBGene00020679

Database of genes from NCBI RefSeq genomes

More...GeneIDi		177235

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_T22B11.5

UCSC genome browser

More...UCSCi		T22B11.5, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081256 Genomic DNA Translation: CCD70240.1
PIRiT15098
RefSeqiNP_500617.1, NM_068216.4

3D structure databases

SMRiO61199
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi42364, 4 interactors
IntActiO61199, 1 interactor
STRINGi6239.T22B11.5a

PTM databases

iPTMnetiO61199

Proteomic databases

EPDiO61199
PaxDbiO61199
PeptideAtlasiO61199

Genome annotation databases

EnsemblMetazoaiT22B11.5a.1; T22B11.5a.1; WBGene00020679
GeneIDi177235
KEGGicel:CELE_T22B11.5
UCSCiT22B11.5, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		177235
WormBaseiT22B11.5a ; CE28486 ; WBGene00020679 ; ogdh-1

Phylogenomic databases

eggNOGiKOG0450, Eukaryota
GeneTreeiENSGT00950000183125
HOGENOMiCLU_004709_1_1_1
InParanoidiO61199
OMAiRDSYCRT
OrthoDBi134699at2759
PhylomeDBiO61199

Enzyme and pathway databases

ReactomeiR-CEL-389661, Glyoxylate metabolism and glycine degradation
R-CEL-71064, Lysine catabolism
R-CEL-71403, Citric acid cycle (TCA cycle)

Miscellaneous databases

Protein Ontology

More...PROi		PR:O61199

Gene expression databases

BgeeiWBGene00020679, Expressed in multi-cellular organism and 5 other tissues
ExpressionAtlasiO61199, baseline and differential

Family and domain databases

Gene3Di3.40.50.11610, 1 hit
InterProiView protein in InterPro
IPR032106, 2-oxogl_dehyd_N
IPR011603, 2oxoglutarate_DH_E1
IPR001017, DH_E1
IPR031717, KGD_C
IPR042179, KGD_C_sf
IPR029061, THDP-binding
IPR005475, Transketolase-like_Pyr-bd
PANTHERiPTHR23152, PTHR23152, 1 hit
PfamiView protein in Pfam
PF16078, 2-oxogl_dehyd_N, 1 hit
PF00676, E1_dh, 1 hit
PF16870, OxoGdeHyase_C, 1 hit
PF02779, Transket_pyr, 1 hit
PIRSFiPIRSF000157, Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861, Transket_pyr, 1 hit
SUPFAMiSSF52518, SSF52518, 2 hits
TIGRFAMsiTIGR00239, 2oxo_dh_E1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiODO1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O61199
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2001
Last modified: April 7, 2021
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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