We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - O61199 (ODO1_CAEEL)
Protein
2-oxoglutarate dehydrogenase, mitochondrial
Gene
ogdh-1
Organism
Caenorhabditis elegans
Status
Functioni
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
By similarityCatalytic activityi
- 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N6-lipoyl-L-lysine + H+ = [dihydrolipoyllysine-residue succinyltransferase]-(R)-N6-(S8-succinyldihydrolipoyl)-L-lysine + CO2By similarityEC:1.2.4.2By similarity
Cofactori
thiamine diphosphateBy similarity
GO - Molecular functioni
- oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB
- thiamine pyrophosphate binding Source: InterPro
GO - Biological processi
- generation of precursor metabolites and energy Source: UniProtKB
- glycolytic process Source: UniProtKB-KW
- tricarboxylic acid cycle Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Glycolysis |
Ligand | Thiamine pyrophosphate |
Enzyme and pathway databases
Reactomei | R-CEL-389661, Glyoxylate metabolism and glycine degradation R-CEL-71064, Lysine catabolism R-CEL-71403, Citric acid cycle (TCA cycle) |
Names & Taxonomyi
Protein namesi | Recommended name: 2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)Alternative name(s): 2-oxoglutarate dehydrogenase complex component E1 Short name: OGDC-E1 Alpha-ketoglutarate dehydrogenase |
Gene namesi | Name:ogdh-1 ORF Names:T22B11.5 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | T22B11.5a ; CE28486 ; WBGene00020679 ; ogdh-1 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix By similarity
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrial membrane Source: UniProtKB
- mitochondrion Source: WormBase
Other locations
- oxoglutarate dehydrogenase complex Source: GO_Central
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | MitochondrionSequence analysis | ||
ChainiPRO_0000234100 | ? – 1029 | 2-oxoglutarate dehydrogenase, mitochondrial |
Proteomic databases
EPDi | O61199 |
PaxDbi | O61199 |
PeptideAtlasi | O61199 |
PTM databases
iPTMneti | O61199 |
Expressioni
Gene expression databases
Bgeei | WBGene00020679, Expressed in multi-cellular organism and 5 other tissues |
ExpressionAtlasi | O61199, baseline and differential |
Interactioni
Protein-protein interaction databases
BioGRIDi | 42364, 4 interactors |
IntActi | O61199, 1 interactor |
STRINGi | 6239.T22B11.5a |
Family & Domainsi
Sequence similaritiesi
Belongs to the alpha-ketoglutarate dehydrogenase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0450, Eukaryota |
GeneTreei | ENSGT00950000183125 |
HOGENOMi | CLU_004709_1_1_1 |
InParanoidi | O61199 |
OMAi | RDSYCRT |
OrthoDBi | 134699at2759 |
PhylomeDBi | O61199 |
Family and domain databases
Gene3Di | 3.40.50.11610, 1 hit |
InterProi | View protein in InterPro IPR032106, 2-oxogl_dehyd_N IPR011603, 2oxoglutarate_DH_E1 IPR001017, DH_E1 IPR031717, KGD_C IPR042179, KGD_C_sf IPR029061, THDP-binding IPR005475, Transketolase-like_Pyr-bd |
PANTHERi | PTHR23152, PTHR23152, 1 hit |
Pfami | View protein in Pfam PF16078, 2-oxogl_dehyd_N, 1 hit PF00676, E1_dh, 1 hit PF16870, OxoGdeHyase_C, 1 hit PF02779, Transket_pyr, 1 hit |
PIRSFi | PIRSF000157, Oxoglu_dh_E1, 1 hit |
SMARTi | View protein in SMART SM00861, Transket_pyr, 1 hit |
SUPFAMi | SSF52518, SSF52518, 2 hits |
TIGRFAMsi | TIGR00239, 2oxo_dh_E1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O61199-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHRASLICRL ASPSRINAIR NASSGKSHIS ASTLVQHRNQ SVAAAVKHEP
60 70 80 90 100
FLNGSSSIYI EQMYEAWLQD PSSVHTSWDA YFRNVEAGAG PGQAFQAPPA
110 120 130 140 150
TAYAGALGVS PAAAQVTTSS APATRLDTNA SVQSISDHLK IQLLIRSYQT
160 170 180 190 200
RGHNIADLDP LGINSADLDD TIPPELELSF YGLGERDLDR EFLLPPTTFI
210 220 230 240 250
SEKKSLTLRE ILQRLKDIYC TSTGVEYMHL NNLEQQDWIR RRFEAPRVTE
260 270 280 290 300
LSHDQKKVLF KRLIRSTKFE EFLAKKWPSE KRFGLEGCEV LIPAMKQVID
310 320 330 340 350
SSSTLGVDSF VIGMPHRGRL NVLANVCRQP LATILSQFST LEPADEGSGD
360 370 380 390 400
VKYHLGVCIE RLNRQSQKNV KIAVVANPSH LEAVDPVVMG KVRAEAFYAG
410 420 430 440 450
DEKCDRTMAI LLHGDAAFAG QGVVLETFNL DDLPSYTTHG AIHIVVNNQI
460 470 480 490 500
GFTTDPRSSR SSPYCTDVGR VVGCPIFHVN VDDPEAVMHV CNVAADWRKT
510 520 530 540 550
FKKDVIVDLV CYRRHGHNEL DEPMFTQPLM YQRIKQTKTA LEKYQEKILN
560 570 580 590 600
EGVANEQYVK EELTKYGSIL EDAYENAQKV TYVRNRDWLD SPWDDFFKKR
610 620 630 640 650
DPLKLPSTGI EQENIEQIIG KFSQYPEGFN LHRGLERTLK GRQQMLKDNS
660 670 680 690 700
LDWACGEALA FGSLLKEGIH VRLSGQDVQR GTFSHRHHVL HDQKVDQKIY
710 720 730 740 750
NPLNDLSEGQ GEYTVCNSSL SEYAVLGFEL GYSMVDPNSL VIWEAQFGDF
760 770 780 790 800
SNTAQCIIDQ FISSGQSKWI RQSGLVMLLP HGYEGMGPEH SSARPERFLQ
810 820 830 840 850
MCNEDDEIDL EKIAFEGTFE AQQLHDTNWI VANCTTPANI YHLLRRQVTM
860 870 880 890 900
PFRKPAVVFS PKSLLRHPMA RSPVEDFQSG SNFQRVIPET GAPSQNPPDV
910 920 930 940 950
KRVVFCTGKV YYDMVAARKH VGKENDVALV RVEQLSPFPY DLVQQECRKY
960 970 980 990 1000
QGAEILWAQE EHKNMGAWSF VQPRINSLLS IDGRATKYAG RLPSSSPATG
1010 1020
NKFTHMQEQK EMMSKVFGVP KSKLEGFKA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketU4PC51 | U4PC51_CAEEL | Oxoglutarate dehydrogenase (succiny... | ogdh-1 CELE_T22B11.5, T22B11.5 | 802 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FO081256 Genomic DNA Translation: CCD70240.1 |
PIRi | T15098 |
RefSeqi | NP_500617.1, NM_068216.4 |
Genome annotation databases
EnsemblMetazoai | T22B11.5a.1; T22B11.5a.1; WBGene00020679 |
GeneIDi | 177235 |
KEGGi | cel:CELE_T22B11.5 |
UCSCi | T22B11.5, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FO081256 Genomic DNA Translation: CCD70240.1 |
PIRi | T15098 |
RefSeqi | NP_500617.1, NM_068216.4 |
3D structure databases
SMRi | O61199 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 42364, 4 interactors |
IntActi | O61199, 1 interactor |
STRINGi | 6239.T22B11.5a |
PTM databases
iPTMneti | O61199 |
Proteomic databases
EPDi | O61199 |
PaxDbi | O61199 |
PeptideAtlasi | O61199 |
Genome annotation databases
EnsemblMetazoai | T22B11.5a.1; T22B11.5a.1; WBGene00020679 |
GeneIDi | 177235 |
KEGGi | cel:CELE_T22B11.5 |
UCSCi | T22B11.5, c. elegans |
Organism-specific databases
CTDi | 177235 |
WormBasei | T22B11.5a ; CE28486 ; WBGene00020679 ; ogdh-1 |
Phylogenomic databases
eggNOGi | KOG0450, Eukaryota |
GeneTreei | ENSGT00950000183125 |
HOGENOMi | CLU_004709_1_1_1 |
InParanoidi | O61199 |
OMAi | RDSYCRT |
OrthoDBi | 134699at2759 |
PhylomeDBi | O61199 |
Enzyme and pathway databases
Reactomei | R-CEL-389661, Glyoxylate metabolism and glycine degradation R-CEL-71064, Lysine catabolism R-CEL-71403, Citric acid cycle (TCA cycle) |
Miscellaneous databases
PROi | PR:O61199 |
Gene expression databases
Bgeei | WBGene00020679, Expressed in multi-cellular organism and 5 other tissues |
ExpressionAtlasi | O61199, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.11610, 1 hit |
InterProi | View protein in InterPro IPR032106, 2-oxogl_dehyd_N IPR011603, 2oxoglutarate_DH_E1 IPR001017, DH_E1 IPR031717, KGD_C IPR042179, KGD_C_sf IPR029061, THDP-binding IPR005475, Transketolase-like_Pyr-bd |
PANTHERi | PTHR23152, PTHR23152, 1 hit |
Pfami | View protein in Pfam PF16078, 2-oxogl_dehyd_N, 1 hit PF00676, E1_dh, 1 hit PF16870, OxoGdeHyase_C, 1 hit PF02779, Transket_pyr, 1 hit |
PIRSFi | PIRSF000157, Oxoglu_dh_E1, 1 hit |
SMARTi | View protein in SMART SM00861, Transket_pyr, 1 hit |
SUPFAMi | SSF52518, SSF52518, 2 hits |
TIGRFAMsi | TIGR00239, 2oxo_dh_E1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ODO1_CAEEL | |
Accessioni | O61199Primary (citable) accession number: O61199 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | October 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families