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Protein

mRNA-capping enzyme

Gene

RNGTT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.3 Publications

Miscellaneous

Isoform 2 to isoform 4 lack mRNA 5'-guanylyltransferase activity due to disruptions of the GTase domain.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei126For RNA 5'-triphosphatase activityBy similarity1
Active sitei294N6-GMP-lysine intermediate1 Publication1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei299GTPBy similarity1
Binding sitei315GTPSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi343 – 345GTPSequence analysis3
Nucleotide bindingi458 – 460GTPSequence analysis3
Nucleotide bindingi528 – 533GTPSequence analysis6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Multifunctional enzyme, Nucleotidyltransferase, Transferase
Biological processHost-virus interaction, mRNA capping, mRNA processing
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS03479-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.7.50 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-72086 mRNA Capping
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
mRNA-capping enzyme
Alternative name(s):
HCAP1
HCE
Including the following 2 domains:
Polynucleotide 5'-triphosphatase (EC:3.1.3.33)
Alternative name(s):
mRNA 5'-triphosphatase
Short name:
TPase
mRNA guanylyltransferase (EC:2.7.7.50)
Alternative name(s):
GTP--RNA guanylyltransferase
Short name:
GTase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNGTT
Synonyms:CAP1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000111880.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10073 RNGTT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603512 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60942

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi234E → A: No effect on GTase activity. 1 Publication1
Mutagenesisi294K → A: Loss of GTase activity. 1 Publication1
Mutagenesisi299R → A: Loss of GTase activity. 1 Publication1
Mutagenesisi345E → A: Loss of GTase activity. 1 Publication1
Mutagenesisi458K → A: Loss of GTase activity. 2 Publications1
Mutagenesisi460K → A: Loss of GTase activity. 2 Publications1
Mutagenesisi528R → A: Strongly reduced GTase activity. 1 Publication1
Mutagenesisi530R → A: Loss of GTase activity. 1 Publication1
Mutagenesisi532D → A: Loss of GTase activity. 1 Publication1
Mutagenesisi533K → A: Loss of GTase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8732

Open Targets

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OpenTargetsi
ENSG00000111880

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34446

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02325 Isopropyl Alcohol

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RNGTT

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002101081 – 597mRNA-capping enzymeAdd BLAST597

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O60942

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60942

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60942

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60942

PeptideAtlas

More...
PeptideAtlasi
O60942

PRoteomics IDEntifications database

More...
PRIDEi
O60942

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49688
49689 [O60942-2]
49690 [O60942-3]
49691 [O60942-4]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
O60942

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60942

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60942

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000111880 Expressed in 221 organ(s), highest expression level in tonsil

CleanEx database of gene expression profiles

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CleanExi
HS_RNGTT

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60942 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003750

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POLR2A (via C-terminus); this enhances guanylyltransferase activity. Binds (via GTase domain) to the elongating phosphorylated form of RNA polymerase II; can form direct interactions with the phosphorylated POLR2A C-terminal domain and indirect interactions via bound RNA (By similarity). Interacts with SUPT5H and RNMT. Interacts with HIV-1 Tat.By similarity2 Publications
(Microbial infection) Interacts with HIV-1 Tat.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P16333-12EBI-1237132,EBI-15578122

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114270, 55 interactors

Database of interacting proteins

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DIPi
DIP-61014N

Protein interaction database and analysis system

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IntActi
O60942, 7 interactors

Molecular INTeraction database

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MINTi
O60942

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358497

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1597
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C46X-ray1.60A/B/C/D1-219[»]
3S24X-ray3.01A/B/C/D/E/F/G229-567[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60942

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60942

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O60942

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 212TPaseAdd BLAST212
Regioni229 – 597GTaseAdd BLAST369
Regioni330 – 386Interaction with POLR2ABy similarityAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi195 – 205Asp/Glu-richAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.Curated
In the C-terminal section; belongs to the eukaryotic GTase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2386 Eukaryota
COG5226 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156953

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006332

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60942

KEGG Orthology (KO)

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KOi
K13917

Identification of Orthologs from Complete Genome Data

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OMAi
PELPEWC

Database of Orthologous Groups

More...
OrthoDBi
1544021at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60942

TreeFam database of animal gene trees

More...
TreeFami
TF314914

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR017074 mRNA_cap_enz_bifunc
IPR001339 mRNA_cap_enzyme
IPR013846 mRNA_cap_enzyme_C
IPR012340 NA-bd_OB-fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00782 DSPc, 1 hit
PF03919 mRNA_cap_C, 1 hit
PF01331 mRNA_cap_enzyme, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF036958 mRNA_capping_HCE, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50249 SSF50249, 1 hit
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O60942-1) [UniParc]FASTAAdd to basket
Also known as: HCE1, HCAP1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHNKIPPRW LNCPRRGQPV AGRFLPLKTM LGPRYDSQVA EENRFHPSML
60 70 80 90 100
SNYLKSLKVK MGLLVDLTNT SRFYDRNDIE KEGIKYIKLQ CKGHGECPTT
110 120 130 140 150
ENTETFIRLC ERFNERNPPE LIGVHCTHGF NRTGFLICAF LVEKMDWSIE
160 170 180 190 200
AAVATFAQAR PPGIYKGDYL KELFRRYGDI EEAPPPPLLP DWCFEDDEDE
210 220 230 240 250
DEDEDGKKES EPGSSASFGK RRKERLKLGA IFLEGVTVKG VTQVTTQPKL
260 270 280 290 300
GEVQQKCHQF CGWEGSGFPG AQPVSMDKQN IKLLDLKPYK VSWKADGTRY
310 320 330 340 350
MMLIDGTNEV FMIDRDNSVF HVSNLEFPFR KDLRMHLSNT LLDGEMIIDR
360 370 380 390 400
VNGQAVPRYL IYDIIKFNSQ PVGDCDFNVR LQCIEREIIS PRHEKMKTGL
410 420 430 440 450
IDKTQEPFSV RNKPFFDICT SRKLLEGNFA KEVSHEMDGL IFQPTGKYKP
460 470 480 490 500
GRCDDILKWK PPSLNSVDFR LKITRMGGEG LLPQNVGLLY VGGYERPFAQ
510 520 530 540 550
IKVTKELKQY DNKIIECKFE NNSWVFMRQR TDKSFPNAYN TAMAVCNSIS
560 570 580 590
NPVTKEMLFE FIDRCTAASQ GQKRKHHLDP DTELMPPPPP KRPRPLT
Length:597
Mass (Da):68,557
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51CEEC1B190603DE
GO
Isoform 2 (identifier: O60942-2) [UniParc]FASTAAdd to basket
Also known as: HCE1A

The sequence of this isoform differs from the canonical sequence as follows:
     424-446: Missing.

Show »
Length:574
Mass (Da):66,042
Checksum:iCFE64E51F6F88232
GO
Isoform 3 (identifier: O60942-3) [UniParc]FASTAAdd to basket
Also known as: HCE1B

The sequence of this isoform differs from the canonical sequence as follows:
     424-446: Missing.
     481-597: Missing.

Show »
Length:457
Mass (Da):52,533
Checksum:i4F3B52CA4F6CC56B
GO
Isoform 4 (identifier: O60942-4) [UniParc]FASTAAdd to basket
Also known as: HCAP1B

The sequence of this isoform differs from the canonical sequence as follows:
     504-597: TKELKQYDNK...PPPKRPRPLT → CLFIFSVLFL...KISCSSTLGG

Show »
Length:541
Mass (Da):61,705
Checksum:iDF795898785EC2D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30M → I in AAB91559 (PubMed:9371772).Curated1
Sequence conflicti212P → T in AAH19954 (PubMed:15489334).Curated1
Sequence conflicti484Q → P in AAB91559 (PubMed:9371772).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046481594R → H1 PublicationCorresponds to variant dbSNP:rs17856595Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003202424 – 446Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_003203481 – 597Missing in isoform 3. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_003204504 – 597TKELK…PRPLT → CLFIFSVLFLDVLLSGIHQN LANNNQHIKISCSSTLGG in isoform 4. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF025654 mRNA Translation: AAB91559.1
AB009022 mRNA Translation: BAA25894.1
AB009023 mRNA Translation: BAA25895.1
AB009024 mRNA Translation: BAA25896.1
AB012142 mRNA Translation: BAA25198.1
AB012143 mRNA Translation: BAA25199.1
AL079342 Genomic DNA No translation available.
AL096868 Genomic DNA No translation available.
AL133408 Genomic DNA No translation available.
AL445530 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48566.1
CH471051 Genomic DNA Translation: EAW48567.1
CH471051 Genomic DNA Translation: EAW48569.1
CH471051 Genomic DNA Translation: EAW48570.1
BC019954 mRNA Translation: AAH19954.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5017.1 [O60942-1]
CCDS69153.1 [O60942-2]

Protein sequence database of the Protein Information Resource

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PIRi
JC5936
JC5937

NCBI Reference Sequences

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RefSeqi
NP_001273355.1, NM_001286426.1 [O60942-2]
NP_001273357.1, NM_001286428.1
NP_003791.3, NM_003800.4 [O60942-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.567378
Hs.627135

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000369475; ENSP00000358487; ENSG00000111880 [O60942-2]
ENST00000369485; ENSP00000358497; ENSG00000111880 [O60942-1]
ENST00000538899; ENSP00000442609; ENSG00000111880 [O60942-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8732

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8732

UCSC genome browser

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UCSCi
uc003pmr.4 human [O60942-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025654 mRNA Translation: AAB91559.1
AB009022 mRNA Translation: BAA25894.1
AB009023 mRNA Translation: BAA25895.1
AB009024 mRNA Translation: BAA25896.1
AB012142 mRNA Translation: BAA25198.1
AB012143 mRNA Translation: BAA25199.1
AL079342 Genomic DNA No translation available.
AL096868 Genomic DNA No translation available.
AL133408 Genomic DNA No translation available.
AL445530 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48566.1
CH471051 Genomic DNA Translation: EAW48567.1
CH471051 Genomic DNA Translation: EAW48569.1
CH471051 Genomic DNA Translation: EAW48570.1
BC019954 mRNA Translation: AAH19954.1
CCDSiCCDS5017.1 [O60942-1]
CCDS69153.1 [O60942-2]
PIRiJC5936
JC5937
RefSeqiNP_001273355.1, NM_001286426.1 [O60942-2]
NP_001273357.1, NM_001286428.1
NP_003791.3, NM_003800.4 [O60942-1]
UniGeneiHs.567378
Hs.627135

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C46X-ray1.60A/B/C/D1-219[»]
3S24X-ray3.01A/B/C/D/E/F/G229-567[»]
ProteinModelPortaliO60942
SMRiO60942
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114270, 55 interactors
DIPiDIP-61014N
IntActiO60942, 7 interactors
MINTiO60942
STRINGi9606.ENSP00000358497

Chemistry databases

DrugBankiDB02325 Isopropyl Alcohol

PTM databases

DEPODiO60942
iPTMnetiO60942
PhosphoSitePlusiO60942

Polymorphism and mutation databases

BioMutaiRNGTT

Proteomic databases

EPDiO60942
jPOSTiO60942
MaxQBiO60942
PaxDbiO60942
PeptideAtlasiO60942
PRIDEiO60942
ProteomicsDBi49688
49689 [O60942-2]
49690 [O60942-3]
49691 [O60942-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8732
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369475; ENSP00000358487; ENSG00000111880 [O60942-2]
ENST00000369485; ENSP00000358497; ENSG00000111880 [O60942-1]
ENST00000538899; ENSP00000442609; ENSG00000111880 [O60942-3]
GeneIDi8732
KEGGihsa:8732
UCSCiuc003pmr.4 human [O60942-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8732
DisGeNETi8732
EuPathDBiHostDB:ENSG00000111880.15

GeneCards: human genes, protein and diseases

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GeneCardsi
RNGTT
HGNCiHGNC:10073 RNGTT
HPAiHPA003750
MIMi603512 gene
neXtProtiNX_O60942
OpenTargetsiENSG00000111880
PharmGKBiPA34446

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2386 Eukaryota
COG5226 LUCA
GeneTreeiENSGT00940000156953
HOVERGENiHBG006332
InParanoidiO60942
KOiK13917
OMAiPELPEWC
OrthoDBi1544021at2759
PhylomeDBiO60942
TreeFamiTF314914

Enzyme and pathway databases

BioCyciMetaCyc:HS03479-MONOMER
BRENDAi2.7.7.50 2681
ReactomeiR-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-72086 mRNA Capping
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RNGTT human
EvolutionaryTraceiO60942

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RNGTT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8732

Protein Ontology

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PROi
PR:O60942

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111880 Expressed in 221 organ(s), highest expression level in tonsil
CleanExiHS_RNGTT
GenevisibleiO60942 HS

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR017074 mRNA_cap_enz_bifunc
IPR001339 mRNA_cap_enzyme
IPR013846 mRNA_cap_enzyme_C
IPR012340 NA-bd_OB-fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF03919 mRNA_cap_C, 1 hit
PF01331 mRNA_cap_enzyme, 1 hit
PIRSFiPIRSF036958 mRNA_capping_HCE, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCE1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60942
Secondary accession number(s): E1P513
, E1P514, O43483, O60257, O60351, Q5TCW8, Q8WUM8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 16, 2019
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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