UniProtKB - O60941 (DTNB_HUMAN)
Dystrobrevin beta
DTNB
Functioni
Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity).
May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470).
May be required for proper maturation and function of a subset of inhibitory synapses (By similarity).
By similarity1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 243 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 246 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 258 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 261 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 267 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 270 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 280 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 284 | Zinc 2PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 238 – 294 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 57 |
GO - Molecular functioni
- zinc ion binding Source: InterPro
GO - Biological processi
- neuron differentiation Source: UniProtKB
- synaptic signaling Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O60941 |
SignaLinki | O60941 |
SIGNORi | O60941 |
Names & Taxonomyi
Protein namesi | Recommended name: Dystrobrevin betaCuratedShort name: DTN-B1 Publication Alternative name(s): Beta-dystrobrevin1 Publication |
Gene namesi | Name:DTNBImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3058, DTNB |
MIMi | 602415, gene |
neXtProti | NX_O60941 |
VEuPathDBi | HostDB:ENSG00000138101 |
Subcellular locationi
Plasma membrane
- Basal cell membrane By similarity
Nucleus
- Nucleus 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- postsynaptic density By similarity
- dendrite By similarity
- postsynapse By similarity
Note: Localized at inhibitory synapses on the dendrites of cerebellar Purkinje cells.By similarity
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- basal plasma membrane Source: UniProtKB-SubCell
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
- dendrite Source: UniProtKB-SubCell
- inhibitory synapse Source: UniProtKB
- postsynaptic density Source: UniProtKB
- synapse Source: GO_Central
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 1838 |
OpenTargetsi | ENSG00000138101 |
PharmGKBi | PA27511 |
Miscellaneous databases
Pharosi | O60941, Tbio |
Genetic variation databases
BioMutai | DTNB |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086878 | 1 – 627 | Dystrobrevin betaAdd BLAST | 627 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine1 Publication | 1 | |
Modified residuei | 11 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 69 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 179 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 212 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 394 | PhosphoserineCombined sources | 1 | |
Modified residuei | 424 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O60941 |
jPOSTi | O60941 |
MassIVEi | O60941 |
MaxQBi | O60941 |
PaxDbi | O60941 |
PeptideAtlasi | O60941 |
PRIDEi | O60941 |
ProteomicsDBi | 25023 33923 49683 [O60941-1] 49684 [O60941-2] 49685 [O60941-3] 49686 [O60941-4] 49687 [O60941-5] |
PTM databases
iPTMneti | O60941 |
PhosphoSitePlusi | O60941 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000138101, Expressed in C1 segment of cervical spinal cord and 164 other tissues |
ExpressionAtlasi | O60941, baseline and differential |
Genevisiblei | O60941, HS |
Organism-specific databases
HPAi | ENSG00000138101, Tissue enhanced (salivary) |
Interactioni
Subunit structurei
Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2 (PubMed:10747910). Binds DTNBP1.
Forms a specific complex composed of DMD, SNTB2 and SNTA1 in neuron; the interaction with SNTB2 and SNTA1 is DMD independent.
Interacts with UTRN and dystrophin short form DP71 in the kidney and liver.
Interacts with SNTB1, SNTB2 and SNTA1 in kidney and liver.
Interacts with KIF5A.
Interacts with HMG20A and HMG20B.
Interacts with OLFM1.
Interacts with PRKAR2B and PRKAR1A (By similarity).
By similarity1 PublicationBinary interactionsi
O60941
Isoform 5 [O60941-5]
Protein-protein interaction databases
BioGRIDi | 108171, 98 interactors |
IntActi | O60941, 80 interactors |
MINTi | O60941 |
STRINGi | 9606.ENSP00000384084 |
Miscellaneous databases
RNActi | O60941, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 399 – 448 | Syntrophin-binding regionAdd BLAST | 50 | |
Regioni | 520 – 565 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 604 – 627 | DisorderedSequence analysisAdd BLAST | 24 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 428 – 529 | Sequence analysisAdd BLAST | 102 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 549 – 563 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 607 – 627 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 238 – 294 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 57 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG4301, Eukaryota |
GeneTreei | ENSGT00940000164272 |
InParanoidi | O60941 |
OMAi | QHIDTDK |
OrthoDBi | 699158at2759 |
PhylomeDBi | O60941 |
TreeFami | TF343849 |
Family and domain databases
Gene3Di | 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR017432, Distrobrevin IPR011992, EF-hand-dom_pair IPR015153, EF-hand_dom_typ1 IPR015154, EF-hand_dom_typ2 IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF09068, EF-hand_2, 1 hit PF09069, EF-hand_3, 1 hit PF00569, ZZ, 1 hit |
PIRSFi | PIRSF038204, Distrobrevin, 1 hit |
SMARTi | View protein in SMART SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL
60 70 80 90 100
HLVDIWNMIE AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH
110 120 130 140 150
QISVEQSISL LLNFMIAAYD SEGRGKLTVF SVKAMLATMC GGKMLDKLRY
160 170 180 190 200
VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA VFEGPSFGYT EHSVRTCFPQ
210 220 230 240 250
QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP VECSYCRCES
260 270 280 290 300
MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS
310 320 330 340 350
HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM
360 370 380 390 400
SSGVPTPTKR LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE
410 420 430 440 450
EHRLIARYAA RLAAEAGNVT RPPTDLSFNF DANKQQRQLI AELENKNREI
460 470 480 490 500
LQEIQRLRLE HEQASQPTPE KAQQNPTLLA ELRLLRQRKD ELEQRMSALQ
510 520 530 540 550
ESRRELMVQL EELMKLLKEE EQKQAAQATG SPHTSPTHGG GRPMPMPVRS
560 570 580 590 600
TSAGSTPTHC PQDSLSGVGG DVQEAFAQGT RRNLRNDLLV AADSITNTMS
610 620
SLVKELHSAE EGAEEEEEKM QNGKDRG
The sequence of this isoform differs from the canonical sequence as follows:
526-558: AQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPT → VSELRNFPPDSRSFARSSFPHINVSPLLPAHHL
559-627: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PEY4 | E9PEY4_HUMAN | Dystrobrevin | DTNB | 590 | Annotation score: | ||
E7EVB6 | E7EVB6_HUMAN | Dystrobrevin | DTNB | 620 | Annotation score: | ||
E9PE76 | E9PE76_HUMAN | Dystrobrevin beta | DTNB | 132 | Annotation score: | ||
F8W9U0 | F8W9U0_HUMAN | Dystrobrevin beta | DTNB | 188 | Annotation score: | ||
E7ES64 | E7ES64_HUMAN | Dystrobrevin beta | DTNB | 149 | Annotation score: | ||
F8WD22 | F8WD22_HUMAN | Dystrobrevin beta | DTNB | 63 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 102 | I → T in BAH13469 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 172 | K → T in BAH13469 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069146 | 97 | P → H1 PublicationCorresponds to variant dbSNP:rs17854576Ensembl. | 1 | |
Natural variantiVAR_069147 | 116 | I → T1 PublicationCorresponds to variant dbSNP:rs17854577Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045534 | 1 – 57 | Missing in isoform 6. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_004223 | 360 – 390 | RLQYS…QHCAR → S in isoform 2 and isoform 5. 3 PublicationsAdd BLAST | 31 | |
Alternative sequenceiVSP_043445 | 519 – 525 | Missing in isoform 5 and isoform 6. 3 Publications | 7 | |
Alternative sequenceiVSP_004224 | 526 – 558 | AQATG…GSTPT → VSELRNFPPDSRSFARSSFP HINVSPLLPAHHL in isoform 3. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_004225 | 559 – 627 | Missing in isoform 3. 1 PublicationAdd BLAST | 69 | |
Alternative sequenceiVSP_004226 | 579 – 608 | Missing in isoform 2, isoform 4 and isoform 5. 4 PublicationsAdd BLAST | 30 | |
Alternative sequenceiVSP_045535 | 609 – 626 | Missing in isoform 6 and isoform 7. 2 PublicationsAdd BLAST | 18 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000404103; ENSP00000385482; ENSG00000138101 [O60941-4] ENST00000405222; ENSP00000384787; ENSG00000138101 [O60941-5] ENST00000406818; ENSP00000384084; ENSG00000138101 ENST00000407038; ENSP00000384767; ENSG00000138101 [O60941-2] ENST00000407661; ENSP00000385193; ENSG00000138101 [O60941-7] |
GeneIDi | 1838 |
KEGGi | hsa:1838 |
MANE-Selecti | ENST00000406818.8; ENSP00000384084.3; NM_021907.5; NP_068707.1 |
UCSCi | uc002rgh.5, human [O60941-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | O60941 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108171, 98 interactors |
IntActi | O60941, 80 interactors |
MINTi | O60941 |
STRINGi | 9606.ENSP00000384084 |
PTM databases
iPTMneti | O60941 |
PhosphoSitePlusi | O60941 |
Genetic variation databases
BioMutai | DTNB |
Proteomic databases
EPDi | O60941 |
jPOSTi | O60941 |
MassIVEi | O60941 |
MaxQBi | O60941 |
PaxDbi | O60941 |
PeptideAtlasi | O60941 |
PRIDEi | O60941 |
ProteomicsDBi | 25023 33923 49683 [O60941-1] 49684 [O60941-2] 49685 [O60941-3] 49686 [O60941-4] 49687 [O60941-5] |
Protocols and materials databases
Antibodypediai | 27711, 267 antibodies from 24 providers |
DNASUi | 1838 |
Genome annotation databases
Ensembli | ENST00000404103; ENSP00000385482; ENSG00000138101 [O60941-4] ENST00000405222; ENSP00000384787; ENSG00000138101 [O60941-5] ENST00000406818; ENSP00000384084; ENSG00000138101 ENST00000407038; ENSP00000384767; ENSG00000138101 [O60941-2] ENST00000407661; ENSP00000385193; ENSG00000138101 [O60941-7] |
GeneIDi | 1838 |
KEGGi | hsa:1838 |
MANE-Selecti | ENST00000406818.8; ENSP00000384084.3; NM_021907.5; NP_068707.1 |
UCSCi | uc002rgh.5, human [O60941-1] |
Organism-specific databases
CTDi | 1838 |
DisGeNETi | 1838 |
GeneCardsi | DTNB |
HGNCi | HGNC:3058, DTNB |
HPAi | ENSG00000138101, Tissue enhanced (salivary) |
MIMi | 602415, gene |
neXtProti | NX_O60941 |
OpenTargetsi | ENSG00000138101 |
PharmGKBi | PA27511 |
VEuPathDBi | HostDB:ENSG00000138101 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4301, Eukaryota |
GeneTreei | ENSGT00940000164272 |
InParanoidi | O60941 |
OMAi | QHIDTDK |
OrthoDBi | 699158at2759 |
PhylomeDBi | O60941 |
TreeFami | TF343849 |
Enzyme and pathway databases
PathwayCommonsi | O60941 |
SignaLinki | O60941 |
SIGNORi | O60941 |
Miscellaneous databases
BioGRID-ORCSi | 1838, 4 hits in 1039 CRISPR screens |
ChiTaRSi | DTNB, human |
GeneWikii | DTNB |
GenomeRNAii | 1838 |
Pharosi | O60941, Tbio |
PROi | PR:O60941 |
RNActi | O60941, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138101, Expressed in C1 segment of cervical spinal cord and 164 other tissues |
ExpressionAtlasi | O60941, baseline and differential |
Genevisiblei | O60941, HS |
Family and domain databases
Gene3Di | 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR017432, Distrobrevin IPR011992, EF-hand-dom_pair IPR015153, EF-hand_dom_typ1 IPR015154, EF-hand_dom_typ2 IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF09068, EF-hand_2, 1 hit PF09069, EF-hand_3, 1 hit PF00569, ZZ, 1 hit |
PIRSFi | PIRSF038204, Distrobrevin, 1 hit |
SMARTi | View protein in SMART SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DTNB_HUMAN | |
Accessioni | O60941Primary (citable) accession number: O60941 Secondary accession number(s): B7Z733 Q9UE16 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | August 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families