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Protein

Inward rectifier potassium channel 13

Gene

KCNJ13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei149Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • inward rectifier potassium channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O60928

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.2.1.8 the inward rectifier k(+) channel (irk-c) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inward rectifier potassium channel 13
Alternative name(s):
Inward rectifier K(+) channel Kir7.1
Potassium channel, inwardly rectifying subfamily J member 13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNJ13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000115474.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6259 KCNJ13

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603208 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60928

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 53CytoplasmicBy similarityAdd BLAST53
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei54 – 78Helical; Name=M1By similarityAdd BLAST25
Topological domaini79 – 105ExtracellularBy similarityAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei106 – 117Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei118 – 124Pore-formingBy similarity7
Topological domaini125 – 133ExtracellularBy similarity9
Transmembranei134 – 155Helical; Name=M2By similarityAdd BLAST22
Topological domaini156 – 360CytoplasmicBy similarityAdd BLAST205

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Snowflake vitreoretinal degeneration (SVD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDevelopmental and progressive hereditary eye disorder that affects multiple tissues within the eye. Diagnostic features of SVD include fibrillar degeneration of the vitreous humor, early-onset cataract, minute crystalline deposits in the neurosensory retina, and retinal detachment.
See also OMIM:193230
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043509162R → W in SVD; overexpression produces a non-selective cation current that depolarizes transfected cells and increases their fragility. 1 PublicationCorresponds to variant dbSNP:rs121918542EnsemblClinVar.1
Leber congenital amaurosis 16 (LCA16)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus.
See also OMIM:614186
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066488117Q → R in LCA16. 1 Publication1
Natural variantiVAR_066490241L → P in LCA16. 1 PublicationCorresponds to variant dbSNP:rs143607153EnsemblClinVar.1

Keywords - Diseasei

Cataract, Disease mutation, Leber congenital amaurosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
3769

MalaCards human disease database

More...
MalaCardsi
KCNJ13
MIMi193230 phenotype
614186 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000115474

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
65 Leber congenital amaurosis
91496 Snowflake vitreoretinal degeneration

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30044

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2146349

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
443

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNJ13

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001549661 – 360Inward rectifier potassium channel 13Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei201Phosphoserine; by PKC1 Publication1
Modified residuei287Phosphoserine; by PKA1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-201 by PKC strongly inhibits ionic currents, while phosphorylation at Ser-287 by PKA increases them.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O60928

PeptideAtlas

More...
PeptideAtlasi
O60928

PRoteomics IDEntifications database

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PRIDEi
O60928

ProteomicsDB human proteome resource

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ProteomicsDBi
49673
49674 [O60928-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60928

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60928

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115474 Expressed in 91 organ(s), highest expression level in pigmented layer of retina

CleanEx database of gene expression profiles

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CleanExi
HS_KCNJ13

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60928 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60928 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000233826

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O60928

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60928

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60928

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi119 – 124Selectivity filterBy similarity6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3827 Eukaryota
ENOG410XQ62 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153512

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000237326

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006178

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60928

KEGG Orthology (KO)

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KOi
K05006

Identification of Orthologs from Complete Genome Data

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OMAi
SSEECPF

Database of Orthologous Groups

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OrthoDBi
956263at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O60928

TreeFam database of animal gene trees

More...
TreeFami
TF313676

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.1400, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR013518 K_chnl_inward-rec_Kir_cyto
IPR008062 KCNJ13
IPR040445 Kir_TM

The PANTHER Classification System

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PANTHERi
PTHR11767 PTHR11767, 1 hit
PTHR11767:SF3 PTHR11767:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01007 IRK, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF005465 GIRK_kir, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01679 KIR7CHANNEL
PR01320 KIRCHANNEL

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81296 SSF81296, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60928-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSSNCKVIA PLLSQRYRRM VTKDGHSTLQ MDGAQRGLAY LRDAWGILMD
60 70 80 90 100
MRWRWMMLVF SASFVVHWLV FAVLWYVLAE MNGDLELDHD APPENHTICV
110 120 130 140 150
KYITSFTAAF SFSLETQLTI GYGTMFPSGD CPSAIALLAI QMLLGLMLEA
160 170 180 190 200
FITGAFVAKI ARPKNRAFSI RFTDTAVVAH MDGKPNLIFQ VANTRPSPLT
210 220 230 240 250
SVRVSAVLYQ ERENGKLYQT SVDFHLDGIS SDECPFFIFP LTYYHSITPS
260 270 280 290 300
SPLATLLQHE NPSHFELVVF LSAMQEGTGE ICQRRTSYLP SEIMLHHCFA
310 320 330 340 350
SLLTRGSKGE YQIKMENFDK TVPEFPTPLV SKSPNRTDLD IHINGQSIDN
360
FQISETGLTE
Length:360
Mass (Da):40,530
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C49D0DBC619BC50
GO
Isoform 2 (identifier: O60928-2) [UniParc]FASTAAdd to basket
Also known as: Kir7.1S

The sequence of this isoform differs from the canonical sequence as follows:
     76-94: YVLAEMNGDLELDHDAPPE → CFCGEDCPAKKSSFFNSLY
     95-360: Missing.

Show »
Length:94
Mass (Da):10,980
Checksum:i6AAE08F28C4307FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JWD6C9JWD6_HUMAN
Inward rectifier potassium channel ...
KCNJ13
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4D1H7C4D1_HUMAN
Inward rectifier potassium channel ...
KCNJ13
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066488117Q → R in LCA16. 1 Publication1
Natural variantiVAR_066489162R → Q Found in a patient with autosomal recessive retinitis pigmentosa. 1 PublicationCorresponds to variant dbSNP:rs757304681Ensembl.1
Natural variantiVAR_043509162R → W in SVD; overexpression produces a non-selective cation current that depolarizes transfected cells and increases their fragility. 1 PublicationCorresponds to variant dbSNP:rs121918542EnsemblClinVar.1
Natural variantiVAR_016193175T → I2 PublicationsCorresponds to variant dbSNP:rs1801251EnsemblClinVar.1
Natural variantiVAR_066490241L → P in LCA16. 1 PublicationCorresponds to variant dbSNP:rs143607153EnsemblClinVar.1
Natural variantiVAR_066491276E → A Found in a patient with autosomal recessive retinitis pigmentosa. 1 PublicationCorresponds to variant dbSNP:rs374411396Ensembl.1
Natural variantiVAR_043510290P → Q1 PublicationCorresponds to variant dbSNP:rs17853727Ensembl.1
Natural variantiVAR_043511309G → C1 PublicationCorresponds to variant dbSNP:rs17857137Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04262776 – 94YVLAE…DAPPE → CFCGEDCPAKKSSFFNSLY in isoform 2. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_04262895 – 360Missing in isoform 2. 2 PublicationsAdd BLAST266

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ007557 mRNA Translation: CAA07552.1
AF061118 mRNA Translation: AAC15769.1
AY758240 mRNA Translation: AAX08098.1
AY758241 mRNA Translation: AAX08099.1
AB013889 mRNA Translation: BAA28271.1
AB013891 mRNA Translation: BAA28273.1
AJ006128 mRNA Translation: CAA06878.1
AK314019 mRNA Translation: BAG36730.1
AC064852 Genomic DNA Translation: AAX93190.1
CH471063 Genomic DNA Translation: EAW71019.1
BC037290 mRNA Translation: AAH37290.1
AF082182 Genomic DNA Translation: AAD08673.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2498.1 [O60928-1]
CCDS54437.1 [O60928-2]

NCBI Reference Sequences

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RefSeqi
NP_001165887.1, NM_001172416.1 [O60928-2]
NP_001165888.1, NM_001172417.1
NP_002233.2, NM_002242.4 [O60928-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.467338

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000233826; ENSP00000233826; ENSG00000115474 [O60928-1]
ENST00000409779; ENSP00000386408; ENSG00000115474 [O60928-2]
ENST00000410029; ENSP00000386251; ENSG00000115474 [O60928-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3769

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3769

UCSC genome browser

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UCSCi
uc002vtn.4 human [O60928-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007557 mRNA Translation: CAA07552.1
AF061118 mRNA Translation: AAC15769.1
AY758240 mRNA Translation: AAX08098.1
AY758241 mRNA Translation: AAX08099.1
AB013889 mRNA Translation: BAA28271.1
AB013891 mRNA Translation: BAA28273.1
AJ006128 mRNA Translation: CAA06878.1
AK314019 mRNA Translation: BAG36730.1
AC064852 Genomic DNA Translation: AAX93190.1
CH471063 Genomic DNA Translation: EAW71019.1
BC037290 mRNA Translation: AAH37290.1
AF082182 Genomic DNA Translation: AAD08673.1
CCDSiCCDS2498.1 [O60928-1]
CCDS54437.1 [O60928-2]
RefSeqiNP_001165887.1, NM_001172416.1 [O60928-2]
NP_001165888.1, NM_001172417.1
NP_002233.2, NM_002242.4 [O60928-1]
UniGeneiHs.467338

3D structure databases

ProteinModelPortaliO60928
SMRiO60928
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000233826

Chemistry databases

BindingDBiO60928
ChEMBLiCHEMBL2146349
GuidetoPHARMACOLOGYi443

Protein family/group databases

TCDBi1.A.2.1.8 the inward rectifier k(+) channel (irk-c) family

PTM databases

iPTMnetiO60928
PhosphoSitePlusiO60928

Polymorphism and mutation databases

BioMutaiKCNJ13

Proteomic databases

PaxDbiO60928
PeptideAtlasiO60928
PRIDEiO60928
ProteomicsDBi49673
49674 [O60928-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3769
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233826; ENSP00000233826; ENSG00000115474 [O60928-1]
ENST00000409779; ENSP00000386408; ENSG00000115474 [O60928-2]
ENST00000410029; ENSP00000386251; ENSG00000115474 [O60928-1]
GeneIDi3769
KEGGihsa:3769
UCSCiuc002vtn.4 human [O60928-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3769
DisGeNETi3769
EuPathDBiHostDB:ENSG00000115474.6

GeneCards: human genes, protein and diseases

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GeneCardsi
KCNJ13

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0002929
HGNCiHGNC:6259 KCNJ13
MalaCardsiKCNJ13
MIMi193230 phenotype
603208 gene
614186 phenotype
neXtProtiNX_O60928
OpenTargetsiENSG00000115474
Orphaneti65 Leber congenital amaurosis
91496 Snowflake vitreoretinal degeneration
PharmGKBiPA30044

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00940000153512
HOGENOMiHOG000237326
HOVERGENiHBG006178
InParanoidiO60928
KOiK05006
OMAiSSEECPF
OrthoDBi956263at2759
PhylomeDBiO60928
TreeFamiTF313676

Enzyme and pathway databases

SIGNORiO60928

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KCNJ13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3769

Protein Ontology

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PROi
PR:O60928

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115474 Expressed in 91 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_KCNJ13
ExpressionAtlasiO60928 baseline and differential
GenevisibleiO60928 HS

Family and domain databases

Gene3Di2.60.40.1400, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR013518 K_chnl_inward-rec_Kir_cyto
IPR008062 KCNJ13
IPR040445 Kir_TM
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF3 PTHR11767:SF3, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01679 KIR7CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCJ13_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60928
Secondary accession number(s): A0PGH1
, O76023, Q53SA1, Q8N3Y4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: January 16, 2019
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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