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Protein

E3 ubiquitin-protein ligase PPP1R11

Gene

PPP1R11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442).2 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • protein phosphatase 1 binding Source: GO_Central
  • protein serine/threonine phosphatase inhibitor activity Source: GO_Central
  • ubiquitin protein ligase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor, Transferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase PPP1R111 Publication (EC:2.3.2.27)
Alternative name(s):
Hemochromatosis candidate gene V protein
Short name:
HCG V
Protein phosphatase 1 regulatory subunit 11
Protein phosphatase inhibitor 3
Gene namesi
Name:PPP1R11
Synonyms:HCGV, TCTE5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204619.7
HGNCiHGNC:9285 PPP1R11
MIMi606670 gene
neXtProtiNX_O60927

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi52H → A: Loss of function in inducing TLR2 degradation. 1 Publication1
Mutagenesisi60 – 62CCC → SSS: Loss of function in inducing TLR2 degradation. 1 Publication3
Mutagenesisi85C → S: Loss of function in inducing TLR2 degradation. 1 Publication1
Mutagenesisi87H → A: Loss of function in inducing TLR2 degradation. 1 Publication1
Mutagenesisi89 – 90HC → AS: Loss of function in inducing TLR2 degradation. 1 Publication2
Mutagenesisi94H → A: Loss of function in inducing TLR2 degradation. 1 Publication1

Organism-specific databases

DisGeNETi6992
OpenTargetsiENSG00000204619
PharmGKBiPA33614

Polymorphism and mutation databases

BioMutaiPPP1R11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002396192 – 126E3 ubiquitin-protein ligase PPP1R11Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei75PhosphothreonineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei109PhosphothreonineCombined sources1

Post-translational modificationi

Auto-ubiquitinated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO60927
MaxQBiO60927
PaxDbiO60927
PeptideAtlasiO60927
PRIDEiO60927
ProteomicsDBi49672
TopDownProteomicsiO60927

PTM databases

iPTMnetiO60927
PhosphoSitePlusiO60927

Miscellaneous databases

PMAP-CutDBiO60927

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000204619 Expressed in 231 organ(s), highest expression level in colonic mucosa
CleanExiHS_PPP1R11
ExpressionAtlasiO60927 baseline and differential
GenevisibleiO60927 HS

Organism-specific databases

HPAiHPA043266
HPA060174

Interactioni

Subunit structurei

Interacts with TLR2 and UBE2D2.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112852, 14 interactors
IntActiO60927, 9 interactors
MINTiO60927
STRINGi9606.ENSP00000365963

Structurei

3D structure databases

DisProtiDP00219
ProteinModelPortaliO60927
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 62Atypical RING finger domain 11 PublicationAdd BLAST11
Regioni85 – 94Atypical RING finger domain 21 Publication10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi105 – 123Pro-richAdd BLAST19

Phylogenomic databases

eggNOGiKOG4102 Eukaryota
ENOG41126IN LUCA
GeneTreeiENSGT00390000001153
HOGENOMiHOG000232107
HOVERGENiHBG080560
InParanoidiO60927
KOiK17553
OMAiCETGHCR
OrthoDBiEOG091G152U
PhylomeDBiO60927
TreeFamiTF352541

Family and domain databases

InterProiView protein in InterPro
IPR011107 PPI_Ypi1
PANTHERiPTHR20835 PTHR20835, 1 hit
PfamiView protein in Pfam
PF07491 PPI_Ypi1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O60927-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN
60 70 80 90 100
EHMGRRSSKC CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR
110 120
ATLGPTPTTP PQPPDPSQPP PGPMQH
Length:126
Mass (Da):13,953
Last modified:August 1, 1998 - v1
Checksum:iD6788A5AAC073549
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SRK2Q5SRK2_HUMAN
E3 ubiquitin-protein ligase PPP1R11
PPP1R11
74Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81003 mRNA Translation: CAC16920.1
X89902 Genomic DNA Translation: CAC16919.1
U53588 Genomic DNA Translation: AAC52082.1
BA000025 Genomic DNA Translation: BAB63334.1
AB088087 Genomic DNA Translation: BAC54919.1
AB202082 Genomic DNA Translation: BAE78601.1
AL669914 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
AL845439 Genomic DNA No translation available.
BC102010 mRNA Translation: AAI02011.1
BC102011 mRNA Translation: AAI02012.1
BC104750 mRNA Translation: AAI04751.1
CCDSiCCDS4671.1
RefSeqiNP_068778.1, NM_021959.2
UniGeneiHs.82887

Genome annotation databases

EnsembliENST00000376772; ENSP00000365963; ENSG00000204619
ENST00000383612; ENSP00000373107; ENSG00000206501
ENST00000431424; ENSP00000411038; ENSG00000236560
ENST00000431977; ENSP00000407981; ENSG00000237829
ENST00000436591; ENSP00000414808; ENSG00000234058
ENST00000437937; ENSP00000394056; ENSG00000233314
ENST00000448378; ENSP00000403557; ENSG00000237403
ENST00000452679; ENSP00000412297; ENSG00000227720
GeneIDi6992
KEGGihsa:6992
UCSCiuc003npb.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81003 mRNA Translation: CAC16920.1
X89902 Genomic DNA Translation: CAC16919.1
U53588 Genomic DNA Translation: AAC52082.1
BA000025 Genomic DNA Translation: BAB63334.1
AB088087 Genomic DNA Translation: BAC54919.1
AB202082 Genomic DNA Translation: BAE78601.1
AL669914 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
AL845439 Genomic DNA No translation available.
BC102010 mRNA Translation: AAI02011.1
BC102011 mRNA Translation: AAI02012.1
BC104750 mRNA Translation: AAI04751.1
CCDSiCCDS4671.1
RefSeqiNP_068778.1, NM_021959.2
UniGeneiHs.82887

3D structure databases

DisProtiDP00219
ProteinModelPortaliO60927
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112852, 14 interactors
IntActiO60927, 9 interactors
MINTiO60927
STRINGi9606.ENSP00000365963

PTM databases

iPTMnetiO60927
PhosphoSitePlusiO60927

Polymorphism and mutation databases

BioMutaiPPP1R11

Proteomic databases

EPDiO60927
MaxQBiO60927
PaxDbiO60927
PeptideAtlasiO60927
PRIDEiO60927
ProteomicsDBi49672
TopDownProteomicsiO60927

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376772; ENSP00000365963; ENSG00000204619
ENST00000383612; ENSP00000373107; ENSG00000206501
ENST00000431424; ENSP00000411038; ENSG00000236560
ENST00000431977; ENSP00000407981; ENSG00000237829
ENST00000436591; ENSP00000414808; ENSG00000234058
ENST00000437937; ENSP00000394056; ENSG00000233314
ENST00000448378; ENSP00000403557; ENSG00000237403
ENST00000452679; ENSP00000412297; ENSG00000227720
GeneIDi6992
KEGGihsa:6992
UCSCiuc003npb.4 human

Organism-specific databases

CTDi6992
DisGeNETi6992
EuPathDBiHostDB:ENSG00000204619.7
GeneCardsiPPP1R11
HGNCiHGNC:9285 PPP1R11
HPAiHPA043266
HPA060174
MIMi606670 gene
neXtProtiNX_O60927
OpenTargetsiENSG00000204619
PharmGKBiPA33614
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4102 Eukaryota
ENOG41126IN LUCA
GeneTreeiENSGT00390000001153
HOGENOMiHOG000232107
HOVERGENiHBG080560
InParanoidiO60927
KOiK17553
OMAiCETGHCR
OrthoDBiEOG091G152U
PhylomeDBiO60927
TreeFamiTF352541

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

ChiTaRSiPPP1R11 human
GeneWikiiPPP1R11
GenomeRNAii6992
PMAP-CutDBiO60927
PROiPR:O60927
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204619 Expressed in 231 organ(s), highest expression level in colonic mucosa
CleanExiHS_PPP1R11
ExpressionAtlasiO60927 baseline and differential
GenevisibleiO60927 HS

Family and domain databases

InterProiView protein in InterPro
IPR011107 PPI_Ypi1
PANTHERiPTHR20835 PTHR20835, 1 hit
PfamiView protein in Pfam
PF07491 PPI_Ypi1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPP1RB_HUMAN
AccessioniPrimary (citable) accession number: O60927
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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