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Protein

Prefoldin subunit 1

Gene

PFDN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: ProtInc
  • protein binding involved in protein folding Source: AgBase
  • unfolded protein binding Source: InterPro

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 1
Gene namesi
Name:PFDN1
Synonyms:PFD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113068.9
HGNCiHGNC:8866 PFDN1
MIMi604897 gene
neXtProtiNX_O60925

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi5201
OpenTargetsiENSG00000113068
PharmGKBiPA33207

Polymorphism and mutation databases

BioMutaiPFDN1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001248302 – 122Prefoldin subunit 1Add BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO60925
MaxQBiO60925
PaxDbiO60925
PeptideAtlasiO60925
PRIDEiO60925
ProteomicsDBi49671
TopDownProteomicsiO60925

2D gel databases

OGPiO60925

PTM databases

iPTMnetiO60925
PhosphoSitePlusiO60925

Expressioni

Gene expression databases

BgeeiENSG00000113068 Expressed in 233 organ(s), highest expression level in frontal cortex
CleanExiHS_PFDN1
ExpressionAtlasiO60925 baseline and differential
GenevisibleiO60925 HS

Organism-specific databases

HPAiHPA006499

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111223, 97 interactors
CORUMiO60925
IntActiO60925, 61 interactors
MINTiO60925
STRINGi9606.ENSP00000261813

Structurei

3D structure databases

ProteinModelPortaliO60925
SMRiO60925
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiENOG410ISJS Eukaryota
ENOG4111Q46 LUCA
GeneTreeiENSGT00390000009786
HOGENOMiHOG000005946
HOVERGENiHBG031813
InParanoidiO60925
KOiK09548
OMAiQSVGRMF
OrthoDBiEOG091G0X1V
PhylomeDBiO60925
TreeFamiTF106490

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR002777 PFD_beta-like
IPR009053 Prefoldin
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O60925-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPVDLELK KAFTELQAKV IDTQQKVKLA DIQIEQLNRT KKHAHLTDTE
60 70 80 90 100
IMTLVDETNM YEGVGRMFIL QSKEAIHSQL LEKQKIAEEK IKELEQKKSY
110 120
LERSVKEAED NIREMLMARR AQ
Length:122
Mass (Da):14,210
Last modified:August 13, 2002 - v2
Checksum:i4C88216612864F87
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RGS4E5RGS4_HUMAN
Prefoldin subunit 1
PFDN1
117Annotation score:
D6RGG5D6RGG5_HUMAN
Prefoldin subunit 1
PFDN1
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86I → V in BAD97114 (Ref. 3) Curated1
Sequence conflicti104 – 105SV → RL in CAA76759 (PubMed:9630229).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17392 mRNA Translation: CAA76759.1
AK223394 mRNA Translation: BAD97114.1
AK315353 mRNA Translation: BAG37749.1
CH471062 Genomic DNA Translation: EAW62071.1
BC003620 mRNA Translation: AAH03620.1
BC006202 mRNA Translation: AAH06202.1
BC011869 mRNA Translation: AAH11869.1
CCDSiCCDS4222.1
RefSeqiNP_002613.2, NM_002622.4
UniGeneiHs.483564

Genome annotation databases

EnsembliENST00000261813; ENSP00000261813; ENSG00000113068
GeneIDi5201
KEGGihsa:5201
UCSCiuc003lff.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17392 mRNA Translation: CAA76759.1
AK223394 mRNA Translation: BAD97114.1
AK315353 mRNA Translation: BAG37749.1
CH471062 Genomic DNA Translation: EAW62071.1
BC003620 mRNA Translation: AAH03620.1
BC006202 mRNA Translation: AAH06202.1
BC011869 mRNA Translation: AAH11869.1
CCDSiCCDS4222.1
RefSeqiNP_002613.2, NM_002622.4
UniGeneiHs.483564

3D structure databases

ProteinModelPortaliO60925
SMRiO60925
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111223, 97 interactors
CORUMiO60925
IntActiO60925, 61 interactors
MINTiO60925
STRINGi9606.ENSP00000261813

PTM databases

iPTMnetiO60925
PhosphoSitePlusiO60925

Polymorphism and mutation databases

BioMutaiPFDN1

2D gel databases

OGPiO60925

Proteomic databases

EPDiO60925
MaxQBiO60925
PaxDbiO60925
PeptideAtlasiO60925
PRIDEiO60925
ProteomicsDBi49671
TopDownProteomicsiO60925

Protocols and materials databases

DNASUi5201
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261813; ENSP00000261813; ENSG00000113068
GeneIDi5201
KEGGihsa:5201
UCSCiuc003lff.2 human

Organism-specific databases

CTDi5201
DisGeNETi5201
EuPathDBiHostDB:ENSG00000113068.9
GeneCardsiPFDN1
HGNCiHGNC:8866 PFDN1
HPAiHPA006499
MIMi604897 gene
neXtProtiNX_O60925
OpenTargetsiENSG00000113068
PharmGKBiPA33207
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISJS Eukaryota
ENOG4111Q46 LUCA
GeneTreeiENSGT00390000009786
HOGENOMiHOG000005946
HOVERGENiHBG031813
InParanoidiO60925
KOiK09548
OMAiQSVGRMF
OrthoDBiEOG091G0X1V
PhylomeDBiO60925
TreeFamiTF106490

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC

Miscellaneous databases

ChiTaRSiPFDN1 human
GeneWikiiPFDN1
GenomeRNAii5201
PROiPR:O60925
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113068 Expressed in 233 organ(s), highest expression level in frontal cortex
CleanExiHS_PFDN1
ExpressionAtlasiO60925 baseline and differential
GenevisibleiO60925 HS

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR002777 PFD_beta-like
IPR009053 Prefoldin
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPFD1_HUMAN
AccessioniPrimary (citable) accession number: O60925
Secondary accession number(s): B2RD02, Q53F95, Q96EX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 13, 2002
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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