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Protein

Cathepsin L2

Gene

CTSV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cysteine protease. May have an important role in corneal physiology.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).1 Publication EC:3.4.22.43

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1381 Publication1
Active sitei2771 Publication1
Active sitei3011 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • aminopeptidase activity Source: Ensembl
  • cysteine-type endopeptidase activity Source: GO_Central
  • cysteine-type peptidase activity Source: ProtInc
  • kininogen binding Source: Ensembl
  • peptide binding Source: Ensembl
  • protein-containing complex binding Source: Ensembl
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.22.43 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-2132295 MHC class II antigen presentation
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O60911

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I29.010

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cathepsin L2 (EC:3.4.22.43)
Alternative name(s):
Cathepsin U
Cathepsin V
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTSV
Synonyms:CATL2, CTSL2, CTSU
ORF Names:UNQ268/PRO305
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000136943.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2538 CTSV

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603308 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60911

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1515

Open Targets

More...
OpenTargetsi
ENSG00000136943

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27036

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3272

Drug and drug target database

More...
DrugBanki
DB02869 3-amino-5-phenylpentane
DB04451 4-Methylpiperazin-1-Yl Carbonyl Group

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2352

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTSV

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002627718 – 113Activation peptideAdd BLAST96
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000026278114 – 334Cathepsin L2Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi135 ↔ 178Combined sources1 Publication
Disulfide bondi169 ↔ 211Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi221N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi270 ↔ 323Combined sources1 Publication
Glycosylationi292N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60911

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60911

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60911

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60911

PeptideAtlas

More...
PeptideAtlasi
O60911

PRoteomics IDEntifications database

More...
PRIDEi
O60911

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49669

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60911

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60911

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136943 Expressed in 175 organ(s), highest expression level in hair follicle

CleanEx database of gene expression profiles

More...
CleanExi
HS_CTSL2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60911 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60911 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017112

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107895, 31 interactors

Protein interaction database and analysis system

More...
IntActi
O60911, 15 interactors

Molecular INTeraction database

More...
MINTi
O60911

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000259470

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O60911

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1334
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FH0X-ray1.60A/B114-334[»]
3H6SX-ray2.22A/B/C/D114-334[»]
3KFQX-ray1.99A/B114-334[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60911

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60911

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O60911

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1543 Eukaryota
COG4870 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154367

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230774

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG011513

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60911

KEGG Orthology (KO)

More...
KOi
K01375

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEGANSD

Database of Orthologous Groups

More...
OrthoDBi
1224404at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60911

TreeFam database of animal gene trees

More...
TreeFami
TF313739

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02248 Peptidase_C1A, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29

The PANTHER Classification System

More...
PANTHERi
PTHR12411 PTHR12411, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00705 PAPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O60911-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLSLVLAAF CLGIASAVPK FDQNLDTKWY QWKATHRRLY GANEEGWRRA
60 70 80 90 100
VWEKNMKMIE LHNGEYSQGK HGFTMAMNAF GDMTNEEFRQ MMGCFRNQKF
110 120 130 140 150
RKGKVFREPL FLDLPKSVDW RKKGYVTPVK NQKQCGSCWA FSATGALEGQ
160 170 180 190 200
MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG GFMARAFQYV KENGGLDSEE
210 220 230 240 250
SYPYVAVDEI CKYRPENSVA NDTGFTVVAP GKEKALMKAV ATVGPISVAM
260 270 280 290 300
DAGHSSFQFY KSGIYFEPDC SSKNLDHGVL VVGYGFEGAN SNNSKYWLVK
310 320 330
NSWGPEWGSN GYVKIAKDKN NHCGIATAAS YPNV
Length:334
Mass (Da):37,329
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD2DE51AC5F242C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81G → P in CAA75029 (PubMed:9563472).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y14734 mRNA Translation: CAA75029.1
AB001928 mRNA Translation: BAA25909.1
AF070448 mRNA Translation: AAC23598.1
AB019534 Genomic DNA Translation: BAA34365.1
AY358641 mRNA Translation: AAQ89004.1
AL445670 Genomic DNA No translation available.
BC023504 mRNA Translation: AAH23504.1
BC110512 mRNA Translation: AAI10513.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6723.1

NCBI Reference Sequences

More...
RefSeqi
NP_001188504.1, NM_001201575.1
NP_001324.2, NM_001333.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.610096

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259470; ENSP00000259470; ENSG00000136943
ENST00000538255; ENSP00000445052; ENSG00000136943

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1515

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1515

UCSC genome browser

More...
UCSCi
uc004awt.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14734 mRNA Translation: CAA75029.1
AB001928 mRNA Translation: BAA25909.1
AF070448 mRNA Translation: AAC23598.1
AB019534 Genomic DNA Translation: BAA34365.1
AY358641 mRNA Translation: AAQ89004.1
AL445670 Genomic DNA No translation available.
BC023504 mRNA Translation: AAH23504.1
BC110512 mRNA Translation: AAI10513.1
CCDSiCCDS6723.1
RefSeqiNP_001188504.1, NM_001201575.1
NP_001324.2, NM_001333.3
UniGeneiHs.610096

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FH0X-ray1.60A/B114-334[»]
3H6SX-ray2.22A/B/C/D114-334[»]
3KFQX-ray1.99A/B114-334[»]
ProteinModelPortaliO60911
SMRiO60911
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107895, 31 interactors
IntActiO60911, 15 interactors
MINTiO60911
STRINGi9606.ENSP00000259470

Chemistry databases

BindingDBiO60911
ChEMBLiCHEMBL3272
DrugBankiDB02869 3-amino-5-phenylpentane
DB04451 4-Methylpiperazin-1-Yl Carbonyl Group
GuidetoPHARMACOLOGYi2352

Protein family/group databases

MEROPSiI29.010

PTM databases

iPTMnetiO60911
PhosphoSitePlusiO60911

Polymorphism and mutation databases

BioMutaiCTSV

Proteomic databases

EPDiO60911
jPOSTiO60911
MaxQBiO60911
PaxDbiO60911
PeptideAtlasiO60911
PRIDEiO60911
ProteomicsDBi49669

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259470; ENSP00000259470; ENSG00000136943
ENST00000538255; ENSP00000445052; ENSG00000136943
GeneIDi1515
KEGGihsa:1515
UCSCiuc004awt.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1515
DisGeNETi1515
EuPathDBiHostDB:ENSG00000136943.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CTSV
HGNCiHGNC:2538 CTSV
HPAiCAB017112
MIMi603308 gene
neXtProtiNX_O60911
OpenTargetsiENSG00000136943
PharmGKBiPA27036

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00940000154367
HOGENOMiHOG000230774
HOVERGENiHBG011513
InParanoidiO60911
KOiK01375
OMAiFEGANSD
OrthoDBi1224404at2759
PhylomeDBiO60911
TreeFamiTF313739

Enzyme and pathway databases

BRENDAi3.4.22.43 2681
ReactomeiR-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-2132295 MHC class II antigen presentation
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
SABIO-RKiO60911

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CTSV human
EvolutionaryTraceiO60911

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Cathepsin_L2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1515

Protein Ontology

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PROi
PR:O60911

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000136943 Expressed in 175 organ(s), highest expression level in hair follicle
CleanExiHS_CTSL2
ExpressionAtlasiO60911 baseline and differential
GenevisibleiO60911 HS

Family and domain databases

CDDicd02248 Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCATL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60911
Secondary accession number(s): O60233, Q2TB86, Q5T1U0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 1, 2000
Last modified: January 16, 2019
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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