CTSV

Functionⁱ

Cysteine protease. May have an important role in corneal physiology.2 Publications

Catalytic activityⁱ

The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).
1 Publication
Manual assertion based on experiment inⁱ
- Ref.3
  "Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization."
  Broemme D., Li Z., Barnes M., Mehler E.
  Biochemistry 38:2377-2385(1999) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
EC:3.4.22.43

Activity regulationⁱ

Inhibited by CST6.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	138	1 Publication	1
Active siteⁱ	277	1 Publication	1
Active siteⁱ	301	1 Publication	1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
autophagic cell death Source: Ensembl
cellular response to starvation Source: Ensembl
decidualization Source: Ensembl
extracellular matrix disassembly Source: Reactome
multicellular organism aging Source: Ensembl
nerve development Source: Ensembl
proteolysis involved in cellular protein catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
regulation of keratinocyte differentiation Source: Reactome
response to glucocorticoid Source: Ensembl
response to glucose Source: Ensembl
response to gonadotropin Source: Ensembl
response to odorant Source: Ensembl
Sertoli cell differentiation Source: Ensembl
spermatogenesis Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol protease

Molecular function

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAⁱ	3.4.22.43 2681
Reactomeⁱ	R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1592389 Activation of Matrix Metalloproteinases R-HSA-1679131 Trafficking and processing of endosomal TLR R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures R-HSA-2132295 MHC class II antigen presentation R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
SABIO-RKⁱ	O60911

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I29.010

MEROPSⁱ

I29.010

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cathepsin L2 (EC:3.4.22.43) Alternative name(s): Cathepsin U Cathepsin V
Gene namesⁱ	Name:CTSV Synonyms:CATL2, CTSL2, CTSU ORF Names:UNQ268/PRO305
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2538 CTSV
MIMⁱ	603308 gene
neXtProtⁱ	NX_O60911

Keywords - Cellular componentⁱ

Lysosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1515
Open Targets More...OpenTargetsⁱ	ENSG00000136943
PharmGKBⁱ	PA27036

Miscellaneous databases

Pharosⁱ	O60911 Tchem

Pharosⁱ

O60911 Tchem

Chemistry databases

ChEMBLⁱ	CHEMBL3272
Drug and drug target database More...DrugBankⁱ	DB02869 3-amino-5-phenylpentane DB04451 4-Methylpiperazin-1-Yl Carbonyl Group
DrugCentral More...DrugCentralⁱ	O60911
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2352

Polymorphism and mutation databases

BioMutaⁱ	CTSV

BioMutaⁱ

CTSV

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST	17
PropeptideⁱPRO_0000026277	18 – 113	Activation peptideAdd BLAST	96
ChainⁱPRO_0000026278	114 – 334	Cathepsin L2Add BLAST	221

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	135 ↔ 178	Combined sources1 Publication
Disulfide bondⁱ	169 ↔ 211	Combined sources1 Publication
Glycosylationⁱ	221	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	270 ↔ 323	Combined sources1 Publication
Glycosylationⁱ	292	N-linked (GlcNAc...) asparagine1 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDⁱ	O60911
jPOSTⁱ	O60911
MassIVEⁱ	O60911
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O60911
PaxDbⁱ	O60911
PeptideAtlas More...PeptideAtlasⁱ	O60911
PRIDEⁱ	O60911
ProteomicsDBⁱ	49669

PTM databases

iPTMnetⁱ	O60911
PhosphoSitePlusⁱ	O60911

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000136943 Expressed in hair follicle and 174 other tissues
ExpressionAtlasⁱ	O60911 baseline and differential
Genevisibleⁱ	O60911 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000136943 Tissue enriched (lymphoid)

HPAⁱ

ENSG00000136943 Tissue enriched (lymphoid)

Interactionⁱ

GO - Molecular functionⁱ

kininogen binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107895, 33 interactors
IntActⁱ	O60911, 34 interactors
Molecular INTeraction database More...MINTⁱ	O60911
STRINGⁱ	9606.ENSP00000445052

Chemistry databases

BindingDBⁱ

O60911

Miscellaneous databases

RNActⁱ	O60911 protein

RNActⁱ

O60911 protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	120 – 123	Combined sources	4
Helixⁱ	138 – 155	Combined sources	18
Helixⁱ	163 – 169	Combined sources	7
Helixⁱ	171 – 173	Combined sources	3
Helixⁱ	177 – 179	Combined sources	3
Helixⁱ	183 – 193	Combined sources	11
Beta strandⁱ	196 – 198	Combined sources	3
Turnⁱ	199 – 201	Combined sources	3
Helixⁱ	215 – 217	Combined sources	3
Beta strandⁱ	218 – 220	Combined sources	3
Beta strandⁱ	225 – 227	Combined sources	3
Helixⁱ	233 – 242	Combined sources	10
Beta strandⁱ	246 – 250	Combined sources	5
Helixⁱ	255 – 258	Combined sources	4
Beta strandⁱ	262 – 265	Combined sources	4
Beta strandⁱ	272 – 274	Combined sources	3
Beta strandⁱ	277 – 289	Combined sources	13
Beta strandⁱ	293 – 300	Combined sources	8
Beta strandⁱ	312 – 316	Combined sources	5
Beta strandⁱ	318 – 321	Combined sources	4
Helixⁱ	322 – 324	Combined sources	3
Turnⁱ	325 – 327	Combined sources	3
Beta strandⁱ	330 – 332	Combined sources	3

Show more details

3D structure databases

SMRⁱ	O60911
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O60911

EvolutionaryTraceⁱ

O60911

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG1543 Eukaryota COG4870 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154367
HOGENOMⁱ	CLU_012184_1_2_1
InParanoidⁱ	O60911
KEGG Orthology (KO) More...KOⁱ	K01375
OMAⁱ	CSHPQGN
Database of Orthologous Groups More...OrthoDBⁱ	1275401at2759
PhylomeDBⁱ	O60911
TreeFamⁱ	TF313739

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02248 Peptidase_C1A, 1 hit
InterProⁱ	View protein in InterPro IPR038765 Papain-like_cys_pep_sf IPR025661 Pept_asp_AS IPR000169 Pept_cys_AS IPR025660 Pept_his_AS IPR000668 Peptidase_C1A_C IPR039417 Peptidase_C1A_papain-like IPR013201 Prot_inhib_I29
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08246 Inhibitor_I29, 1 hit PF00112 Peptidase_C1, 1 hit
PRINTSⁱ	PR00705 PAPAIN
SMARTⁱ	View protein in SMART SM00848 Inhibitor_I29, 1 hit SM00645 Pept_C1, 1 hit
SUPFAMⁱ	SSF54001 SSF54001, 1 hit
PROSITEⁱ	View protein in PROSITE PS00640 THIOL_PROTEASE_ASN, 1 hit PS00139 THIOL_PROTEASE_CYS, 1 hit PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O60911-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNLSLVLAAF CLGIASAVPK FDQNLDTKWY QWKATHRRLY GANEEGWRRA 
        60         70         80         90        100
VWEKNMKMIE LHNGEYSQGK HGFTMAMNAF GDMTNEEFRQ MMGCFRNQKF 
       110        120        130        140        150
RKGKVFREPL FLDLPKSVDW RKKGYVTPVK NQKQCGSCWA FSATGALEGQ 
       160        170        180        190        200
MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG GFMARAFQYV KENGGLDSEE 
       210        220        230        240        250
SYPYVAVDEI CKYRPENSVA NDTGFTVVAP GKEKALMKAV ATVGPISVAM 
       260        270        280        290        300
DAGHSSFQFY KSGIYFEPDC SSKNLDHGVL VVGYGFEGAN SNNSKYWLVK 
       310        320        330 
NSWGPEWGSN GYVKIAKDKN NHCGIATAAS YPNV

Length:334

Mass (Da):37,329

Last modified:December 1, 2000 - v2

Checksum:ⁱCD2DE51AC5F242C8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	81	G → P in CAA75029 (PubMed:9563472).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y14734 mRNA Translation: CAA75029.1 AB001928 mRNA Translation: BAA25909.1 AF070448 mRNA Translation: AAC23598.1 AB019534 Genomic DNA Translation: BAA34365.1 AY358641 mRNA Translation: AAQ89004.1 AL445670 Genomic DNA No translation available. BC023504 mRNA Translation: AAH23504.1 BC110512 mRNA Translation: AAI10513.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6723.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001188504.1, NM_001201575.1 NP_001324.2, NM_001333.3

Genome annotation databases

Ensemblⁱ	ENST00000259470; ENSP00000259470; ENSG00000136943 ENST00000538255; ENSP00000445052; ENSG00000136943
GeneIDⁱ	1515
KEGGⁱ	hsa:1515
UCSC genome browser More...UCSCⁱ	uc004awt.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O60911	Cathepsin L2, isoform CRA_a		HUMAN		334	UniRef100_O60911

Protein	Similar proteins		Species	Score	Length	Source
O60911	Cathepsin L2, isoform CRA_a		HUMAN		334	UniRef90_O60911
Cathepsin V		NOMLE		335
CTSV isoform 1		PONAB		334
Cathepsin V		COLAP		334
Cathepsin V		PANPA		334
+15

Protein	Similar proteins		Species	Score	Length	Source
O60911	Cathepsin L1		RAT		334	UniRef50_P07154
Cathepsin L1	)	MOUSE		334
Cathepsin L1		PIG		334
Cathepsin L1		CHLAE		333
Cathepsin L2		BOVIN		334
+180

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y14734 mRNA Translation: CAA75029.1 AB001928 mRNA Translation: BAA25909.1 AF070448 mRNA Translation: AAC23598.1 AB019534 Genomic DNA Translation: BAA34365.1 AY358641 mRNA Translation: AAQ89004.1 AL445670 Genomic DNA No translation available. BC023504 mRNA Translation: AAH23504.1 BC110512 mRNA Translation: AAI10513.1
CCDSⁱ	CCDS6723.1
RefSeqⁱ	NP_001188504.1, NM_001201575.1 NP_001324.2, NM_001333.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1FH0	X-ray	1.60	A/B	114-334	[»]
	3H6S	X-ray	2.22	A/B/C/D	114-334	[»]
	3KFQ	X-ray	1.99	A/B	114-334	[»]
SMRⁱ	O60911
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107895, 33 interactors
IntActⁱ	O60911, 34 interactors
MINTⁱ	O60911
STRINGⁱ	9606.ENSP00000445052

Chemistry databases

BindingDBⁱ	O60911
ChEMBLⁱ	CHEMBL3272
DrugBankⁱ	DB02869 3-amino-5-phenylpentane DB04451 4-Methylpiperazin-1-Yl Carbonyl Group
DrugCentralⁱ	O60911
GuidetoPHARMACOLOGYⁱ	2352

Protein family/group databases

MEROPSⁱ	I29.010

MEROPSⁱ

I29.010

PTM databases

iPTMnetⁱ	O60911
PhosphoSitePlusⁱ	O60911

Polymorphism and mutation databases

BioMutaⁱ	CTSV

BioMutaⁱ

CTSV

Proteomic databases

EPDⁱ	O60911
jPOSTⁱ	O60911
MassIVEⁱ	O60911
MaxQBⁱ	O60911
PaxDbⁱ	O60911
PeptideAtlasⁱ	O60911
PRIDEⁱ	O60911
ProteomicsDBⁱ	49669

Protocols and materials databases

Antibodypediaⁱ	28731 354 antibodies

Antibodypediaⁱ

28731 354 antibodies

Genome annotation databases

Ensemblⁱ	ENST00000259470; ENSP00000259470; ENSG00000136943 ENST00000538255; ENSP00000445052; ENSG00000136943
GeneIDⁱ	1515
KEGGⁱ	hsa:1515
UCSCⁱ	uc004awt.4 human

Organism-specific databases

CTDⁱ	1515
DisGeNETⁱ	1515
GeneCardsⁱ	CTSV
HGNCⁱ	HGNC:2538 CTSV
HPAⁱ	ENSG00000136943 Tissue enriched (lymphoid)
MIMⁱ	603308 gene
neXtProtⁱ	NX_O60911
OpenTargetsⁱ	ENSG00000136943
PharmGKBⁱ	PA27036
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1543 Eukaryota COG4870 LUCA
GeneTreeⁱ	ENSGT00940000154367
HOGENOMⁱ	CLU_012184_1_2_1
InParanoidⁱ	O60911
KOⁱ	K01375
OMAⁱ	CSHPQGN
OrthoDBⁱ	1275401at2759
PhylomeDBⁱ	O60911
TreeFamⁱ	TF313739

Enzyme and pathway databases

BRENDAⁱ	3.4.22.43 2681
Reactomeⁱ	R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1592389 Activation of Matrix Metalloproteinases R-HSA-1679131 Trafficking and processing of endosomal TLR R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures R-HSA-2132295 MHC class II antigen presentation R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
SABIO-RKⁱ	O60911

Miscellaneous databases

ChiTaRSⁱ	CTSV human
EvolutionaryTraceⁱ	O60911
GeneWikiⁱ	Cathepsin_L2
GenomeRNAiⁱ	1515
Pharosⁱ	O60911 Tchem
Protein Ontology More...PROⁱ	PR:O60911
RNActⁱ	O60911 protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136943 Expressed in hair follicle and 174 other tissues
ExpressionAtlasⁱ	O60911 baseline and differential
Genevisibleⁱ	O60911 HS

Family and domain databases

CDDⁱ	cd02248 Peptidase_C1A, 1 hit
InterProⁱ	View protein in InterPro IPR038765 Papain-like_cys_pep_sf IPR025661 Pept_asp_AS IPR000169 Pept_cys_AS IPR025660 Pept_his_AS IPR000668 Peptidase_C1A_C IPR039417 Peptidase_C1A_papain-like IPR013201 Prot_inhib_I29
Pfamⁱ	View protein in Pfam PF08246 Inhibitor_I29, 1 hit PF00112 Peptidase_C1, 1 hit
PRINTSⁱ	PR00705 PAPAIN
SMARTⁱ	View protein in SMART SM00848 Inhibitor_I29, 1 hit SM00645 Pept_C1, 1 hit
SUPFAMⁱ	SSF54001 SSF54001, 1 hit
PROSITEⁱ	View protein in PROSITE PS00640 THIOL_PROTEASE_ASN, 1 hit PS00139 THIOL_PROTEASE_CYS, 1 hit PS00639 THIOL_PROTEASE_HIS, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CATL2_HUMAN
Accessionⁱ	O60911Primary (citable) accession number: O60911 Secondary accession number(s): O60233, Q2TB86, Q5T1U0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	December 1, 2000
	Last modified:	April 22, 2020
	This is version 192 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Peptidase families
Classification of peptidase families and list of entries
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O60911 (CATL2_HUMAN)

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Cathepsin L2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Extracellular region or secreted

Lysosome

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ