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Protein

Receptor activity-modifying protein 3

Gene

RAMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.2 Publications

GO - Molecular functioni

  • adrenomedullin receptor activity Source: UniProtKB
  • coreceptor activity Source: GO_Central
  • protein transporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 3
Alternative name(s):
Calcitonin-receptor-like receptor activity-modifying protein 3
Short name:
CRLR activity-modifying protein 3
Gene namesi
Name:RAMP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000122679.8
HGNCiHGNC:9845 RAMP3
MIMi605155 gene
neXtProtiNX_O60896

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 118ExtracellularSequence analysisAdd BLAST95
Transmembranei119 – 138HelicalSequence analysisAdd BLAST20
Topological domaini139 – 148CytoplasmicSequence analysis10

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10268
OpenTargetsiENSG00000122679
PharmGKBiPA34204

Chemistry databases

ChEMBLiCHEMBL2111191
DrugBankiDB01278 Pramlintide
GuidetoPHARMACOLOGYi53

Polymorphism and mutation databases

BioMutaiRAMP3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003017624 – 148Receptor activity-modifying protein 3Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi40 ↔ 72By similarity
Disulfide bondi57 ↔ 104By similarity
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO60896
PeptideAtlasiO60896
PRIDEiO60896
ProteomicsDBi49659

Expressioni

Tissue specificityi

Strongly expressed in lung, breast, immune system and fetal tissues.1 Publication

Gene expression databases

BgeeiENSG00000122679 Expressed in 165 organ(s), highest expression level in right lung
CleanExiHS_RAMP3
ExpressionAtlasiO60896 baseline and differential
GenevisibleiO60896 HS

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1.By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi115559, 7 interactors
ComplexPortaliCPX-3148 Adrenomedullin receptor AM2 complex
CPX-3187 Amylin receptor 3 complex
CORUMiO60896
IntActiO60896, 9 interactors
STRINGi9606.ENSP00000242249

Chemistry databases

BindingDBiO60896

Structurei

3D structure databases

ProteinModelPortaliO60896
SMRiO60896
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXGF Eukaryota
ENOG4111U8C LUCA
GeneTreeiENSGT00390000016200
HOGENOMiHOG000253018
HOVERGENiHBG061268
InParanoidiO60896
KOiK08449
PhylomeDBiO60896
TreeFamiTF333286

Family and domain databases

Gene3Di1.10.150.510, 1 hit
InterProiView protein in InterPro
IPR006985 RAMP
IPR038126 RAMP_sf
PANTHERiPTHR14076 PTHR14076, 1 hit
PfamiView protein in Pfam
PF04901 RAMP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O60896-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METGALRRPQ LLPLLLLLCG GCPRAGGCNE TGMLERLPLC GKAFADMMGK
60 70 80 90 100
VDVWKWCNLS EFIVYYESFT NCTEMEANVV GCYWPNPLAQ GFITGIHRQF
110 120 130 140
FSNCTVDRVH LEDPPDEVLI PLIVIPVVLT VAMAGLVVWR SKRTDTLL
Length:148
Mass (Da):16,518
Last modified:August 1, 1998 - v1
Checksum:iEEEE312496EF513C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KR56J3KR56_HUMAN
Receptor activity-modifying protein...
RAMP3
151Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03443726G → D. Corresponds to variant dbSNP:rs10272187Ensembl.1
Natural variantiVAR_05362833M → L1 PublicationCorresponds to variant dbSNP:rs11550711Ensembl.1
Natural variantiVAR_02460256W → R. Corresponds to variant dbSNP:rs2074654Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001016 mRNA Translation: CAA04474.1
AY265459 mRNA Translation: AAP23300.1
AC004844 Genomic DNA No translation available.
BC022304 mRNA Translation: AAH22304.1
BC053852 mRNA Translation: AAH53852.1
CCDSiCCDS5503.1
RefSeqiNP_005847.1, NM_005856.2
UniGeneiHs.25691

Genome annotation databases

EnsembliENST00000242249; ENSP00000242249; ENSG00000122679
ENST00000481345; ENSP00000419012; ENSG00000122679
GeneIDi10268
KEGGihsa:10268
UCSCiuc003tnb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001016 mRNA Translation: CAA04474.1
AY265459 mRNA Translation: AAP23300.1
AC004844 Genomic DNA No translation available.
BC022304 mRNA Translation: AAH22304.1
BC053852 mRNA Translation: AAH53852.1
CCDSiCCDS5503.1
RefSeqiNP_005847.1, NM_005856.2
UniGeneiHs.25691

3D structure databases

ProteinModelPortaliO60896
SMRiO60896
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115559, 7 interactors
ComplexPortaliCPX-3148 Adrenomedullin receptor AM2 complex
CPX-3187 Amylin receptor 3 complex
CORUMiO60896
IntActiO60896, 9 interactors
STRINGi9606.ENSP00000242249

Chemistry databases

BindingDBiO60896
ChEMBLiCHEMBL2111191
DrugBankiDB01278 Pramlintide
GuidetoPHARMACOLOGYi53

Polymorphism and mutation databases

BioMutaiRAMP3

Proteomic databases

PaxDbiO60896
PeptideAtlasiO60896
PRIDEiO60896
ProteomicsDBi49659

Protocols and materials databases

DNASUi10268
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242249; ENSP00000242249; ENSG00000122679
ENST00000481345; ENSP00000419012; ENSG00000122679
GeneIDi10268
KEGGihsa:10268
UCSCiuc003tnb.4 human

Organism-specific databases

CTDi10268
DisGeNETi10268
EuPathDBiHostDB:ENSG00000122679.8
GeneCardsiRAMP3
HGNCiHGNC:9845 RAMP3
MIMi605155 gene
neXtProtiNX_O60896
OpenTargetsiENSG00000122679
PharmGKBiPA34204
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXGF Eukaryota
ENOG4111U8C LUCA
GeneTreeiENSGT00390000016200
HOGENOMiHOG000253018
HOVERGENiHBG061268
InParanoidiO60896
KOiK08449
PhylomeDBiO60896
TreeFamiTF333286

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Miscellaneous databases

ChiTaRSiRAMP3 human
GeneWikiiRAMP3
GenomeRNAii10268
PROiPR:O60896
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122679 Expressed in 165 organ(s), highest expression level in right lung
CleanExiHS_RAMP3
ExpressionAtlasiO60896 baseline and differential
GenevisibleiO60896 HS

Family and domain databases

Gene3Di1.10.150.510, 1 hit
InterProiView protein in InterPro
IPR006985 RAMP
IPR038126 RAMP_sf
PANTHERiPTHR14076 PTHR14076, 1 hit
PfamiView protein in Pfam
PF04901 RAMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAMP3_HUMAN
AccessioniPrimary (citable) accession number: O60896
Secondary accession number(s): Q7Z2Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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