UniProtKB - O60885 (BRD4_HUMAN)
Bromodomain-containing protein 4
BRD4
Functioni
Miscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 140 | Acetylated histones1 Publication | 1 | |
Binding sitei | 140 | Inhibitor | 1 | |
Binding sitei | 433 | Acetylated histones1 Publication | 1 | |
Binding sitei | 433 | Inhibitor | 1 |
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- lysine-acetylated histone binding Source: UniProtKB
- p53 binding Source: UniProtKB
- P-TEFb complex binding Source: UniProtKB
- RNA polymerase II CTD heptapeptide repeat kinase activity Source: MGI
- RNA polymerase II C-terminal domain binding Source: MGI
- transcription coregulator activity Source: UniProtKB
GO - Biological processi
- cellular response to DNA damage stimulus Source: UniProtKB
- chromatin organization Source: UniProtKB-KW
- chromatin remodeling Source: UniProtKB
- negative regulation of DNA damage checkpoint Source: UniProtKB
- positive regulation of G2/M transition of mitotic cell cycle Source: MGI
- positive regulation of histone H3-K36 trimethylation Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of transcription elongation from RNA polymerase II promoter Source: UniProtKB
- regulation of inflammatory response Source: UniProtKB
- regulation of phosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
- regulation of transcription involved in G1/S transition of mitotic cell cycle Source: MGI
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Chromatin regulator |
Biological process | DNA damage, Host-virus interaction, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | O60885 |
Reactomei | R-HSA-9679191, Potential therapeutics for SARS |
SIGNORi | O60885 |
Names & Taxonomyi
Protein namesi | Recommended name: Bromodomain-containing protein 4Alternative name(s): Protein HUNK1 |
Gene namesi | Name:BRD4 Synonyms:HUNK1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13575, BRD4 |
MIMi | 608749, gene |
neXtProti | NX_O60885 |
VEuPathDBi | HostDB:ENSG00000141867.17 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Chromosome 2 Publications
Note: Associates with acetylated chromatin (PubMed:21890894, PubMed:16109376). Released from chromatin upon deacetylation of histones that can be triggered by different signals such as activation of the JNK pathway or nocodazole treatment (PubMed:21890894, PubMed:16109376). Preferentially localizes to mitotic chromosomes, while it does not localizes to meiotic chromosomes (PubMed:21890894, PubMed:16109376).2 Publications
Other locations
- Chromosome 1 Publication
Nucleus
- condensed nuclear chromosome Source: MGI
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromosome Source: UniProtKB
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 140 | N → A: Abolishes binding to acetylated histones. 2 Publications | 1 | |
Mutagenesisi | 433 | N → A: Abolishes binding to acetylated histones. 1 Publication | 1 | |
Mutagenesisi | 492 – 494 | SSS → ASA: Impaired phosphorylation by CK2 and binding to acetylated histones. 1 Publication | 3 | |
Mutagenesisi | 498 – 500 | SST → AAA: Impaired phosphorylation by CK2 and binding to acetylated histones. 1 Publication | 3 | |
Mutagenesisi | 503 | S → A: Impaired phosphorylation by CK2 and binding to acetylated histones. 1 Publication | 1 | |
Mutagenesisi | 651 – 653 | EIE → AIA: Decreases interaction with JMJD6 and NSD3.No effect on interaction with histone 4 acetylated. 1 Publication | 3 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 719 – 720 | Breakpoint for translocation to form BDR4-NUTM1 fusion protein | 2 |
Organism-specific databases
DisGeNETi | 23476 |
MalaCardsi | BRD4 |
OpenTargetsi | ENSG00000141867 |
Orphaneti | 443167, NUT midline carcinoma |
PharmGKBi | PA25416 |
Miscellaneous databases
Pharosi | O60885, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1163125 |
DrugCentrali | O60885 |
GuidetoPHARMACOLOGYi | 1945 |
Genetic variation databases
BioMutai | BRD4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211183 | 1 – 1362 | Bromodomain-containing protein 4Add BLAST | 1362 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 99 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 470 | PhosphoserineCombined sources | 1 | |
Modified residuei | 484 | Phosphoserine; by CK21 Publication | 1 | |
Modified residuei | 488 | Phosphoserine; by CK21 Publication | 1 | |
Modified residuei | 492 | Phosphoserine; by CK21 Publication | 1 | |
Modified residuei | 494 | Phosphoserine; by CK21 Publication | 1 | |
Modified residuei | 498 | Phosphoserine; by CK21 Publication | 1 | |
Modified residuei | 499 | Phosphoserine; by CK21 Publication | 1 | |
Modified residuei | 503 | Phosphoserine; by CK21 Publication | 1 | |
Cross-linki | 585 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 601 | PhosphoserineCombined sources | 1 | |
Cross-linki | 645 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 694 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1050 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1111 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 1111 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 1111 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 1117 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1126 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1197 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1201 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1204 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O60885 |
jPOSTi | O60885 |
MassIVEi | O60885 |
MaxQBi | O60885 |
PaxDbi | O60885 |
PeptideAtlasi | O60885 |
PRIDEi | O60885 |
ProteomicsDBi | 49651 [O60885-1] 49652 [O60885-2] 62139 |
PTM databases
GlyGeni | O60885, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | O60885 |
MetOSitei | O60885 |
PhosphoSitePlusi | O60885 |
SwissPalmi | O60885 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000141867, Expressed in amniotic fluid and 250 other tissues |
ExpressionAtlasi | O60885, baseline and differential |
Genevisiblei | O60885, HS |
Organism-specific databases
HPAi | ENSG00000141867, Low tissue specificity |
Interactioni
Subunit structurei
Binds acetylated histone H4 (PubMed:29176719).
Interacts with p53/TP53; the interaction is direct (PubMed:23317504).
Interacts (via CTD region) with CDK9 and CCNT1, acting as an associated component of P-TEFb complex (PubMed:16109376, PubMed:16109377, PubMed:23317504, PubMed:24360279).
Interacts with RELA (when acetylated at 'Lys-310')(PubMed:19103749).
Interacts (via NET domain) with NSD3, CHD4, BICRA and ATAD5 (PubMed:21555454,PubMed:29176719). The interaction with BICRA bridges BRD4 to the GBAF complex (PubMed:29374058, PubMed:16109376, PubMed:16109377, PubMed:19103749, PubMed:21555454, PubMed:23317504).
Interacts (via NET domain) with JMJD6 (via JmjC and N-terminal domains); the interaction is stronger in presence of ssRNA and recruits JMJD6 on distal enhancers (PubMed:24360279, PubMed:21555454, PubMed:29176719).
Interacts with NSD3 (PubMed:29176719). Isoform B: interacts with NCAPD3 and SMC2 (PubMed:23728299).
9 Publications(Microbial infection) Interacts with bovine papillomavirus type 1 regulatory protein E2. This interactions may serve for the tethering of viral genomes to host mitotic chromosomes allowing successful partitioning of the viral genome during cell division.
1 Publication(Microbial infection) Interacts with Epstein-Barr virus (EBV) protein EBNA1; this interaction facilitates transcriptional activation by EBNA1.
1 Publication(Microbial infection) Interacts with human herpes virus-8 (HHV-8) protein LANA.
1 PublicationBinary interactionsi
Hide detailsO60885
Isoform A [O60885-1]
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- lysine-acetylated histone binding Source: UniProtKB
- p53 binding Source: UniProtKB
- RNA polymerase II C-terminal domain binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 117036, 130 interactors |
CORUMi | O60885 |
DIPi | DIP-39776N |
IntActi | O60885, 60 interactors |
MINTi | O60885 |
STRINGi | 9606.ENSP00000263377 |
Chemistry databases
BindingDBi | O60885 |
Miscellaneous databases
RNActi | O60885, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | O60885 |
SASBDBi | O60885 |
SMRi | O60885 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O60885 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 75 – 147 | Bromo 1PROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 368 – 440 | Bromo 2PROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 600 – 682 | NETPROSITE-ProRule annotationAdd BLAST | 83 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 484 – 503 | NPS regionAdd BLAST | 20 | |
Regioni | 524 – 579 | BID regionAdd BLAST | 56 | |
Regioni | 1047 – 1362 | C-terminal (CTD) regionAdd BLAST | 316 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 535 – 594 | Lys-richAdd BLAST | 60 | |
Compositional biasi | 692 – 717 | Ser-richAdd BLAST | 26 | |
Compositional biasi | 703 – 714 | Poly-SerAdd BLAST | 12 | |
Compositional biasi | 738 – 743 | Poly-His | 6 | |
Compositional biasi | 757 – 761 | Poly-Pro | 5 | |
Compositional biasi | 764 – 770 | Poly-Pro | 7 | |
Compositional biasi | 771 – 775 | Poly-Gln | 5 | |
Compositional biasi | 776 – 783 | Poly-Pro | 8 | |
Compositional biasi | 954 – 964 | Poly-ProAdd BLAST | 11 | |
Compositional biasi | 974 – 986 | Poly-ProAdd BLAST | 13 | |
Compositional biasi | 1011 – 1014 | Poly-Pro | 4 | |
Compositional biasi | 1028 – 1033 | Poly-Pro | 6 | |
Compositional biasi | 1283 – 1300 | Poly-GlnAdd BLAST | 18 | |
Compositional biasi | 1301 – 1308 | Poly-Ala | 8 | |
Compositional biasi | 1335 – 1338 | Poly-Arg | 4 |
Domaini
Keywords - Domaini
Bromodomain, RepeatPhylogenomic databases
eggNOGi | KOG1474, Eukaryota |
GeneTreei | ENSGT00940000154549 |
HOGENOMi | CLU_001499_0_3_1 |
InParanoidi | O60885 |
OMAi | ERMRWAR |
OrthoDBi | 619848at2759 |
PhylomeDBi | O60885 |
TreeFami | TF317345 |
Family and domain databases
CDDi | cd05497, Bromo_Brdt_I_like, 1 hit cd05498, Bromo_Brdt_II_like, 1 hit |
DisProti | DP01898 |
Gene3Di | 1.20.1270.220, 1 hit 1.20.920.10, 2 hits |
IDEALi | IID00111 |
InterProi | View protein in InterPro IPR031354, BRD4_CDT IPR043508, Bromo_Brdt_I IPR043509, Bromo_Brdt_II IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR027353, NET_dom IPR038336, NET_sf |
Pfami | View protein in Pfam PF17035, BET, 1 hit PF17105, BRD4_CDT, 1 hit PF00439, Bromodomain, 2 hits |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00297, BROMO, 2 hits |
SUPFAMi | SSF47370, SSF47370, 2 hits |
PROSITEi | View protein in PROSITE PS00633, BROMODOMAIN_1, 1 hit PS50014, BROMODOMAIN_2, 2 hits PS51525, NET, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAESGPGTR LRNLPVMGDG LETSQMSTTQ AQAQPQPANA ASTNPPPPET
60 70 80 90 100
SNPNKPKRQT NQLQYLLRVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI
110 120 130 140 150
IKTPMDMGTI KKRLENNYYW NAQECIQDFN TMFTNCYIYN KPGDDIVLMA
160 170 180 190 200
EALEKLFLQK INELPTEETE IMIVQAKGRG RGRKETGTAK PGVSTVPNTT
210 220 230 240 250
QASTPPQTQT PQPNPPPVQA TPHPFPAVTP DLIVQTPVMT VVPPQPLQTP
260 270 280 290 300
PPVPPQPQPP PAPAPQPVQS HPPIIAATPQ PVKTKKGVKR KADTTTPTTI
310 320 330 340 350
DPIHEPPSLP PEPKTTKLGQ RRESSRPVKP PKKDVPDSQQ HPAPEKSSKV
360 370 380 390 400
SEQLKCCSGI LKEMFAKKHA AYAWPFYKPV DVEALGLHDY CDIIKHPMDM
410 420 430 440 450
STIKSKLEAR EYRDAQEFGA DVRLMFSNCY KYNPPDHEVV AMARKLQDVF
460 470 480 490 500
EMRFAKMPDE PEEPVVAVSS PAVPPPTKVV APPSSSDSSS DSSSDSDSST
510 520 530 540 550
DDSEEERAQR LAELQEQLKA VHEQLAALSQ PQQNKPKKKE KDKKEKKKEK
560 570 580 590 600
HKRKEEVEEN KKSKAKEPPP KKTKKNNSSN SNVSKKEPAP MKSKPPPTYE
610 620 630 640 650
SEEEDKCKPM SYEEKRQLSL DINKLPGEKL GRVVHIIQSR EPSLKNSNPD
660 670 680 690 700
EIEIDFETLK PSTLRELERY VTSCLRKKRK PQAEKVDVIA GSSKMKGFSS
710 720 730 740 750
SESESSSESS SSDSEDSETE MAPKSKKKGH PGREQKKHHH HHHQQMQQAP
760 770 780 790 800
APVPQQPPPP PQQPPPPPPP QQQQQPPPPP PPPSMPQQAA PAMKSSPPPF
810 820 830 840 850
IATQVPVLEP QLPGSVFDPI GHFTQPILHL PQPELPPHLP QPPEHSTPPH
860 870 880 890 900
LNQHAVVSPP ALHNALPQQP SRPSNRAAAL PPKPARPPAV SPALTQTPLL
910 920 930 940 950
PQPPMAQPPQ VLLEDEEPPA PPLTSMQMQL YLQQLQKVQP PTPLLPSVKV
960 970 980 990 1000
QSQPPPPLPP PPHPSVQQQL QQQPPPPPPP QPQPPPQQQH QPPPRPVHLQ
1010 1020 1030 1040 1050
PMQFSTHIQQ PPPPQGQQPP HPPPGQQPPP PQPAKPQQVI QHHHSPRHHK
1060 1070 1080 1090 1100
SDPYSTGHLR EAPSPLMIHS PQMSQFQSLT HQSPPQQNVQ PKKQELRAAS
1110 1120 1130 1140 1150
VVQPQPLVVV KEEKIHSPII RSEPFSPSLR PEPPKHPESI KAPVHLPQRP
1160 1170 1180 1190 1200
EMKPVDVGRP VIRPPEQNAP PPGAPDKDKQ KQEPKTPVAP KKDLKIKNMG
1210 1220 1230 1240 1250
SWASLVQKHP TTPSSTAKSS SDSFEQFRRA AREKEEREKA LKAQAEHAEK
1260 1270 1280 1290 1300
EKERLRQERM RSREDEDALE QARRAHEEAR RRQEQQQQQR QEQQQQQQQQ
1310 1320 1330 1340 1350
AAAVAAAATP QAQSSQPQSM LDQQRELARK REQERRRREA MAATIDMNFQ
1360
SDLLSIFEEN LF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QYW0 | M0QYW0_HUMAN | Bromodomain containing 4, isoform C... | BRD4 hCG_2000917 | 146 | Annotation score: | ||
M0QZD9 | M0QZD9_HUMAN | Bromodomain-containing protein 4 | BRD4 | 572 | Annotation score: | ||
M0R0H4 | M0R0H4_HUMAN | Bromodomain-containing protein 4 | BRD4 | 105 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041919 | 37 | P → S1 PublicationCorresponds to variant dbSNP:rs35177876Ensembl. | 1 | |
Natural variantiVAR_041920 | 371 | A → G1 PublicationCorresponds to variant dbSNP:rs55805532Ensembl. | 1 | |
Natural variantiVAR_041921 | 563 | S → N1 PublicationCorresponds to variant dbSNP:rs55970906Ensembl. | 1 | |
Natural variantiVAR_041922 | 598 | T → S1 PublicationCorresponds to variant dbSNP:rs34362023Ensembl. | 1 | |
Natural variantiVAR_041923 | 669 | R → H1 PublicationCorresponds to variant dbSNP:rs35824241Ensembl. | 1 | |
Natural variantiVAR_048427 | 1097 | R → H. Corresponds to variant dbSNP:rs35676845Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047671 | 720 – 1362 | EMAPK…EENLF → AFCTSGDFVSPGPSPYHSHV QCGRFREMLRWFLVDVEQTA AGQPHRQSAAGPAITWAPAI AYPSPECARCCVGCS in isoform B. 1 PublicationAdd BLAST | 643 | |
Alternative sequenceiVSP_010902 | 720 – 722 | EMA → GPA in isoform C. 1 Publication | 3 | |
Alternative sequenceiVSP_010903 | 723 – 1362 | Missing in isoform C. 1 PublicationAdd BLAST | 640 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF386649 mRNA Translation: AAL26987.1 Y12059 mRNA Translation: CAA72780.1 AC004798 Genomic DNA Translation: AAC27978.1 Different initiation. AC003111 Genomic DNA No translation available. AC005776 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84470.1 BC035266 mRNA Translation: AAH35266.1 AY166680 mRNA Translation: AAO22237.1 Different termination. |
CCDSi | CCDS12328.1 [O60885-1] CCDS46004.1 [O60885-2] CCDS82307.1 [O60885-3] |
RefSeqi | NP_001317313.1, NM_001330384.1 [O60885-3] NP_055114.1, NM_014299.2 [O60885-2] NP_490597.1, NM_058243.2 [O60885-1] XP_011526156.1, XM_011527854.1 XP_011526158.1, XM_011527856.2 |
Genome annotation databases
Ensembli | ENST00000263377; ENSP00000263377; ENSG00000141867 [O60885-1] ENST00000360016; ENSP00000353112; ENSG00000141867 [O60885-3] ENST00000371835; ENSP00000360901; ENSG00000141867 [O60885-2] |
GeneIDi | 23476 |
KEGGi | hsa:23476 |
UCSCi | uc002nar.4, human [O60885-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF386649 mRNA Translation: AAL26987.1 Y12059 mRNA Translation: CAA72780.1 AC004798 Genomic DNA Translation: AAC27978.1 Different initiation. AC003111 Genomic DNA No translation available. AC005776 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84470.1 BC035266 mRNA Translation: AAH35266.1 AY166680 mRNA Translation: AAO22237.1 Different termination. |
CCDSi | CCDS12328.1 [O60885-1] CCDS46004.1 [O60885-2] CCDS82307.1 [O60885-3] |
RefSeqi | NP_001317313.1, NM_001330384.1 [O60885-3] NP_055114.1, NM_014299.2 [O60885-2] NP_490597.1, NM_058243.2 [O60885-1] XP_011526156.1, XM_011527854.1 XP_011526158.1, XM_011527856.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2I8N | NMR | - | A | 352-457 | [»] | |
2LSP | NMR | - | B | 333-460 | [»] | |
2MJV | NMR | - | B | 333-460 | [»] | |
2N3K | NMR | - | A | 600-678 | [»] | |
2NCZ | NMR | - | A | 601-683 | [»] | |
2ND0 | NMR | - | A | 601-683 | [»] | |
2ND1 | NMR | - | A | 601-683 | [»] | |
2NNU | X-ray | 1.59 | B | 1343-1362 | [»] | |
2OSS | X-ray | 1.35 | A | 44-168 | [»] | |
2OUO | X-ray | 1.89 | A | 333-460 | [»] | |
2YEL | X-ray | 1.65 | A | 44-168 | [»] | |
2YEM | X-ray | 2.30 | A/B | 333-460 | [»] | |
3MXF | X-ray | 1.60 | A | 42-168 | [»] | |
3P5O | X-ray | 1.60 | A | 44-168 | [»] | |
3SVF | X-ray | 1.98 | A | 44-168 | [»] | |
3SVG | X-ray | 1.68 | A | 44-168 | [»] | |
3U5J | X-ray | 1.60 | A | 44-168 | [»] | |
3U5K | X-ray | 1.80 | A/B/C/D | 44-168 | [»] | |
3U5L | X-ray | 1.39 | A | 44-168 | [»] | |
3UVW | X-ray | 1.37 | A | 44-168 | [»] | |
3UVX | X-ray | 1.91 | A | 44-168 | [»] | |
3UVY | X-ray | 2.02 | A | 44-168 | [»] | |
3UW9 | X-ray | 2.30 | A/B/C/D | 44-168 | [»] | |
3ZYU | X-ray | 1.50 | A/B | 44-168 | [»] | |
4A9L | X-ray | 1.60 | A | 44-168 | [»] | |
4BJX | X-ray | 1.59 | A | 44-168 | [»] | |
4BW1 | X-ray | 1.40 | A | 44-168 | [»] | |
4BW2 | X-ray | 1.92 | A | 44-168 | [»] | |
4BW3 | X-ray | 1.50 | A | 44-168 | [»] | |
4BW4 | X-ray | 1.67 | A | 44-168 | [»] | |
4C66 | X-ray | 1.87 | A | 44-167 | [»] | |
4C67 | X-ray | 1.55 | A | 44-168 | [»] | |
4CFK | X-ray | 1.55 | A | 44-168 | [»] | |
4CFL | X-ray | 1.32 | A | 44-168 | [»] | |
4CL9 | X-ray | 1.40 | A | 44-168 | [»] | |
4CLB | X-ray | 1.60 | A | 44-168 | [»] | |
4DON | X-ray | 1.52 | A | 44-166 | [»] | |
4E96 | X-ray | 1.92 | A | 44-168 | [»] | |
4F3I | X-ray | 1.40 | A | 44-168 | [»] | |
4GPJ | X-ray | 1.60 | A | 44-168 | [»] | |
4HBV | X-ray | 1.63 | A | 42-168 | [»] | |
4HBW | X-ray | 1.69 | A | 42-168 | [»] | |
4HBX | X-ray | 1.62 | A | 42-168 | [»] | |
4HBY | X-ray | 1.59 | A | 44-168 | [»] | |
4HXK | X-ray | 1.61 | A | 44-167 | [»] | |
4HXL | X-ray | 1.52 | A | 44-167 | [»] | |
4HXM | X-ray | 1.50 | A | 44-166 | [»] | |
4HXN | X-ray | 1.49 | A | 44-167 | [»] | |
4HXO | X-ray | 1.76 | A | 44-167 | [»] | |
4HXP | X-ray | 1.73 | A | 44-166 | [»] | |
4HXR | X-ray | 1.53 | A | 44-167 | [»] | |
4HXS | X-ray | 1.43 | A | 44-166 | [»] | |
4IOO | X-ray | 1.25 | A | 44-168 | [»] | |
4IOQ | X-ray | 1.50 | A | 44-168 | [»] | |
4IOR | X-ray | 1.40 | A | 44-168 | [»] | |
4J0R | X-ray | 1.72 | A | 44-168 | [»] | |
4J0S | X-ray | 1.84 | A | 44-168 | [»] | |
4J3I | X-ray | 1.24 | A | 44-168 | [»] | |
4KV1 | X-ray | 1.50 | A/B | 41-168 | [»] | |
4KV4 | X-ray | 2.00 | A | 351-459 | [»] | |
4LR6 | X-ray | 1.29 | A | 42-168 | [»] | |
4LRG | X-ray | 2.21 | A | 42-168 | [»] | |
4LYI | X-ray | 1.30 | A | 44-168 | [»] | |
4LYS | X-ray | 1.83 | A | 44-168 | [»] | |
4LYW | X-ray | 1.95 | A | 44-168 | [»] | |
4LZR | X-ray | 1.85 | A | 44-168 | [»] | |
4LZS | X-ray | 2.20 | A | 44-168 | [»] | |
4MEN | X-ray | 1.81 | A | 44-168 | [»] | |
4MEO | X-ray | 1.72 | A | 44-168 | [»] | |
4MEP | X-ray | 1.85 | A | 44-168 | [»] | |
4MEQ | X-ray | 1.77 | A | 44-168 | [»] | |
4MR3 | X-ray | 1.68 | A | 44-168 | [»] | |
4MR4 | X-ray | 1.66 | A | 44-168 | [»] | |
4NQM | X-ray | 1.58 | A | 44-168 | [»] | |
4NR8 | X-ray | 1.64 | A | 44-168 | [»] | |
4NUC | X-ray | 1.40 | A | 44-168 | [»] | |
4NUD | X-ray | 1.20 | A | 44-168 | [»] | |
4NUE | X-ray | 1.30 | A | 44-168 | [»] | |
4O70 | X-ray | 1.55 | A/B | 44-168 | [»] | |
4O71 | X-ray | 1.36 | A/B | 44-168 | [»] | |
4O72 | X-ray | 1.40 | A | 44-168 | [»] | |
4O74 | X-ray | 1.45 | A/B | 44-168 | [»] | |
4O75 | X-ray | 1.55 | A | 44-168 | [»] | |
4O76 | X-ray | 1.70 | A/B/C/D | 44-168 | [»] | |
4O77 | X-ray | 2.00 | A/B | 44-168 | [»] | |
4O78 | X-ray | 1.34 | A | 44-168 | [»] | |
4O7A | X-ray | 1.34 | A | 44-168 | [»] | |
4O7B | X-ray | 1.50 | A | 44-168 | [»] | |
4O7C | X-ray | 1.55 | A | 44-168 | [»] | |
4O7E | X-ray | 1.85 | A/B | 44-168 | [»] | |
4O7F | X-ray | 1.80 | A/B | 44-168 | [»] | |
4OGI | X-ray | 1.73 | A/B | 44-168 | [»] | |
4OGJ | X-ray | 1.65 | A/B | 44-168 | [»] | |
4PCE | X-ray | 1.29 | A | 44-168 | [»] | |
4PCI | X-ray | 1.25 | A | 44-168 | [»] | |
4PS5 | X-ray | 1.40 | A/B | 44-168 | [»] | |
4QB3 | X-ray | 0.94 | A | 44-168 | [»] | |
4QR3 | X-ray | 1.37 | A | 44-166 | [»] | |
4QR4 | X-ray | 1.28 | A | 44-166 | [»] | |
4QR5 | X-ray | 1.41 | A | 44-166 | [»] | |
4QZS | X-ray | 1.45 | A | 44-168 | [»] | |
4UIX | X-ray | 1.58 | A/B/C | 44-168 | [»] | |
4UIY | X-ray | 1.30 | A | 44-168 | [»] | |
4UIZ | X-ray | 1.19 | A | 44-168 | [»] | |
4UYD | X-ray | 1.37 | A | 44-183 | [»] | |
4WHW | X-ray | 1.34 | A | 44-168 | [»] | |
4WIV | X-ray | 1.56 | A | 44-168 | [»] | |
4X2I | X-ray | 1.20 | A | 42-166 | [»] | |
4XY9 | X-ray | 1.83 | A | 42-168 | [»] | |
4XYA | X-ray | 2.05 | A | 42-168 | [»] | |
4YH3 | X-ray | 1.60 | A | 44-170 | [»] | |
4YH4 | X-ray | 1.33 | A | 44-170 | [»] | |
4Z1Q | X-ray | 1.40 | A/B | 42-167 | [»] | |
4Z1S | X-ray | 1.06 | A/B | 42-166 | [»] | |
4Z93 | X-ray | 1.27 | A | 349-460 | [»] | |
4ZC9 | X-ray | 0.99 | A | 44-168 | [»] | |
4ZW1 | X-ray | 1.75 | A | 44-168 | [»] | |
5A5S | X-ray | 1.36 | A | 44-168 | [»] | |
5A85 | X-ray | 1.72 | A | 44-168 | [»] | |
5ACY | X-ray | 2.01 | A/B | 44-168 | [»] | |
5AD2 | X-ray | 2.01 | A/B | 44-168 | [»] | |
5AD3 | X-ray | 1.49 | A/B | 44-168 | [»] | |
5BT4 | X-ray | 1.50 | A/B/C | 44-168 | [»] | |
5CFW | X-ray | 1.15 | A | 44-168 | [»] | |
5COI | X-ray | 1.62 | A | 44-168 | [»] | |
5CP5 | X-ray | 1.79 | A | 44-168 | [»] | |
5CPE | X-ray | 1.62 | A | 44-168 | [»] | |
5CQT | X-ray | 1.60 | A | 44-168 | [»] | |
5CRM | X-ray | 1.99 | A | 44-168 | [»] | |
5CRZ | X-ray | 2.12 | A | 44-168 | [»] | |
5CS8 | X-ray | 1.62 | A | 44-168 | [»] | |
5CTL | X-ray | 2.51 | A | 44-168 | [»] | |
5CY9 | X-ray | 1.55 | A | 44-168 | [»] | |
5D0C | X-ray | 1.49 | A | 44-168 | [»] | |
5D24 | X-ray | 1.65 | A | 43-168 | [»] | |
5D25 | X-ray | 1.70 | A | 43-168 | [»] | |
5D26 | X-ray | 1.82 | A | 42-168 | [»] | |
5D3H | X-ray | 1.70 | A | 44-168 | [»] | |
5D3J | X-ray | 1.70 | A | 43-168 | [»] | |
5D3L | X-ray | 1.50 | A | 42-168 | [»] | |
5D3N | X-ray | 2.15 | A | 43-168 | [»] | |
5D3P | X-ray | 1.95 | A | 42-168 | [»] | |
5D3R | X-ray | 2.20 | A | 42-168 | [»] | |
5D3S | X-ray | 1.75 | A | 44-168 | [»] | |
5D3T | X-ray | 1.93 | A | 42-168 | [»] | |
5DLX | X-ray | 1.90 | A | 44-168 | [»] | |
5DLZ | X-ray | 1.70 | A | 44-168 | [»] | |
5DW2 | X-ray | 1.12 | A | 44-170 | [»] | |
5DX4 | X-ray | 2.30 | A | 44-168 | [»] | |
5E0R | X-ray | 1.35 | A | 44-168 | [»] | |
5EGU | X-ray | 2.21 | A/B/C/D | 44-168 | [»] | |
5EI4 | X-ray | 1.05 | A | 44-168 | [»] | |
5EIS | X-ray | 1.60 | A | 44-168 | [»] | |
5F5Z | X-ray | 1.76 | A | 44-168 | [»] | |
5F60 | X-ray | 1.35 | A | 44-168 | [»] | |
5F61 | X-ray | 1.45 | A/B | 44-168 | [»] | |
5F62 | X-ray | 1.35 | A | 44-168 | [»] | |
5F63 | X-ray | 1.45 | A | 44-168 | [»] | |
5FBX | X-ray | 1.85 | A | 44-168 | [»] | |
5H21 | X-ray | 1.59 | A | 44-167 | [»] | |
5HCL | X-ray | 1.50 | A | 44-168 | [»] | |
5HLS | X-ray | 2.18 | A | 42-168 | [»] | |
5HM0 | X-ray | 1.40 | A | 42-168 | [»] | |
5HQ5 | X-ray | 1.60 | A | 44-168 | [»] | |
5HQ6 | X-ray | 1.95 | A | 44-166 | [»] | |
5HQ7 | X-ray | 1.90 | A | 44-167 | [»] | |
5I80 | X-ray | 1.45 | A | 42-167 | [»] | |
5I88 | X-ray | 1.40 | A | 42-167 | [»] | |
5IGK | X-ray | 1.70 | A | 44-168 | [»] | |
5JWM | X-ray | 1.71 | A/B | 333-460 | [»] | |
5KDH | X-ray | 1.50 | A | 44-168 | [»] | |
5KHM | X-ray | 1.48 | A/B | 44-168 | [»] | |
5KJ0 | X-ray | 1.51 | A | 44-168 | [»] | |
5KU3 | X-ray | 1.14 | A | 42-167 | [»] | |
5LJ1 | X-ray | 1.90 | A | 42-168 | [»] | |
5LJ2 | X-ray | 1.19 | A | 42-168 | [»] | |
5LRQ | X-ray | 1.70 | A | 42-163 | [»] | |
5LUU | X-ray | 1.61 | A | 44-168 | [»] | |
5M39 | X-ray | 1.38 | A/B | 42-168 | [»] | |
5M3A | X-ray | 1.65 | A | 44-168 | [»] | |
5MKZ | X-ray | 1.62 | A | 44-168 | [»] | |
5MLI | X-ray | 1.63 | A | 42-168 | [»] | |
5N2M | X-ray | 1.54 | A | 44-168 | [»] | |
5NNC | X-ray | 2.22 | A/B | 44-168 | [»] | |
5NND | X-ray | 1.82 | A/B | 44-168 | [»] | |
5NNE | X-ray | 1.15 | A | 44-168 | [»] | |
5NNF | X-ray | 1.15 | A | 44-168 | [»] | |
5NNG | X-ray | 1.20 | A | 44-168 | [»] | |
5O97 | X-ray | 1.30 | A | 44-168 | [»] | |
5OVB | X-ray | 1.95 | A/B | 44-168 | [»] | |
5OWM | X-ray | 1.50 | A | 44-168 | [»] | |
5OWW | X-ray | 1.50 | A/B/C/D | 44-168 | [»] | |
5T35 | X-ray | 2.70 | A/E | 333-460 | [»] | |
5TI2 | X-ray | 1.65 | A | 44-168 | [»] | |
5TI3 | X-ray | 1.70 | A | 44-168 | [»] | |
5TI4 | X-ray | 1.62 | A | 44-168 | [»] | |
5TI5 | X-ray | 1.83 | A | 44-168 | [»] | |
5TI6 | X-ray | 1.70 | A | 44-168 | [»] | |
5TI7 | X-ray | 1.65 | A | 44-168 | [»] | |
5U28 | X-ray | 1.80 | A | 44-180 | [»] | |
5U2C | X-ray | 3.30 | A/B | 342-460 | [»] | |
5U2E | X-ray | 1.99 | A/B | 42-180 | [»] | |
5U2F | X-ray | 2.52 | A/B | 42-180 | [»] | |
5UEO | X-ray | 1.85 | A/B | 352-457 | [»] | |
5UEP | X-ray | 1.77 | A | 352-457 | [»] | |
5UEQ | X-ray | 1.70 | A | 352-457 | [»] | |
5UER | X-ray | 1.87 | A | 352-457 | [»] | |
5UES | X-ray | 1.62 | A | 352-457 | [»] | |
5UET | X-ray | 2.29 | A | 352-457 | [»] | |
5UEU | X-ray | 2.26 | A/B | 352-457 | [»] | |
5UEV | X-ray | 1.94 | A | 352-457 | [»] | |
5UEX | X-ray | 2.29 | A | 352-457 | [»] | |
5UEY | X-ray | 2.41 | A | 352-457 | [»] | |
5UEZ | X-ray | 1.51 | A | 352-457 | [»] | |
5UF0 | X-ray | 1.35 | A | 352-457 | [»] | |
5ULA | X-ray | 1.50 | A/B | 44-168 | [»] | |
5UOO | X-ray | 1.69 | A | 333-460 | [»] | |
5UVS | X-ray | 2.15 | A | 352-457 | [»] | |
5UVT | X-ray | 1.67 | A | 352-457 | [»] | |
5UVU | X-ray | 1.66 | A | 352-457 | [»] | |
5UVV | X-ray | 1.99 | A/B | 352-457 | [»] | |
5UVW | X-ray | 2.14 | A/B/C | 57-165 | [»] | |
5UVX | X-ray | 1.53 | A/B | 352-457 | [»] | |
5UVY | X-ray | 2.25 | A | 352-457 | [»] | |
5UVZ | X-ray | 1.63 | A | 352-457 | [»] | |
5V67 | X-ray | 1.78 | A | 44-168 | [»] | |
5VBO | X-ray | 1.30 | A | 44-168 | [»] | |
5VBP | X-ray | 1.83 | A/B | 44-168 | [»] | |
5VOM | X-ray | 1.67 | A/B | 44-168 | [»] | |
5VZS | X-ray | 1.71 | A/B | 42-168 | [»] | |
5W55 | X-ray | 1.35 | A | 42-168 | [»] | |
5WA5 | X-ray | 1.17 | A | 42-168 | [»] | |
5WMA | X-ray | 1.40 | A | 44-168 | [»] | |
5WMD | X-ray | 1.27 | A | 44-168 | [»] | |
5WMG | X-ray | 1.19 | A | 44-168 | [»] | |
5WUU | X-ray | 1.72 | A | 44-167 | [»] | |
5XHY | X-ray | 1.98 | A | 44-166 | [»] | |
5XI2 | X-ray | 1.91 | A | 44-166 | [»] | |
5XI3 | X-ray | 1.67 | A | 44-166 | [»] | |
5XI4 | X-ray | 1.49 | A | 44-166 | [»] | |
5Y1Y | X-ray | 1.91 | A | 44-167 | [»] | |
5Y8C | X-ray | 1.42 | A | 44-166 | [»] | |
5Y8W | X-ray | 1.76 | A | 44-168 | [»] | |
5Y8Y | X-ray | 1.87 | A | 44-168 | [»] | |
5Y8Z | X-ray | 1.84 | A | 44-168 | [»] | |
5Y93 | X-ray | 1.62 | A | 44-168 | [»] | |
5Y94 | X-ray | 2.00 | A | 44-168 | [»] | |
5YOU | X-ray | 1.50 | A | 42-168 | [»] | |
5YOV | X-ray | 1.45 | A | 42-168 | [»] | |
5YQX | X-ray | 1.82 | A | 44-167 | [»] | |
5Z1R | X-ray | 1.62 | A | 44-168 | [»] | |
5Z1S | X-ray | 1.42 | A | 44-168 | [»] | |
5Z1T | X-ray | 1.42 | A | 44-168 | [»] | |
5Z5T | X-ray | 1.99 | A | 44-167 | [»] | |
5Z5U | X-ray | 1.63 | A | 44-167 | [»] | |
5Z5V | X-ray | 1.66 | A | 44-167 | [»] | |
5Z8G | X-ray | 1.70 | A | 44-168 | [»] | |
5Z8R | X-ray | 2.00 | A | 44-168 | [»] | |
5Z8Z | X-ray | 1.80 | A | 44-168 | [»] | |
5Z90 | X-ray | 1.80 | A | 44-168 | [»] | |
5Z9C | NMR | - | A | 53-168 | [»] | |
5Z9K | X-ray | 1.89 | A | 44-168 | [»] | |
6AFR | X-ray | 2.00 | A | 44-168 | [»] | |
6AJV | X-ray | 1.45 | A | 42-168 | [»] | |
6AJW | X-ray | 1.40 | A | 42-168 | [»] | |
6AJX | X-ray | 1.89 | A | 42-168 | [»] | |
6AJY | X-ray | 1.60 | A | 42-168 | [»] | |
6AJZ | Other | 1.30 | A | 42-168 | [»] | |
6BN7 | X-ray | 3.50 | C | 42-168 | [»] | |
6BN8 | X-ray | 3.99 | C | 42-168 | [»] | |
6BN9 | X-ray | 4.38 | C | 42-168 | [»] | |
6BNB | X-ray | 6.34 | C | 42-168 | [»] | |
6BNH | NMR | - | A | 601-683 | [»] | |
6BOY | X-ray | 3.33 | C | 42-168 | [»] | |
6C7Q | X-ray | 1.51 | A | 333-460 | [»] | |
6C7R | X-ray | 1.50 | A | 44-165 | [»] | |
6CD4 | X-ray | 1.23 | A | 42-168 | [»] | |
6CD5 | X-ray | 1.58 | A | 44-168 | [»] | |
6CIS | X-ray | 1.51 | A | 44-166 | [»] | |
6CIY | X-ray | 1.68 | A | 44-168 | [»] | |
6CJ1 | X-ray | 1.53 | A | 44-166 | [»] | |
6CJ2 | X-ray | 1.47 | A | 42-166 | [»] | |
6CKR | X-ray | 1.62 | A/B | 44-168 | [»] | |
6CKS | X-ray | 1.72 | A | 44-168 | [»] | |
6CZU | X-ray | 1.47 | A | 42-170 | [»] | |
6CZV | X-ray | 1.88 | A | 42-170 | [»] | |
6DJC | X-ray | 1.46 | A/B | 44-173 | [»] | |
6DL2 | X-ray | 1.47 | A | 44-168 | [»] | |
6DMJ | X-ray | 1.15 | A | 44-168 | [»] | |
6DML | X-ray | 1.50 | A | 44-168 | [»] | |
6DNE | X-ray | 2.96 | A/B | 44-477 | [»] | |
6DUV | X-ray | 1.80 | A/B | 347-458 | [»] | |
6E4A | X-ray | 1.26 | A/B | 44-170 | [»] | |
6FFD | X-ray | 1.83 | A | 347-463 | [»] | |
6FNX | X-ray | 1.19 | A | 44-168 | [»] | |
6FO5 | X-ray | 0.95 | A | 44-168 | [»] | |
6FSY | X-ray | 1.34 | A | 42-168 | [»] | |
6FT3 | X-ray | 1.28 | A | 42-168 | [»] | |
6FT4 | X-ray | 1.34 | A | 42-168 | [»] | |
6G0D | X-ray | 1.31 | A | 42-168 | [»] | |
6G0E | X-ray | 1.61 | A | 42-168 | [»] | |
6G0F | X-ray | 1.62 | A | 42-168 | [»] | |
6G0G | X-ray | 1.48 | A | 42-168 | [»] | |
6G0H | X-ray | 1.91 | A | 42-168 | [»] | |
6G0O | X-ray | 1.40 | A | 42-168 | [»] | |
6G0P | X-ray | 1.30 | A | 42-168 | [»] | |
6G0Q | X-ray | 1.40 | A | 42-168 | [»] | |
6G0R | X-ray | 1.25 | A | 42-168 | [»] | |
6G0S | X-ray | 1.48 | A/B | 42-168 | [»] | |
6HDQ | X-ray | 1.70 | A | 44-168 | [»] | |
6HOV | X-ray | 1.85 | A | 44-168 | [»] | |
6I7X | X-ray | 1.20 | A | 44-168 | [»] | |
6I7Y | X-ray | 1.00 | A | 44-168 | [»] | |
6IN1 | X-ray | 1.50 | A | 42-168 | [»] | |
6JI3 | X-ray | 2.20 | A | 44-166 | [»] | |
6JI4 | X-ray | 1.60 | A | 44-166 | [»] | |
6JI5 | X-ray | 2.00 | A | 44-166 | [»] | |
6JJ3 | X-ray | 1.72 | A | 44-167 | [»] | |
6JJ5 | X-ray | 1.20 | A | 44-167 | [»] | |
6JJ6 | X-ray | 1.40 | A | 44-167 | [»] | |
6JJB | X-ray | 1.51 | A | 44-167 | [»] | |
6KEC | X-ray | 1.35 | A | 44-168 | [»] | |
6KED | X-ray | 2.55 | A | 44-168 | [»] | |
6KEE | X-ray | 2.12 | A | 44-168 | [»] | |
6KEF | X-ray | 2.44 | A | 44-168 | [»] | |
6KEG | X-ray | 2.23 | A | 44-168 | [»] | |
6KEH | X-ray | 1.55 | A | 44-168 | [»] | |
6KEI | X-ray | 1.45 | A | 44-168 | [»] | |
6KEJ | X-ray | 1.85 | A | 44-168 | [»] | |
6KEK | X-ray | 1.55 | A | 44-168 | [»] | |
6KO2 | X-ray | 1.50 | A | 351-457 | [»] | |
6MAU | X-ray | 2.11 | A | 44-170 | [»] | |
6MH1 | X-ray | 1.60 | A/B | 44-168 | [»] | |
6MH7 | X-ray | 1.74 | A/B | 44-168 | [»] | |
6MNL | NMR | - | B | 333-460 | [»] | |
6P05 | X-ray | 1.54 | A | 44-168 | [»] | |
6PRT | X-ray | 1.30 | A | 43-168 | [»] | |
6PS9 | X-ray | 1.21 | A | 44-168 | [»] | |
6PSB | X-ray | 1.59 | A | 44-168 | [»] | |
6Q3Y | X-ray | 1.20 | A/B | 42-168 | [»] | |
6Q3Z | X-ray | 2.00 | A/B | 44-168 | [»] | |
6S25 | X-ray | 1.10 | A | 44-168 | [»] | |
6SE4 | X-ray | 1.38 | A | 44-168 | [»] | |
6SIS | X-ray | 3.50 | A/E | 333-460 | [»] | |
6SWN | X-ray | 1.28 | AAA | 44-168 | [»] | |
6SWQ | X-ray | 1.60 | AAA | 44-168 | [»] | |
6TPX | X-ray | 1.48 | AAA | 44-168 | [»] | |
6TPY | X-ray | 1.80 | AAA | 44-168 | [»] | |
6TPZ | X-ray | 1.30 | AAA | 44-168 | [»] | |
6U0D | X-ray | 1.43 | A | 44-168 | [»] | |
6U6K | X-ray | 1.70 | A | 42-168 | [»] | |
6U6L | X-ray | 2.60 | A | 347-464 | [»] | |
6U72 | X-ray | 2.30 | A/B | 42-168 | [»] | |
6U74 | X-ray | 1.85 | A/B/C/D | 42-168 | [»] | |
6U8G | X-ray | 2.60 | A/B/C/D | 42-168 | [»] | |
6U8I | X-ray | 2.50 | A | 347-464 | [»] | |
6U8M | X-ray | 1.95 | A/B | 42-168 | [»] | |
6ULS | X-ray | 1.50 | A | 42-168 | [»] | |
6UVJ | X-ray | 1.38 | A | 44-168 | [»] | |
6UVM | X-ray | 1.51 | A | 44-168 | [»] | |
6UWU | X-ray | 2.00 | A | 44-168 | [»] | |
6UWX | X-ray | 1.31 | A | 44-168 | [»] | |
6V0U | X-ray | 1.40 | A | 44-168 | [»] | |
6V1K | X-ray | 1.75 | A | 44-168 | [»] | |
6V1L | X-ray | 2.10 | A | 44-168 | [»] | |
6V1U | X-ray | 1.73 | A | 44-168 | [»] | |
6VIW | X-ray | 2.43 | A/B/C | 57-168 | [»] | |
6VIX | X-ray | 2.12 | A/B/C/D | 352-457 | [»] | |
6VIZ | X-ray | 2.39 | A/B/C | 57-168 | [»] | |
6VUB | X-ray | 1.50 | A | 44-168 | [»] | |
6VUC | X-ray | 1.55 | A | 44-168 | [»] | |
6VUF | X-ray | 1.59 | A/B | 44-168 | [»] | |
6VUJ | X-ray | 1.48 | A | 44-168 | [»] | |
6WGX | X-ray | 1.53 | A/B | 44-168 | [»] | |
6WW8 | X-ray | 2.30 | A | 43-180 | [»] | |
6X7B | X-ray | 1.95 | A/B | 44-176 | [»] | |
6X7C | X-ray | 2.70 | A | 44-176 | [»] | |
6X7D | X-ray | 2.50 | A/B | 44-176 | [»] | |
6XUZ | X-ray | 1.07 | A | 44-168 | [»] | |
6XV3 | X-ray | 1.47 | A/B/C/D | 44-168 | [»] | |
6XV7 | X-ray | 1.67 | A | 44-168 | [»] | |
6XVC | X-ray | 1.10 | B | 44-168 | [»] | |
6YIN | X-ray | 1.53 | A | 44-168 | [»] | |
6YQN | X-ray | 1.05 | A | 44-168 | [»] | |
6YQO | X-ray | 1.07 | A | 44-168 | [»] | |
6YQP | X-ray | 1.25 | A | 44-168 | [»] | |
6Z7G | X-ray | 1.59 | AAA | 44-168 | [»] | |
6Z7L | X-ray | 1.62 | AAA | 44-168 | [»] | |
6Z7M | X-ray | 1.26 | AAA | 44-168 | [»] | |
6ZB3 | X-ray | 1.42 | AAA | 44-168 | [»] | |
6ZED | X-ray | 1.08 | AAA | 44-168 | [»] | |
6ZEL | X-ray | 1.12 | AAA | 44-168 | [»] | |
6ZF9 | X-ray | 1.20 | AAA | 44-168 | [»] | |
7A9U | X-ray | 1.44 | AAA | 44-168 | [»] | |
BMRBi | O60885 | |||||
SASBDBi | O60885 | |||||
SMRi | O60885 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117036, 130 interactors |
CORUMi | O60885 |
DIPi | DIP-39776N |
IntActi | O60885, 60 interactors |
MINTi | O60885 |
STRINGi | 9606.ENSP00000263377 |
Chemistry databases
BindingDBi | O60885 |
ChEMBLi | CHEMBL1163125 |
DrugCentrali | O60885 |
GuidetoPHARMACOLOGYi | 1945 |
PTM databases
GlyGeni | O60885, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | O60885 |
MetOSitei | O60885 |
PhosphoSitePlusi | O60885 |
SwissPalmi | O60885 |
Genetic variation databases
BioMutai | BRD4 |
Proteomic databases
EPDi | O60885 |
jPOSTi | O60885 |
MassIVEi | O60885 |
MaxQBi | O60885 |
PaxDbi | O60885 |
PeptideAtlasi | O60885 |
PRIDEi | O60885 |
ProteomicsDBi | 49651 [O60885-1] 49652 [O60885-2] 62139 |
Protocols and materials databases
ABCDi | O60885, 2 sequenced antibodies |
Antibodypediai | 13956, 399 antibodies |
Genome annotation databases
Ensembli | ENST00000263377; ENSP00000263377; ENSG00000141867 [O60885-1] ENST00000360016; ENSP00000353112; ENSG00000141867 [O60885-3] ENST00000371835; ENSP00000360901; ENSG00000141867 [O60885-2] |
GeneIDi | 23476 |
KEGGi | hsa:23476 |
UCSCi | uc002nar.4, human [O60885-1] |
Organism-specific databases
CTDi | 23476 |
DisGeNETi | 23476 |
GeneCardsi | BRD4 |
HGNCi | HGNC:13575, BRD4 |
HPAi | ENSG00000141867, Low tissue specificity |
MalaCardsi | BRD4 |
MIMi | 608749, gene |
neXtProti | NX_O60885 |
OpenTargetsi | ENSG00000141867 |
Orphaneti | 443167, NUT midline carcinoma |
PharmGKBi | PA25416 |
VEuPathDBi | HostDB:ENSG00000141867.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1474, Eukaryota |
GeneTreei | ENSGT00940000154549 |
HOGENOMi | CLU_001499_0_3_1 |
InParanoidi | O60885 |
OMAi | ERMRWAR |
OrthoDBi | 619848at2759 |
PhylomeDBi | O60885 |
TreeFami | TF317345 |
Enzyme and pathway databases
PathwayCommonsi | O60885 |
Reactomei | R-HSA-9679191, Potential therapeutics for SARS |
SIGNORi | O60885 |
Miscellaneous databases
BioGRID-ORCSi | 23476, 655 hits in 897 CRISPR screens |
ChiTaRSi | BRD4, human |
EvolutionaryTracei | O60885 |
GeneWikii | BRD4 |
GenomeRNAii | 23476 |
Pharosi | O60885, Tchem |
PROi | PR:O60885 |
RNActi | O60885, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141867, Expressed in amniotic fluid and 250 other tissues |
ExpressionAtlasi | O60885, baseline and differential |
Genevisiblei | O60885, HS |
Family and domain databases
CDDi | cd05497, Bromo_Brdt_I_like, 1 hit cd05498, Bromo_Brdt_II_like, 1 hit |
DisProti | DP01898 |
Gene3Di | 1.20.1270.220, 1 hit 1.20.920.10, 2 hits |
IDEALi | IID00111 |
InterProi | View protein in InterPro IPR031354, BRD4_CDT IPR043508, Bromo_Brdt_I IPR043509, Bromo_Brdt_II IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR027353, NET_dom IPR038336, NET_sf |
Pfami | View protein in Pfam PF17035, BET, 1 hit PF17105, BRD4_CDT, 1 hit PF00439, Bromodomain, 2 hits |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00297, BROMO, 2 hits |
SUPFAMi | SSF47370, SSF47370, 2 hits |
PROSITEi | View protein in PROSITE PS00633, BROMODOMAIN_1, 1 hit PS50014, BROMODOMAIN_2, 2 hits PS51525, NET, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BRD4_HUMAN | |
Accessioni | O60885Primary (citable) accession number: O60885 Secondary accession number(s): O60433 Q96PD3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | January 31, 2002 | |
Last modified: | February 10, 2021 | |
This is version 197 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references