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Protein

G-protein coupled receptor 37-like 1

Gene

GPR37L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).By similarity3 Publications

Caution

Has been reported to act as a receptor for prosaposin (PSAP) (PubMed:23690594). However, it has also been shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor (PubMed:27072655).3 Publications

GO - Molecular functioni

  • G protein-coupled peptide receptor activity Source: ParkinsonsUK-UCL
  • G protein-coupled receptor activity Source: UniProtKB
  • peptide binding Source: ParkinsonsUK-UCL
  • prosaposin receptor activity Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 37-like 1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name:
ETBR-LP-2
Gene namesi
Name:GPR37L1
Synonyms:ETBRLP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000170075.8
HGNCiHGNC:14923 GPR37L1
MIMi617630 gene
neXtProtiNX_O60883

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 134ExtracellularSequence analysisAdd BLAST109
Transmembranei135 – 155Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini156 – 167CytoplasmicSequence analysisAdd BLAST12
Transmembranei168 – 188Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini189 – 205ExtracellularSequence analysisAdd BLAST17
Transmembranei206 – 226Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini227 – 251CytoplasmicSequence analysisAdd BLAST25
Transmembranei252 – 272Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini273 – 310ExtracellularSequence analysisAdd BLAST38
Transmembranei311 – 331Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini332 – 361CytoplasmicSequence analysisAdd BLAST30
Transmembranei362 – 382Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini383 – 398ExtracellularSequence analysisAdd BLAST16
Transmembranei399 – 419Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini420 – 481CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9283
OpenTargetsiENSG00000170075
PharmGKBiPA28883

Chemistry databases

ChEMBLiCHEMBL5892
GuidetoPHARMACOLOGYi104

Polymorphism and mutation databases

BioMutaiGPR37L1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001279626 – 481G-protein coupled receptor 37-like 1Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79O-linked (GalNAc...) threonine1 Publication1
Glycosylationi85O-linked (GalNAc...) threonine1 Publication1
Glycosylationi86O-linked (GalNAc...) serine1 Publication1
Glycosylationi95O-linked (GalNAc...) threonine1 Publication1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi203 ↔ 286PROSITE-ProRule annotation
Modified residuei471PhosphoserineBy similarity1
Modified residuei479PhosphothreonineBy similarity1

Post-translational modificationi

O-glycosylated.1 Publication
Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity.1 Publication
Ubiquitinated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO60883
PeptideAtlasiO60883
PRIDEiO60883
ProteomicsDBi49649

PTM databases

GlyConnecti661
iPTMnetiO60883
PhosphoSitePlusiO60883
UniCarbKBiO60883

Expressioni

Tissue specificityi

Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594). Expressed in the central nervous system (PubMed:9539149).2 Publications

Gene expression databases

BgeeiENSG00000170075 Expressed in 101 organ(s), highest expression level in medial globus pallidus
CleanExiHS_GPR37L1
GenevisibleiO60883 HS

Organism-specific databases

HPAiHPA064454

Interactioni

Subunit structurei

Interacts with the PTCH1 receptor.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PRCPP427852EBI-2927498,EBI-2803892

Protein-protein interaction databases

IntActiO60883, 47 interactors
STRINGi9606.ENSP00000356251

Chemistry databases

BindingDBiO60883

Structurei

3D structure databases

ProteinModelPortaliO60883
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi418 – 439Cys-richAdd BLAST22

Domaini

The N-terminal region is required for constitutive signal transduction.1 Publication

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119177
HOGENOMiHOG000252922
HOVERGENiHBG051808
InParanoidiO60883
KOiK04244
OMAiTEMSSSI
OrthoDBiEOG091G053G
PhylomeDBiO60883
TreeFamiTF331292

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003909 GPR37_orph
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01421 GPR37ORPHANR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60883-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRWLWPLAVS LAVILAVGLS RVSGGAPLHL GRHRAETQEQ QSRSKRGTED
60 70 80 90 100
EEAKGVQQYV PEEWAEYPRP IHPAGLQPTK PLVATSPNPG KDGGTPDSGQ
110 120 130 140 150
ELRGNLTGAP GQRLQIQNPL YPVTESSYSA YAIMLLALVV FAVGIVGNLS
160 170 180 190 200
VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD
210 220 230 240 250
VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA
260 270 280 290 300
KLAVIWVGSM TLAVPELLLW QLAQEPAPTM GTLDSCIMKP SASLPESLYS
310 320 330 340 350
LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKSECRASKH
360 370 380 390 400
EQCESQLNST VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI
410 420 430 440 450
NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASEASAANG
460 470 480
SDNKLKTEVS SSIYFHKPRE SPPLLPLGTP C
Length:481
Mass (Da):52,771
Last modified:November 2, 2010 - v2
Checksum:iEE9DFE0446E3AF24
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204R → S in BAG35876 (PubMed:14702039).Curated1
Sequence conflicti433C → F in BAG35876 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04745581P → A. Corresponds to variant dbSNP:rs3795594Ensembl.1
Natural variantiVAR_04745690G → D2 PublicationsCorresponds to variant dbSNP:rs3795595Ensembl.1
Natural variantiVAR_04745791K → R1 PublicationCorresponds to variant dbSNP:rs17854616Ensembl.1
Natural variantiVAR_080868349K → N Found in siblings with a novel form of progressive myoclonus epilepsy; unknown pathological significance; no effect on expression levels, cell surface location, signaling activity or ubiquitination. 1 PublicationCorresponds to variant dbSNP:rs372386575EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16280 mRNA Translation: CAA76153.1
AK313044 mRNA Translation: BAG35876.1
AK222639 mRNA Translation: BAD96359.1
AL592300 Genomic DNA No translation available.
BC050334 mRNA Translation: AAH50334.1
CCDSiCCDS1420.1
RefSeqiNP_004758.3, NM_004767.3
UniGeneiHs.132049
Hs.604697

Genome annotation databases

EnsembliENST00000367282; ENSP00000356251; ENSG00000170075
GeneIDi9283
KEGGihsa:9283
UCSCiuc001gxj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16280 mRNA Translation: CAA76153.1
AK313044 mRNA Translation: BAG35876.1
AK222639 mRNA Translation: BAD96359.1
AL592300 Genomic DNA No translation available.
BC050334 mRNA Translation: AAH50334.1
CCDSiCCDS1420.1
RefSeqiNP_004758.3, NM_004767.3
UniGeneiHs.132049
Hs.604697

3D structure databases

ProteinModelPortaliO60883
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO60883, 47 interactors
STRINGi9606.ENSP00000356251

Chemistry databases

BindingDBiO60883
ChEMBLiCHEMBL5892
GuidetoPHARMACOLOGYi104

Protein family/group databases

GPCRDBiSearch...

PTM databases

GlyConnecti661
iPTMnetiO60883
PhosphoSitePlusiO60883
UniCarbKBiO60883

Polymorphism and mutation databases

BioMutaiGPR37L1

Proteomic databases

PaxDbiO60883
PeptideAtlasiO60883
PRIDEiO60883
ProteomicsDBi49649

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367282; ENSP00000356251; ENSG00000170075
GeneIDi9283
KEGGihsa:9283
UCSCiuc001gxj.4 human

Organism-specific databases

CTDi9283
DisGeNETi9283
EuPathDBiHostDB:ENSG00000170075.8
GeneCardsiGPR37L1
H-InvDBiHIX0200009
HGNCiHGNC:14923 GPR37L1
HPAiHPA064454
MIMi617630 gene
neXtProtiNX_O60883
OpenTargetsiENSG00000170075
PharmGKBiPA28883
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119177
HOGENOMiHOG000252922
HOVERGENiHBG051808
InParanoidiO60883
KOiK04244
OMAiTEMSSSI
OrthoDBiEOG091G053G
PhylomeDBiO60883
TreeFamiTF331292

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSiGPR37L1 human
GeneWikiiGPR37L1
GenomeRNAii9283
PROiPR:O60883
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170075 Expressed in 101 organ(s), highest expression level in medial globus pallidus
CleanExiHS_GPR37L1
GenevisibleiO60883 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003909 GPR37_orph
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01421 GPR37ORPHANR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG37L1_HUMAN
AccessioniPrimary (citable) accession number: O60883
Secondary accession number(s): B2R7M9, Q5SXP7, Q86VP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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