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Entry version 168 (07 Oct 2020)
Sequence version 2 (02 Nov 2010)
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Protein

G-protein coupled receptor 37-like 1

Gene

GPR37L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).By similarity3 Publications

Caution

Has been reported to act as a receptor for prosaposin (PSAP) (PubMed:23690594). However, it has also been shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor (PubMed:27072655).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
O60883

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-375276, Peptide ligand-binding receptors
R-HSA-418594, G alpha (i) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G-protein coupled receptor 37-like 1
Alternative name(s):
Endothelin B receptor-like protein 2
Short name:
ETBR-LP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR37L1
Synonyms:ETBRLP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170075.8

Human Gene Nomenclature Database

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HGNCi
HGNC:14923, GPR37L1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617630, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60883

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 134ExtracellularSequence analysisAdd BLAST109
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei135 – 155Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini156 – 167CytoplasmicSequence analysisAdd BLAST12
Transmembranei168 – 188Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini189 – 205ExtracellularSequence analysisAdd BLAST17
Transmembranei206 – 226Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini227 – 251CytoplasmicSequence analysisAdd BLAST25
Transmembranei252 – 272Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini273 – 310ExtracellularSequence analysisAdd BLAST38
Transmembranei311 – 331Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini332 – 361CytoplasmicSequence analysisAdd BLAST30
Transmembranei362 – 382Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini383 – 398ExtracellularSequence analysisAdd BLAST16
Transmembranei399 – 419Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini420 – 481CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9283

Open Targets

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OpenTargetsi
ENSG00000170075

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28883

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
O60883, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5892

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
104

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GPR37L1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001279626 – 481G-protein coupled receptor 37-like 1Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi79O-linked (GalNAc...) threonine1 Publication1
Glycosylationi85O-linked (GalNAc...) threonine1 Publication1
Glycosylationi86O-linked (GalNAc...) serine1 Publication1
Glycosylationi95O-linked (GalNAc...) threonine1 Publication1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107O-linked (GalNAc...) threonine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi203 ↔ 286PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei471PhosphoserineBy similarity1
Modified residuei479PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.1 Publication
Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity.1 Publication
Ubiquitinated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O60883

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60883

PeptideAtlas

More...
PeptideAtlasi
O60883

PRoteomics IDEntifications database

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PRIDEi
O60883

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
49649

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
661, 1 O-Linked glycan (6 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
O60883, 7 sites, 1 O-linked glycan (6 sites)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60883

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60883

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
O60883

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594). Expressed in the central nervous system (PubMed:9539149).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170075, Expressed in medial globus pallidus and 119 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60883, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000170075, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the PTCH1 receptor.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O60883
With#Exp.IntAct
ADGRB3 [O60242]3EBI-2927498,EBI-2682765
AQP1 [P29972]3EBI-2927498,EBI-745213
AQP10 [Q96PS8]3EBI-2927498,EBI-12820279
ARL13B [Q3SXY8]3EBI-2927498,EBI-11343438
CD46 - isoform D [P15529-3]3EBI-2927498,EBI-13046140
CISD2 [Q8N5K1]3EBI-2927498,EBI-1045797
CLDN7 [O95471]3EBI-2927498,EBI-740744
CLDND2 [Q8NHS1]3EBI-2927498,EBI-11959453
CLEC2A [Q6UVW9]3EBI-2927498,EBI-15839595
CREB3L1 [Q96BA8]3EBI-2927498,EBI-6942903
CYB561A3 [Q8NBI2]3EBI-2927498,EBI-10269179
ELOVL4 [Q9GZR5]3EBI-2927498,EBI-18535450
ERG28 [Q9UKR5]3EBI-2927498,EBI-711490
FAM209A [Q5JX71]3EBI-2927498,EBI-18304435
FFAR2 [O15552]3EBI-2927498,EBI-2833872
FXYD3 - isoform 3 [Q14802-3]3EBI-2927498,EBI-12175685
GPR152 [Q8TDT2]3EBI-2927498,EBI-13345167
GPR42 [O15529]3EBI-2927498,EBI-18076404
GPX8 [Q8TED1]3EBI-2927498,EBI-11721746
IGFBP5 [P24593]3EBI-2927498,EBI-720480
INSIG2 [Q9Y5U4]3EBI-2927498,EBI-8503746
JAGN1 [Q8N5M9]3EBI-2927498,EBI-10266796
LHFPL5 [Q8TAF8]3EBI-2927498,EBI-2820517
PDCD1LG2 [Q9BQ51]3EBI-2927498,EBI-16427978
PLN [P26678]3EBI-2927498,EBI-692836
PRCP [P42785]2EBI-2927498,EBI-2803892
RNF122 [Q9H9V4]3EBI-2927498,EBI-2129998
RPRM [Q9NS64]3EBI-2927498,EBI-1052363
SCARB2 [Q14108]3EBI-2927498,EBI-1564650
SCARF1 [Q14162]3EBI-2927498,EBI-12056025
SEC22A [Q96IW7]3EBI-2927498,EBI-8652744
SERP1 [Q9Y6X1]3EBI-2927498,EBI-10329948
SLC30A8 [Q8IWU4]3EBI-2927498,EBI-10262251
STOM [P27105]3EBI-2927498,EBI-1211440
SYNPR [Q8TBG9]3EBI-2927498,EBI-10273251
THAP4 [Q8WY91]3EBI-2927498,EBI-726691
THSD7B [C9JKN6]3EBI-2927498,EBI-17192156
TM4SF4 [P48230]3EBI-2927498,EBI-8650934
TMEM147 [Q9BVK8]3EBI-2927498,EBI-348587
TMEM243 [Q9BU79]3EBI-2927498,EBI-12887458
TMEM248 [Q9NWD8]3EBI-2927498,EBI-10314986
TMEM52B [Q4KMG9]3EBI-2927498,EBI-18178701
TMEM54 [Q969K7]3EBI-2927498,EBI-3922833
TMEM80 [Q96HE8]3EBI-2927498,EBI-11742770
TMEM86A [Q8N2M4]3EBI-2927498,EBI-12015604
TMEM86B [Q8N661]3EBI-2927498,EBI-2548832
TMEM97 [Q5BJF2]3EBI-2927498,EBI-12111910
TNFRSF10C [O14798]3EBI-2927498,EBI-717441
TSPAN12 [O95859]3EBI-2927498,EBI-2466403
UNC93B1 [Q9H1C4]3EBI-2927498,EBI-4401271
UPK1B [O75841]3EBI-2927498,EBI-12237619
A0A087WZY13EBI-2927498,EBI-13387614

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114700, 52 interactors

Protein interaction database and analysis system

More...
IntActi
O60883, 53 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356251

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O60883

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O60883, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi418 – 439Cys-richAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region is required for constitutive signal transduction.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214374

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029119_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60883

KEGG Orthology (KO)

More...
KOi
K04244

Identification of Orthologs from Complete Genome Data

More...
OMAi
CVCRPLG

Database of Orthologous Groups

More...
OrthoDBi
568030at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60883

TreeFam database of animal gene trees

More...
TreeFami
TF331292

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR003909, GPR37_orph

The PANTHER Classification System

More...
PANTHERi
PTHR46216, PTHR46216, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00237, GPCRRHODOPSN
PR01421, GPR37ORPHANR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O60883-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRWLWPLAVS LAVILAVGLS RVSGGAPLHL GRHRAETQEQ QSRSKRGTED
60 70 80 90 100
EEAKGVQQYV PEEWAEYPRP IHPAGLQPTK PLVATSPNPG KDGGTPDSGQ
110 120 130 140 150
ELRGNLTGAP GQRLQIQNPL YPVTESSYSA YAIMLLALVV FAVGIVGNLS
160 170 180 190 200
VMCIVWHSYY LKSAWNSILA SLALWDFLVL FFCLPIVIFN EITKQRLLGD
210 220 230 240 250
VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR PIERCQSILA
260 270 280 290 300
KLAVIWVGSM TLAVPELLLW QLAQEPAPTM GTLDSCIMKP SASLPESLYS
310 320 330 340 350
LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKSECRASKH
360 370 380 390 400
EQCESQLNST VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI
410 420 430 440 450
NQFSTFFKGA ITPVLLLCIC RPLGQAFLDC CCCCCCEECG GASEASAANG
460 470 480
SDNKLKTEVS SSIYFHKPRE SPPLLPLGTP C
Length:481
Mass (Da):52,771
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE9DFE0446E3AF24
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti204R → S in BAG35876 (PubMed:14702039).Curated1
Sequence conflicti433C → F in BAG35876 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04745581P → A. Corresponds to variant dbSNP:rs3795594Ensembl.1
Natural variantiVAR_04745690G → D2 PublicationsCorresponds to variant dbSNP:rs3795595Ensembl.1
Natural variantiVAR_04745791K → R1 PublicationCorresponds to variant dbSNP:rs17854616Ensembl.1
Natural variantiVAR_080868349K → N Found in siblings with a novel form of progressive myoclonus epilepsy; unknown pathological significance; no effect on expression levels, cell surface location, signaling activity or ubiquitination. 1 PublicationCorresponds to variant dbSNP:rs372386575EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Y16280 mRNA Translation: CAA76153.1
AK313044 mRNA Translation: BAG35876.1
AK222639 mRNA Translation: BAD96359.1
AL592300 Genomic DNA No translation available.
BC050334 mRNA Translation: AAH50334.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1420.1

NCBI Reference Sequences

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RefSeqi
NP_004758.3, NM_004767.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000367282; ENSP00000356251; ENSG00000170075

Database of genes from NCBI RefSeq genomes

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GeneIDi
9283

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9283

UCSC genome browser

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UCSCi
uc001gxj.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16280 mRNA Translation: CAA76153.1
AK313044 mRNA Translation: BAG35876.1
AK222639 mRNA Translation: BAD96359.1
AL592300 Genomic DNA No translation available.
BC050334 mRNA Translation: AAH50334.1
CCDSiCCDS1420.1
RefSeqiNP_004758.3, NM_004767.3

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi114700, 52 interactors
IntActiO60883, 53 interactors
STRINGi9606.ENSP00000356251

Chemistry databases

BindingDBiO60883
ChEMBLiCHEMBL5892
GuidetoPHARMACOLOGYi104

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

GlyConnecti661, 1 O-Linked glycan (6 sites)
GlyGeniO60883, 7 sites, 1 O-linked glycan (6 sites)
iPTMnetiO60883
PhosphoSitePlusiO60883
UniCarbKBiO60883

Polymorphism and mutation databases

BioMutaiGPR37L1

Proteomic databases

MassIVEiO60883
PaxDbiO60883
PeptideAtlasiO60883
PRIDEiO60883
ProteomicsDBi49649

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
20649, 292 antibodies

Genome annotation databases

EnsembliENST00000367282; ENSP00000356251; ENSG00000170075
GeneIDi9283
KEGGihsa:9283
UCSCiuc001gxj.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9283
DisGeNETi9283
EuPathDBiHostDB:ENSG00000170075.8

GeneCards: human genes, protein and diseases

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GeneCardsi
GPR37L1
HGNCiHGNC:14923, GPR37L1
HPAiENSG00000170075, Tissue enriched (brain)
MIMi617630, gene
neXtProtiNX_O60883
OpenTargetsiENSG00000170075
PharmGKBiPA28883

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT01000000214374
HOGENOMiCLU_029119_0_0_1
InParanoidiO60883
KOiK04244
OMAiCVCRPLG
OrthoDBi568030at2759
PhylomeDBiO60883
TreeFamiTF331292

Enzyme and pathway databases

PathwayCommonsiO60883
ReactomeiR-HSA-375276, Peptide ligand-binding receptors
R-HSA-418594, G alpha (i) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9283, 7 hits in 865 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GPR37L1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GPR37L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9283
PharosiO60883, Tbio

Protein Ontology

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PROi
PR:O60883
RNActiO60883, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170075, Expressed in medial globus pallidus and 119 other tissues
GenevisibleiO60883, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR003909, GPR37_orph
PANTHERiPTHR46216, PTHR46216, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR01421, GPR37ORPHANR
PROSITEiView protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG37L1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60883
Secondary accession number(s): B2R7M9, Q5SXP7, Q86VP7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 2, 2010
Last modified: October 7, 2020
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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