UniProtKB - O60880 (SH21A_HUMAN)
SH2 domain-containing protein 1A
SH2D1A
Functioni
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999).
However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214).
Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity).
May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
By similarity1 Publication2 PublicationsGO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- cell-cell signaling Source: InterPro
- cellular defense response Source: InterPro
- humoral immune response Source: Ensembl
- innate immune response Source: UniProtKB-KW
- negative regulation of T cell receptor signaling pathway Source: UniProtKB
- positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
- regulation of immune response Source: UniProtKB
Keywordsi
Biological process | Adaptive immunity, Immunity, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | O60880 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
SignaLinki | O60880 |
Names & Taxonomyi
Protein namesi | Recommended name: SH2 domain-containing protein 1AAlternative name(s): Duncan disease SH2-protein Signaling lymphocytic activation molecule-associated protein Short name: SLAM-associated protein T-cell signal transduction molecule SAP |
Gene namesi | Name:SH2D1A Synonyms:DSHP, SAP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10820, SH2D1A |
MIMi | 300490, gene |
neXtProti | NX_O60880 |
VEuPathDBi | HostDB:ENSG00000183918 |
Pathology & Biotechi
Involvement in diseasei
Lymphoproliferative syndrome, X-linked, 1 (XLP1)11 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048005 | 7 | Y → C in XLP1; reduced protein stability and reduced affinity for SLAMF1, decreases interaction with FYN. 4 PublicationsCorresponds to variant dbSNP:rs1569527111EnsemblClinVar. | 1 | |
Natural variantiVAR_048006 | 8 | H → D in XLP1. 1 Publication | 1 | |
Natural variantiVAR_048007 | 16 | G → D in XLP1; abolishes interaction with SLAMF1. 1 Publication | 1 | |
Natural variantiVAR_048008 | 27 | G → S in XLP1. 1 Publication | 1 | |
Natural variantiVAR_048009 | 28 | S → R in XLP1; reduced protein stability. 3 Publications | 1 | |
Natural variantiVAR_048010 | 31 | L → P in XLP1; reduced protein stability and reduced affinity for SLAMF1 and FYN. 2 Publications | 1 | |
Natural variantiVAR_005612 | 32 | R → T in XLP1. 2 PublicationsCorresponds to variant dbSNP:rs111033624EnsemblClinVar. | 1 | |
Natural variantiVAR_048011 | 33 | D → Y in XLP1. 1 Publication | 1 | |
Natural variantiVAR_048012 | 42 | C → W in XLP1; loss of interaction with CD84 and reduced affinity for SLAMF1. 2 Publications | 1 | |
Natural variantiVAR_048013 | 49 | G → V in XLP1. 1 Publication | 1 | |
Natural variantiVAR_048014 | 53 | T → I in XLP1; loss of interaction with CD84; loss of interaction with non-phosphorylated SLAMF1. 3 Publications | 1 | |
Natural variantiVAR_048015 | 54 | Y → C in XLP1; reduced protein stability and reduced affinity for SLAMF1 and FYN. 3 Publications | 1 | |
Natural variantiVAR_018307 | 55 | R → L in XLP1; reduced affinity for SLAMF1 and FYN. 2 PublicationsCorresponds to variant dbSNP:rs111033630EnsemblClinVar. | 1 | |
Natural variantiVAR_005613 | 68 | T → I in XLP1; loss of interaction with CD84; strongly reduced affinity for SLAMF1. 3 PublicationsCorresponds to variant dbSNP:rs111033627EnsemblClinVar. | 1 | |
Natural variantiVAR_048017 | 84 | I → T in XLP1; reduced protein stability. 1 Publication | 1 | |
Natural variantiVAR_048018 | 87 | F → S in XLP1; reduced protein stability and reduced affinity for SLAMF1 and FYN. 3 Publications | 1 | |
Natural variantiVAR_048019 | 99 | Q → P in XLP1; reduced protein stability and strongly reduced affinity for SLAMF1, disrupts interaction with FYN. 4 Publications | 1 | |
Natural variantiVAR_005614 | 101 | P → L in XLP1; reduced protein stability and reduced affinity for SLAMF1, decreases interaction with FYN. 4 PublicationsCorresponds to variant dbSNP:rs111033626EnsemblClinVar. | 1 | |
Natural variantiVAR_048020 | 102 | V → G in XLP1; reduced protein stability and strongly reduced affinity for SLAMF1, decreases interaction with FYN. 4 Publications | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 32 | R → Q: Strongly reduced affinity for SLAMF1. 1 Publication | 1 | |
Mutagenesisi | 78 | R → E: Disrupts interaction with FYN. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 4068 |
GeneReviewsi | SH2D1A |
MalaCardsi | SH2D1A |
MIMi | 308240, phenotype |
OpenTargetsi | ENSG00000183918 |
Orphaneti | 538931, X-linked lymphoproliferative disease due to SH2D1A deficiency |
PharmGKBi | PA35728 |
Miscellaneous databases
Pharosi | O60880, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2321636 |
Genetic variation databases
BioMutai | SH2D1A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097722 | 1 – 128 | SH2 domain-containing protein 1AAdd BLAST | 128 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 89 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | O60880 |
MassIVEi | O60880 |
MaxQBi | O60880 |
PaxDbi | O60880 |
PeptideAtlasi | O60880 |
PRIDEi | O60880 |
ProteomicsDBi | 49642 [O60880-1] 49643 [O60880-2] 49644 [O60880-3] 49645 [O60880-4] 49646 [O60880-5] 49647 [O60880-6] |
PTM databases
iPTMneti | O60880 |
PhosphoSitePlusi | O60880 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000183918, Expressed in thymus and 137 other tissues |
ExpressionAtlasi | O60880, baseline and differential |
Genevisiblei | O60880, HS |
Organism-specific databases
HPAi | ENSG00000183918, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Interacts with NTRK1, NTRK2 and NTRK3 (By similarity).
Interacts with CD84, CD244, LY9, SLAMF1 and FYN.
By similarity7 PublicationsBinary interactionsi
O60880
Isoform A [O60880-1]
With | #Exp. | IntAct |
---|---|---|
ARHGEF6 [Q15052] | 3 | EBI-15552052,EBI-1642523 |
ARHGEF7 [Q14155] | 5 | EBI-15552052,EBI-717515 |
CD244 [Q9BZW8] | 2 | EBI-15552052,EBI-1580565 |
SLAMF1 [Q13291] | 2 | EBI-15552052,EBI-4315002 |
Protein-protein interaction databases
BioGRIDi | 110246, 35 interactors |
DIPi | DIP-40768N |
IntActi | O60880, 34 interactors |
MINTi | O60880 |
STRINGi | 9606.ENSP00000360181 |
Chemistry databases
BindingDBi | O60880 |
Miscellaneous databases
RNActi | O60880, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O60880 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O60880 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 104 | SH2PROSITE-ProRule annotationAdd BLAST | 99 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 67 – 92 | Interaction with FYN SH3 domainBy similarityAdd BLAST | 26 | |
Regioni | 106 – 128 | DisorderedSequence analysisAdd BLAST | 23 |
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG0565, Eukaryota |
GeneTreei | ENSGT00940000155920 |
HOGENOMi | CLU_125532_1_0_1 |
InParanoidi | O60880 |
OMAi | PDQGIAI |
OrthoDBi | 1417830at2759 |
PhylomeDBi | O60880 |
TreeFami | TF343096 |
Family and domain databases
CDDi | cd10400, SH2_SAP1a, 1 hit |
DisProti | DP02714 |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR017289, SH2_prot_1A IPR035876, SH2D1A_SH2 |
Pfami | View protein in Pfam PF00017, SH2, 1 hit |
PIRSFi | PIRSF037828, SH2_p1A, 1 hit |
PRINTSi | PR00401, SH2DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY
60 70 80 90 100
IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY
110 120
PVEKKSSARS TQGTTGIRED PDVCLKAP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y573 | A0A2R8Y573_HUMAN | SH2 domain-containing protein 1A | SH2D1A | 77 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048005 | 7 | Y → C in XLP1; reduced protein stability and reduced affinity for SLAMF1, decreases interaction with FYN. 4 PublicationsCorresponds to variant dbSNP:rs1569527111EnsemblClinVar. | 1 | |
Natural variantiVAR_048006 | 8 | H → D in XLP1. 1 Publication | 1 | |
Natural variantiVAR_048007 | 16 | G → D in XLP1; abolishes interaction with SLAMF1. 1 Publication | 1 | |
Natural variantiVAR_048008 | 27 | G → S in XLP1. 1 Publication | 1 | |
Natural variantiVAR_048009 | 28 | S → R in XLP1; reduced protein stability. 3 Publications | 1 | |
Natural variantiVAR_048010 | 31 | L → P in XLP1; reduced protein stability and reduced affinity for SLAMF1 and FYN. 2 Publications | 1 | |
Natural variantiVAR_005612 | 32 | R → T in XLP1. 2 PublicationsCorresponds to variant dbSNP:rs111033624EnsemblClinVar. | 1 | |
Natural variantiVAR_048011 | 33 | D → Y in XLP1. 1 Publication | 1 | |
Natural variantiVAR_048012 | 42 | C → W in XLP1; loss of interaction with CD84 and reduced affinity for SLAMF1. 2 Publications | 1 | |
Natural variantiVAR_048013 | 49 | G → V in XLP1. 1 Publication | 1 | |
Natural variantiVAR_048014 | 53 | T → I in XLP1; loss of interaction with CD84; loss of interaction with non-phosphorylated SLAMF1. 3 Publications | 1 | |
Natural variantiVAR_048015 | 54 | Y → C in XLP1; reduced protein stability and reduced affinity for SLAMF1 and FYN. 3 Publications | 1 | |
Natural variantiVAR_018307 | 55 | R → L in XLP1; reduced affinity for SLAMF1 and FYN. 2 PublicationsCorresponds to variant dbSNP:rs111033630EnsemblClinVar. | 1 | |
Natural variantiVAR_048016 | 57 | S → P in one XLP1 patient; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_005613 | 68 | T → I in XLP1; loss of interaction with CD84; strongly reduced affinity for SLAMF1. 3 PublicationsCorresponds to variant dbSNP:rs111033627EnsemblClinVar. | 1 | |
Natural variantiVAR_048017 | 84 | I → T in XLP1; reduced protein stability. 1 Publication | 1 | |
Natural variantiVAR_048018 | 87 | F → S in XLP1; reduced protein stability and reduced affinity for SLAMF1 and FYN. 3 Publications | 1 | |
Natural variantiVAR_048019 | 99 | Q → P in XLP1; reduced protein stability and strongly reduced affinity for SLAMF1, disrupts interaction with FYN. 4 Publications | 1 | |
Natural variantiVAR_005614 | 101 | P → L in XLP1; reduced protein stability and reduced affinity for SLAMF1, decreases interaction with FYN. 4 PublicationsCorresponds to variant dbSNP:rs111033626EnsemblClinVar. | 1 | |
Natural variantiVAR_048020 | 102 | V → G in XLP1; reduced protein stability and strongly reduced affinity for SLAMF1, decreases interaction with FYN. 4 Publications | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004388 | 40 – 128 | VYCLC…CLKAP → ITVTFIHTECPRQKQVLGVL SISEARSRHCNTSAVSS in isoform E. CuratedAdd BLAST | 89 | |
Alternative sequenceiVSP_004387 | 47 – 128 | YHGYI…CLKAP → QHLGYIKDISGK in isoform C. CuratedAdd BLAST | 82 | |
Alternative sequenceiVSP_004389 | 47 – 128 | YHGYI…CLKAP → ISEARSRHCNTSAVSS in isoform F. CuratedAdd BLAST | 82 | |
Alternative sequenceiVSP_004386 | 68 – 128 | TAPGV…CLKAP → HFRSQIKA in isoform B. CuratedAdd BLAST | 61 | |
Alternative sequenceiVSP_004390 | 114 – 116 | Missing in isoform D. Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL023657 mRNA Translation: CAA19222.1 AF073019 mRNA Translation: AAC62631.1 AF072930 mRNA Translation: AAC62630.1 AB586694 mRNA Translation: BAJ19023.1 AF100539 mRNA Translation: AAC79712.1 AF100540 mRNA Translation: AAC79713.1 AF100541 mRNA Translation: AAC79714.1 AF100542 mRNA Translation: AAC79715.1 AF100543 mRNA Translation: AAC79716.1 AK311911 mRNA Translation: BAG34852.1 CR542031 mRNA Translation: CAG46828.1 CR542043 mRNA Translation: CAG46840.1 AL022718 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11848.1 CH471107 Genomic DNA Translation: EAX11849.1 BC020732 mRNA Translation: AAH20732.1 |
CCDSi | CCDS14608.1 [O60880-1] CCDS48162.1 [O60880-4] |
RefSeqi | NP_001108409.1, NM_001114937.2 [O60880-4] NP_002342.1, NM_002351.4 [O60880-1] |
Genome annotation databases
Ensembli | ENST00000360027; ENSP00000353126; ENSG00000183918 [O60880-4] ENST00000371139; ENSP00000360181; ENSG00000183918 ENST00000477673; ENSP00000477094; ENSG00000183918 [O60880-5] |
GeneIDi | 4068 |
KEGGi | hsa:4068 |
MANE-Selecti | ENST00000371139.9; ENSP00000360181.5; NM_002351.5; NP_002342.1 |
UCSCi | uc004euf.6, human [O60880-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SH2D1Abase SH2D1A mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL023657 mRNA Translation: CAA19222.1 AF073019 mRNA Translation: AAC62631.1 AF072930 mRNA Translation: AAC62630.1 AB586694 mRNA Translation: BAJ19023.1 AF100539 mRNA Translation: AAC79712.1 AF100540 mRNA Translation: AAC79713.1 AF100541 mRNA Translation: AAC79714.1 AF100542 mRNA Translation: AAC79715.1 AF100543 mRNA Translation: AAC79716.1 AK311911 mRNA Translation: BAG34852.1 CR542031 mRNA Translation: CAG46828.1 CR542043 mRNA Translation: CAG46840.1 AL022718 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11848.1 CH471107 Genomic DNA Translation: EAX11849.1 BC020732 mRNA Translation: AAH20732.1 |
CCDSi | CCDS14608.1 [O60880-1] CCDS48162.1 [O60880-4] |
RefSeqi | NP_001108409.1, NM_001114937.2 [O60880-4] NP_002342.1, NM_002351.4 [O60880-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1D1Z | X-ray | 1.40 | A/B/C/D | 1-104 | [»] | |
1D4T | X-ray | 1.10 | A | 1-104 | [»] | |
1D4W | X-ray | 1.80 | A/B | 1-104 | [»] | |
1KA6 | NMR | - | A | 1-128 | [»] | |
1KA7 | NMR | - | A | 1-128 | [»] | |
1M27 | X-ray | 2.50 | A | 1-104 | [»] | |
SMRi | O60880 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110246, 35 interactors |
DIPi | DIP-40768N |
IntActi | O60880, 34 interactors |
MINTi | O60880 |
STRINGi | 9606.ENSP00000360181 |
Chemistry databases
BindingDBi | O60880 |
ChEMBLi | CHEMBL2321636 |
PTM databases
iPTMneti | O60880 |
PhosphoSitePlusi | O60880 |
Genetic variation databases
BioMutai | SH2D1A |
Proteomic databases
jPOSTi | O60880 |
MassIVEi | O60880 |
MaxQBi | O60880 |
PaxDbi | O60880 |
PeptideAtlasi | O60880 |
PRIDEi | O60880 |
ProteomicsDBi | 49642 [O60880-1] 49643 [O60880-2] 49644 [O60880-3] 49645 [O60880-4] 49646 [O60880-5] 49647 [O60880-6] |
Protocols and materials databases
Antibodypediai | 30053, 465 antibodies from 41 providers |
DNASUi | 4068 |
Genome annotation databases
Ensembli | ENST00000360027; ENSP00000353126; ENSG00000183918 [O60880-4] ENST00000371139; ENSP00000360181; ENSG00000183918 ENST00000477673; ENSP00000477094; ENSG00000183918 [O60880-5] |
GeneIDi | 4068 |
KEGGi | hsa:4068 |
MANE-Selecti | ENST00000371139.9; ENSP00000360181.5; NM_002351.5; NP_002342.1 |
UCSCi | uc004euf.6, human [O60880-1] |
Organism-specific databases
CTDi | 4068 |
DisGeNETi | 4068 |
GeneCardsi | SH2D1A |
GeneReviewsi | SH2D1A |
HGNCi | HGNC:10820, SH2D1A |
HPAi | ENSG00000183918, Tissue enriched (lymphoid) |
MalaCardsi | SH2D1A |
MIMi | 300490, gene 308240, phenotype |
neXtProti | NX_O60880 |
OpenTargetsi | ENSG00000183918 |
Orphaneti | 538931, X-linked lymphoproliferative disease due to SH2D1A deficiency |
PharmGKBi | PA35728 |
VEuPathDBi | HostDB:ENSG00000183918 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0565, Eukaryota |
GeneTreei | ENSGT00940000155920 |
HOGENOMi | CLU_125532_1_0_1 |
InParanoidi | O60880 |
OMAi | PDQGIAI |
OrthoDBi | 1417830at2759 |
PhylomeDBi | O60880 |
TreeFami | TF343096 |
Enzyme and pathway databases
PathwayCommonsi | O60880 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
SignaLinki | O60880 |
Miscellaneous databases
BioGRID-ORCSi | 4068, 4 hits in 660 CRISPR screens |
ChiTaRSi | SH2D1A, human |
EvolutionaryTracei | O60880 |
GeneWikii | SH2D1A |
GenomeRNAii | 4068 |
Pharosi | O60880, Tbio |
PROi | PR:O60880 |
RNActi | O60880, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183918, Expressed in thymus and 137 other tissues |
ExpressionAtlasi | O60880, baseline and differential |
Genevisiblei | O60880, HS |
Family and domain databases
CDDi | cd10400, SH2_SAP1a, 1 hit |
DisProti | DP02714 |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR017289, SH2_prot_1A IPR035876, SH2D1A_SH2 |
Pfami | View protein in Pfam PF00017, SH2, 1 hit |
PIRSFi | PIRSF037828, SH2_p1A, 1 hit |
PRINTSi | PR00401, SH2DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SH21A_HUMAN | |
Accessioni | O60880Primary (citable) accession number: O60880 Secondary accession number(s): A8MSW0 Q9UNR0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | August 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references