UniProtKB - O60870 (KIN17_HUMAN)
DNA/RNA-binding protein KIN17
KIN
Functioni
Miscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 28 – 50 | C2H2-typeSequence analysisAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: ProtInc
- double-stranded DNA binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
GO - Biological processi
- cellular response to DNA damage stimulus Source: UniProtKB
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- DNA replication Source: UniProtKB
- mRNA processing Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding, RNA-binding |
Biological process | DNA damage, DNA recombination, DNA repair, DNA replication, Host-virus interaction, mRNA processing, Stress response |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O60870 |
Reactomei | R-HSA-8876725, Protein methylation |
Names & Taxonomyi
Protein namesi | Recommended name: DNA/RNA-binding protein KIN17Alternative name(s): Binding to curved DNA KIN, antigenic determinant of recA protein homolog |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000151657.11 |
HGNCi | HGNC:6327, KIN |
MIMi | 601720, gene |
neXtProti | NX_O60870 |
Subcellular locationi
Nucleus
- nuclear matrix Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
- intracellular membrane-bounded organelle Source: HPA
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 135 | K → R: Almost complete loss of in vitro methylation by METTL22. 1 Publication | 1 | |
Mutagenesisi | 302 | K → E: Significant reduction of RNA-binding activity. 1 Publication | 1 | |
Mutagenesisi | 391 | K → E: Significant reduction of RNA-binding activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 22944 |
OpenTargetsi | ENSG00000151657 |
PharmGKBi | PA30113 |
Miscellaneous databases
Pharosi | O60870, Tbio |
Polymorphism and mutation databases
BioMutai | KIN |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000289134 | 1 – 393 | DNA/RNA-binding protein KIN17Add BLAST | 393 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 135 | N6,N6,N6-trimethyllysine; by METTL22; in vitroCombined sources1 Publication | 1 | |
Modified residuei | 135 | N6-methyllysineCombined sources | 1 |
Keywords - PTMi
MethylationProteomic databases
EPDi | O60870 |
jPOSTi | O60870 |
MassIVEi | O60870 |
MaxQBi | O60870 |
PaxDbi | O60870 |
PeptideAtlasi | O60870 |
PRIDEi | O60870 |
ProteomicsDBi | 49638 [O60870-1] 5403 |
PTM databases
iPTMneti | O60870 |
MetOSitei | O60870 |
PhosphoSitePlusi | O60870 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000151657, Expressed in monocyte and 228 other tissues |
ExpressionAtlasi | O60870, baseline and differential |
Genevisiblei | O60870, HS |
Organism-specific databases
HPAi | ENSG00000151657, Low tissue specificity |
Interactioni
Subunit structurei
Associated with DNA polymerase alpha, RFC1 and cyclin A, in multiprotein DNA replication complexes. Also associates with replication origins at the G1/S phase boundary and throughout the S phase in vivo.
1 Publication(Microbial infection) Interacts with SV40 large T antigen.
1 PublicationProtein-protein interaction databases
BioGRIDi | 116600, 44 interactors |
CORUMi | O60870 |
IntActi | O60870, 6 interactors |
MINTi | O60870 |
STRINGi | 9606.ENSP00000368881 |
Miscellaneous databases
RNActi | O60870, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | O60870 |
SMRi | O60870 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O60870 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 51 – 160 | Winged helix-turn-helix (wHTH)Add BLAST | 110 | |
Regioni | 284 – 334 | C-terminal subdomain A1 PublicationAdd BLAST | 51 | |
Regioni | 340 – 391 | C-terminal subdomain B1 PublicationAdd BLAST | 52 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 147 – 180 | Sequence analysisAdd BLAST | 34 | |
Coiled coili | 250 – 277 | Sequence analysisAdd BLAST | 28 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 28 – 50 | C2H2-typeSequence analysisAdd BLAST | 23 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2837, Eukaryota |
GeneTreei | ENSGT00390000005903 |
HOGENOMi | CLU_030065_1_0_1 |
InParanoidi | O60870 |
OMAi | NPGKFLH |
OrthoDBi | 1420569at2759 |
PhylomeDBi | O60870 |
TreeFami | TF314393 |
Family and domain databases
CDDi | cd13155, KOW_KIN17, 1 hit |
Gene3Di | 1.10.10.2030, 1 hit 2.30.30.30, 1 hit |
InterProi | View protein in InterPro IPR019447, DNA/RNA-bd_Kin17_cons_domain IPR037321, KIN17-like IPR038254, KIN17_WH-like_sf IPR041330, KN17_SH3 IPR041995, KOW_KIN17 IPR014722, Rib_L2_dom2 IPR036236, Znf_C2H2_sf |
PANTHERi | PTHR12805, PTHR12805, 1 hit |
Pfami | View protein in Pfam PF10357, Kin17_mid, 1 hit PF18131, KN17_SH3, 1 hit |
SMARTi | View protein in SMART SM01253, Kin17_mid, 1 hit |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGKSDFLTPK AIANRIKSKG LQKLRWYCQM CQKQCRDENG FKCHCMSESH
60 70 80 90 100
QRQLLLASEN PQQFMDYFSE EFRNDFLELL RRRFGTKRVH NNIVYNEYIS
110 120 130 140 150
HREHIHMNAT QWETLTDFTK WLGREGLCKV DETPKGWYIQ YIDRDPETIR
160 170 180 190 200
RQLELEKKKK QDLDDEEKTA KFIEEQVRRG LEGKEQEVPT FTELSRENDE
210 220 230 240 250
EKVTFNLSKG ACSSSGATSS KSSTLGPSAL KTIGSSASVK RKESSQSSTQ
260 270 280 290 300
SKEKKKKKSA LDEIMEIEEE KKRTARTDYW LQPEIIVKII TKKLGEKYHK
310 320 330 340 350
KKAIVKEVID KYTAVVKMID SGDKLKLDQT HLETVIPAPG KRILVLNGGY
360 370 380 390
RGNEGTLESI NEKTFSATIV IETGPLKGRR VEGIQYEDIS KLA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketS4R357 | S4R357_HUMAN | DNA/RNA-binding protein KIN17 | KIN | 108 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056074 | 374 – 393 | GPLKG…ISKLA → V in isoform 2. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ005273 mRNA Translation: CAA06462.1 AK301789 mRNA Translation: BAG63244.1 AL158044 Genomic DNA No translation available. BC017309 mRNA Translation: AAH17309.1 |
CCDSi | CCDS7080.1 [O60870-1] |
RefSeqi | NP_036443.1, NM_012311.3 [O60870-1] XP_011517729.1, XM_011519427.1 [O60870-2] |
Genome annotation databases
Ensembli | ENST00000379562; ENSP00000368881; ENSG00000151657 [O60870-1] |
GeneIDi | 22944 |
KEGGi | hsa:22944 |
UCSCi | uc001ijt.4, human [O60870-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ005273 mRNA Translation: CAA06462.1 AK301789 mRNA Translation: BAG63244.1 AL158044 Genomic DNA No translation available. BC017309 mRNA Translation: AAH17309.1 |
CCDSi | CCDS7080.1 [O60870-1] |
RefSeqi | NP_036443.1, NM_012311.3 [O60870-1] XP_011517729.1, XM_011519427.1 [O60870-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CKK | X-ray | 1.45 | A | 268-393 | [»] | |
2V1N | NMR | - | A | 51-160 | [»] | |
BMRBi | O60870 | |||||
SMRi | O60870 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116600, 44 interactors |
CORUMi | O60870 |
IntActi | O60870, 6 interactors |
MINTi | O60870 |
STRINGi | 9606.ENSP00000368881 |
PTM databases
iPTMneti | O60870 |
MetOSitei | O60870 |
PhosphoSitePlusi | O60870 |
Polymorphism and mutation databases
BioMutai | KIN |
Proteomic databases
EPDi | O60870 |
jPOSTi | O60870 |
MassIVEi | O60870 |
MaxQBi | O60870 |
PaxDbi | O60870 |
PeptideAtlasi | O60870 |
PRIDEi | O60870 |
ProteomicsDBi | 49638 [O60870-1] 5403 |
Protocols and materials databases
Antibodypediai | 4279, 116 antibodies |
Genome annotation databases
Ensembli | ENST00000379562; ENSP00000368881; ENSG00000151657 [O60870-1] |
GeneIDi | 22944 |
KEGGi | hsa:22944 |
UCSCi | uc001ijt.4, human [O60870-1] |
Organism-specific databases
CTDi | 22944 |
DisGeNETi | 22944 |
EuPathDBi | HostDB:ENSG00000151657.11 |
GeneCardsi | KIN |
HGNCi | HGNC:6327, KIN |
HPAi | ENSG00000151657, Low tissue specificity |
MIMi | 601720, gene |
neXtProti | NX_O60870 |
OpenTargetsi | ENSG00000151657 |
PharmGKBi | PA30113 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2837, Eukaryota |
GeneTreei | ENSGT00390000005903 |
HOGENOMi | CLU_030065_1_0_1 |
InParanoidi | O60870 |
OMAi | NPGKFLH |
OrthoDBi | 1420569at2759 |
PhylomeDBi | O60870 |
TreeFami | TF314393 |
Enzyme and pathway databases
PathwayCommonsi | O60870 |
Reactomei | R-HSA-8876725, Protein methylation |
Miscellaneous databases
BioGRID-ORCSi | 22944, 727 hits in 846 CRISPR screens |
ChiTaRSi | KIN, human |
EvolutionaryTracei | O60870 |
GeneWikii | KIN_(gene) |
GenomeRNAii | 22944 |
Pharosi | O60870, Tbio |
PROi | PR:O60870 |
RNActi | O60870, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151657, Expressed in monocyte and 228 other tissues |
ExpressionAtlasi | O60870, baseline and differential |
Genevisiblei | O60870, HS |
Family and domain databases
CDDi | cd13155, KOW_KIN17, 1 hit |
Gene3Di | 1.10.10.2030, 1 hit 2.30.30.30, 1 hit |
InterProi | View protein in InterPro IPR019447, DNA/RNA-bd_Kin17_cons_domain IPR037321, KIN17-like IPR038254, KIN17_WH-like_sf IPR041330, KN17_SH3 IPR041995, KOW_KIN17 IPR014722, Rib_L2_dom2 IPR036236, Znf_C2H2_sf |
PANTHERi | PTHR12805, PTHR12805, 1 hit |
Pfami | View protein in Pfam PF10357, Kin17_mid, 1 hit PF18131, KN17_SH3, 1 hit |
SMARTi | View protein in SMART SM01253, Kin17_mid, 1 hit |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KIN17_HUMAN | |
Accessioni | O60870Primary (citable) accession number: O60870 Secondary accession number(s): B4DX32 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | January 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM