EDF1

Functionⁱ

Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.4 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	92 – 111	H-T-H motifPROSITE-ProRule annotationAdd BLAST		20

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB-KW
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
sequence-specific DNA binding Source: InterPro
TFIID-class transcription factor complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12040021
transcription coactivator activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10567391
- 12040021

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

endothelial cell differentiation
Source: UniProtKB
Traceable author statementⁱ
- 12040021
multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 9813014
positive regulation of DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10567391
positive regulation of transcription, DNA-templated
Source: UniProtKB
Traceable author statementⁱ
- 8164657
regulation of lipid metabolic process
Source: UniProtKB
Traceable author statementⁱ
- 12040021
regulation of transcription, DNA-templated
Source: UniProtKB
Traceable author statementⁱ
- 12040021
- 8164657

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Calmodulin-binding, Developmental protein, DNA-binding
Biological process	Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	O60869

SIGNORⁱ

O60869

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endothelial differentiation-related factor 1 Short name: EDF-1 Alternative name(s): Multiprotein-bridging factor 1 Short name: MBF1
Gene namesⁱ	Name:EDF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000107223.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3164 EDF1
MIMⁱ	605107 gene
neXtProtⁱ	NX_O60869

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	40	T → D: Loss of interaction with CALM; when associated with D-58; D-91 and D-111. 1 Publication	1
Mutagenesisⁱ	58	T → D: Loss of interaction with CALM; when associated with D-40; D-91 and D-111. 1 Publication	1
Mutagenesisⁱ	65	T → D: No effect on CALM-binding. No effect; when associated with D-74. 1 Publication	1
Mutagenesisⁱ	74	T → D: No effect on CALM-binding. No effect; when associated with D-65. 1 Publication	1
Mutagenesisⁱ	87	S → A: No effect on CALM-binding. 1 Publication	1
Mutagenesisⁱ	87	S → D: Loss of interaction with CALM and higher affinity for TBP. Same effect; when associated with D-65 and D-74. 1 Publication	1
Mutagenesisⁱ	91	T → A: No effect on CALM-binding. 1 Publication	1
Mutagenesisⁱ	91	T → D: Partial loss of interaction with CALM. Complete loss of interaction; when associated with D-40; D-58 and D-111. 1 Publication	1
Mutagenesisⁱ	111	S → D: Loss of interaction with CALM; when associated with D-40; D-58 and D-91. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8721
Open Targets More...OpenTargetsⁱ	ENSG00000107223
PharmGKBⁱ	PA27604

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000149795	2 – 148	Endothelial differentiation-related factor 1Add BLAST		147

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	4	PhosphoserineCombined sources	1
Modified residueⁱ	25	N6-methyllysineCombined sources	1

Post-translational modificationⁱ

Phosphorylated (by PKA and PKC).2 Publications

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	O60869
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O60869
PaxDbⁱ	O60869
PeptideAtlas More...PeptideAtlasⁱ	O60869
PRIDEⁱ	O60869
ProteomicsDBⁱ	49636 49637 [O60869-2]
TopDownProteomicsⁱ	O60869-1 [O60869-1]

PTM databases

iPTMnetⁱ	O60869
PhosphoSitePlusⁱ	O60869

Expressionⁱ

Tissue specificityⁱ

Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues.3 Publications

Developmental stageⁱ

Expressed in fetal tissues. More abundant in kidney.1 Publication

Inductionⁱ

Down-regulated by HIV-1 Tat or phorbol ester (TPA) treatment in endothelial cells (at mRNA and protein levels).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000107223 Expressed in 226 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_EDF1
Genevisibleⁱ	O60869 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035642

HPAⁱ

HPA035642

Interactionⁱ

Subunit structureⁱ

Interacts with TBP and the transcription factor IID (TFIID) complex, NR5A2, NR1H3 and PPARG. Interaction with TBP is regulated by phosphorylation. Binds NR5A1, ATF1, FOS and JUN via their conserved basic region. Binding to calmodulin is regulated by calcium and phosphorylation of the IQ motif.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MEOX2	P50222	3	EBI-781301,EBI-748397
NR1H3	Q13133	4	EBI-781301,EBI-781356
NR5A1	Q04752	4	EBI-781310,EBI-850837	From Bos taurus.
NR5A2	O00482	2	EBI-781301,EBI-781320
NS	P03495	2	EBI-781301,EBI-2548993	From Influenza A virus (strain A/Udorn/307/1972 H3N2).
PPARG	P37231	4	EBI-781301,EBI-781384
TBP	P20226	2	EBI-781310,EBI-355371

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB-KW
TFIID-class transcription factor complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12040021

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114260, 26 interactors
IntActⁱ	O60869, 20 interactors
Molecular INTeraction database More...MINTⁱ	O60869
STRINGⁱ	9606.ENSP00000224073

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	76 – 86	Combined sources	11
Turnⁱ	87 – 89	Combined sources	3
Helixⁱ	92 – 99	Combined sources	8
Helixⁱ	103 – 111	Combined sources	9
Helixⁱ	118 – 128	Combined sources	11
Turnⁱ	135 – 138	Combined sources	4
Beta strandⁱ	140 – 143	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	O60869
SMRⁱ	O60869
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O60869

EvolutionaryTraceⁱ

O60869

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	81 – 135	HTH cro/C1-typePROSITE-ProRule annotationAdd BLAST		55

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	37 – 113	Interaction with NR5A2, PPARG and NR1H31 PublicationAdd BLAST		77
Regionⁱ	69 – 108	Interaction with TBP and NR5A11 PublicationAdd BLAST		40

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	81 – 88	IQ motif		8

Domainⁱ

The IQ motif, which is involved in calmodulin binding, overlaps with the binding domain for nuclear receptors and transcription factors. Its phosphorylation probably allows a switch between the two activities of the protein (By similarity).By similarity

Phylogenomic databases

eggNOGⁱ	KOG3398 Eukaryota COG1813 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008519
HOGENOMⁱ	HOG000195726
HOVERGENⁱ	HBG051440
InParanoidⁱ	O60869
KEGG Orthology (KO) More...KOⁱ	K03627
OMAⁱ	IADYECG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RRN
PhylomeDBⁱ	O60869
TreeFamⁱ	TF300064

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00093 HTH_XRE, 1 hit
InterProⁱ	View protein in InterPro IPR001387 Cro/C1-type_HTH IPR010982 Lambda_DNA-bd_dom_sf IPR013729 MBF1_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01381 HTH_3, 1 hit PF08523 MBF1, 1 hit
SMARTⁱ	View protein in SMART SM00530 HTH_XRE, 1 hit
SUPFAMⁱ	SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS50943 HTH_CROC1, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: O60869-1) [UniParc]FASTA Add to basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAESDWDTVT VLRKKGPTAA QAKSKQAILA AQRRGEDVET SKKWAAGQNK 
        60         70         80         90        100
QHSITKNTAK LDRETEELHH DRVTLEVGKV IQQGRQSKGL TQKDLATKIN 
       110        120        130        140 
EKPQVIADYE SGRAIPNNQV LGKIERAIGL KLRGKDIGKP IEKGPRAK

Length:148

Mass (Da):16,369

Last modified:August 1, 1998 - v1

Checksum:ⁱADC2C5384BF85C11

GO

Isoform 2 (identifier: O60869-2) [UniParc]FASTA Add to basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
130-148: LKLRGKDIGKPIEKGPRAK → ECPSTLRRVR

« Hide

        10         20         30         40         50
MAESDWDTVT VLRKKGPTAA QAKSKQAILA AQRRGEDVET SKKWAAGQNK 
        60         70         80         90        100
QHSITKNTAK LDRETEELHH DRVTLEVGKV IQQGRQSKGL TQKDLATKIN 
       110        120        130 
EKPQVIADYE SGRAIPNNQV LGKIERAIGE CPSTLRRVR

Show »

Length:139

Mass (Da):15,481

Checksum:ⁱ9F30DE6890D7E801

GO

Isoform 3 (identifier: O60869-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
129-148: GLKLRGKDIGKPIEKGPRAK → DVGTRSARVLRAQ

« Hide

        10         20         30         40         50
MAESDWDTVT VLRKKGPTAA QAKSKQAILA AQRRGEDVET SKKWAAGQNK 
        60         70         80         90        100
QHSITKNTAK LDRETEELHH DRVTLEVGKV IQQGRQSKGL TQKDLATKIN 
       110        120        130        140 
EKPQVIADYE SGRAIPNNQV LGKIERAIDV GTRSARVLRA Q

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »

Length:141

Mass (Da):15,636

Checksum:ⁱE31C8E26A4679A23

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054701	129 – 148	GLKLR…GPRAK → DVGTRSARVLRAQ in isoform 3. CuratedAdd BLAST		20
Alternative sequenceⁱVSP_013336	130 – 148	LKLRG…GPRAK → ECPSTLRRVR in isoform 2. 1 PublicationAdd BLAST		19

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ005259 mRNA Translation: CAA06446.1 AB002282 mRNA Translation: BAA88073.1 AB002283 mRNA Translation: BAA88074.1 CR541914 mRNA Translation: CAG46712.1 BT009863 mRNA Translation: AAP88865.1 AL355987 Genomic DNA No translation available. BC015500 mRNA Translation: AAH15500.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS65193.1 [O60869-3] CCDS7011.1 [O60869-1] CCDS7012.1 [O60869-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001268226.1, NM_001281297.1 [O60869-3] NP_001268227.1, NM_001281298.1 NP_001268228.1, NM_001281299.1 NP_003783.1, NM_003792.3 [O60869-1] NP_694880.1, NM_153200.2 [O60869-2]
UniGeneⁱ	Hs.174050

Genome annotation databases

Ensemblⁱ	ENST00000224073; ENSP00000224073; ENSG00000107223 [O60869-1] ENST00000371648; ENSP00000360711; ENSG00000107223 [O60869-2] ENST00000371649; ENSP00000360712; ENSG00000107223 [O60869-3]
GeneIDⁱ	8721
KEGGⁱ	hsa:8721
UCSC genome browser More...UCSCⁱ	uc004cjt.3 human [O60869-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O60869	Endothelial differentiation-related factor 1		BOVIN		148	UniRef100_O60869
Endothelial differentiation related factor 1		PONAB		141
LOW QUALITY PROTEIN: endothelial differentiation-related factor 1		ODORO		190
Endothelial differentiation-related factor 1 isoform alpha (Fragment)		MACMU		135
Uncharacterized protein		PROCO		148
+14

Protein	Similar proteins		Species	Score	Length	Source
O60869	Endothelial differentiation-related factor 1		BOVIN		148	UniRef90_O60869
Endothelial differentiation related factor 1		PONAB		141
LOW QUALITY PROTEIN: endothelial differentiation-related factor 1		ODORO		190
Endothelial differentiation-related factor 1 isoform alpha (Fragment)		MACMU		135
Uncharacterized protein		PROCO		148
+14
O60869-2	Isoform 3 of Endothelial differentiation-related factor 1		HUMAN		141	UniRef90_O60869-3
Uncharacterized protein		CALJA		169
Uncharacterized protein		NOMLE		150
EDF1 isoform 2		PANTR		141
Uncharacterized protein		PANPA		115
+18
O60869-3	Uncharacterized protein		CALJA		169	UniRef90_O60869-3
Uncharacterized protein		NOMLE		150
EDF1 isoform 2		PANTR		141
Uncharacterized protein		PANPA		115
Uncharacterized protein		MACMU		141
+18

Protein	Similar proteins		Species	Score	Length	Source
O60869	Endothelial differentiation-related factor 1		BOVIN		148	UniRef50_O60869
Endothelial differentiation-related factor 1		MOUSE		148
Endothelial differentiation-related factor 1		RAT		148
Endothelial differentiation related factor 1		PONAB		141
LOW QUALITY PROTEIN: endothelial differentiation-related factor 1		ODORO		190
+27
O60869-2	Isoform 3 of Endothelial differentiation-related factor 1		HUMAN		141	UniRef50_O60869-3
Uncharacterized protein		CALJA		169
Uncharacterized protein		NOMLE		150
Uncharacterized protein		MACMU		141
Uncharacterized protein		CERAT		141
+49
O60869-3	Uncharacterized protein		CALJA		169	UniRef50_O60869-3
Uncharacterized protein		NOMLE		150
Uncharacterized protein		MACMU		141
Uncharacterized protein		CERAT		141
Uncharacterized protein		PAPAN		141
+49

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ005259 mRNA Translation: CAA06446.1 AB002282 mRNA Translation: BAA88073.1 AB002283 mRNA Translation: BAA88074.1 CR541914 mRNA Translation: CAG46712.1 BT009863 mRNA Translation: AAP88865.1 AL355987 Genomic DNA No translation available. BC015500 mRNA Translation: AAH15500.1
CCDSⁱ	CCDS65193.1 [O60869-3] CCDS7011.1 [O60869-1] CCDS7012.1 [O60869-2]
RefSeqⁱ	NP_001268226.1, NM_001281297.1 [O60869-3] NP_001268227.1, NM_001281298.1 NP_001268228.1, NM_001281299.1 NP_003783.1, NM_003792.3 [O60869-1] NP_694880.1, NM_153200.2 [O60869-2]
UniGeneⁱ	Hs.174050

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1X57	NMR	-	A	71-148	[»]
ProteinModelPortalⁱ	O60869
SMRⁱ	O60869
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114260, 26 interactors
IntActⁱ	O60869, 20 interactors
MINTⁱ	O60869
STRINGⁱ	9606.ENSP00000224073

PTM databases

iPTMnetⁱ	O60869
PhosphoSitePlusⁱ	O60869

Proteomic databases

EPDⁱ	O60869
MaxQBⁱ	O60869
PaxDbⁱ	O60869
PeptideAtlasⁱ	O60869
PRIDEⁱ	O60869
ProteomicsDBⁱ	49636 49637 [O60869-2]
TopDownProteomicsⁱ	O60869-1 [O60869-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8721
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000224073; ENSP00000224073; ENSG00000107223 [O60869-1] ENST00000371648; ENSP00000360711; ENSG00000107223 [O60869-2] ENST00000371649; ENSP00000360712; ENSG00000107223 [O60869-3]
GeneIDⁱ	8721
KEGGⁱ	hsa:8721
UCSCⁱ	uc004cjt.3 human [O60869-1]

Organism-specific databases

CTDⁱ	8721
DisGeNETⁱ	8721
EuPathDBⁱ	HostDB:ENSG00000107223.12
GeneCardsⁱ	EDF1
HGNCⁱ	HGNC:3164 EDF1
HPAⁱ	HPA035642
MIMⁱ	605107 gene
neXtProtⁱ	NX_O60869
OpenTargetsⁱ	ENSG00000107223
PharmGKBⁱ	PA27604
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3398 Eukaryota COG1813 LUCA
GeneTreeⁱ	ENSGT00390000008519
HOGENOMⁱ	HOG000195726
HOVERGENⁱ	HBG051440
InParanoidⁱ	O60869
KOⁱ	K03627
OMAⁱ	IADYECG
OrthoDBⁱ	EOG091G0RRN
PhylomeDBⁱ	O60869
TreeFamⁱ	TF300064

Enzyme and pathway databases

SIGNORⁱ	O60869

SIGNORⁱ

O60869

Miscellaneous databases

ChiTaRSⁱ	EDF1 human
EvolutionaryTraceⁱ	O60869
GeneWikiⁱ	EDF1
GenomeRNAiⁱ	8721
Protein Ontology More...PROⁱ	PR:O60869
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000107223 Expressed in 226 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_EDF1
Genevisibleⁱ	O60869 HS

Family and domain databases

CDDⁱ	cd00093 HTH_XRE, 1 hit
InterProⁱ	View protein in InterPro IPR001387 Cro/C1-type_HTH IPR010982 Lambda_DNA-bd_dom_sf IPR013729 MBF1_N
Pfamⁱ	View protein in Pfam PF01381 HTH_3, 1 hit PF08523 MBF1, 1 hit
SMARTⁱ	View protein in SMART SM00530 HTH_XRE, 1 hit
SUPFAMⁱ	SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS50943 HTH_CROC1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EDF1_HUMAN
Accessionⁱ	O60869Primary (citable) accession number: O60869 Secondary accession number(s): Q5T5T2, Q9UIM1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
	Last sequence update:	August 1, 1998
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniProtKB - O60869 (EDF1_HUMAN)

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Endothelial differentiation-related factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ