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Protein

Growth arrest-specific protein 7

Gene

GAS7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central
  • DNA-binding transcription factor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
O60861

SIGNOR Signaling Network Open Resource

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SIGNORi
O60861

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Growth arrest-specific protein 7
Short name:
GAS-7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GAS7
Synonyms:KIAA0394
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000007237.18

Human Gene Nomenclature Database

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HGNCi
HGNC:4169 GAS7

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603127 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O60861

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with KMT2A/MLL1.1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
8522

Open Targets

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OpenTargetsi
ENSG00000007237

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28583

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GAS7

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760571 – 476Growth arrest-specific protein 7Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei117PhosphoserineCombined sources1
Modified residuei163PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60861

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O60861

PeptideAtlas

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PeptideAtlasi
O60861

PRoteomics IDEntifications database

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PRIDEi
O60861

ProteomicsDB human proteome resource

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ProteomicsDBi
49633
49634 [O60861-1]
49635 [O60861-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60861

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60861

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000007237 Expressed in 244 organ(s), highest expression level in cerebellum

CleanEx database of gene expression profiles

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CleanExi
HS_GAS7

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60861 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60861 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA004838
HPA064678

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
WDYHV1Q96HA84EBI-11745923,EBI-741158

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114094, 23 interactors

Protein interaction database and analysis system

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IntActi
O60861, 21 interactors

Molecular INTeraction database

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MINTi
O60861

STRING: functional protein association networks

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STRINGi
9606.ENSP00000407552

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LX7NMR-A1-60[»]
2YSHNMR-A79-111[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60861

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60861

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O60861

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 62SH3PROSITE-ProRule annotationAdd BLAST62
Domaini77 – 110WWPROSITE-ProRule annotationAdd BLAST34
Domaini196 – 456F-BARPROSITE-ProRule annotationAdd BLAST261

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili309 – 419Sequence analysisAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi67 – 70Poly-Pro4

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0940 Eukaryota
KOG2398 Eukaryota
ENOG410Z5NV LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156268

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000294146

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001320

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60861

KEGG Orthology (KO)

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KOi
K18618

Identification of Orthologs from Complete Genome Data

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OMAi
RHKNSLP

Database of Orthologous Groups

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OrthoDBi
530520at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O60861

TreeFam database of animal gene trees

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TreeFami
TF328986

Family and domain databases

Conserved Domains Database

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CDDi
cd07649 F-BAR_GAS7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR037957 GAS7_F-BAR
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00611 FCH, 1 hit
PF14604 SH3_9, 1 hit
PF00397 WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 1 hit
SM00456 WW, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
SSF51045 SSF51045, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: O60861-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGARCRTLY PFSGERHGQG LRFAAGELIT LLQVPDGGWW EGEKEDGLRG
60 70 80 90 100
WFPASYVQLL EKPGMVPPPP GEESQTVILP PGWQSYLSPQ GRRYYVNTTT
110 120 130 140 150
NETTWERPSS SPGIPASPGS HRSSLPPTVN GYHASGTPAH PPETAHMSVR
160 170 180 190 200
KSTGDSQNLG SSSPSKKQSK ENTITINCVT FPHPDTMPEQ QLLKPTEWSY
210 220 230 240 250
CDYFWADKKD PQGNGTVAGF ELLLQKQLKG KQMQKEMSEF IRERIKIEED
260 270 280 290 300
YAKNLAKLSQ NSLASQEEGS LGEAWAQVKK SLADEAEVHL KFSAKLHSEV
310 320 330 340 350
EKPLMNFREN FKKDMKKCDH HIADLRKQLA SRYASVEKAR KALTERQRDL
360 370 380 390 400
EMKTQQLEIK LSNKTEEDIK KARRKSTQAG DDLMRCVDLY NQAQSKWFEE
410 420 430 440 450
MVTTTLELER LEVERVEMIR QHLCQYTQLR HETDMFNQST VEPVDQLLRK
460 470
VDPAKDRELW VREHKTGNIR PVDMEI
Length:476
Mass (Da):54,371
Last modified:December 16, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57BFB99907652745
GO
Isoform 1 (identifier: O60861-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Show »
Length:412
Mass (Da):47,266
Checksum:iB65049D5F18254A7
GO
Isoform 2 (identifier: O60861-2) [UniParc]FASTAAdd to basket
Also known as: GAS7-CB

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: Missing.
     141-156: PPETAHMSVRKSTGDS → MSNMENSFDDVSCLSP

Show »
Length:336
Mass (Da):39,206
Checksum:iB57E482E417B5F39
GO
Isoform 4 (identifier: O60861-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.
     61-61: E → M

Show »
Length:416
Mass (Da):47,680
Checksum:i56CCB6E52CC680F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS68A0A0A0MS68_HUMAN
Growth arrest-specific protein 7
GAS7
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTB1J3KTB1_HUMAN
Growth arrest-specific protein 7
GAS7
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS47J3KS47_HUMAN
Growth arrest-specific protein 7
GAS7
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLH8J3QLH8_HUMAN
Growth arrest-specific protein 7
GAS7
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS26J3QS26_HUMAN
Growth arrest-specific protein 7
GAS7
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR80J3QR80_HUMAN
Growth arrest-specific protein 7
GAS7
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA23690 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti301E → D in CAA12177 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0068021 – 140Missing in isoform 2. 2 PublicationsAdd BLAST140
Alternative sequenceiVSP_0359881 – 64Missing in isoform 1. 3 PublicationsAdd BLAST64
Alternative sequenceiVSP_0442941 – 60Missing in isoform 4. 2 PublicationsAdd BLAST60
Alternative sequenceiVSP_04429561E → M in isoform 4. 2 Publications1
Alternative sequenceiVSP_006803141 – 156PPETA…STGDS → MSNMENSFDDVSCLSP in isoform 2. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ224876 mRNA Translation: CAA12177.1
AB007854 mRNA Translation: BAA23690.2 Different initiation.
AY327406 mRNA Translation: AAP92798.1
BT006891 mRNA Translation: AAP35537.1
AK292987 mRNA Translation: BAF85676.1
AK315162 mRNA Translation: BAG37606.1
AC000003 Genomic DNA No translation available.
AC005747 Genomic DNA No translation available.
AC026591 Genomic DNA No translation available.
AC083783 Genomic DNA No translation available.
AC107938 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90013.1
CH471108 Genomic DNA Translation: EAW90011.1
CH471108 Genomic DNA Translation: EAW90012.1
BC001152 mRNA Translation: AAH01152.1
BC006454 mRNA Translation: AAH06454.2
AF231998 mRNA Translation: AAG26332.2 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11152.1 [O60861-3]
CCDS42263.1 [O60861-4]
CCDS45611.1 [O60861-2]
CCDS58518.1 [O60861-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001124303.1, NM_001130831.1 [O60861-1]
NP_003635.2, NM_003644.2 [O60861-2]
NP_958836.1, NM_201432.1 [O60861-4]
NP_958839.1, NM_201433.1 [O60861-3]
XP_005256888.1, XM_005256831.3 [O60861-1]
XP_005256889.1, XM_005256832.3 [O60861-1]
XP_011522346.1, XM_011524044.2 [O60861-1]
XP_016880728.1, XM_017025239.1 [O60861-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.462214

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000323816; ENSP00000322608; ENSG00000007237 [O60861-4]
ENST00000432992; ENSP00000407552; ENSG00000007237 [O60861-3]
ENST00000437099; ENSP00000410108; ENSG00000007237 [O60861-1]
ENST00000542249; ENSP00000443265; ENSG00000007237 [O60861-1]
ENST00000579158; ENSP00000463527; ENSG00000007237 [O60861-1]
ENST00000580865; ENSP00000463873; ENSG00000007237 [O60861-2]
ENST00000585266; ENSP00000464240; ENSG00000007237 [O60861-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8522

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8522

UCSC genome browser

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UCSCi
uc002gmg.2 human [O60861-3]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224876 mRNA Translation: CAA12177.1
AB007854 mRNA Translation: BAA23690.2 Different initiation.
AY327406 mRNA Translation: AAP92798.1
BT006891 mRNA Translation: AAP35537.1
AK292987 mRNA Translation: BAF85676.1
AK315162 mRNA Translation: BAG37606.1
AC000003 Genomic DNA No translation available.
AC005747 Genomic DNA No translation available.
AC026591 Genomic DNA No translation available.
AC083783 Genomic DNA No translation available.
AC107938 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90013.1
CH471108 Genomic DNA Translation: EAW90011.1
CH471108 Genomic DNA Translation: EAW90012.1
BC001152 mRNA Translation: AAH01152.1
BC006454 mRNA Translation: AAH06454.2
AF231998 mRNA Translation: AAG26332.2 Sequence problems.
CCDSiCCDS11152.1 [O60861-3]
CCDS42263.1 [O60861-4]
CCDS45611.1 [O60861-2]
CCDS58518.1 [O60861-1]
RefSeqiNP_001124303.1, NM_001130831.1 [O60861-1]
NP_003635.2, NM_003644.2 [O60861-2]
NP_958836.1, NM_201432.1 [O60861-4]
NP_958839.1, NM_201433.1 [O60861-3]
XP_005256888.1, XM_005256831.3 [O60861-1]
XP_005256889.1, XM_005256832.3 [O60861-1]
XP_011522346.1, XM_011524044.2 [O60861-1]
XP_016880728.1, XM_017025239.1 [O60861-1]
UniGeneiHs.462214

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LX7NMR-A1-60[»]
2YSHNMR-A79-111[»]
ProteinModelPortaliO60861
SMRiO60861
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114094, 23 interactors
IntActiO60861, 21 interactors
MINTiO60861
STRINGi9606.ENSP00000407552

PTM databases

iPTMnetiO60861
PhosphoSitePlusiO60861

Polymorphism and mutation databases

BioMutaiGAS7

Proteomic databases

jPOSTiO60861
PaxDbiO60861
PeptideAtlasiO60861
PRIDEiO60861
ProteomicsDBi49633
49634 [O60861-1]
49635 [O60861-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8522
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323816; ENSP00000322608; ENSG00000007237 [O60861-4]
ENST00000432992; ENSP00000407552; ENSG00000007237 [O60861-3]
ENST00000437099; ENSP00000410108; ENSG00000007237 [O60861-1]
ENST00000542249; ENSP00000443265; ENSG00000007237 [O60861-1]
ENST00000579158; ENSP00000463527; ENSG00000007237 [O60861-1]
ENST00000580865; ENSP00000463873; ENSG00000007237 [O60861-2]
ENST00000585266; ENSP00000464240; ENSG00000007237 [O60861-4]
GeneIDi8522
KEGGihsa:8522
UCSCiuc002gmg.2 human [O60861-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8522
DisGeNETi8522
EuPathDBiHostDB:ENSG00000007237.18

GeneCards: human genes, protein and diseases

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GeneCardsi
GAS7
HGNCiHGNC:4169 GAS7
HPAiHPA004838
HPA064678
MIMi603127 gene
neXtProtiNX_O60861
OpenTargetsiENSG00000007237
PharmGKBiPA28583

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0940 Eukaryota
KOG2398 Eukaryota
ENOG410Z5NV LUCA
GeneTreeiENSGT00940000156268
HOGENOMiHOG000294146
HOVERGENiHBG001320
InParanoidiO60861
KOiK18618
OMAiRHKNSLP
OrthoDBi530520at2759
PhylomeDBiO60861
TreeFamiTF328986

Enzyme and pathway databases

SignaLinkiO60861
SIGNORiO60861

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GAS7 human
EvolutionaryTraceiO60861

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GAS7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8522

Protein Ontology

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PROi
PR:O60861

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000007237 Expressed in 244 organ(s), highest expression level in cerebellum
CleanExiHS_GAS7
ExpressionAtlasiO60861 baseline and differential
GenevisibleiO60861 HS

Family and domain databases

CDDicd07649 F-BAR_GAS7, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR037957 GAS7_F-BAR
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF14604 SH3_9, 1 hit
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 1 hit
SM00456 WW, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGAS7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60861
Secondary accession number(s): A8KAC2
, B2RCK9, O43144, Q53Y77, Q7Z571
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 16, 2008
Last modified: January 16, 2019
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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