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Protein

Zymogen granule membrane protein 16

Gene

ZG16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein transport Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport
LigandLectin

Protein family/group databases

UniLectiniO60844

Names & Taxonomyi

Protein namesi
Recommended name:
Zymogen granule membrane protein 16
Short name:
Zymogen granule protein 16
Short name:
hZG16
Alternative name(s):
Secretory lectin ZG16
Gene namesi
Name:ZG16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000174992.7
HGNCiHGNC:30961 ZG16
neXtProtiNX_O60844

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Extracellular matrix, Golgi apparatus, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164727719

Polymorphism and mutation databases

BioMutaiZG16

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
ChainiPRO_000001757017 – 167Zymogen granule membrane protein 16Add BLAST151

Proteomic databases

PaxDbiO60844
PeptideAtlasiO60844
PRIDEiO60844
ProteomicsDBi49629

PTM databases

iPTMnetiO60844
PhosphoSitePlusiO60844

Expressioni

Tissue specificityi

Highly expressed in liver. Detected at lower levels in colon, ileum and jejunum.1 Publication

Gene expression databases

BgeeiENSG00000174992 Expressed in 46 organ(s), highest expression level in sigmoid colon
GenevisibleiO60844 HS

Organism-specific databases

HPAiHPA052066
HPA052512

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi576089, 4 interactors
IntActiO60844, 12 interactors
STRINGi9606.ENSP00000383563

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO60844
SMRiO60844
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60844

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 159Jacalin-type lectinPROSITE-ProRule annotationAdd BLAST136

Sequence similaritiesi

Belongs to the jacalin lectin family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE5W Eukaryota
ENOG41122DQ LUCA
HOGENOMiHOG000015245
HOVERGENiHBG079379
InParanoidiO60844
OrthoDBiEOG091G0Y3H
PhylomeDBiO60844
TreeFamiTF333440

Family and domain databases

Gene3Di2.100.10.30, 1 hit
InterProiView protein in InterPro
IPR001229 Jacalin-like_lectin_dom
IPR036404 Jacalin-like_lectin_dom_sf
IPR033563 ZG16
PANTHERiPTHR33589:SF4 PTHR33589:SF4, 1 hit
PfamiView protein in Pfam
PF01419 Jacalin, 1 hit
SMARTiView protein in SMART
SM00915 Jacalin, 1 hit
SUPFAMiSSF51101 SSF51101, 1 hit
PROSITEiView protein in PROSITE
PS51752 JACALIN_LECTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60844-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTVALLALL CASASGNAIQ ARSSSYSGEY GGGGGKRFSH SGNQLDGPIT
60 70 80 90 100
ALRVRVNTYY IVGLQVRYGK VWSDYVGGRN GDLEEIFLHP GESVIQVSGK
110 120 130 140 150
YKWYLKKLLF VTDKGRYLSF GKDSGTSFNA VPLHPNTVLR FISGRSGSLI
160
DAIGLHWDVY PSSCSRC
Length:167
Mass (Da):18,147
Last modified:April 16, 2014 - v2
Checksum:i247AE2FB4FC180A3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03458732G → S1 PublicationCorresponds to variant dbSNP:rs235636Ensembl.1
Natural variantiVAR_070695109L → V5 Publications1
Natural variantiVAR_034588162S → T. Corresponds to variant dbSNP:rs235638Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB092813 mRNA Translation: BAC20361.1
AK312002 mRNA Translation: BAG34940.1
AK125559 mRNA Translation: BAG54214.1
AC009133 Genomic DNA No translation available.
AC002301 Genomic DNA Translation: AAC08708.1
CH471238 Genomic DNA Translation: EAW80011.1
BC029149 mRNA Translation: AAH29149.1
BC150656 mRNA Translation: AAI50657.1
CCDSiCCDS54000.1
RefSeqiNP_689551.2, NM_152338.3
UniGeneiHs.632195

Genome annotation databases

EnsembliENST00000400752; ENSP00000383563; ENSG00000174992
GeneIDi653808
KEGGihsa:653808
UCSCiuc002dtr.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB092813 mRNA Translation: BAC20361.1
AK312002 mRNA Translation: BAG34940.1
AK125559 mRNA Translation: BAG54214.1
AC009133 Genomic DNA No translation available.
AC002301 Genomic DNA Translation: AAC08708.1
CH471238 Genomic DNA Translation: EAW80011.1
BC029149 mRNA Translation: AAH29149.1
BC150656 mRNA Translation: AAI50657.1
CCDSiCCDS54000.1
RefSeqiNP_689551.2, NM_152338.3
UniGeneiHs.632195

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3APAX-ray1.65A21-159[»]
3VY6X-ray2.00A21-159[»]
3VY7X-ray2.14A21-159[»]
3VZEX-ray1.90A21-159[»]
3VZFX-ray2.80A21-159[»]
3VZGX-ray2.70A21-159[»]
ProteinModelPortaliO60844
SMRiO60844
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi576089, 4 interactors
IntActiO60844, 12 interactors
STRINGi9606.ENSP00000383563

Protein family/group databases

UniLectiniO60844

PTM databases

iPTMnetiO60844
PhosphoSitePlusiO60844

Polymorphism and mutation databases

BioMutaiZG16

Proteomic databases

PaxDbiO60844
PeptideAtlasiO60844
PRIDEiO60844
ProteomicsDBi49629

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400752; ENSP00000383563; ENSG00000174992
GeneIDi653808
KEGGihsa:653808
UCSCiuc002dtr.5 human

Organism-specific databases

CTDi653808
EuPathDBiHostDB:ENSG00000174992.7
GeneCardsiZG16
H-InvDBiHIX0012923
HGNCiHGNC:30961 ZG16
HPAiHPA052066
HPA052512
neXtProtiNX_O60844
PharmGKBiPA164727719
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE5W Eukaryota
ENOG41122DQ LUCA
HOGENOMiHOG000015245
HOVERGENiHBG079379
InParanoidiO60844
OrthoDBiEOG091G0Y3H
PhylomeDBiO60844
TreeFamiTF333440

Miscellaneous databases

EvolutionaryTraceiO60844
GeneWikiiZG16
GenomeRNAii653808
PROiPR:O60844

Gene expression databases

BgeeiENSG00000174992 Expressed in 46 organ(s), highest expression level in sigmoid colon
GenevisibleiO60844 HS

Family and domain databases

Gene3Di2.100.10.30, 1 hit
InterProiView protein in InterPro
IPR001229 Jacalin-like_lectin_dom
IPR036404 Jacalin-like_lectin_dom_sf
IPR033563 ZG16
PANTHERiPTHR33589:SF4 PTHR33589:SF4, 1 hit
PfamiView protein in Pfam
PF01419 Jacalin, 1 hit
SMARTiView protein in SMART
SM00915 Jacalin, 1 hit
SUPFAMiSSF51101 SSF51101, 1 hit
PROSITEiView protein in PROSITE
PS51752 JACALIN_LECTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZG16_HUMAN
AccessioniPrimary (citable) accession number: O60844
Secondary accession number(s): B2R4Z3, B9EK72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: April 16, 2014
Last modified: September 12, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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