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Protein

PRAME family member 11

Gene

PRAMEF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PRAME family member 11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRAMEF11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000239810.3

Human Gene Nomenclature Database

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HGNCi
HGNC:14086 PRAMEF11

neXtProt; the human protein knowledge platform

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neXtProti
NX_O60813

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000239810

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671148

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRAMEF11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001569851 – 478PRAME family member 11Add BLAST478

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O60813

PeptideAtlas

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PeptideAtlasi
O60813

PRoteomics IDEntifications database

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PRIDEi
O60813

ProteomicsDB human proteome resource

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ProteomicsDBi
49606

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60813

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60813

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000239810 Expressed in 4 organ(s), highest expression level in left testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000439551

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60813

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati99 – 126LRR 1; degenerateBy similarityAdd BLAST28
Repeati181 – 205LRR 2; degenerateBy similarityAdd BLAST25
Repeati206 – 232LRR 3; degenerateBy similarityAdd BLAST27
Repeati233 – 268LRR 4; degenerateBy similarityAdd BLAST36
Repeati269 – 294LRR 5By similarityAdd BLAST26
Repeati295 – 326LRR 6By similarityAdd BLAST32
Repeati327 – 347LRR 7By similarityAdd BLAST21
Repeati351 – 378LRR 8By similarityAdd BLAST28
Repeati379 – 403LRR 9By similarityAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PRAME family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410KDY5 Eukaryota
ENOG4111EBM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153708

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231112

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006326

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60813

Identification of Orthologs from Complete Genome Data

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OMAi
FIESSWI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G05PP

TreeFam database of animal gene trees

More...
TreeFami
TF332708

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038286 PRAME, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O60813-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMSIRIPPR LLELAGRSLL RDQALAVSTL EELPTELFPP LFMEAFSRRR
60 70 80 90 100
CEALKLMVQA WPFRRLPLRP LIKMPCLEAF QAVLDGLDAL LTQGVRPRRW
110 120 130 140 150
KLQVLDLQDV CENFWMVWSE AMAHGCFLNA KRNKKPVQDC PRMRGRQPLT
160 170 180 190 200
VFVELWLKNR TLDEYLTCLL LWVKQRRDLL HLCCKKLKIL GMPFRNIRSI
210 220 230 240 250
LKMVNLDCIQ EVEVNCKWIL PILTQFTPYL GHLRNLQKLV LSHMDVSRYV
260 270 280 290 300
SPEQKKEIVT QFTTQFLKLR CLQKLYMNSV SFLEGHLDQL LSCLKTSLKV
310 320 330 340 350
LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV
360 370 380 390 400
AATLEYLDLD DCGIIDSQVN AILPALSRCF ELNTFSFCGN PICMATLENL
410 420 430 440 450
LSHTIILKNL CLELYPAPQE SYGADGTLCW SRFAQIRAEL MKKVRHLRHP
460 470
KRILFCTDNC PDHGDRSFYD LEADQYCC
Length:478
Mass (Da):55,344
Last modified:March 28, 2018 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC22EF55879C975C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135K → T in CAB41252 (Ref. 3) Curated1
Sequence conflicti135K → T in AAI44427 (PubMed:15489334).Curated1
Sequence conflicti145G → E in CAB41252 (Ref. 3) Curated1
Sequence conflicti233L → M in AAI44427 (PubMed:15489334).Curated1
Sequence conflicti412L → V in AAI44427 (PubMed:15489334).Curated1
Sequence conflicti419Q → R in AAI44427 (PubMed:15489334).Curated1
Sequence conflicti442 – 443KK → NR in AAI44427 (PubMed:15489334).Curated2
Sequence conflicti446H → D in AAI44427 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC245034 Genomic DNA No translation available.
BC144426 mRNA Translation: AAI44427.1
AL049680 mRNA Translation: CAB41252.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS53268.2

NCBI Reference Sequences

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RefSeqi
NP_001139816.2, NM_001146344.2
XP_011539781.1, XM_011541479.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.551617

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000619922; ENSP00000480027; ENSG00000239810
ENST00000633392; ENSP00000488512; ENSG00000281934

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
440560

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:440560

UCSC genome browser

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UCSCi
uc031tph.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245034 Genomic DNA No translation available.
BC144426 mRNA Translation: AAI44427.1
AL049680 mRNA Translation: CAB41252.1
CCDSiCCDS53268.2
RefSeqiNP_001139816.2, NM_001146344.2
XP_011539781.1, XM_011541479.2
UniGeneiHs.551617

3D structure databases

ProteinModelPortaliO60813
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000439551

PTM databases

iPTMnetiO60813
PhosphoSitePlusiO60813

Polymorphism and mutation databases

BioMutaiPRAMEF11

Proteomic databases

PaxDbiO60813
PeptideAtlasiO60813
PRIDEiO60813
ProteomicsDBi49606

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000619922; ENSP00000480027; ENSG00000239810
ENST00000633392; ENSP00000488512; ENSG00000281934
GeneIDi440560
KEGGihsa:440560
UCSCiuc031tph.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
440560
EuPathDBiHostDB:ENSG00000239810.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRAMEF11
HGNCiHGNC:14086 PRAMEF11
neXtProtiNX_O60813
OpenTargetsiENSG00000239810
PharmGKBiPA142671148

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KDY5 Eukaryota
ENOG4111EBM LUCA
GeneTreeiENSGT00940000153708
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiO60813
OMAiFIESSWI
OrthoDBiEOG091G05PP
TreeFamiTF332708

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
440560

Protein Ontology

More...
PROi
PR:O60813

Gene expression databases

BgeeiENSG00000239810 Expressed in 4 organ(s), highest expression level in left testis

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRA11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60813
Secondary accession number(s): A0A087WW85, B7ZMC2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 28, 2018
Last modified: December 5, 2018
This is version 120 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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