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Entry version 175 (02 Jun 2021)
Sequence version 1 (01 Aug 1998)
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Protein

Heterogeneous nuclear ribonucleoprotein C-like 1

Gene

HNRNPCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O60812

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein C-like 1
Short name:
hnRNP C-like-1
Alternative name(s):
hnRNP core protein C-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HNRNPCL1
Synonyms:HNRPCL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29295, HNRNPCL1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60812

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000179172.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000179172

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162391240

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O60812, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HNRNPCL1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818481 – 293Heterogeneous nuclear ribonucleoprotein C-like 1Add BLAST293

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60812

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60812

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O60812

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60812

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60812

PeptideAtlas

More...
PeptideAtlasi
O60812

PRoteomics IDEntifications database

More...
PRIDEi
O60812

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49605

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60812

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60812

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O60812

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179172, Expressed in vastus lateralis and 123 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60812, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000179172, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131227, 128 interactors

Protein interaction database and analysis system

More...
IntActi
O60812, 58 interactors

Molecular INTeraction database

More...
MINTi
O60812

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000479365

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O60812, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60812

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 87RRMPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni137 – 177DisorderedSequence analysisAdd BLAST41
Regioni206 – 293DisorderedSequence analysisAdd BLAST88

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili177 – 225Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi145 – 168Polar residuesSequence analysisAdd BLAST24
Compositional biasi206 – 244Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi245 – 263Acidic residuesSequence analysisAdd BLAST19
Compositional biasi271 – 293Acidic residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM HNRPC family. RALY subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0118, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153402

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_079090_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60812

Identification of Orthologs from Complete Genome Data

More...
OMAi
MECEGGA

Database of Orthologous Groups

More...
OrthoDBi
1315388at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60812

TreeFam database of animal gene trees

More...
TreeFami
TF330974

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017347, hnRNP_C
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076, RRM_1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037992, hnRNP-C_Raly, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O60812-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNVTNKMD PHSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIAGCSVHK
60 70 80 90 100
GFAFVQYDKE KNARAAVAGE DGRMIASQVV DINLAAEPKV NRGNAGVKRS
110 120 130 140 150
AAEMYGSSFD LDYGFQRDYY DGMYSFPARV PPPPPIALAV VPSKRQRLSG
160 170 180 190 200
NTSRRGKSGF NSKSGKRGSS KSGKLKGDDL QAIKQELTQI KQKVDSLLEN
210 220 230 240 250
LEKIEKEQSK QEVEVKNAKS EEEQSSSSMK KDETHVKMES EGGAEDSAEE
260 270 280 290
GDPLDDDVNE DQGDDQLELI KDDEKEAEEG EDDRDSTNGQ DDS
Length:293
Mass (Da):32,142
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC87938AE3189D8E2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05982481D → V. Corresponds to variant dbSNP:rs2982092Ensembl.1
Natural variantiVAR_052225208Q → H. Corresponds to variant dbSNP:rs6702447Ensembl.1
Natural variantiVAR_033723258V → D. Corresponds to variant dbSNP:rs2076063Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL022101 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71752.1
BC137258 mRNA Translation: AAI37259.1
BC171866 mRNA Translation: AAI71866.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30591.1

NCBI Reference Sequences

More...
RefSeqi
NP_001013653.1, NM_001013631.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317869; ENSP00000365370; ENSG00000179172
ENST00000634171; ENSP00000488130; ENSG00000282175

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
343069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:343069

UCSC genome browser

More...
UCSCi
uc010obf.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022101 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71752.1
BC137258 mRNA Translation: AAI37259.1
BC171866 mRNA Translation: AAI71866.1
CCDSiCCDS30591.1
RefSeqiNP_001013653.1, NM_001013631.2

3D structure databases

SMRiO60812
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131227, 128 interactors
IntActiO60812, 58 interactors
MINTiO60812
STRINGi9606.ENSP00000479365

PTM databases

iPTMnetiO60812
PhosphoSitePlusiO60812
SwissPalmiO60812

Genetic variation databases

BioMutaiHNRNPCL1

Proteomic databases

EPDiO60812
jPOSTiO60812
MassIVEiO60812
MaxQBiO60812
PaxDbiO60812
PeptideAtlasiO60812
PRIDEiO60812
ProteomicsDBi49605

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
65448, 112 antibodies

The DNASU plasmid repository

More...
DNASUi
343069

Genome annotation databases

EnsembliENST00000317869; ENSP00000365370; ENSG00000179172
ENST00000634171; ENSP00000488130; ENSG00000282175
GeneIDi343069
KEGGihsa:343069
UCSCiuc010obf.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
343069

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HNRNPCL1
HGNCiHGNC:29295, HNRNPCL1
HPAiENSG00000179172, Tissue enhanced (blood)
neXtProtiNX_O60812
OpenTargetsiENSG00000179172
PharmGKBiPA162391240
VEuPathDBiHostDB:ENSG00000179172.8

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0118, Eukaryota
GeneTreeiENSGT00940000153402
HOGENOMiCLU_079090_0_0_1
InParanoidiO60812
OMAiMECEGGA
OrthoDBi1315388at2759
PhylomeDBiO60812
TreeFamiTF330974

Enzyme and pathway databases

PathwayCommonsiO60812

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
343069, 99 hits in 909 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
343069
PharosiO60812, Tdark

Protein Ontology

More...
PROi
PR:O60812
RNActiO60812, protein

Gene expression databases

BgeeiENSG00000179172, Expressed in vastus lateralis and 123 other tissues
GenevisibleiO60812, HS

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR017347, hnRNP_C
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
PfamiView protein in Pfam
PF00076, RRM_1, 1 hit
PIRSFiPIRSF037992, hnRNP-C_Raly, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60812
Secondary accession number(s): B2RP44
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: August 1, 1998
Last modified: June 2, 2021
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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