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Protein

Heterogeneous nuclear ribonucleoprotein C-like 1

Gene

HNRNPCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein C-like 1
Short name:
hnRNP C-like-1
Alternative name(s):
hnRNP core protein C-like 1
Gene namesi
Name:HNRNPCL1
Synonyms:HNRPCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000179172.8
HGNCiHGNC:29295 HNRNPCL1
neXtProtiNX_O60812

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179172
PharmGKBiPA162391240

Polymorphism and mutation databases

BioMutaiHNRNPCL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818481 – 293Heterogeneous nuclear ribonucleoprotein C-like 1Add BLAST293

Proteomic databases

EPDiO60812
MaxQBiO60812
PaxDbiO60812
PeptideAtlasiO60812
PRIDEiO60812
ProteomicsDBi49605

PTM databases

iPTMnetiO60812
PhosphoSitePlusiO60812
SwissPalmiO60812

Expressioni

Gene expression databases

BgeeiENSG00000179172 Expressed in 116 organ(s), highest expression level in vastus lateralis
CleanExiHS_HNRNPCL1
GenevisibleiO60812 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPCL2B2RXH84EBI-1046507,EBI-9512317

Protein-protein interaction databases

BioGridi131227, 99 interactors
IntActiO60812, 34 interactors
MINTiO60812
STRINGi9606.ENSP00000365370

Structurei

3D structure databases

ProteinModelPortaliO60812
SMRiO60812
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 87RRMPROSITE-ProRule annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili177 – 225Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the RRM HNRPC family. RALY subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00390000006718
HOGENOMiHOG000231958
HOVERGENiHBG002302
InParanoidiO60812
OMAiMECEGGA
OrthoDBiEOG091G0O1Q
PhylomeDBiO60812
TreeFamiTF330974

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR017347 hnRNP_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PIRSFiPIRSF037992 hnRNP-C_Raly, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

O60812-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNVTNKMD PHSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIAGCSVHK
60 70 80 90 100
GFAFVQYDKE KNARAAVAGE DGRMIASQVV DINLAAEPKV NRGNAGVKRS
110 120 130 140 150
AAEMYGSSFD LDYGFQRDYY DGMYSFPARV PPPPPIALAV VPSKRQRLSG
160 170 180 190 200
NTSRRGKSGF NSKSGKRGSS KSGKLKGDDL QAIKQELTQI KQKVDSLLEN
210 220 230 240 250
LEKIEKEQSK QEVEVKNAKS EEEQSSSSMK KDETHVKMES EGGAEDSAEE
260 270 280 290
GDPLDDDVNE DQGDDQLELI KDDEKEAEEG EDDRDSTNGQ DDS
Length:293
Mass (Da):32,142
Last modified:August 1, 1998 - v1
Checksum:iC87938AE3189D8E2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05982481D → V. Corresponds to variant dbSNP:rs2982092Ensembl.1
Natural variantiVAR_052225208Q → H. Corresponds to variant dbSNP:rs6702447Ensembl.1
Natural variantiVAR_033723258V → D. Corresponds to variant dbSNP:rs2076063Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022101 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71752.1
BC137258 mRNA Translation: AAI37259.1
BC171866 mRNA Translation: AAI71866.1
CCDSiCCDS30591.1
RefSeqiNP_001013653.1, NM_001013631.2
UniGeneiHs.502617

Genome annotation databases

EnsembliENST00000317869; ENSP00000365370; ENSG00000179172
ENST00000634171; ENSP00000488130; ENSG00000282175
GeneIDi343069
KEGGihsa:343069
UCSCiuc010obf.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022101 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71752.1
BC137258 mRNA Translation: AAI37259.1
BC171866 mRNA Translation: AAI71866.1
CCDSiCCDS30591.1
RefSeqiNP_001013653.1, NM_001013631.2
UniGeneiHs.502617

3D structure databases

ProteinModelPortaliO60812
SMRiO60812
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131227, 99 interactors
IntActiO60812, 34 interactors
MINTiO60812
STRINGi9606.ENSP00000365370

PTM databases

iPTMnetiO60812
PhosphoSitePlusiO60812
SwissPalmiO60812

Polymorphism and mutation databases

BioMutaiHNRNPCL1

Proteomic databases

EPDiO60812
MaxQBiO60812
PaxDbiO60812
PeptideAtlasiO60812
PRIDEiO60812
ProteomicsDBi49605

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317869; ENSP00000365370; ENSG00000179172
ENST00000634171; ENSP00000488130; ENSG00000282175
GeneIDi343069
KEGGihsa:343069
UCSCiuc010obf.2 human

Organism-specific databases

CTDi343069
EuPathDBiHostDB:ENSG00000179172.8
GeneCardsiHNRNPCL1
H-InvDBiHIX0028700
HIX0159705
HGNCiHGNC:29295 HNRNPCL1
neXtProtiNX_O60812
OpenTargetsiENSG00000179172
PharmGKBiPA162391240
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00390000006718
HOGENOMiHOG000231958
HOVERGENiHBG002302
InParanoidiO60812
OMAiMECEGGA
OrthoDBiEOG091G0O1Q
PhylomeDBiO60812
TreeFamiTF330974

Miscellaneous databases

GenomeRNAii343069
PROiPR:O60812

Gene expression databases

BgeeiENSG00000179172 Expressed in 116 organ(s), highest expression level in vastus lateralis
CleanExiHS_HNRNPCL1
GenevisibleiO60812 HS

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR017347 hnRNP_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PIRSFiPIRSF037992 hnRNP-C_Raly, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHNRC1_HUMAN
AccessioniPrimary (citable) accession number: O60812
Secondary accession number(s): B2RP44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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Main funding by: National Institutes of Health

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