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UniProtKB - O60810 (PRAM4_HUMAN)
Protein
PRAME family member 4
Gene
PRAMEF4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- negative regulation of apoptotic process Source: InterPro
- negative regulation of cell differentiation Source: InterPro
- negative regulation of transcription, DNA-templated Source: InterPro
- positive regulation of cell population proliferation Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | O60810 |
Names & Taxonomyi
Protein namesi | Recommended name: PRAME family member 4Imported |
Gene namesi | Name:PRAMEF4Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:31971, PRAMEF4 |
neXtProti | NX_O60810 |
VEuPathDBi | HostDB:ENSG00000243073 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000243073 |
PharmGKBi | PA142671141 |
Miscellaneous databases
Pharosi | O60810, Tdark |
Genetic variation databases
BioMutai | PRAMEF4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156978 | 1 – 478 | PRAME family member 4Add BLAST | 478 |
Proteomic databases
MassIVEi | O60810 |
PaxDbi | O60810 |
PeptideAtlasi | O60810 |
PRIDEi | O60810 |
ProteomicsDBi | 49603 |
PTM databases
iPTMneti | O60810 |
PhosphoSitePlusi | O60810 |
SwissPalmi | O60810 |
Expressioni
Gene expression databases
Bgeei | ENSG00000243073, Expressed in liver and 4 other tissues |
Genevisiblei | O60810, HS |
Organism-specific databases
HPAi | ENSG00000243073, Not detected |
Interactioni
Protein-protein interaction databases
IntActi | O60810, 2 interactors |
MINTi | O60810 |
STRINGi | 9606.ENSP00000235349 |
Miscellaneous databases
RNActi | O60810, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 99 – 126 | LRR 1; degenerateBy similarityAdd BLAST | 28 | |
Repeati | 181 – 205 | LRR 2; degenerateBy similarityAdd BLAST | 25 | |
Repeati | 206 – 232 | LRR 3; degenerateBy similarityAdd BLAST | 27 | |
Repeati | 233 – 268 | LRR 4; degenerateBy similarityAdd BLAST | 36 | |
Repeati | 269 – 294 | LRR 5By similarityAdd BLAST | 26 | |
Repeati | 295 – 326 | LRR 6By similarityAdd BLAST | 32 | |
Repeati | 327 – 347 | LRR 7By similarityAdd BLAST | 21 | |
Repeati | 351 – 378 | LRR 8By similarityAdd BLAST | 28 | |
Repeati | 379 – 403 | LRR 9By similarityAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the PRAME family.Curated
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | ENOG502QWSJ, Eukaryota |
GeneTreei | ENSGT01030000234531 |
HOGENOMi | CLU_039635_2_1_1 |
InParanoidi | O60810 |
OMAi | WPRRCKL |
OrthoDBi | 631249at2759 |
TreeFami | TF332708 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR032675, LRR_dom_sf IPR026271, PRAME_family |
PIRSFi | PIRSF038286, PRAME, 1 hit |
i Sequence
Sequence statusi: Complete.
O60810-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKMSIWTPPR LLELAGRSLL RDQALAMSTL EELPTELFPP LFMEAFSRRR
60 70 80 90 100
CEALKLMVQS WPFRRLPLRP LIKMPCLEAF QAVLDGLDAL LNLGVRPRRW
110 120 130 140 150
KLQVLDLQDV CENFWMVWSE AMAHGCFLNA KRNKKPVEDC PRMKGRQPLT
160 170 180 190 200
VFVELWLKNR TLDEYLTCLL LWVKQRKDLL HLCCKKLKIL GMPFRNIRSI
210 220 230 240 250
LKMVNLDCIQ EVEVNCKWVL PILTQFTPYL GHMRNLQKLI LSHMDVSRYV
260 270 280 290 300
SPEQKKEIVT QFTTQFLKLR CLQKLYMNSV SFLEGHLDQL LSCLKTSLKF
310 320 330 340 350
LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV
360 370 380 390 400
AATLEYLDLD DCGIIDSQVN AILPALSRCF ELNTFSFCGN PICMATLENL
410 420 430 440 450
LSHTIILKNL CVELYPAPRE SYGADGTLCW SRFAQIRAEL MNRVRDLRHP
460 470
KRILFCTDYC PDCGNRSFYD LEADQYCC
Sequence cautioni
The sequence CAB41253 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 144 | K → R in CAB41253 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053607 | 85 | D → E. Corresponds to variant dbSNP:rs4625290Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC245034 Genomic DNA No translation available. AL022101 Genomic DNA No translation available. AL049681 mRNA Translation: CAB41253.1 Different initiation. |
CCDSi | CCDS30592.1 |
RefSeqi | NP_001009611.2, NM_001009611.4 |
Genome annotation databases
Ensembli | ENST00000235349; ENSP00000235349; ENSG00000243073 ENST00000632563; ENSP00000488161; ENSG00000282584 |
GeneIDi | 400735 |
KEGGi | hsa:400735 |
MANE-Selecti | ENST00000235349.6; ENSP00000235349.5; NM_001009611.4; NP_001009611.2 |
UCSCi | uc001aun.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC245034 Genomic DNA No translation available. AL022101 Genomic DNA No translation available. AL049681 mRNA Translation: CAB41253.1 Different initiation. |
CCDSi | CCDS30592.1 |
RefSeqi | NP_001009611.2, NM_001009611.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | O60810, 2 interactors |
MINTi | O60810 |
STRINGi | 9606.ENSP00000235349 |
PTM databases
iPTMneti | O60810 |
PhosphoSitePlusi | O60810 |
SwissPalmi | O60810 |
Genetic variation databases
BioMutai | PRAMEF4 |
Proteomic databases
MassIVEi | O60810 |
PaxDbi | O60810 |
PeptideAtlasi | O60810 |
PRIDEi | O60810 |
ProteomicsDBi | 49603 |
Protocols and materials databases
DNASUi | 400735 |
Genome annotation databases
Ensembli | ENST00000235349; ENSP00000235349; ENSG00000243073 ENST00000632563; ENSP00000488161; ENSG00000282584 |
GeneIDi | 400735 |
KEGGi | hsa:400735 |
MANE-Selecti | ENST00000235349.6; ENSP00000235349.5; NM_001009611.4; NP_001009611.2 |
UCSCi | uc001aun.3, human |
Organism-specific databases
CTDi | 400735 |
GeneCardsi | PRAMEF4 |
HGNCi | HGNC:31971, PRAMEF4 |
HPAi | ENSG00000243073, Not detected |
neXtProti | NX_O60810 |
OpenTargetsi | ENSG00000243073 |
PharmGKBi | PA142671141 |
VEuPathDBi | HostDB:ENSG00000243073 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWSJ, Eukaryota |
GeneTreei | ENSGT01030000234531 |
HOGENOMi | CLU_039635_2_1_1 |
InParanoidi | O60810 |
OMAi | WPRRCKL |
OrthoDBi | 631249at2759 |
TreeFami | TF332708 |
Enzyme and pathway databases
PathwayCommonsi | O60810 |
Miscellaneous databases
BioGRID-ORCSi | 400735, 8 hits in 951 CRISPR screens |
ChiTaRSi | PRAMEF4, human |
GenomeRNAii | 400735 |
Pharosi | O60810, Tdark |
PROi | PR:O60810 |
RNActi | O60810, protein |
Gene expression databases
Bgeei | ENSG00000243073, Expressed in liver and 4 other tissues |
Genevisiblei | O60810, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR032675, LRR_dom_sf IPR026271, PRAME_family |
PIRSFi | PIRSF038286, PRAME, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRAM4_HUMAN | |
Accessioni | O60810Primary (citable) accession number: O60810 Secondary accession number(s): Q5LJB5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 20, 2016 | |
Last modified: | February 23, 2022 | |
This is version 130 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families