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Protein

PRAME family member 4

Gene

PRAMEF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 4Imported
Gene namesi
Name:PRAMEF4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000243073.3
HGNCiHGNC:31971 PRAMEF4
neXtProtiNX_O60810

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000243073
PharmGKBiPA142671141

Polymorphism and mutation databases

BioMutaiPRAMEF4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569781 – 478PRAME family member 4Add BLAST478

Proteomic databases

PaxDbiO60810
PRIDEiO60810
ProteomicsDBi49603

PTM databases

iPTMnetiO60810
PhosphoSitePlusiO60810

Expressioni

Gene expression databases

BgeeiENSG00000243073 Expressed in 2 organ(s), highest expression level in blood
GenevisibleiO60810 HS

Interactioni

Protein-protein interaction databases

IntActiO60810, 1 interactor
MINTiO60810

Structurei

3D structure databases

ProteinModelPortaliO60810
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati99 – 126LRR 1; degenerateBy similarityAdd BLAST28
Repeati181 – 205LRR 2; degenerateBy similarityAdd BLAST25
Repeati206 – 232LRR 3; degenerateBy similarityAdd BLAST27
Repeati233 – 268LRR 4; degenerateBy similarityAdd BLAST36
Repeati269 – 294LRR 5By similarityAdd BLAST26
Repeati295 – 326LRR 6By similarityAdd BLAST32
Repeati327 – 347LRR 7By similarityAdd BLAST21
Repeati351 – 378LRR 8By similarityAdd BLAST28
Repeati379 – 403LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KDY5 Eukaryota
ENOG4111EBM LUCA
GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiO60810
OMAiERTMNEF
OrthoDBiEOG091G05PP
TreeFamiTF332708

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit

Sequencei

Sequence statusi: Complete.

O60810-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMSIWTPPR LLELAGRSLL RDQALAMSTL EELPTELFPP LFMEAFSRRR
60 70 80 90 100
CEALKLMVQS WPFRRLPLRP LIKMPCLEAF QAVLDGLDAL LNLGVRPRRW
110 120 130 140 150
KLQVLDLQDV CENFWMVWSE AMAHGCFLNA KRNKKPVEDC PRMKGRQPLT
160 170 180 190 200
VFVELWLKNR TLDEYLTCLL LWVKQRKDLL HLCCKKLKIL GMPFRNIRSI
210 220 230 240 250
LKMVNLDCIQ EVEVNCKWVL PILTQFTPYL GHMRNLQKLI LSHMDVSRYV
260 270 280 290 300
SPEQKKEIVT QFTTQFLKLR CLQKLYMNSV SFLEGHLDQL LSCLKTSLKF
310 320 330 340 350
LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV
360 370 380 390 400
AATLEYLDLD DCGIIDSQVN AILPALSRCF ELNTFSFCGN PICMATLENL
410 420 430 440 450
LSHTIILKNL CVELYPAPRE SYGADGTLCW SRFAQIRAEL MNRVRDLRHP
460 470
KRILFCTDYC PDCGNRSFYD LEADQYCC
Length:478
Mass (Da):55,439
Last modified:January 20, 2016 - v5
Checksum:i87B63A5E00C24702
GO

Sequence cautioni

The sequence CAB41253 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144K → R in CAB41253 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05360785D → E. Corresponds to variant dbSNP:rs4625290Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245034 Genomic DNA No translation available.
AL022101 Genomic DNA No translation available.
AL049681 mRNA Translation: CAB41253.1 Different initiation.
CCDSiCCDS30592.1
RefSeqiNP_001009611.2, NM_001009611.4
UniGeneiHs.551617

Genome annotation databases

EnsembliENST00000235349; ENSP00000235349; ENSG00000243073
ENST00000632563; ENSP00000488161; ENSG00000282584
GeneIDi400735
KEGGihsa:400735
UCSCiuc001aun.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245034 Genomic DNA No translation available.
AL022101 Genomic DNA No translation available.
AL049681 mRNA Translation: CAB41253.1 Different initiation.
CCDSiCCDS30592.1
RefSeqiNP_001009611.2, NM_001009611.4
UniGeneiHs.551617

3D structure databases

ProteinModelPortaliO60810
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO60810, 1 interactor
MINTiO60810

PTM databases

iPTMnetiO60810
PhosphoSitePlusiO60810

Polymorphism and mutation databases

BioMutaiPRAMEF4

Proteomic databases

PaxDbiO60810
PRIDEiO60810
ProteomicsDBi49603

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000235349; ENSP00000235349; ENSG00000243073
ENST00000632563; ENSP00000488161; ENSG00000282584
GeneIDi400735
KEGGihsa:400735
UCSCiuc001aun.3 human

Organism-specific databases

CTDi400735
EuPathDBiHostDB:ENSG00000243073.3
GeneCardsiPRAMEF4
HGNCiHGNC:31971 PRAMEF4
neXtProtiNX_O60810
OpenTargetsiENSG00000243073
PharmGKBiPA142671141
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KDY5 Eukaryota
ENOG4111EBM LUCA
GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiO60810
OMAiERTMNEF
OrthoDBiEOG091G05PP
TreeFamiTF332708

Miscellaneous databases

PROiPR:O60810

Gene expression databases

BgeeiENSG00000243073 Expressed in 2 organ(s), highest expression level in blood
GenevisibleiO60810 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRAM4_HUMAN
AccessioniPrimary (citable) accession number: O60810
Secondary accession number(s): Q5LJB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 20, 2016
Last modified: November 7, 2018
This is version 112 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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