PRAMEF4

Functionⁱ

GO - Biological processⁱ

negative regulation of apoptotic process Source: InterPro
negative regulation of cell differentiation Source: InterPro
negative regulation of transcription, DNA-templated Source: InterPro
positive regulation of cell proliferation Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PRAME family member 4Imported
Gene namesⁱ	Name:PRAMEF4Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000243073.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31971 PRAMEF4
neXtProtⁱ	NX_O60810

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000243073
PharmGKBⁱ	PA142671141

Polymorphism and mutation databases

BioMutaⁱ	PRAMEF4

BioMutaⁱ

PRAMEF4

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000156978	1 – 478	PRAME family member 4Add BLAST		478

Proteomic databases

PaxDbⁱ	O60810
PRIDEⁱ	O60810
ProteomicsDBⁱ	49603

PTM databases

iPTMnetⁱ	O60810
PhosphoSitePlusⁱ	O60810

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000243073 Expressed in 2 organ(s), highest expression level in blood
Genevisibleⁱ	O60810 HS

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	O60810, 1 interactor
Molecular INTeraction database More...MINTⁱ	O60810

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O60810
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	99 – 126	LRR 1; degenerateBy similarityAdd BLAST	28
Repeatⁱ	181 – 205	LRR 2; degenerateBy similarityAdd BLAST	25
Repeatⁱ	206 – 232	LRR 3; degenerateBy similarityAdd BLAST	27
Repeatⁱ	233 – 268	LRR 4; degenerateBy similarityAdd BLAST	36
Repeatⁱ	269 – 294	LRR 5By similarityAdd BLAST	26
Repeatⁱ	295 – 326	LRR 6By similarityAdd BLAST	32
Repeatⁱ	327 – 347	LRR 7By similarityAdd BLAST	21
Repeatⁱ	351 – 378	LRR 8By similarityAdd BLAST	28
Repeatⁱ	379 – 403	LRR 9By similarityAdd BLAST	25

Sequence similaritiesⁱ

Belongs to the PRAME family.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410KDY5 Eukaryota ENOG4111EBM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119028
HOGENOMⁱ	HOG000231112
HOVERGENⁱ	HBG006326
InParanoidⁱ	O60810
OMAⁱ	ERTMNEF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05PP
TreeFamⁱ	TF332708

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR032675 LRR_dom_sf IPR026271 PRAME_family
PIRSFⁱ	PIRSF038286 PRAME, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O60810-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKMSIWTPPR LLELAGRSLL RDQALAMSTL EELPTELFPP LFMEAFSRRR 
        60         70         80         90        100
CEALKLMVQS WPFRRLPLRP LIKMPCLEAF QAVLDGLDAL LNLGVRPRRW 
       110        120        130        140        150
KLQVLDLQDV CENFWMVWSE AMAHGCFLNA KRNKKPVEDC PRMKGRQPLT 
       160        170        180        190        200
VFVELWLKNR TLDEYLTCLL LWVKQRKDLL HLCCKKLKIL GMPFRNIRSI 
       210        220        230        240        250
LKMVNLDCIQ EVEVNCKWVL PILTQFTPYL GHMRNLQKLI LSHMDVSRYV 
       260        270        280        290        300
SPEQKKEIVT QFTTQFLKLR CLQKLYMNSV SFLEGHLDQL LSCLKTSLKF 
       310        320        330        340        350
LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV 
       360        370        380        390        400
AATLEYLDLD DCGIIDSQVN AILPALSRCF ELNTFSFCGN PICMATLENL 
       410        420        430        440        450
LSHTIILKNL CVELYPAPRE SYGADGTLCW SRFAQIRAEL MNRVRDLRHP 
       460        470 
KRILFCTDYC PDCGNRSFYD LEADQYCC

Length:478

Mass (Da):55,439

Last modified:January 20, 2016 - v5

Checksum:ⁱ87B63A5E00C24702

GO

Sequence cautionⁱ

The sequence CAB41253 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	144	K → R in CAB41253 (Ref. 2) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053607	85	D → E. Corresponds to variant dbSNP:rs4625290Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC245034 Genomic DNA No translation available. AL022101 Genomic DNA No translation available. AL049681 mRNA Translation: CAB41253.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30592.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001009611.2, NM_001009611.4
UniGeneⁱ	Hs.551617

Genome annotation databases

Ensemblⁱ	ENST00000235349; ENSP00000235349; ENSG00000243073 ENST00000632563; ENSP00000488161; ENSG00000282584
GeneIDⁱ	400735
KEGGⁱ	hsa:400735
UCSC genome browser More...UCSCⁱ	uc001aun.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O60810	PRAME family member 11		HUMAN		478	UniRef90_O60810
PRAMEF15 isoform 1		PANTR		478
Uncharacterized protein		GORGO		478
PRAMEF5 isoform 1		PONAB		475
PRAME family member 25		HUMAN		478
+15

Protein	Similar proteins		Species	Score	Length	Source
O60810	PRAME family member 9/15		HUMAN		478	UniRef50_O60810
PRAMEF15 isoform 1		PANTR		478
Uncharacterized protein		GORGO		478
PRAMEF5 isoform 1		PONAB		475
Uncharacterized protein		PROCO		479
+404

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC245034 Genomic DNA No translation available. AL022101 Genomic DNA No translation available. AL049681 mRNA Translation: CAB41253.1 Different initiation.
CCDSⁱ	CCDS30592.1
RefSeqⁱ	NP_001009611.2, NM_001009611.4
UniGeneⁱ	Hs.551617

3D structure databases

ProteinModelPortalⁱ	O60810
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	O60810, 1 interactor
MINTⁱ	O60810

PTM databases

iPTMnetⁱ	O60810
PhosphoSitePlusⁱ	O60810

Polymorphism and mutation databases

BioMutaⁱ	PRAMEF4

BioMutaⁱ

PRAMEF4

Proteomic databases

PaxDbⁱ	O60810
PRIDEⁱ	O60810
ProteomicsDBⁱ	49603

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000235349; ENSP00000235349; ENSG00000243073 ENST00000632563; ENSP00000488161; ENSG00000282584
GeneIDⁱ	400735
KEGGⁱ	hsa:400735
UCSCⁱ	uc001aun.3 human

Organism-specific databases

CTDⁱ	400735
EuPathDBⁱ	HostDB:ENSG00000243073.3
GeneCardsⁱ	PRAMEF4
HGNCⁱ	HGNC:31971 PRAMEF4
neXtProtⁱ	NX_O60810
OpenTargetsⁱ	ENSG00000243073
PharmGKBⁱ	PA142671141
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410KDY5 Eukaryota ENOG4111EBM LUCA
GeneTreeⁱ	ENSGT00760000119028
HOGENOMⁱ	HOG000231112
HOVERGENⁱ	HBG006326
InParanoidⁱ	O60810
OMAⁱ	ERTMNEF
OrthoDBⁱ	EOG091G05PP
TreeFamⁱ	TF332708

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O60810

PROⁱ

PR:O60810

Gene expression databases

Bgeeⁱ	ENSG00000243073 Expressed in 2 organ(s), highest expression level in blood
Genevisibleⁱ	O60810 HS

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR032675 LRR_dom_sf IPR026271 PRAME_family
PIRSFⁱ	PIRSF038286 PRAME, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRAM4_HUMAN
Accessionⁱ	O60810Primary (citable) accession number: O60810 Secondary accession number(s): Q5LJB5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	January 20, 2016
	Last modified:	November 7, 2018
	This is version 112 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O60810 (PRAM4_HUMAN)

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PRAME family member 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ