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Protein

Target of Myb protein 1

Gene

TOM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in intracellular trafficking. Probable association with membranes.

GO - Molecular functioni

  • clathrin binding Source: UniProtKB

GO - Biological processi

  • endocytosis Source: UniProtKB
  • endosomal transport Source: UniProtKB
  • intracellular protein transport Source: InterPro
  • neutrophil degranulation Source: Reactome
  • protein transport Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Target of Myb protein 1
Gene namesi
Name:TOM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100284.20
HGNCiHGNC:11982 TOM1
MIMi604700 gene
neXtProtiNX_O60784

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10043
OpenTargetsiENSG00000100284
PharmGKBiPA36666

Polymorphism and mutation databases

BioMutaiTOM1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726281 – 492Target of Myb protein 1Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei164PhosphothreonineCombined sources1
Modified residuei176PhosphoserineBy similarity1
Modified residuei180PhosphoserineBy similarity1
Modified residuei355PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Cross-linki385Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei461PhosphoserineCombined sources1
Modified residuei462PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO60784
MaxQBiO60784
PaxDbiO60784
PeptideAtlasiO60784
PRIDEiO60784
ProteomicsDBi49597
49598 [O60784-2]
49599 [O60784-3]
49600 [O60784-4]
TopDownProteomicsiO60784-2 [O60784-2]

PTM databases

iPTMnetiO60784
PhosphoSitePlusiO60784

Miscellaneous databases

PMAP-CutDBiO60784

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in skeletal muscle, heart, placenta and liver.1 Publication

Gene expression databases

BgeeiENSG00000100284 Expressed in 165 organ(s), highest expression level in gastrocnemius
CleanExiHS_TOM1
ExpressionAtlasiO60784 baseline and differential
GenevisibleiO60784 HS

Organism-specific databases

HPAiHPA000818
HPA001749

Interactioni

Subunit structurei

Interacts with ZFYVE16; interaction is required to target it to endosomes.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115354, 43 interactors
DIPiDIP-30844N
IntActiO60784, 23 interactors
MINTiO60784
STRINGi9606.ENSP00000413697

Structurei

Secondary structure

1492
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO60784
SMRiO60784
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60784

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 152VHSPROSITE-ProRule annotationAdd BLAST133
Domaini215 – 303GATPROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Belongs to the TOM1 family.Curated

Phylogenomic databases

eggNOGiKOG1087 Eukaryota
ENOG410Y26G LUCA
GeneTreeiENSGT00930000150885
HOGENOMiHOG000285970
HOVERGENiHBG025068
InParanoidiO60784
OMAiQGNPFAT
OrthoDBiEOG091G08M1
PhylomeDBiO60784
TreeFamiTF314105

Family and domain databases

Gene3Di1.20.58.160, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR004152 GAT_dom
IPR038425 GAT_sf
IPR014645 TOM1
IPR002014 VHS_dom
PfamiView protein in Pfam
PF03127 GAT, 1 hit
PF00790 VHS, 1 hit
PIRSFiPIRSF036948 TOM1, 1 hit
SMARTiView protein in SMART
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50909 GAT, 1 hit
PS50179 VHS, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60784-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA
60 70 80 90 100
LRAVKKRIVG NKNFHEVMLA LTVLETCVKN CGHRFHVLVA SQDFVESVLV
110 120 130 140 150
RTILPKNNPP TIVHDKVLNL IQSWADAFRS SPDLTGVVTI YEDLRRKGLE
160 170 180 190 200
FPMTDLDMLS PIHTPQRTVF NSETQSGQDS VGTDSSQQED SGQHAAPLPA
210 220 230 240 250
PPILSGDTPI APTPEQIGKL RSELEMVSGN VRVMSEMLTE LVPTQAEPAD
260 270 280 290 300
LELLQELNRT CRAMQQRVLE LIPQIANEQL TEELLIVNDN LNNVFLRHER
310 320 330 340 350
FERFRTGQTT KAPSEAEPAA DLIDMGPDPA ATGNLSSQLA GMNLGSSSVR
360 370 380 390 400
AGLQSLEASG RLEDEFDMFA LTRGSSLADQ RKEVKYEAPQ ATDGLAGALD
410 420 430 440 450
ARQQSTGAIP VTQACLMEDI EQWLSTDVGN DAEEPKGVTS EEFDKFLEER
460 470 480 490
AKAADRLPNL SSPSAEGPPG PPSGPAPRKK TQEKDDDMLF AL
Length:492
Mass (Da):53,818
Last modified:August 1, 1999 - v2
Checksum:iC7D77B5669476242
GO
Isoform 2 (identifier: O60784-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     441-442: EE → EGK

Note: No experimental confirmation available.
Show »
Length:493
Mass (Da):53,875
Checksum:i01BB90C04783CC89
GO
Isoform 3 (identifier: O60784-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-167: Missing.

Note: No experimental confirmation available.
Show »
Length:447
Mass (Da):48,673
Checksum:i457262C1877D9580
GO
Isoform 4 (identifier: O60784-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     441-442: EE → EGK

Note: No experimental confirmation available.
Show »
Length:460
Mass (Da):50,269
Checksum:i2203E9E4F1835281
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6UW50Q6UW50_HUMAN
TOM1
TOM1 UNQ1844
209Annotation score:
B0QY01B0QY01_HUMAN
Target of Myb protein 1
TOM1
334Annotation score:
B0QY02B0QY02_HUMAN
Target of Myb protein 1
TOM1
151Annotation score:
H7BYN7H7BYN7_HUMAN
Target of Myb protein 1
TOM1
133Annotation score:
F8WE29F8WE29_HUMAN
Target of Myb protein 1
TOM1
83Annotation score:
V9GZ68V9GZ68_HUMAN
Target of Myb protein 1
TOM1
125Annotation score:
V9GYF4V9GYF4_HUMAN
Target of Myb protein 1
TOM1
134Annotation score:
F8WBB0F8WBB0_HUMAN
Target of Myb protein 1
TOM1
97Annotation score:
F8WAW7F8WAW7_HUMAN
Target of Myb protein 1
TOM1
69Annotation score:
F8WB30F8WB30_HUMAN
Target of Myb protein 1
TOM1
25Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215E → G in BAG60163 (PubMed:14702039).Curated1
Sequence conflicti249A → V in BAG57130 (PubMed:14702039).Curated1
Sequence conflicti346S → P in BAG60163 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05384584R → H. Corresponds to variant dbSNP:rs11558473Ensembl.1
Natural variantiVAR_034567264M → V. Corresponds to variant dbSNP:rs34371697Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0383641 – 33Missing in isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_038365123 – 167Missing in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_038366441 – 442EE → EGK in isoform 2 and isoform 4. 2 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006973 mRNA Translation: CAA07362.1
CR456595 mRNA Translation: CAG30481.1
AK293694 mRNA Translation: BAG57130.1
AK297827 mRNA Translation: BAG60163.1
AL008635 Genomic DNA No translation available.
Z82244 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60055.1
BC046151 mRNA Translation: AAH46151.1
CCDSiCCDS13913.1 [O60784-1]
CCDS46696.1 [O60784-2]
CCDS46697.1 [O60784-3]
CCDS46698.1 [O60784-4]
RefSeqiNP_001129201.1, NM_001135729.1 [O60784-4]
NP_001129202.1, NM_001135730.1 [O60784-3]
NP_001129204.1, NM_001135732.1 [O60784-2]
NP_005479.1, NM_005488.2 [O60784-1]
UniGeneiHs.474705

Genome annotation databases

EnsembliENST00000411850; ENSP00000413697; ENSG00000100284 [O60784-2]
ENST00000425375; ENSP00000394924; ENSG00000100284 [O60784-3]
ENST00000447733; ENSP00000398876; ENSG00000100284 [O60784-4]
ENST00000449058; ENSP00000394466; ENSG00000100284 [O60784-1]
GeneIDi10043
KEGGihsa:10043
UCSCiuc003ann.3 human [O60784-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006973 mRNA Translation: CAA07362.1
CR456595 mRNA Translation: CAG30481.1
AK293694 mRNA Translation: BAG57130.1
AK297827 mRNA Translation: BAG60163.1
AL008635 Genomic DNA No translation available.
Z82244 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60055.1
BC046151 mRNA Translation: AAH46151.1
CCDSiCCDS13913.1 [O60784-1]
CCDS46696.1 [O60784-2]
CCDS46697.1 [O60784-3]
CCDS46698.1 [O60784-4]
RefSeqiNP_001129201.1, NM_001135729.1 [O60784-4]
NP_001129202.1, NM_001135730.1 [O60784-3]
NP_001129204.1, NM_001135732.1 [O60784-2]
NP_005479.1, NM_005488.2 [O60784-1]
UniGeneiHs.474705

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ELKX-ray1.50A/B1-153[»]
1WRDX-ray1.75A215-312[»]
2N2NNMR-A215-309[»]
2N9DNMR-A215-309[»]
ProteinModelPortaliO60784
SMRiO60784
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115354, 43 interactors
DIPiDIP-30844N
IntActiO60784, 23 interactors
MINTiO60784
STRINGi9606.ENSP00000413697

PTM databases

iPTMnetiO60784
PhosphoSitePlusiO60784

Polymorphism and mutation databases

BioMutaiTOM1

Proteomic databases

EPDiO60784
MaxQBiO60784
PaxDbiO60784
PeptideAtlasiO60784
PRIDEiO60784
ProteomicsDBi49597
49598 [O60784-2]
49599 [O60784-3]
49600 [O60784-4]
TopDownProteomicsiO60784-2 [O60784-2]

Protocols and materials databases

DNASUi10043
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000411850; ENSP00000413697; ENSG00000100284 [O60784-2]
ENST00000425375; ENSP00000394924; ENSG00000100284 [O60784-3]
ENST00000447733; ENSP00000398876; ENSG00000100284 [O60784-4]
ENST00000449058; ENSP00000394466; ENSG00000100284 [O60784-1]
GeneIDi10043
KEGGihsa:10043
UCSCiuc003ann.3 human [O60784-1]

Organism-specific databases

CTDi10043
DisGeNETi10043
EuPathDBiHostDB:ENSG00000100284.20
GeneCardsiTOM1
H-InvDBiHIX0175450
HGNCiHGNC:11982 TOM1
HPAiHPA000818
HPA001749
MIMi604700 gene
neXtProtiNX_O60784
OpenTargetsiENSG00000100284
PharmGKBiPA36666
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1087 Eukaryota
ENOG410Y26G LUCA
GeneTreeiENSGT00930000150885
HOGENOMiHOG000285970
HOVERGENiHBG025068
InParanoidiO60784
OMAiQGNPFAT
OrthoDBiEOG091G08M1
PhylomeDBiO60784
TreeFamiTF314105

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiTOM1 human
EvolutionaryTraceiO60784
GeneWikiiTOM1
GenomeRNAii10043
PMAP-CutDBiO60784
PROiPR:O60784
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100284 Expressed in 165 organ(s), highest expression level in gastrocnemius
CleanExiHS_TOM1
ExpressionAtlasiO60784 baseline and differential
GenevisibleiO60784 HS

Family and domain databases

Gene3Di1.20.58.160, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR004152 GAT_dom
IPR038425 GAT_sf
IPR014645 TOM1
IPR002014 VHS_dom
PfamiView protein in Pfam
PF03127 GAT, 1 hit
PF00790 VHS, 1 hit
PIRSFiPIRSF036948 TOM1, 1 hit
SMARTiView protein in SMART
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50909 GAT, 1 hit
PS50179 VHS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOM1_HUMAN
AccessioniPrimary (citable) accession number: O60784
Secondary accession number(s): B4DEL9
, B4DNA1, Q5TIJ6, Q86X74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: August 1, 1999
Last modified: November 7, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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