SLC19A2

Protein namesⁱ	Recommended name: Thiamine transporter 1 Short name: ThTr-1 Short name: ThTr1 Alternative name(s): Solute carrier family 19 member 2 Thiamine carrier 1 Short name: TC1
Gene namesⁱ	Name:SLC19A2 Synonyms:THT1, TRMA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000117479.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10938 SLC19A2
MIMⁱ	603941 gene
neXtProtⁱ	NX_O60779

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 28	CytoplasmicSequence analysisAdd BLAST	28
Transmembraneⁱ	29 – 46	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	47 – 72	ExtracellularSequence analysisAdd BLAST	26
Transmembraneⁱ	73 – 91	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	92 – 99	CytoplasmicSequence analysis	8
Transmembraneⁱ	100 – 118	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	119 – 128	ExtracellularSequence analysis	10
Transmembraneⁱ	129 – 149	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	150 – 165	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	166 – 185	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	186 – 191	ExtracellularSequence analysis	6
Transmembraneⁱ	192 – 208	HelicalSequence analysisAdd BLAST	17
Topological domainⁱ	209 – 285	CytoplasmicSequence analysisAdd BLAST	77
Transmembraneⁱ	286 – 310	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	311 – 337	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	338 – 354	HelicalSequence analysisAdd BLAST	17
Topological domainⁱ	355 – 363	CytoplasmicSequence analysis	9
Transmembraneⁱ	364 – 380	HelicalSequence analysisAdd BLAST	17
Topological domainⁱ	381 – 386	ExtracellularSequence analysis	6
Transmembraneⁱ	387 – 409	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	410 – 419	CytoplasmicSequence analysis	10
Transmembraneⁱ	420 – 443	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	444 – 455	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	456 – 479	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	480 – 497	CytoplasmicSequence analysisAdd BLAST	18

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Thiamine-responsive megaloblastic anemia syndrome (TRMA)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disease characterized by megaloblastic anemia, diabetes mellitus, and sensorineural deafness. Onset is typically between infancy and adolescence, but all of the cardinal findings are often not present initially. The anemia, and sometimes the diabetes, improves with high doses of thiamine. Other more variable features include optic atrophy, congenital heart defects, short stature, and stroke.

Keywords - Diseaseⁱ

Deafness, Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10560
GeneReviewsⁱ	SLC19A2
MalaCards human disease database More...MalaCardsⁱ	SLC19A2
MIMⁱ	249270 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000117479
Orphanetⁱ	49827 Thiamine-responsive megaloblastic anemia syndrome
PharmGKBⁱ	PA35825

Chemistry databases

ChEMBLⁱ	CHEMBL3079
Drug and drug target database More...DrugBankⁱ	DB00152 Thiamine

Polymorphism and mutation databases

BioMutaⁱ	SLC19A2

BioMutaⁱ

SLC19A2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000178663	1 – 497	Thiamine transporter 1Add BLAST		497

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Glycosylationⁱ	63	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	222	PhosphoserineCombined sources	1
Glycosylationⁱ	314	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	O60779
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O60779
PaxDbⁱ	O60779
PeptideAtlas More...PeptideAtlasⁱ	O60779
PRIDEⁱ	O60779
ProteomicsDBⁱ	49594 49595 [O60779-2]

PTM databases

iPTMnetⁱ	O60779
PhosphoSitePlusⁱ	O60779

Expressionⁱ

Tissue specificityⁱ

Ubiquitous; most abundant in skeletal and cardiac muscle. Medium expression in placenta, heart, liver and kidney, low in lung.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000117479 Expressed in 219 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_SLC19A2
ExpressionAtlasⁱ	O60779 baseline and differential
Genevisibleⁱ	O60779 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA006119 HPA016599

HPAⁱ

HPA006119
HPA016599

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	115811, 42 interactors
IntActⁱ	O60779, 1 interactor
STRINGⁱ	9606.ENSP00000236137

Chemistry databases

BindingDBⁱ

O60779

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O60779
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3810 Eukaryota ENOG410XT34 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046382
HOVERGENⁱ	HBG054198
InParanoidⁱ	O60779
KEGG Orthology (KO) More...KOⁱ	K14610
OMAⁱ	LVRYKPV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BSJ
PhylomeDBⁱ	O60779
TreeFamⁱ	TF313684

Family and domain databases

InterProⁱ	View protein in InterPro IPR002666 Folate_carrier IPR036259 MFS_trans_sf IPR028338 ThTr-1
PANTHERⁱ	PTHR10686 PTHR10686, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01770 Folate_carrier, 1 hit
PIRSFⁱ	PIRSF028739 Folate_carrier, 1 hit PIRSF500794 Thiamine_transporter_1, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: O60779-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVPGPVSRR AAAAAATVLL RTARVRRECW FLPTALLCAY GFFASLRPSE 
        60         70         80         90        100
PFLTPYLLGP DKNLTEREVF NEIYPVWTYS YLVLLFPVFL ATDYLRYKPV 
       110        120        130        140        150
VLLQGLSLIV TWFMLLYAQG LLAIQFLEFF YGIATATEIA YYSYIYSVVD 
       160        170        180        190        200
LGMYQKVTSY CRSATLVGFT VGSVLGQILV SVAGWSLFSL NVISLTCVSV 
       210        220        230        240        250
AFAVAWFLPM PQKSLFFHHI PSTCQRVNGI KVQNGGIVTD TPASNHLPGW 
       260        270        280        290        300
EDIESKIPLN MEEPPVEEPE PKPDRLLVLK VLWNDFLMCY SSRPLLCWSV 
       310        320        330        340        350
WWALSTCGYF QVVNYTQGLW EKVMPSRYAA IYNGGVEAVS TLLGAVAVFA 
       360        370        380        390        400
VGYIKISWST WGEMTLSLFS LLIAAAVYIM DTVGNIWVCY ASYVVFRIIY 
       410        420        430        440        450
MLLITIATFQ IAANLSMERY ALVFGVNTFI ALALQTLLTL IVVDASGLGL 
       460        470        480        490 
EITTQFLIYA SYFALIAVVF LASGAVSVMK KCRKLEDPQS SSQVTTS

Length:497

Mass (Da):55,400

Last modified:January 24, 2001 - v2

Checksum:ⁱ87A993E2B6FBFE96

GO

Isoform 2 (identifier: O60779-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
69-269: Missing.

« Hide

        10         20         30         40         50
MDVPGPVSRR AAAAAATVLL RTARVRRECW FLPTALLCAY GFFASLRPSE 
        60         70         80         90        100
PFLTPYLLGP DKNLTEREEP KPDRLLVLKV LWNDFLMCYS SRPLLCWSVW 
       110        120        130        140        150
WALSTCGYFQ VVNYTQGLWE KVMPSRYAAI YNGGVEAVST LLGAVAVFAV 
       160        170        180        190        200
GYIKISWSTW GEMTLSLFSL LIAAAVYIMD TVGNIWVCYA SYVVFRIIYM 
       210        220        230        240        250
LLITIATFQI AANLSMERYA LVFGVNTFIA LALQTLLTLI VVDASGLGLE 
       260        270        280        290 
ITTQFLIYAS YFALIAVVFL ASGAVSVMKK CRKLEDPQSS SQVTTS

Show »

Length:296

Mass (Da):32,858

Checksum:ⁱA8C5CDFF6D54540C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A2R8Y5B5	A0A2R8Y5B5_HUMAN		Solute carrier family 19 (Thiamine ... Solute carrier family 19 (Thiamine transporter), member 2, isoform CRA_b (Thiamine transporter 1)	SLC19A2 hCG_38014	464	Annotation score:

Sequence cautionⁱ

The sequence BAG64936 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_010249	93	D → H in TRMA. 1 Publication	1
Natural variantⁱVAR_010250	143	S → F in TRMA. 1 PublicationCorresponds to variant dbSNP:rs761957186EnsemblClinVar.	1
Natural variantⁱVAR_010248	172	G → D in TRMA. 1 PublicationCorresponds to variant dbSNP:rs28937595EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_036467	69 – 269	Missing in isoform 2. 1 PublicationAdd BLAST		201

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF160812 mRNA Translation: AAF15129.1 AJ238413 Genomic DNA Translation: CAB50771.1 AJ237724 mRNA Translation: CAB50770.1 AF135488 mRNA Translation: AAD45985.1 AF158233 Genomic DNA Translation: AAD51280.1 Sequence problems. AF160186 Genomic DNA Translation: AAD51283.1 Sequence problems. AF160756 Genomic DNA Translation: AAD54242.1 AF153330 mRNA Translation: AAD43534.1 AF272359 mRNA Translation: AAK54468.1 AK304021 mRNA Translation: BAG64936.1 Different initiation. AK313779 mRNA Translation: BAG36517.1 AK316465 mRNA Translation: BAH14836.1 AL021068 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90843.1 CH471067 Genomic DNA Translation: EAW90846.1 BC018514 mRNA Translation: AAH18514.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1280.1 [O60779-1] CCDS81398.1 [O60779-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001306596.1, NM_001319667.1 [O60779-2] NP_008927.1, NM_006996.2 [O60779-1]
UniGeneⁱ	Hs.30246

Genome annotation databases

Ensemblⁱ	ENST00000236137; ENSP00000236137; ENSG00000117479 [O60779-1] ENST00000367804; ENSP00000356778; ENSG00000117479 [O60779-2] ENST00000646527; ENSP00000495500; ENSG00000117479 [O60779-1]
GeneIDⁱ	10560
KEGGⁱ	hsa:10560
UCSC genome browser More...UCSCⁱ	uc001gge.5 human [O60779-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O60779	Solute carrier family 19 (Thiamine transporter), member 2, isoform CRA_a		HUMAN		497	UniRef100_O60779
SLC19A2 isoform 1		PANTR		497
Uncharacterized protein		PANPA		497
O60779-2	Solute carrier family 19 (Thiamine transporter), member 2, isoform CRA_c		HUMAN		296	UniRef100_A0A024R8Y5
SLC19A2 isoform 2		PANTR		296
Uncharacterized protein		PANPA		296
Solute carrier family 19 member 2		GORGO		296

Protein	Similar proteins		Species	Score	Length	Source
O60779	Solute carrier family 19 (Thiamine transporter), member 2, isoform CRA_a		HUMAN		497	UniRef90_O60779
SLC19A2 isoform 1		PANTR		497
Uncharacterized protein		PANPA		497
Solute carrier family 19 member 2		SAIBB		498
Uncharacterized protein		AOTNA		498
+45
O60779-2	Uncharacterized protein		ICTTR		296	UniRef90_I3N5R6
Solute carrier family 19 member 2		SAIBB		297
Uncharacterized protein		Cebus capucinus imitator		297
Uncharacterized protein		AOTNA		297
Solute carrier family 19 (Thiamine transporter), member 2, isoform CRA_c		HUMAN		296
+21

Protein	Similar proteins		Species	Score	Length	Source
O60779	Thiamine transporter 1		MOUSE		498	UniRef50_O60779
Solute carrier family 19 (Thiamine transporter), member 2, isoform CRA_a		HUMAN		497
SLC19A2 isoform 1		PANTR		497
Uncharacterized protein		PANPA		497
Solute carrier family 19 member 2		SAIBB		498
+194
O60779-2	Solute carrier family 19 member 2 (Fragment)		RAT		256	UniRef50_A0A096MJN0
Thiamine transporter 1		MOUSE		297
Uncharacterized protein		RHIBE		294
Solute carrier family 19 member 2		SAIBB		297
Uncharacterized protein		Cebus capucinus imitator		297
+30

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF160812 mRNA Translation: AAF15129.1 AJ238413 Genomic DNA Translation: CAB50771.1 AJ237724 mRNA Translation: CAB50770.1 AF135488 mRNA Translation: AAD45985.1 AF158233 Genomic DNA Translation: AAD51280.1 Sequence problems. AF160186 Genomic DNA Translation: AAD51283.1 Sequence problems. AF160756 Genomic DNA Translation: AAD54242.1 AF153330 mRNA Translation: AAD43534.1 AF272359 mRNA Translation: AAK54468.1 AK304021 mRNA Translation: BAG64936.1 Different initiation. AK313779 mRNA Translation: BAG36517.1 AK316465 mRNA Translation: BAH14836.1 AL021068 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90843.1 CH471067 Genomic DNA Translation: EAW90846.1 BC018514 mRNA Translation: AAH18514.1
CCDSⁱ	CCDS1280.1 [O60779-1] CCDS81398.1 [O60779-2]
RefSeqⁱ	NP_001306596.1, NM_001319667.1 [O60779-2] NP_008927.1, NM_006996.2 [O60779-1]
UniGeneⁱ	Hs.30246

3D structure databases

ProteinModelPortalⁱ	O60779
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115811, 42 interactors
IntActⁱ	O60779, 1 interactor
STRINGⁱ	9606.ENSP00000236137

Chemistry databases

BindingDBⁱ	O60779
ChEMBLⁱ	CHEMBL3079
DrugBankⁱ	DB00152 Thiamine

Protein family/group databases

TCDBⁱ	2.A.48.1.2 the reduced folate carrier (rfc) family

TCDBⁱ

2.A.48.1.2 the reduced folate carrier (rfc) family

PTM databases

iPTMnetⁱ	O60779
PhosphoSitePlusⁱ	O60779

Polymorphism and mutation databases

BioMutaⁱ	SLC19A2

BioMutaⁱ

SLC19A2

Proteomic databases

EPDⁱ	O60779
MaxQBⁱ	O60779
PaxDbⁱ	O60779
PeptideAtlasⁱ	O60779
PRIDEⁱ	O60779
ProteomicsDBⁱ	49594 49595 [O60779-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000236137; ENSP00000236137; ENSG00000117479 [O60779-1] ENST00000367804; ENSP00000356778; ENSG00000117479 [O60779-2] ENST00000646527; ENSP00000495500; ENSG00000117479 [O60779-1]
GeneIDⁱ	10560
KEGGⁱ	hsa:10560
UCSCⁱ	uc001gge.5 human [O60779-1]

Organism-specific databases

CTDⁱ	10560
DisGeNETⁱ	10560
EuPathDBⁱ	HostDB:ENSG00000117479.12
GeneCardsⁱ	SLC19A2
GeneReviewsⁱ	SLC19A2
HGNCⁱ	HGNC:10938 SLC19A2
HPAⁱ	HPA006119 HPA016599
MalaCardsⁱ	SLC19A2
MIMⁱ	249270 phenotype 603941 gene
neXtProtⁱ	NX_O60779
OpenTargetsⁱ	ENSG00000117479
Orphanetⁱ	49827 Thiamine-responsive megaloblastic anemia syndrome
PharmGKBⁱ	PA35825
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3810 Eukaryota ENOG410XT34 LUCA
GeneTreeⁱ	ENSGT00510000046382
HOVERGENⁱ	HBG054198
InParanoidⁱ	O60779
KOⁱ	K14610
OMAⁱ	LVRYKPV
OrthoDBⁱ	EOG091G0BSJ
PhylomeDBⁱ	O60779
TreeFamⁱ	TF313684

Enzyme and pathway databases

Reactomeⁱ	R-HSA-196819 Vitamin B1 (thiamin) metabolism
SABIO-RKⁱ	O60779

Miscellaneous databases

ChiTaRSⁱ	SLC19A2 human
GeneWikiⁱ	SLC19A2
GenomeRNAiⁱ	10560
Protein Ontology More...PROⁱ	PR:O60779
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000117479 Expressed in 219 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_SLC19A2
ExpressionAtlasⁱ	O60779 baseline and differential
Genevisibleⁱ	O60779 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002666 Folate_carrier IPR036259 MFS_trans_sf IPR028338 ThTr-1
PANTHERⁱ	PTHR10686 PTHR10686, 1 hit
Pfamⁱ	View protein in Pfam PF01770 Folate_carrier, 1 hit
PIRSFⁱ	PIRSF028739 Folate_carrier, 1 hit PIRSF500794 Thiamine_transporter_1, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S19A2_HUMAN
Accessionⁱ	O60779Primary (citable) accession number: O60779 Secondary accession number(s): B2R9H0 Q9UN43
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	January 24, 2001
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O60779 (S19A2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Thiamine transporter 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ