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UniProtKB - O60774 (FMO6_HUMAN)
Protein
Putative dimethylaniline monooxygenase [N-oxide-forming] 6
Gene
FMO6P
Organism
Homo sapiens (Human)
Status
Functioni
It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full-length transcripts.
Caution
Could be the product of a pseudogene.Curated
Catalytic activityi
- EC:1.14.13.8
Cofactori
FADBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 32 | FADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 9 – 13 | FADBy similarity | 5 | |
Nucleotide bindingi | 40 – 41 | FADBy similarity | 2 | |
Nucleotide bindingi | 61 – 62 | FADBy similarity | 2 | |
Nucleotide bindingi | 195 – 198 | NADPBy similarity | 4 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: InterPro
- monooxygenase activity Source: GO_Central
- N,N-dimethylaniline monooxygenase activity Source: UniProtKB-EC
- NADP binding Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | FAD, Flavoprotein, NADP |
Enzyme and pathway databases
PathwayCommonsi | O60774 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (EC:1.14.13.8)Alternative name(s): Dimethylaniline oxidase 6 Flavin-containing monooxygenase 6 Short name: FMO 6 |
Gene namesi | Name:FMO6P Synonyms:FMO6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24024, FMO6P |
neXtProti | NX_O60774 |
Subcellular locationi
Endoplasmic reticulum
- Microsome membrane By similarity; Single-pass membrane protein Sequence analysis
- Endoplasmic reticulum membrane By similarity; Single-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 518 – 538 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Organism-specific databases
PharmGKBi | PA142671753 |
Miscellaneous databases
Pharosi | O60774, Tdark |
Genetic variation databases
BioMutai | HGNC:24024 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000147669 | 1 – 539 | Putative dimethylaniline monooxygenase [N-oxide-forming] 6Add BLAST | 539 |
Proteomic databases
jPOSTi | O60774 |
MassIVEi | O60774 |
PaxDbi | O60774 |
PeptideAtlasi | O60774 |
PRIDEi | O60774 |
PTM databases
iPTMneti | O60774 |
PhosphoSitePlusi | O60774 |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000236166 |
Miscellaneous databases
RNActi | O60774, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the FMO family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1399, Eukaryota |
InParanoidi | O60774 |
PhylomeDBi | O60774 |
TreeFami | TF105285 |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR000960, Flavin_mOase IPR020946, Flavin_mOase-like IPR002255, Flavin_mOase_3 |
Pfami | View protein in Pfam PF00743, FMO-like, 1 hit |
PIRSFi | PIRSF000332, FMO, 1 hit |
PRINTSi | PR00370, FMOXYGENASE PR01123, FMOXYGENASE3 |
SUPFAMi | SSF51905, SSF51905, 2 hits |
i Sequence
Sequence statusi: Complete.
O60774-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKRVGIIGA GVSGLAAIWC CLEEGLEPTC FERSDDVGGL WKFSDHTEEG
60 70 80 90 100
RASIYQSVFT NSSKEMMCFP DFPYPDDYPN YIHHSKLQEY IKTYAQKKDL
110 120 130 140 150
LRYIQFETLV SGIKKCPSFL VTGQWVVVTE KDGKQESTIF DAVMICSGHH
160 170 180 190 200
VYPNLPTDSF PGLDQFRGNY LHSRDYKNPE AFKGKRVLVI GLGNSGSDIA
210 220 230 240 250
VELSRLATQV IISTRSASWV MSRVWDDGYP WDMMYVTRFA SFLRNVLPSF
260 270 280 290 300
ISDWLYVQKM NTWFKHENYG LMPLNGSLRK EPVFNDELPS RILCGTLSIK
310 320 330 340 350
PSVKEFTETS AVFEDGTMFE AIDSVIFATG YDYSYPFLDE TIMKSRNNEV
360 370 380 390 400
TLFKGIFPPL MEKPTLAVIG LVQSLGAAIP TADLQAWWAA KVFANSCTLP
410 420 430 440 450
TTNEMMDDTD EKMGKKLKCM FSSFFMFGQS QTLQTDYITY VDELGSFIGA
460 470 480 490 500
KPNIPWLFLT DPRLALEVYF GPCSPYQFRL MGPGKWDGAR NAILTQWNRT
510 520 530
VKPTRTRVVS EVQRPHPFYN LLKMLSFPLL LLAVTLTFY
Polymorphismi
There are two alleles; one major, FMO6X105 (truncated form) and one minor, FMO6Q105, (shown here) (full-length form similar to the protein found in other mammals) (PubMed:12527699). A nonsense mutation transforms the Gln-105 into a premature stop codon (PubMed:12527699). The truncated protein is catalytically inactive (PubMed:12527699).1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_015371 | 127 | V → I1 PublicationCorresponds to variant dbSNP:rs61731844Ensembl. | 1 | |
Natural variantiVAR_015372 | 257 | V → I1 PublicationCorresponds to variant dbSNP:rs2272797Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL021026 Genomic DNA No translation available. |
Genome annotation databases
UCSCi | uc057ngh.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL021026 Genomic DNA No translation available. |
3D structure databases
SMRi | O60774 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000236166 |
PTM databases
iPTMneti | O60774 |
PhosphoSitePlusi | O60774 |
Genetic variation databases
BioMutai | HGNC:24024 |
Proteomic databases
jPOSTi | O60774 |
MassIVEi | O60774 |
PaxDbi | O60774 |
PeptideAtlasi | O60774 |
PRIDEi | O60774 |
Genome annotation databases
UCSCi | uc057ngh.1, human |
Organism-specific databases
GeneCardsi | FMO6P |
HGNCi | HGNC:24024, FMO6P |
neXtProti | NX_O60774 |
PharmGKBi | PA142671753 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1399, Eukaryota |
InParanoidi | O60774 |
PhylomeDBi | O60774 |
TreeFami | TF105285 |
Enzyme and pathway databases
PathwayCommonsi | O60774 |
Miscellaneous databases
Pharosi | O60774, Tdark |
RNActi | O60774, protein |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR000960, Flavin_mOase IPR020946, Flavin_mOase-like IPR002255, Flavin_mOase_3 |
Pfami | View protein in Pfam PF00743, FMO-like, 1 hit |
PIRSFi | PIRSF000332, FMO, 1 hit |
PRINTSi | PR00370, FMOXYGENASE PR01123, FMOXYGENASE3 |
SUPFAMi | SSF51905, SSF51905, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | FMO6_HUMAN | |
Accessioni | O60774Primary (citable) accession number: O60774 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | August 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families