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Protein

Zinc finger protein 354A

Gene

ZNF354A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 488C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri494 – 516C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription by RNA polymerase II Source: ProtInc
  • sensory perception of sound Source: ProtInc

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354A
Alternative name(s):
Transcription factor 17
Short name:
TCF-17
Zinc finger protein eZNF
Gene namesi
Name:ZNF354A
Synonyms:EZNF, HKL1, TCF17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000169131.10
HGNCiHGNC:11628 ZNF354A
MIMi602444 gene
neXtProtiNX_O60765

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6940
OpenTargetsiENSG00000169131
PharmGKBiPA36383

Polymorphism and mutation databases

BioMutaiZNF354A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472381 – 605Zinc finger protein 354AAdd BLAST605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki268Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO60765
PaxDbiO60765
PeptideAtlasiO60765
PRIDEiO60765
ProteomicsDBi49592

PTM databases

iPTMnetiO60765
PhosphoSitePlusiO60765

Expressioni

Tissue specificityi

Expressed in kidney and inner ear.

Gene expression databases

BgeeiENSG00000169131 Expressed in 201 organ(s), highest expression level in bone marrow
CleanExiHS_ZNF354A
ExpressionAtlasiO60765 baseline and differential
GenevisibleiO60765 HS

Organism-specific databases

HPAiHPA052043

Interactioni

Protein-protein interaction databases

BioGridi112800, 16 interactors
STRINGi9606.ENSP00000337122

Structurei

3D structure databases

ProteinModelPortaliO60765
SMRiO60765
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 488C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri494 – 516C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150883
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO60765
KOiK09228
OMAiRNVPWDL
OrthoDBiEOG091G02KC
PhylomeDBiO60765
TreeFamiTF350822

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O60765-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGQREARP QVSLTFEDVA VLFTRDEWRK LAPSQRNLYR DVMLENYRNL
60 70 80 90 100
VSLGLPFTKP KVISLLQQGE DPWEVEKDGS GVSSLGSKSS HKTTKSTQTQ
110 120 130 140 150
DSSFQGLILK RSNRNVPWDL KLEKPYIYEG RLEKKQDKKG SFQIVSATHK
160 170 180 190 200
KIPTIERSHK NTELSQNFSP KSVLIRQQIL PREKTPPKCE IQGNSLKQNS
210 220 230 240 250
QLLNQPKITA DKRYKCSLCE KTFINTSSLR KHEKNHSGEK LFKCKECSKA
260 270 280 290 300
FSQSSALIQH QITHTGEKPY ICKECGKAFT LSTSLYKHLR THTVEKSYRC
310 320 330 340 350
KECGKSFSRR SGLFIHQKIH AEENPCKYNP GRKASSCSTS LSGCQRIHSR
360 370 380 390 400
KKSYLCNECG NTFKSSSSLR YHQRIHTGEK PFKCSECGRA FSQSASLIQH
410 420 430 440 450
ERIHTGEKPY RCNECGKGFT SISRLNRHRI IHTGEKFYNC NECGKALSSH
460 470 480 490 500
STLIIHERIH TGEKPCKCKV CGKAFRQSSA LIQHQRMHTG ERPYKCNECG
510 520 530 540 550
KTFRCNSSLS NHQRIHTGEK PYRCEECGIS FGQSSALIQH RRIHTGEKPF
560 570 580 590 600
KCNTCGKTFR QSSSRIAHQR IHTGEKPYEC NTCGKLFNHR SSLTNHYKIH

IEEDP
Length:605
Mass (Da):69,237
Last modified:October 3, 2006 - v2
Checksum:i464D20BBD9045AF9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RGC2E5RGC2_HUMAN
Zinc finger protein 354A
ZNF354A
66Annotation score:
E5RHT5E5RHT5_HUMAN
Zinc finger protein 354A
ZNF354A
135Annotation score:
A0A1W2PQE6A0A1W2PQE6_HUMAN
Zinc finger protein 354A
ZNF354A
128Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti437F → Y in BAA25182 (PubMed:9465904).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89928 mRNA Translation: BAA25182.1
AF116030 mRNA Translation: AAD05335.1
CCDSiCCDS4438.1
RefSeqiNP_005640.2, NM_005649.2
XP_016865280.1, XM_017009791.1
UniGeneiHs.484324

Genome annotation databases

EnsembliENST00000335815; ENSP00000337122; ENSG00000169131
GeneIDi6940
KEGGihsa:6940

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89928 mRNA Translation: BAA25182.1
AF116030 mRNA Translation: AAD05335.1
CCDSiCCDS4438.1
RefSeqiNP_005640.2, NM_005649.2
XP_016865280.1, XM_017009791.1
UniGeneiHs.484324

3D structure databases

ProteinModelPortaliO60765
SMRiO60765
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112800, 16 interactors
STRINGi9606.ENSP00000337122

PTM databases

iPTMnetiO60765
PhosphoSitePlusiO60765

Polymorphism and mutation databases

BioMutaiZNF354A

Proteomic databases

EPDiO60765
PaxDbiO60765
PeptideAtlasiO60765
PRIDEiO60765
ProteomicsDBi49592

Protocols and materials databases

DNASUi6940
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335815; ENSP00000337122; ENSG00000169131
GeneIDi6940
KEGGihsa:6940

Organism-specific databases

CTDi6940
DisGeNETi6940
EuPathDBiHostDB:ENSG00000169131.10
GeneCardsiZNF354A
HGNCiHGNC:11628 ZNF354A
HPAiHPA052043
MIMi602444 gene
neXtProtiNX_O60765
OpenTargetsiENSG00000169131
PharmGKBiPA36383
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150883
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO60765
KOiK09228
OMAiRNVPWDL
OrthoDBiEOG091G02KC
PhylomeDBiO60765
TreeFamiTF350822

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii6940
PROiPR:O60765
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169131 Expressed in 201 organ(s), highest expression level in bone marrow
CleanExiHS_ZNF354A
ExpressionAtlasiO60765 baseline and differential
GenevisibleiO60765 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZ354A_HUMAN
AccessioniPrimary (citable) accession number: O60765
Secondary accession number(s): Q9UNJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2006
Last modified: November 7, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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