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UniProtKB - O60765 (Z354A_HUMAN)
Protein
Zinc finger protein 354A
Gene
ZNF354A
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 214 – 236 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 242 – 264 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 270 – 292 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 320 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 404 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 410 – 432 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 438 – 460 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 488 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 494 – 516 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 522 – 544 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 550 – 572 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 578 – 600 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
- sensory perception of sound Source: ProtInc
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O60765 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | O60765 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 354AAlternative name(s): Transcription factor 17 Short name: TCF-17 Zinc finger protein eZNF |
Gene namesi | Name:ZNF354A Synonyms:EZNF, HKL1, TCF17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11628, ZNF354A |
MIMi | 602444, gene |
neXtProti | NX_O60765 |
VEuPathDBi | HostDB:ENSG00000169131 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6940 |
OpenTargetsi | ENSG00000169131 |
PharmGKBi | PA36383 |
Miscellaneous databases
Pharosi | O60765, Tbio |
Genetic variation databases
BioMutai | ZNF354A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047238 | 1 – 605 | Zinc finger protein 354AAdd BLAST | 605 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 110 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 121 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 139 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 171 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 268 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | O60765 |
jPOSTi | O60765 |
MassIVEi | O60765 |
PaxDbi | O60765 |
PeptideAtlasi | O60765 |
PRIDEi | O60765 |
ProteomicsDBi | 49592 |
PTM databases
GlyGeni | O60765, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O60765 |
PhosphoSitePlusi | O60765 |
Expressioni
Tissue specificityi
Expressed in kidney and inner ear.
Gene expression databases
Bgeei | ENSG00000169131, Expressed in bone marrow and 211 other tissues |
ExpressionAtlasi | O60765, baseline and differential |
Genevisiblei | O60765, HS |
Organism-specific databases
HPAi | ENSG00000169131, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 112800, 37 interactors |
IntActi | O60765, 11 interactors |
STRINGi | 9606.ENSP00000337122 |
Miscellaneous databases
RNActi | O60765, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 85 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 74 – 106 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 82 – 106 | Polar residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 214 – 236 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 242 – 264 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 270 – 292 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 320 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 404 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 410 – 432 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 438 – 460 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 488 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 494 – 516 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 522 – 544 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 550 – 572 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 578 – 600 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161487 |
HOGENOMi | CLU_002678_57_1_1 |
InParanoidi | O60765 |
OMAi | TNHYKTH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O60765 |
TreeFami | TF350822 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 13 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O60765-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAGQREARP QVSLTFEDVA VLFTRDEWRK LAPSQRNLYR DVMLENYRNL
60 70 80 90 100
VSLGLPFTKP KVISLLQQGE DPWEVEKDGS GVSSLGSKSS HKTTKSTQTQ
110 120 130 140 150
DSSFQGLILK RSNRNVPWDL KLEKPYIYEG RLEKKQDKKG SFQIVSATHK
160 170 180 190 200
KIPTIERSHK NTELSQNFSP KSVLIRQQIL PREKTPPKCE IQGNSLKQNS
210 220 230 240 250
QLLNQPKITA DKRYKCSLCE KTFINTSSLR KHEKNHSGEK LFKCKECSKA
260 270 280 290 300
FSQSSALIQH QITHTGEKPY ICKECGKAFT LSTSLYKHLR THTVEKSYRC
310 320 330 340 350
KECGKSFSRR SGLFIHQKIH AEENPCKYNP GRKASSCSTS LSGCQRIHSR
360 370 380 390 400
KKSYLCNECG NTFKSSSSLR YHQRIHTGEK PFKCSECGRA FSQSASLIQH
410 420 430 440 450
ERIHTGEKPY RCNECGKGFT SISRLNRHRI IHTGEKFYNC NECGKALSSH
460 470 480 490 500
STLIIHERIH TGEKPCKCKV CGKAFRQSSA LIQHQRMHTG ERPYKCNECG
510 520 530 540 550
KTFRCNSSLS NHQRIHTGEK PYRCEECGIS FGQSSALIQH RRIHTGEKPF
560 570 580 590 600
KCNTCGKTFR QSSSRIAHQR IHTGEKPYEC NTCGKLFNHR SSLTNHYKIH
IEEDP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RHT5 | E5RHT5_HUMAN | Zinc finger protein 354A | ZNF354A | 135 | Annotation score: | ||
E5RGC2 | E5RGC2_HUMAN | Zinc finger protein 354A | ZNF354A | 66 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 437 | F → Y in BAA25182 (PubMed:9465904).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D89928 mRNA Translation: BAA25182.1 AF116030 mRNA Translation: AAD05335.1 |
CCDSi | CCDS4438.1 |
RefSeqi | NP_005640.2, NM_005649.2 XP_016865280.1, XM_017009791.1 |
Genome annotation databases
Ensembli | ENST00000335815; ENSP00000337122; ENSG00000169131 |
GeneIDi | 6940 |
KEGGi | hsa:6940 |
MANE-Selecti | ENST00000335815.7; ENSP00000337122.2; NM_005649.3; NP_005640.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D89928 mRNA Translation: BAA25182.1 AF116030 mRNA Translation: AAD05335.1 |
CCDSi | CCDS4438.1 |
RefSeqi | NP_005640.2, NM_005649.2 XP_016865280.1, XM_017009791.1 |
3D structure databases
SMRi | O60765 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112800, 37 interactors |
IntActi | O60765, 11 interactors |
STRINGi | 9606.ENSP00000337122 |
PTM databases
GlyGeni | O60765, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O60765 |
PhosphoSitePlusi | O60765 |
Genetic variation databases
BioMutai | ZNF354A |
Proteomic databases
EPDi | O60765 |
jPOSTi | O60765 |
MassIVEi | O60765 |
PaxDbi | O60765 |
PeptideAtlasi | O60765 |
PRIDEi | O60765 |
ProteomicsDBi | 49592 |
Protocols and materials databases
Antibodypediai | 17609, 61 antibodies from 23 providers |
DNASUi | 6940 |
Genome annotation databases
Ensembli | ENST00000335815; ENSP00000337122; ENSG00000169131 |
GeneIDi | 6940 |
KEGGi | hsa:6940 |
MANE-Selecti | ENST00000335815.7; ENSP00000337122.2; NM_005649.3; NP_005640.2 |
Organism-specific databases
CTDi | 6940 |
DisGeNETi | 6940 |
GeneCardsi | ZNF354A |
HGNCi | HGNC:11628, ZNF354A |
HPAi | ENSG00000169131, Low tissue specificity |
MIMi | 602444, gene |
neXtProti | NX_O60765 |
OpenTargetsi | ENSG00000169131 |
PharmGKBi | PA36383 |
VEuPathDBi | HostDB:ENSG00000169131 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161487 |
HOGENOMi | CLU_002678_57_1_1 |
InParanoidi | O60765 |
OMAi | TNHYKTH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O60765 |
TreeFami | TF350822 |
Enzyme and pathway databases
PathwayCommonsi | O60765 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | O60765 |
Miscellaneous databases
BioGRID-ORCSi | 6940, 11 hits in 1028 CRISPR screens |
GenomeRNAii | 6940 |
Pharosi | O60765, Tbio |
PROi | PR:O60765 |
RNActi | O60765, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169131, Expressed in bone marrow and 211 other tissues |
ExpressionAtlasi | O60765, baseline and differential |
Genevisiblei | O60765, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 13 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Z354A_HUMAN | |
Accessioni | O60765Primary (citable) accession number: O60765 Secondary accession number(s): Q9UNJ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | October 3, 2006 | |
Last modified: | February 23, 2022 | |
This is version 189 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families