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Entry version 182 (13 Feb 2019)
Sequence version 1 (01 Aug 1998)
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Protein

Dolichol-phosphate mannosyltransferase subunit 1

Gene

DPM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:ENSG00000000419-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.83 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-162699 Synthesis of dolichyl-phosphate mannose
R-HSA-4717374 Defective DPM1 causes DPM1-CDG (CDG-1e)

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT2 Glycosyltransferase Family 2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dolichol-phosphate mannosyltransferase subunit 1 (EC:2.4.1.83)
Alternative name(s):
Dolichol-phosphate mannose synthase subunit 1
Short name:
DPM synthase subunit 1
Dolichyl-phosphate beta-D-mannosyltransferase subunit 1
Mannose-P-dolichol synthase subunit 1
Short name:
MPD synthase subunit 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DPM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000000419.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3005 DPM1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603503 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60762

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital disorder of glycosylation 1E (CDG1E)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Some CDG1E patients have features consistent with a dystroglycanopathy and congenital muscular dystrophy, including O-mannosylation defect, camptodactyly, elevated creatine kinase, motor delay and dystrophic changes on muscel biopsy.
See also OMIM:608799
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01234192R → G in CDG1E. 2 PublicationsCorresponds to variant dbSNP:rs121908583EnsemblClinVar.1
Natural variantiVAR_070592152G → V in CDG1E; abolishes interaction with DPM3. 1 PublicationCorresponds to variant dbSNP:rs587777116EnsemblClinVar.1
Natural variantiVAR_019841248S → P in CDG1E. 1 PublicationCorresponds to variant dbSNP:rs587777114EnsemblClinVar.1

Keywords - Diseasei

Congenital disorder of glycosylation, Congenital muscular dystrophy, Disease mutation, Dystroglycanopathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
8813

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
DPM1

MalaCards human disease database

More...
MalaCardsi
DPM1
MIMi608799 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000000419

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79322 DPM1-CDG

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27463

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DPM1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000591702 – 260Dolichol-phosphate mannosyltransferase subunit 1Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60762

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60762

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60762

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60762

PeptideAtlas

More...
PeptideAtlasi
O60762

PRoteomics IDEntifications database

More...
PRIDEi
O60762

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49589

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60762

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60762

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000000419 Expressed in 244 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60762 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60762 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051818

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114340, 40 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O60762

Protein interaction database and analysis system

More...
IntActi
O60762, 37 interactors

Molecular INTeraction database

More...
MINTi
O60762

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360644

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60762

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60762

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2978 Eukaryota
COG0463 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153481

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000283250

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018967

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60762

KEGG Orthology (KO)

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KOi
K00721

Database of Orthologous Groups

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OrthoDBi
1445102at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O60762

TreeFam database of animal gene trees

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TreeFami
TF105617

Family and domain databases

Conserved Domains Database

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CDDi
cd06442 DPM1_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039528 DPM1-like
IPR001173 Glyco_trans_2-like
IPR029044 Nucleotide-diphossugar_trans

The PANTHER Classification System

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PANTHERi
PTHR43398 PTHR43398, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00535 Glycos_transf_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448 SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O60762-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLEVSRSP RRSRRELEVR SPRQNKYSVL LPTYNERENL PLIVWLLVKS
60 70 80 90 100
FSESGINYEI IIIDDGSPDG TRDVAEQLEK IYGSDRILLR PREKKLGLGT
110 120 130 140 150
AYIHGMKHAT GNYIIIMDAD LSHHPKFIPE FIRKQKEGNF DIVSGTRYKG
160 170 180 190 200
NGGVYGWDLK RKIISRGANF LTQILLRPGA SDLTGSFRLY RKEVLEKLIE
210 220 230 240 250
KCVSKGYVFQ MEMIVRARQL NYTIGEVPIS FVDRVYGESK LGGNEIVSFL
260
KGLLTLFATT
Length:260
Mass (Da):29,634
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9792145BFC8F0514
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5QPK2Q5QPK2_HUMAN
Dolichol-phosphate mannosyltransfer...
DPM1
287Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QPJ9Q5QPJ9_HUMAN
Dolichol-phosphate mannosyltransfer...
DPM1
221Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y368H0Y368_HUMAN
Dolichol-phosphate mannosyltransfer...
DPM1
295Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9S → G in AAH08466 (PubMed:15489334).Curated1
Sequence conflicti15R → W in AAC98797 (PubMed:9223280).Curated1
Sequence conflicti135Q → K in AAC98797 (PubMed:9223280).Curated1
Sequence conflicti143V → A in AAC98797 (PubMed:9223280).Curated1
Sequence conflicti154V → I in AAC98797 (PubMed:9223280).Curated1
Sequence conflicti177R → T in AAC98797 (PubMed:9223280).Curated1
Sequence conflicti191R → P in AAC98797 (PubMed:9223280).Curated1
Sequence conflicti220L → M in AAH08466 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01234192R → G in CDG1E. 2 PublicationsCorresponds to variant dbSNP:rs121908583EnsemblClinVar.1
Natural variantiVAR_070592152G → V in CDG1E; abolishes interaction with DPM3. 1 PublicationCorresponds to variant dbSNP:rs587777116EnsemblClinVar.1
Natural variantiVAR_019841248S → P in CDG1E. 1 PublicationCorresponds to variant dbSNP:rs587777114EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D86198 mRNA Translation: BAA25646.1
D86202 Genomic DNA Translation: BAA25647.1
CR456926 mRNA Translation: CAG33207.1
AK289569 mRNA Translation: BAF82258.1
AL034553 Genomic DNA No translation available.
BC007073 mRNA Translation: AAH07073.1
BC008466 mRNA Translation: AAH08466.1
BC016322 mRNA Translation: AAH16322.1
AF007875 mRNA Translation: AAC98797.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13434.1

NCBI Reference Sequences

More...
RefSeqi
NP_001303963.1, NM_001317034.1
NP_001303964.1, NM_001317035.1
NP_001303965.1, NM_001317036.1
NP_003850.1, NM_003859.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.654951

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371588; ENSP00000360644; ENSG00000000419

Database of genes from NCBI RefSeq genomes

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GeneIDi
8813

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8813

UCSC genome browser

More...
UCSCi
uc002xvw.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86198 mRNA Translation: BAA25646.1
D86202 Genomic DNA Translation: BAA25647.1
CR456926 mRNA Translation: CAG33207.1
AK289569 mRNA Translation: BAF82258.1
AL034553 Genomic DNA No translation available.
BC007073 mRNA Translation: AAH07073.1
BC008466 mRNA Translation: AAH08466.1
BC016322 mRNA Translation: AAH16322.1
AF007875 mRNA Translation: AAC98797.1
CCDSiCCDS13434.1
RefSeqiNP_001303963.1, NM_001317034.1
NP_001303964.1, NM_001317035.1
NP_001303965.1, NM_001317036.1
NP_003850.1, NM_003859.2
UniGeneiHs.654951

3D structure databases

ProteinModelPortaliO60762
SMRiO60762
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114340, 40 interactors
CORUMiO60762
IntActiO60762, 37 interactors
MINTiO60762
STRINGi9606.ENSP00000360644

Protein family/group databases

CAZyiGT2 Glycosyltransferase Family 2

PTM databases

iPTMnetiO60762
PhosphoSitePlusiO60762

Polymorphism and mutation databases

BioMutaiDPM1

Proteomic databases

EPDiO60762
jPOSTiO60762
MaxQBiO60762
PaxDbiO60762
PeptideAtlasiO60762
PRIDEiO60762
ProteomicsDBi49589

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8813
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371588; ENSP00000360644; ENSG00000000419
GeneIDi8813
KEGGihsa:8813
UCSCiuc002xvw.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8813
DisGeNETi8813
EuPathDBiHostDB:ENSG00000000419.12

GeneCards: human genes, protein and diseases

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GeneCardsi
DPM1
GeneReviewsiDPM1
HGNCiHGNC:3005 DPM1
HPAiHPA051818
MalaCardsiDPM1
MIMi603503 gene
608799 phenotype
neXtProtiNX_O60762
OpenTargetsiENSG00000000419
Orphaneti79322 DPM1-CDG
PharmGKBiPA27463

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2978 Eukaryota
COG0463 LUCA
GeneTreeiENSGT00940000153481
HOGENOMiHOG000283250
HOVERGENiHBG018967
InParanoidiO60762
KOiK00721
OrthoDBi1445102at2759
PhylomeDBiO60762
TreeFamiTF105617

Enzyme and pathway databases

UniPathwayi
UPA00378

BioCyciMetaCyc:ENSG00000000419-MONOMER
BRENDAi2.4.1.83 2681
ReactomeiR-HSA-162699 Synthesis of dolichyl-phosphate mannose
R-HSA-4717374 Defective DPM1 causes DPM1-CDG (CDG-1e)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DPM1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DPM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8813

Protein Ontology

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PROi
PR:O60762

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000000419 Expressed in 244 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiO60762 baseline and differential
GenevisibleiO60762 HS

Family and domain databases

CDDicd06442 DPM1_like, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR039528 DPM1-like
IPR001173 Glyco_trans_2-like
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR43398 PTHR43398, 1 hit
PfamiView protein in Pfam
PF00535 Glycos_transf_2, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60762
Secondary accession number(s): O15157, Q6IB78, Q96HK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 1, 1998
Last modified: February 13, 2019
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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