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Protein

Cytohesin-interacting protein

Gene

CYTIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.

GO - Biological processi

  • regulation of cell adhesion Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Cytohesin-interacting protein
Alternative name(s):
Cytohesin binder and regulator
Short name:
CYBR
Cytohesin-associated scaffolding protein
Short name:
CASP
Cytohesin-binding protein HE
Short name:
Cbp HE
Pleckstrin homology Sec7 and coiled-coil domains-binding protein
Gene namesi
Name:CYTIP
Synonyms:PSCDBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115165.9
HGNCiHGNC:9506 CYTIP
MIMi604448 gene
neXtProtiNX_O60759

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi82K → E: No membrane-association. No change in the binding to CYTH1; when associated with A-90 and A-92. 1 Publication1
Mutagenesisi90F → A: No membrane-association. No change in the binding to CYTH1; when associated with E-82 and A-92. 1 Publication1
Mutagenesisi92I → A: No membrane-association. No change in the binding to CYTH1; when associated with E-82 and A-90. 1 Publication1

Organism-specific databases

DisGeNETi9595
OpenTargetsiENSG00000115165
PharmGKBiPA164718652

Polymorphism and mutation databases

BioMutaiCYTIP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000970611 – 359Cytohesin-interacting proteinAdd BLAST359

Proteomic databases

MaxQBiO60759
PaxDbiO60759
PeptideAtlasiO60759
PRIDEiO60759
ProteomicsDBi49587

PTM databases

iPTMnetiO60759
PhosphoSitePlusiO60759

Expressioni

Tissue specificityi

Expressed in lymph nodes, thymus, spleen, lung, peripheral blood leukocytes and bone marrow.2 Publications

Inductioni

By TNF and bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiENSG00000115165 Expressed in 183 organ(s), highest expression level in blood
CleanExiHS_CYTIP
ExpressionAtlasiO60759 baseline and differential
GenevisibleiO60759 HS

Organism-specific databases

HPAiHPA007191

Interactioni

Subunit structurei

Interacts with CYTH1 and SNX27.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CYTH1Q154384EBI-997814,EBI-997830

Protein-protein interaction databases

BioGridi114961, 9 interactors
IntActiO60759, 7 interactors
STRINGi9606.ENSP00000264192

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO60759
SMRiO60759
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60759

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 166PDZPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 188Interaction with CYTH1Add BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili166 – 188Sequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi241 – 323Ser-richAdd BLAST83

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410ITA8 Eukaryota
ENOG4111KMM LUCA
GeneTreeiENSGT00530000063734
HOGENOMiHOG000231871
HOVERGENiHBG053061
InParanoidiO60759
OMAiEGFTHKQ
OrthoDBiEOG091G0NRM
PhylomeDBiO60759
TreeFamiTF316315

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60759-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLQRLLQHS SNGNLADFCA GPAYSSYSTL TGSLTMDDNR RIQMLADTVA
60 70 80 90 100
TLPRGRKQLA LTRSSSLSDF SWSQRKLVTV EKQDNETFGF EIQSYRPQNQ
110 120 130 140 150
NACSSEMFTL ICKIQEDSPA HCAGLQAGDV LANINGVSTE GFTYKQVVDL
160 170 180 190 200
IRSSGNLLTI ETLNGTMILK RTELEAKLQV LKQTLKQKWV EYRSLQLQEH
210 220 230 240 250
RLLHGDAANC PSLENMDLDE LSLFGPLPGP GPALVDRNRL SSESSCKSWL
260 270 280 290 300
SSMTMDSEDG YQTCVSEDSS RGAFSRQTST DDECFIPKEG DDFLRRSSSR
310 320 330 340 350
RNRSISNTSS GSMSPLWEGN LSSMFGTLPR KSRKGSVRKQ LLKFIPGLHR

AVEEEESRF
Length:359
Mass (Da):40,010
Last modified:September 27, 2005 - v2
Checksum:i76F0E0ED02EDD8C2
GO
Isoform 2 (identifier: O60759-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):28,172
Checksum:iCE3E6B4FB0C6FA26
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JSM2C9JSM2_HUMAN
Cytohesin-interacting protein
CYTIP
131Annotation score:
C9JRF8C9JRF8_HUMAN
Cytohesin-interacting protein
CYTIP
74Annotation score:
C9JNN8C9JNN8_HUMAN
Cytohesin-interacting protein
CYTIP
36Annotation score:
F8WF61F8WF61_HUMAN
Cytohesin-interacting protein
CYTIP
61Annotation score:

Sequence cautioni

The sequence AAA16575 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278T → Q in AAA16575 (PubMed:8241278).Curated1
Sequence conflicti339 – 341KQL → RVA in AAA16575 (PubMed:8241278).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02353437D → N1 PublicationCorresponds to variant dbSNP:rs1042038Ensembl.1
Natural variantiVAR_05128783Q → E. Corresponds to variant dbSNP:rs2229345Ensembl.1
Natural variantiVAR_064706329P → S Found in a renal cell carcinoma case; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555021 – 106Missing in isoform 2. 1 PublicationAdd BLAST106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068836 mRNA Translation: AAC19129.1
AK301544 mRNA Translation: BAG63041.1
AC019201 Genomic DNA Translation: AAY14898.1
BC036449 mRNA Translation: AAH36449.1
L06633 mRNA Translation: AAA16575.1 Different initiation.
CCDSiCCDS2204.1 [O60759-1]
PIRiS43424
RefSeqiNP_004279.3, NM_004288.4 [O60759-1]
XP_016860875.1, XM_017005386.1 [O60759-2]
UniGeneiHs.270

Genome annotation databases

EnsembliENST00000264192; ENSP00000264192; ENSG00000115165 [O60759-1]
GeneIDi9595
KEGGihsa:9595
UCSCiuc002tzj.2 human [O60759-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068836 mRNA Translation: AAC19129.1
AK301544 mRNA Translation: BAG63041.1
AC019201 Genomic DNA Translation: AAY14898.1
BC036449 mRNA Translation: AAH36449.1
L06633 mRNA Translation: AAA16575.1 Different initiation.
CCDSiCCDS2204.1 [O60759-1]
PIRiS43424
RefSeqiNP_004279.3, NM_004288.4 [O60759-1]
XP_016860875.1, XM_017005386.1 [O60759-2]
UniGeneiHs.270

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z17X-ray2.70A67-163[»]
ProteinModelPortaliO60759
SMRiO60759
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114961, 9 interactors
IntActiO60759, 7 interactors
STRINGi9606.ENSP00000264192

PTM databases

iPTMnetiO60759
PhosphoSitePlusiO60759

Polymorphism and mutation databases

BioMutaiCYTIP

Proteomic databases

MaxQBiO60759
PaxDbiO60759
PeptideAtlasiO60759
PRIDEiO60759
ProteomicsDBi49587

Protocols and materials databases

DNASUi9595
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264192; ENSP00000264192; ENSG00000115165 [O60759-1]
GeneIDi9595
KEGGihsa:9595
UCSCiuc002tzj.2 human [O60759-1]

Organism-specific databases

CTDi9595
DisGeNETi9595
EuPathDBiHostDB:ENSG00000115165.9
GeneCardsiCYTIP
HGNCiHGNC:9506 CYTIP
HPAiHPA007191
MIMi604448 gene
neXtProtiNX_O60759
OpenTargetsiENSG00000115165
PharmGKBiPA164718652
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITA8 Eukaryota
ENOG4111KMM LUCA
GeneTreeiENSGT00530000063734
HOGENOMiHOG000231871
HOVERGENiHBG053061
InParanoidiO60759
OMAiEGFTHKQ
OrthoDBiEOG091G0NRM
PhylomeDBiO60759
TreeFamiTF316315

Miscellaneous databases

EvolutionaryTraceiO60759
GeneWikiiPSCDBP
GenomeRNAii9595
PROiPR:O60759
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115165 Expressed in 183 organ(s), highest expression level in blood
CleanExiHS_CYTIP
ExpressionAtlasiO60759 baseline and differential
GenevisibleiO60759 HS

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYTIP_HUMAN
AccessioniPrimary (citable) accession number: O60759
Secondary accession number(s): B4DWH9, Q15630, Q8NE32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: September 12, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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