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Protein

Eukaryotic translation initiation factor 1b

Gene

EIF1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in translation.

GO - Molecular functioni

  • ribosomal small subunit binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • translation initiation factor activity Source: GO_Central

GO - Biological processi

  • regulation of translational initiation Source: UniProtKB

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1b
Short name:
eIF1b
Alternative name(s):
Protein translation factor SUI1 homolog GC20
Gene namesi
Name:EIF1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114784.3
HGNCiHGNC:30792 EIF1B
neXtProtiNX_O60739

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000114784
PharmGKBiPA143485452

Polymorphism and mutation databases

BioMutaiEIF1B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001305582 – 113Eukaryotic translation initiation factor 1bAdd BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60739
PaxDbiO60739
PeptideAtlasiO60739
PRIDEiO60739
ProteomicsDBi49582
TopDownProteomicsiO60739

PTM databases

iPTMnetiO60739
PhosphoSitePlusiO60739

Expressioni

Gene expression databases

BgeeiENSG00000114784 Expressed in 235 organ(s), highest expression level in frontal cortex
CleanExiHS_EIF1B
ExpressionAtlasiO60739 baseline and differential
GenevisibleiO60739 HS

Interactioni

Protein-protein interaction databases

BioGridi115578, 37 interactors
IntActiO60739, 6 interactors
MINTiO60739
STRINGi9606.ENSP00000232905

Structurei

3D structure databases

ProteinModelPortaliO60739
SMRiO60739
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SUI1 family.Curated

Phylogenomic databases

eggNOGiKOG1770 Eukaryota
COG0023 LUCA
GeneTreeiENSGT00390000015789
HOGENOMiHOG000279813
HOVERGENiHBG000295
InParanoidiO60739
KOiK03113
OMAiMSAIQNF
OrthoDBiEOG091G10OC
PhylomeDBiO60739
TreeFamiTF314417

Family and domain databases

CDDicd11566 eIF1_SUI1, 1 hit
InterProiView protein in InterPro
IPR001950 SUI1
IPR036877 SUI1_dom_sf
IPR005874 SUI1_euk
PfamiView protein in Pfam
PF01253 SUI1, 1 hit
PIRSFiPIRSF004499 SUI1_euk, 1 hit
SUPFAMiSSF55159 SSF55159, 1 hit
TIGRFAMsiTIGR01160 SUI1_MOF2, 1 hit
PROSITEiView protein in PROSITE
PS50296 SUI1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60739-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTIQNLQSF DPFADATKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI
60 70 80 90 100
ADDYDKKKLV KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLLEV
110
GIVKEEQLKV HGF
Length:113
Mass (Da):12,824
Last modified:December 1, 2000 - v2
Checksum:i4522A8B692654FE1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27T → L in AAC17112 (Ref. 1) Curated1
Sequence conflicti41R → G in AAC17112 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064607 mRNA Translation: AAC17112.1
AF077052 mRNA Translation: AAD27785.1
AF263452 mRNA Translation: AAF79182.1
BC006996 mRNA Translation: AAH06996.1
CCDSiCCDS2690.1
RefSeqiNP_005866.1, NM_005875.2
UniGeneiHs.315230

Genome annotation databases

EnsembliENST00000232905; ENSP00000232905; ENSG00000114784
GeneIDi10289
KEGGihsa:10289

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064607 mRNA Translation: AAC17112.1
AF077052 mRNA Translation: AAD27785.1
AF263452 mRNA Translation: AAF79182.1
BC006996 mRNA Translation: AAH06996.1
CCDSiCCDS2690.1
RefSeqiNP_005866.1, NM_005875.2
UniGeneiHs.315230

3D structure databases

ProteinModelPortaliO60739
SMRiO60739
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115578, 37 interactors
IntActiO60739, 6 interactors
MINTiO60739
STRINGi9606.ENSP00000232905

PTM databases

iPTMnetiO60739
PhosphoSitePlusiO60739

Polymorphism and mutation databases

BioMutaiEIF1B

Proteomic databases

EPDiO60739
PaxDbiO60739
PeptideAtlasiO60739
PRIDEiO60739
ProteomicsDBi49582
TopDownProteomicsiO60739

Protocols and materials databases

DNASUi10289
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232905; ENSP00000232905; ENSG00000114784
GeneIDi10289
KEGGihsa:10289

Organism-specific databases

CTDi10289
EuPathDBiHostDB:ENSG00000114784.3
GeneCardsiEIF1B
HGNCiHGNC:30792 EIF1B
neXtProtiNX_O60739
OpenTargetsiENSG00000114784
PharmGKBiPA143485452
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1770 Eukaryota
COG0023 LUCA
GeneTreeiENSGT00390000015789
HOGENOMiHOG000279813
HOVERGENiHBG000295
InParanoidiO60739
KOiK03113
OMAiMSAIQNF
OrthoDBiEOG091G10OC
PhylomeDBiO60739
TreeFamiTF314417

Miscellaneous databases

ChiTaRSiEIF1B human
GeneWikiiEIF1B
GenomeRNAii10289
PROiPR:O60739

Gene expression databases

BgeeiENSG00000114784 Expressed in 235 organ(s), highest expression level in frontal cortex
CleanExiHS_EIF1B
ExpressionAtlasiO60739 baseline and differential
GenevisibleiO60739 HS

Family and domain databases

CDDicd11566 eIF1_SUI1, 1 hit
InterProiView protein in InterPro
IPR001950 SUI1
IPR036877 SUI1_dom_sf
IPR005874 SUI1_euk
PfamiView protein in Pfam
PF01253 SUI1, 1 hit
PIRSFiPIRSF004499 SUI1_euk, 1 hit
SUPFAMiSSF55159 SSF55159, 1 hit
TIGRFAMsiTIGR01160 SUI1_MOF2, 1 hit
PROSITEiView protein in PROSITE
PS50296 SUI1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEIF1B_HUMAN
AccessioniPrimary (citable) accession number: O60739
Secondary accession number(s): Q9UQF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Translation initiation factors
    List of translation initiation factor entries
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Main funding by: National Institutes of Health

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