UniProtKB - O60732 (MAGC1_HUMAN)
Protein
Melanoma-associated antigen C1
Gene
MAGEC1
Organism
Homo sapiens (Human)
Status
Functioni
Keywordsi
Molecular function | Tumor antigen |
Enzyme and pathway databases
PathwayCommonsi | O60732 |
Names & Taxonomyi
Protein namesi | Recommended name: Melanoma-associated antigen C1Alternative name(s): Cancer/testis antigen 7.1 Short name: CT7.1 MAGE-C1 antigen |
Gene namesi | Name:MAGEC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000155495.8 |
HGNCi | HGNC:6812, MAGEC1 |
MIMi | 300223, gene |
neXtProti | NX_O60732 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9947 |
OpenTargetsi | ENSG00000155495 |
PharmGKBi | PA30558 |
Miscellaneous databases
Pharosi | O60732, Tbio |
Polymorphism and mutation databases
BioMutai | MAGEC1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156720 | 1 – 1142 | Melanoma-associated antigen C1Add BLAST | 1142 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 63 | PhosphoserineCombined sources | 1 | |
Modified residuei | 207 | PhosphoserineCombined sources | 1 | |
Modified residuei | 382 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1063 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O60732 |
MassIVEi | O60732 |
MaxQBi | O60732 |
PaxDbi | O60732 |
PeptideAtlasi | O60732 |
PRIDEi | O60732 |
ProteomicsDBi | 49577 [O60732-1] 77 |
PTM databases
iPTMneti | O60732 |
PhosphoSitePlusi | O60732 |
Expressioni
Tissue specificityi
Expressed in testis and in tumors of a wide variety of histologic types.
Gene expression databases
Bgeei | ENSG00000155495, Expressed in right testis and 27 other tissues |
Genevisiblei | O60732, HS |
Organism-specific databases
HPAi | ENSG00000155495, Tissue enriched (testis) |
Interactioni
Binary interactionsi
O60732
With | #Exp. | IntAct |
---|---|---|
CTAG1B [P78358] | 6 | EBI-1188463,EBI-1188472 |
Protein-protein interaction databases
BioGRIDi | 115272, 11 interactors |
IntActi | O60732, 8 interactors |
STRINGi | 9606.ENSP00000285879 |
Miscellaneous databases
RNActi | O60732, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 908 – 1106 | MAGEPROSITE-ProRule annotationAdd BLAST | 199 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000164535 |
HOGENOMi | CLU_277023_0_0_1 |
InParanoidi | O60732 |
OMAi | HYFPQSP |
OrthoDBi | 1195799at2759 |
PhylomeDBi | O60732 |
TreeFami | TF328505 |
Family and domain databases
Gene3Di | 1.10.10.1200, 1 hit 1.10.10.1210, 1 hit |
InterProi | View protein in InterPro IPR037445, MAGE IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 11 hits |
Pfami | View protein in Pfam PF01454, MAGE, 1 hit |
SMARTi | View protein in SMART SM01373, MAGE, 1 hit |
PROSITEi | View protein in PROSITE PS50838, MAGE, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O60732-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGDKDMPTAG MPSLLQSSSE SPQSCPEGED SQSPLQIPQS SPESDDTLYP
60 70 80 90 100
LQSPQSRSEG EDSSDPLQRP PEGKDSQSPL QIPQSSPEGD DTQSPLQNSQ
110 120 130 140 150
SSPEGKDSLS PLEISQSPPE GEDVQSPLQN PASSFFSSAL LSIFQSSPES
160 170 180 190 200
TQSPFEGFPQ SVLQIPVSAA SSSTLVSIFQ SSPESTQSPF EGFPQSPLQI
210 220 230 240 250
PVSRSFSSTL LSIFQSSPER TQSTFEGFAQ SPLQIPVSPS SSSTLLSLFQ
260 270 280 290 300
SFSERTQSTF EGFAQSSLQI PVSPSFSSTL VSLFQSSPER TQSTFEGFPQ
310 320 330 340 350
SPLQIPVSSS SSSTLLSLFQ SSPERTHSTF EGFPQSLLQI PMTSSFSSTL
360 370 380 390 400
LSIFQSSPES AQSTFEGFPQ SPLQIPGSPS FSSTLLSLFQ SSPERTHSTF
410 420 430 440 450
EGFPQSPLQI PMTSSFSSTL LSILQSSPES AQSAFEGFPQ SPLQIPVSSS
460 470 480 490 500
FSYTLLSLFQ SSPERTHSTF EGFPQSPLQI PVSSSSSSST LLSLFQSSPE
510 520 530 540 550
CTQSTFEGFP QSPLQIPQSP PEGENTHSPL QIVPSLPEWE DSLSPHYFPQ
560 570 580 590 600
SPPQGEDSLS PHYFPQSPPQ GEDSLSPHYF PQSPQGEDSL SPHYFPQSPP
610 620 630 640 650
QGEDSMSPLY FPQSPLQGEE FQSSLQSPVS ICSSSTPSSL PQSFPESSQS
660 670 680 690 700
PPEGPVQSPL HSPQSPPEGM HSQSPLQSPE SAPEGEDSLS PLQIPQSPLE
710 720 730 740 750
GEDSLSSLHF PQSPPEWEDS LSPLHFPQFP PQGEDFQSSL QSPVSICSSS
760 770 780 790 800
TSLSLPQSFP ESPQSPPEGP AQSPLQRPVS SFFSYTLASL LQSSHESPQS
810 820 830 840 850
PPEGPAQSPL QSPVSSFPSS TSSSLSQSSP VSSFPSSTSS SLSKSSPESP
860 870 880 890 900
LQSPVISFSS STSLSPFSEE SSSPVDEYTS SSDTLLESDS LTDSESLIES
910 920 930 940 950
EPLFTYTLDE KVDELARFLL LKYQVKQPIT KAEMLTNVIS RYTGYFPVIF
960 970 980 990 1000
RKAREFIEIL FGISLREVDP DDSYVFVNTL DLTSEGCLSD EQGMSQNRLL
1010 1020 1030 1040 1050
ILILSIIFIK GTYASEEVIW DVLSGIGVRA GREHFAFGEP RELLTKVWVQ
1060 1070 1080 1090 1100
EHYLEYREVP NSSPPRYEFL WGPRAHSEVI KRKVVEFLAM LKNTVPITFP
1110 1120 1130 1140
SSYKDALKDV EERAQAIIDT TDDSTATESA SSSVMSPSFS SE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 221 – 225 | TQSTF → SQRTS (PubMed:9485030).Curated | 5 | |
Sequence conflicti | 221 – 225 | TQSTF → SQRTS (PubMed:9618514).Curated | 5 | |
Sequence conflicti | 239 | P → S (PubMed:9485030).Curated | 1 | |
Sequence conflicti | 239 | P → S (PubMed:9618514).Curated | 1 | |
Sequence conflicti | 252 – 253 | FS → SP (PubMed:9485030).Curated | 2 | |
Sequence conflicti | 252 – 253 | FS → SP (PubMed:9618514).Curated | 2 | |
Sequence conflicti | 264 | A → P (PubMed:9485030).Curated | 1 | |
Sequence conflicti | 264 | A → P (PubMed:9618514).Curated | 1 | |
Sequence conflicti | 267 | S → P (PubMed:9485030).Curated | 1 | |
Sequence conflicti | 267 | S → P (PubMed:9618514).Curated | 1 | |
Sequence conflicti | 274 | P → R (PubMed:9485030).Curated | 1 | |
Sequence conflicti | 274 | P → R (PubMed:9618514).Curated | 1 | |
Sequence conflicti | 281 – 283 | VSL → LSI (PubMed:9485030).Curated | 3 | |
Sequence conflicti | 281 – 283 | VSL → LSI (PubMed:9618514).Curated | 3 | |
Sequence conflicti | 299 | P → A (PubMed:9485030).Curated | 1 | |
Sequence conflicti | 299 | P → A (PubMed:9618514).Curated | 1 | |
Sequence conflicti | 309 – 311 | SSS → PSF in AAC24227 (PubMed:9618514).Curated | 3 | |
Sequence conflicti | 316 – 318 | LSL → VSI in AAC24227 (PubMed:9618514).Curated | 3 | |
Sequence conflicti | 337 | L → P in AAC24227 (PubMed:9618514).Curated | 1 | |
Sequence conflicti | 342 – 343 | MT → VS in AAC24227 (PubMed:9618514).Curated | 2 | |
Sequence conflicti | 353 | I → L in AAC24227 (PubMed:9618514).Curated | 1 | |
Sequence conflicti | 360 – 361 | SA → RT in AAC24227 (PubMed:9618514).Curated | 2 | |
Sequence conflicti | 467 | H → Q in AAC18837 (PubMed:9485030).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053501 | 25 | C → Y1 PublicationCorresponds to variant dbSNP:rs176036Ensembl. | 1 | |
Natural variantiVAR_053502 | 151 | T → I2 PublicationsCorresponds to variant dbSNP:rs176037Ensembl. | 1 | |
Natural variantiVAR_053503 | 257 | Q → H. Corresponds to variant dbSNP:rs143440588Ensembl. | 1 | |
Natural variantiVAR_053504 | 276 | F → S. Corresponds to variant dbSNP:rs75148863Ensembl. | 1 | |
Natural variantiVAR_060068 | 327 | H → Q2 PublicationsCorresponds to variant dbSNP:rs176047Ensembl. | 1 | |
Natural variantiVAR_062121 | 709 | H → Y. Corresponds to variant dbSNP:rs56256227Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056382 | 1 – 933 | Missing in isoform 2. 1 PublicationAdd BLAST | 933 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF064589 Genomic DNA Translation: AAC18837.1 AF056334 mRNA Translation: AAC24227.1 AL022152 Genomic DNA No translation available. BC127771 mRNA Translation: AAI27772.1 |
CCDSi | CCDS35417.1 [O60732-1] |
RefSeqi | NP_005453.2, NM_005462.4 [O60732-1] XP_011529720.1, XM_011531418.2 [O60732-1] |
Genome annotation databases
Ensembli | ENST00000285879; ENSP00000285879; ENSG00000155495 [O60732-1] ENST00000406005; ENSP00000385500; ENSG00000155495 [O60732-2] |
GeneIDi | 9947 |
KEGGi | hsa:9947 |
UCSCi | uc004fbt.4, human [O60732-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF064589 Genomic DNA Translation: AAC18837.1 AF056334 mRNA Translation: AAC24227.1 AL022152 Genomic DNA No translation available. BC127771 mRNA Translation: AAI27772.1 |
CCDSi | CCDS35417.1 [O60732-1] |
RefSeqi | NP_005453.2, NM_005462.4 [O60732-1] XP_011529720.1, XM_011531418.2 [O60732-1] |
3D structure databases
SMRi | O60732 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115272, 11 interactors |
IntActi | O60732, 8 interactors |
STRINGi | 9606.ENSP00000285879 |
PTM databases
iPTMneti | O60732 |
PhosphoSitePlusi | O60732 |
Polymorphism and mutation databases
BioMutai | MAGEC1 |
Proteomic databases
EPDi | O60732 |
MassIVEi | O60732 |
MaxQBi | O60732 |
PaxDbi | O60732 |
PeptideAtlasi | O60732 |
PRIDEi | O60732 |
ProteomicsDBi | 49577 [O60732-1] 77 |
Protocols and materials databases
Antibodypediai | 528, 139 antibodies |
Genome annotation databases
Ensembli | ENST00000285879; ENSP00000285879; ENSG00000155495 [O60732-1] ENST00000406005; ENSP00000385500; ENSG00000155495 [O60732-2] |
GeneIDi | 9947 |
KEGGi | hsa:9947 |
UCSCi | uc004fbt.4, human [O60732-1] |
Organism-specific databases
CTDi | 9947 |
DisGeNETi | 9947 |
EuPathDBi | HostDB:ENSG00000155495.8 |
GeneCardsi | MAGEC1 |
HGNCi | HGNC:6812, MAGEC1 |
HPAi | ENSG00000155495, Tissue enriched (testis) |
MIMi | 300223, gene |
neXtProti | NX_O60732 |
OpenTargetsi | ENSG00000155495 |
PharmGKBi | PA30558 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000164535 |
HOGENOMi | CLU_277023_0_0_1 |
InParanoidi | O60732 |
OMAi | HYFPQSP |
OrthoDBi | 1195799at2759 |
PhylomeDBi | O60732 |
TreeFami | TF328505 |
Enzyme and pathway databases
PathwayCommonsi | O60732 |
Miscellaneous databases
BioGRID-ORCSi | 9947, 5 hits in 470 CRISPR screens |
GenomeRNAii | 9947 |
Pharosi | O60732, Tbio |
PROi | PR:O60732 |
RNActi | O60732, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000155495, Expressed in right testis and 27 other tissues |
Genevisiblei | O60732, HS |
Family and domain databases
Gene3Di | 1.10.10.1200, 1 hit 1.10.10.1210, 1 hit |
InterProi | View protein in InterPro IPR037445, MAGE IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 11 hits |
Pfami | View protein in Pfam PF01454, MAGE, 1 hit |
SMARTi | View protein in SMART SM01373, MAGE, 1 hit |
PROSITEi | View protein in PROSITE PS50838, MAGE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MAGC1_HUMAN | |
Accessioni | O60732Primary (citable) accession number: O60732 Secondary accession number(s): A0PK03, O75451, Q8TCV4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | June 27, 2006 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations