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Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene

ICMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Catalytic activityi

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.PROSITE-ProRule annotation

Cofactori

Zn2+By similarityNote: Divalent metal cations. Probably Zn2+.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
SABIO-RKiO60725

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.100)
Alternative name(s):
Isoprenylcysteine carboxylmethyltransferase
Prenylated protein carboxyl methyltransferase
Short name:
PPMT
Prenylcysteine carboxyl methyltransferase
Short name:
pcCMT
Gene namesi
Name:ICMT
Synonyms:PCCMT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116237.15
HGNCiHGNC:5350 ICMT
MIMi605851 gene
neXtProtiNX_O60725

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 33HelicalSequence analysisAdd BLAST17
Topological domaini34 – 41LumenalSequence analysis8
Transmembranei42 – 59HelicalSequence analysisAdd BLAST18
Topological domaini60 – 69CytoplasmicSequence analysis10
Transmembranei70 – 87HelicalSequence analysisAdd BLAST18
Topological domaini88 – 92LumenalSequence analysis5
Transmembranei93 – 112HelicalSequence analysisAdd BLAST20
Topological domaini113 – 131CytoplasmicSequence analysisAdd BLAST19
Transmembranei132 – 149HelicalSequence analysisAdd BLAST18
Topological domaini150 – 154LumenalSequence analysis5
Transmembranei155 – 174HelicalSequence analysisAdd BLAST20
Topological domaini175 – 212CytoplasmicSequence analysisAdd BLAST38
Transmembranei213 – 228HelicalSequence analysisAdd BLAST16
Topological domaini229LumenalSequence analysis1
Transmembranei230 – 244HelicalSequence analysisAdd BLAST15
Topological domaini245 – 284CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23463
OpenTargetsiENSG00000116237
PharmGKBiPA29598

Chemistry databases

ChEMBLiCHEMBL4699

Polymorphism and mutation databases

BioMutaiICMT

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002098941 – 284Protein-S-isoprenylcysteine O-methyltransferaseAdd BLAST284

Proteomic databases

EPDiO60725
PaxDbiO60725
PeptideAtlasiO60725
PRIDEiO60725
ProteomicsDBi49571

PTM databases

iPTMnetiO60725
PhosphoSitePlusiO60725

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.1 Publication

Gene expression databases

BgeeiENSG00000116237 Expressed in 235 organ(s), highest expression level in adrenal tissue
CleanExiHS_ICMT
ExpressionAtlasiO60725 baseline and differential
GenevisibleiO60725 HS

Organism-specific databases

HPAiHPA032024
HPA032025

Interactioni

Protein-protein interaction databases

BioGridi117026, 15 interactors
IntActiO60725, 15 interactors
MINTiO60725
STRINGi9606.ENSP00000343552

Chemistry databases

BindingDBiO60725

Structurei

3D structure databases

ProteinModelPortaliO60725
SMRiO60725
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2628 Eukaryota
COG2020 LUCA
GeneTreeiENSGT00390000017394
HOGENOMiHOG000213961
HOVERGENiHBG019034
InParanoidiO60725
KOiK00587
OMAiLPFIRGY
OrthoDBiEOG091G0HSB
PhylomeDBiO60725
TreeFamiTF313769

Family and domain databases

InterProiView protein in InterPro
IPR007269 ICMT_MeTrfase
IPR025770 PPMT_MeTrfase
PfamiView protein in Pfam
PF04140 ICMT, 1 hit
PROSITEiView protein in PROSITE
PS51564 SAM_ICMT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O60725-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGCAARAPP GSEARLSLAT FLLGASVLAL PLLTRAGLQG RTGLALYVAG
60 70 80 90 100
LNALLLLLYR PPRYQIAIRA CFLGFVFGCG TLLSFSQSSW SHFGWYMCSL
110 120 130 140 150
SLFHYSEYLV TAVNNPKSLS LDSFLLNHSL EYTVAALSSW LEFTLENIFW
160 170 180 190 200
PELKQITWLS VTGLLMVVFG ECLRKAAMFT AGSNFNHVVQ NEKSDTHTLV
210 220 230 240 250
TSGVYAWFRH PSYVGWFYWS IGTQVMLCNP ICGVSYALTV WRFFRDRTEE
260 270 280
EEISLIHFFG EEYLEYKKRV PTGLPFIKGV KVDL
Length:284
Mass (Da):31,938
Last modified:August 1, 1998 - v1
Checksum:iC86741B13ACA611C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z750Q7Z750_HUMAN
Protein-S-isoprenylcysteine O-methy...
ICMT
116Annotation score:
K7EQW0K7EQW0_HUMAN
Protein-S-isoprenylcysteine O-methy...
ICMT
94Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064084 mRNA Translation: AAC16554.1
CR541671 mRNA Translation: CAG46472.1
CR541711 mRNA Translation: CAG46512.1
AL031847 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71522.1
BC028168 mRNA Translation: AAH28168.1
CCDSiCCDS61.1
RefSeqiNP_036537.1, NM_012405.3
UniGeneiHs.515688

Genome annotation databases

EnsembliENST00000343813; ENSP00000343552; ENSG00000116237
GeneIDi23463
KEGGihsa:23463
UCSCiuc001amk.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064084 mRNA Translation: AAC16554.1
CR541671 mRNA Translation: CAG46472.1
CR541711 mRNA Translation: CAG46512.1
AL031847 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71522.1
BC028168 mRNA Translation: AAH28168.1
CCDSiCCDS61.1
RefSeqiNP_036537.1, NM_012405.3
UniGeneiHs.515688

3D structure databases

ProteinModelPortaliO60725
SMRiO60725
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117026, 15 interactors
IntActiO60725, 15 interactors
MINTiO60725
STRINGi9606.ENSP00000343552

Chemistry databases

BindingDBiO60725
ChEMBLiCHEMBL4699

PTM databases

iPTMnetiO60725
PhosphoSitePlusiO60725

Polymorphism and mutation databases

BioMutaiICMT

Proteomic databases

EPDiO60725
PaxDbiO60725
PeptideAtlasiO60725
PRIDEiO60725
ProteomicsDBi49571

Protocols and materials databases

DNASUi23463
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343813; ENSP00000343552; ENSG00000116237
GeneIDi23463
KEGGihsa:23463
UCSCiuc001amk.4 human

Organism-specific databases

CTDi23463
DisGeNETi23463
EuPathDBiHostDB:ENSG00000116237.15
GeneCardsiICMT
HGNCiHGNC:5350 ICMT
HPAiHPA032024
HPA032025
MIMi605851 gene
neXtProtiNX_O60725
OpenTargetsiENSG00000116237
PharmGKBiPA29598
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2628 Eukaryota
COG2020 LUCA
GeneTreeiENSGT00390000017394
HOGENOMiHOG000213961
HOVERGENiHBG019034
InParanoidiO60725
KOiK00587
OMAiLPFIRGY
OrthoDBiEOG091G0HSB
PhylomeDBiO60725
TreeFamiTF313769

Enzyme and pathway databases

ReactomeiR-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
SABIO-RKiO60725

Miscellaneous databases

GeneWikiiICMT
GenomeRNAii23463
PROiPR:O60725
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116237 Expressed in 235 organ(s), highest expression level in adrenal tissue
CleanExiHS_ICMT
ExpressionAtlasiO60725 baseline and differential
GenevisibleiO60725 HS

Family and domain databases

InterProiView protein in InterPro
IPR007269 ICMT_MeTrfase
IPR025770 PPMT_MeTrfase
PfamiView protein in Pfam
PF04140 ICMT, 1 hit
PROSITEiView protein in PROSITE
PS51564 SAM_ICMT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiICMT_HUMAN
AccessioniPrimary (citable) accession number: O60725
Secondary accession number(s): Q6FHT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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