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UniProtKB - O60725 (ICMT_HUMAN)

Entry version 167 (10 Feb 2021)
Sequence version 1 (01 Aug 1998)
Previous versions | rss
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Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene

ICMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Competitively inhibited by N-acetyl-S-trans,trans-farnesyl-l-cysteine (AFC).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei190S-adenosyl-L-methionineBy similarity1
Binding sitei205S-adenosyl-L-methionineBy similarity1
Binding sitei247SubstrateBy similarity1
Binding sitei251S-adenosyl-L-methionineBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O60725

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-163841, Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-9648002, RAS processing

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		O60725

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.1001 Publication)
Alternative name(s):
Isoprenylcysteine carboxylmethyltransferase
Prenylated protein carboxyl methyltransferase
Short name:
PPMT
Prenylcysteine carboxyl methyltransferase
Short name:
pcCMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ICMT
Synonyms:PCCMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5350, ICMT

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605851, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60725

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116237.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 33HelicalSequence analysisAdd BLAST17
Topological domaini34 – 41LumenalSequence analysis8
Transmembranei42 – 59HelicalSequence analysisAdd BLAST18
Topological domaini60 – 69CytoplasmicSequence analysis10
Transmembranei70 – 87HelicalSequence analysisAdd BLAST18
Topological domaini88 – 92LumenalSequence analysis5
Transmembranei93 – 112HelicalSequence analysisAdd BLAST20
Topological domaini113 – 131CytoplasmicSequence analysisAdd BLAST19
Transmembranei132 – 149HelicalSequence analysisAdd BLAST18
Topological domaini150 – 154LumenalSequence analysis5
Transmembranei155 – 174HelicalSequence analysisAdd BLAST20
Topological domaini175 – 212CytoplasmicSequence analysisAdd BLAST38
Transmembranei213 – 228HelicalSequence analysisAdd BLAST16
Topological domaini229LumenalSequence analysis1
Transmembranei230 – 244HelicalSequence analysisAdd BLAST15
Topological domaini245 – 284CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23463

Open Targets

More...OpenTargetsi		ENSG00000116237

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29598

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60725, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4699

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ICMT

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002098941 – 284Protein-S-isoprenylcysteine O-methyltransferaseAdd BLAST284

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O60725

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O60725

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60725

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60725

PeptideAtlas

More...PeptideAtlasi		O60725

PRoteomics IDEntifications database

More...PRIDEi		O60725

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49571

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60725

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60725

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116237, Expressed in adrenal tissue and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60725, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60725, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116237, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117026, 38 interactors

Protein interaction database and analysis system

More...IntActi		O60725, 24 interactors

Molecular INTeraction database

More...MINTi		O60725

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000343552

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O60725

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60725, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60725

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni197 – 200S-adenosyl-L-methionine bindingBy similarity4
Regioni210 – 213S-adenosyl-L-methionine bindingBy similarity4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2628, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017394

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_065200_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60725

Identification of Orthologs from Complete Genome Data

More...OMAi		LPFIRGY

Database of Orthologous Groups

More...OrthoDBi		1479599at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60725

TreeFam database of animal gene trees

More...TreeFami		TF313769

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007269, ICMT_MeTrfase
IPR025770, PPMT_MeTrfase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04140, ICMT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51564, SAM_ICMT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O60725-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGCAARAPP GSEARLSLAT FLLGASVLAL PLLTRAGLQG RTGLALYVAG 
        60         70         80         90        100
LNALLLLLYR PPRYQIAIRA CFLGFVFGCG TLLSFSQSSW SHFGWYMCSL 
       110        120        130        140        150
SLFHYSEYLV TAVNNPKSLS LDSFLLNHSL EYTVAALSSW LEFTLENIFW 
       160        170        180        190        200
PELKQITWLS VTGLLMVVFG ECLRKAAMFT AGSNFNHVVQ NEKSDTHTLV 
       210        220        230        240        250
TSGVYAWFRH PSYVGWFYWS IGTQVMLCNP ICGVSYALTV WRFFRDRTEE 
       260        270        280 
EEISLIHFFG EEYLEYKKRV PTGLPFIKGV KVDL
Length:284
Mass (Da):31,938
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC86741B13ACA611C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z750Q7Z750_HUMAN
Protein-S-isoprenylcysteine O-methy...
ICMT
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQW0K7EQW0_HUMAN
Protein-S-isoprenylcysteine O-methy...
ICMT
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF064084 mRNA Translation: AAC16554.1
CR541671 mRNA Translation: CAG46472.1
CR541711 mRNA Translation: CAG46512.1
AL031847 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71522.1
BC028168 mRNA Translation: AAH28168.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS61.1

NCBI Reference Sequences

More...RefSeqi		NP_036537.1, NM_012405.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000343813; ENSP00000343552; ENSG00000116237

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23463

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23463

UCSC genome browser

More...UCSCi		uc001amk.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064084 mRNA Translation: AAC16554.1
CR541671 mRNA Translation: CAG46472.1
CR541711 mRNA Translation: CAG46512.1
AL031847 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71522.1
BC028168 mRNA Translation: AAH28168.1
CCDSiCCDS61.1
RefSeqiNP_036537.1, NM_012405.3

3D structure databases

SMRiO60725
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117026, 38 interactors
IntActiO60725, 24 interactors
MINTiO60725
STRINGi9606.ENSP00000343552

Chemistry databases

BindingDBiO60725
ChEMBLiCHEMBL4699

PTM databases

iPTMnetiO60725
PhosphoSitePlusiO60725

Genetic variation databases

BioMutaiICMT

Proteomic databases

EPDiO60725
jPOSTiO60725
MassIVEiO60725
PaxDbiO60725
PeptideAtlasiO60725
PRIDEiO60725
ProteomicsDBi49571

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27272, 182 antibodies

The DNASU plasmid repository

More...DNASUi		23463

Genome annotation databases

EnsembliENST00000343813; ENSP00000343552; ENSG00000116237
GeneIDi23463
KEGGihsa:23463
UCSCiuc001amk.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23463
DisGeNETi23463

GeneCards: human genes, protein and diseases

More...GeneCardsi		ICMT
HGNCiHGNC:5350, ICMT
HPAiENSG00000116237, Low tissue specificity
MIMi605851, gene
neXtProtiNX_O60725
OpenTargetsiENSG00000116237
PharmGKBiPA29598
VEuPathDBiHostDB:ENSG00000116237.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2628, Eukaryota
GeneTreeiENSGT00390000017394
HOGENOMiCLU_065200_0_1_1
InParanoidiO60725
OMAiLPFIRGY
OrthoDBi1479599at2759
PhylomeDBiO60725
TreeFamiTF313769

Enzyme and pathway databases

PathwayCommonsiO60725
ReactomeiR-HSA-163841, Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-9648002, RAS processing
SABIO-RKiO60725

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23463, 59 hits in 883 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ICMT, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ICMT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23463
PharosiO60725, Tchem

Protein Ontology

More...PROi		PR:O60725
RNActiO60725, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116237, Expressed in adrenal tissue and 249 other tissues
ExpressionAtlasiO60725, baseline and differential
GenevisibleiO60725, HS

Family and domain databases

InterProiView protein in InterPro
IPR007269, ICMT_MeTrfase
IPR025770, PPMT_MeTrfase
PfamiView protein in Pfam
PF04140, ICMT, 1 hit
PROSITEiView protein in PROSITE
PS51564, SAM_ICMT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICMT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60725
Secondary accession number(s): Q6FHT0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: February 10, 2021
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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