UniProtKB - O60725 (ICMT_HUMAN)

BLAST

>sp|O60725|ICMT_HUMAN Protein-S-isoprenylcysteine O-methyltransferase OS=Homo sapiens OX=9606 GN=ICMT PE=1 SV=1
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL

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History
Entry version 153 (07 Nov 2018)
Sequence version 1 (01 Aug 1998)
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Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene

ICMT

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Catalytic activityⁱ

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.PROSITE-ProRule annotation

Cofactorⁱ

Zn²⁺By similarityNote: Divalent metal cations. Probably Zn²⁺.By similarity

GO - Molecular functionⁱ

protein C-terminal carboxyl O-methyltransferase activity
Source: ProtInc
Traceable author statementⁱ
- 9614111
protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein modification process
Source: ProtInc
Traceable author statementⁱ
- 9614111
C-terminal protein methylation
Source: ProtInc
Traceable author statementⁱ
- 10441503
post-translational protein modification Source: Reactome
protein targeting to membrane
Source: ProtInc
Traceable author statementⁱ
- 9614111

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Methyltransferase, Transferase
Ligand	S-adenosyl-L-methionine

Enzyme and pathway databases

Reactomeⁱ	R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
SABIO-RKⁱ	O60725

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.100) Alternative name(s): Isoprenylcysteine carboxylmethyltransferase Prenylated protein carboxyl methyltransferase Short name: PPMT Prenylcysteine carboxyl methyltransferase Short name: pcCMT
Gene namesⁱ	Name:ICMT Synonyms:PCCMT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116237.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5350 ICMT
MIMⁱ	605851 gene
neXtProtⁱ	NX_O60725

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 16	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	17 – 33	HelicalSequence analysisAdd BLAST	17
Topological domainⁱ	34 – 41	LumenalSequence analysis	8
Transmembraneⁱ	42 – 59	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	60 – 69	CytoplasmicSequence analysis	10
Transmembraneⁱ	70 – 87	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	88 – 92	LumenalSequence analysis	5
Transmembraneⁱ	93 – 112	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	113 – 131	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	132 – 149	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	150 – 154	LumenalSequence analysis	5
Transmembraneⁱ	155 – 174	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	175 – 212	CytoplasmicSequence analysisAdd BLAST	38
Transmembraneⁱ	213 – 228	HelicalSequence analysisAdd BLAST	16
Topological domainⁱ	229	LumenalSequence analysis	1
Transmembraneⁱ	230 – 244	HelicalSequence analysisAdd BLAST	15
Topological domainⁱ	245 – 284	CytoplasmicSequence analysisAdd BLAST	40

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23463
Open Targets More...OpenTargetsⁱ	ENSG00000116237
PharmGKBⁱ	PA29598

Chemistry databases

ChEMBLⁱ	CHEMBL4699

ChEMBLⁱ

CHEMBL4699

Polymorphism and mutation databases

BioMutaⁱ	ICMT

BioMutaⁱ

ICMT

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000209894	1 – 284	Protein-S-isoprenylcysteine O-methyltransferaseAdd BLAST		284

Proteomic databases

EPDⁱ	O60725
PaxDbⁱ	O60725
PeptideAtlas More...PeptideAtlasⁱ	O60725
PRIDEⁱ	O60725
ProteomicsDBⁱ	49571

PTM databases

iPTMnetⁱ	O60725
PhosphoSitePlusⁱ	O60725

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000116237 Expressed in 235 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_ICMT
ExpressionAtlasⁱ	O60725 baseline and differential
Genevisibleⁱ	O60725 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA032024 HPA032025

HPAⁱ

HPA032024
HPA032025

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	117026, 15 interactors
IntActⁱ	O60725, 15 interactors
Molecular INTeraction database More...MINTⁱ	O60725
STRINGⁱ	9606.ENSP00000343552

Chemistry databases

BindingDBⁱ

O60725

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O60725
SMRⁱ	O60725
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2628 Eukaryota COG2020 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017394
HOGENOMⁱ	HOG000213961
HOVERGENⁱ	HBG019034
InParanoidⁱ	O60725
KEGG Orthology (KO) More...KOⁱ	K00587
OMAⁱ	LPFIRGY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HSB
PhylomeDBⁱ	O60725
TreeFamⁱ	TF313769

Family and domain databases

InterProⁱ	View protein in InterPro IPR007269 ICMT_MeTrfase IPR025770 PPMT_MeTrfase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04140 ICMT, 1 hit
PROSITEⁱ	View protein in PROSITE PS51564 SAM_ICMT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

O60725-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAGCAARAPP GSEARLSLAT FLLGASVLAL PLLTRAGLQG RTGLALYVAG 
        60         70         80         90        100
LNALLLLLYR PPRYQIAIRA CFLGFVFGCG TLLSFSQSSW SHFGWYMCSL 
       110        120        130        140        150
SLFHYSEYLV TAVNNPKSLS LDSFLLNHSL EYTVAALSSW LEFTLENIFW 
       160        170        180        190        200
PELKQITWLS VTGLLMVVFG ECLRKAAMFT AGSNFNHVVQ NEKSDTHTLV 
       210        220        230        240        250
TSGVYAWFRH PSYVGWFYWS IGTQVMLCNP ICGVSYALTV WRFFRDRTEE 
       260        270        280 
EEISLIHFFG EEYLEYKKRV PTGLPFIKGV KVDL

Length:284

Mass (Da):31,938

Last modified:August 1, 1998 - v1

Checksum:ⁱC86741B13ACA611C

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q7Z750	Q7Z750_HUMAN	Protein-S-isoprenylcysteine O-methy... Protein-S-isoprenylcysteine O-methyltransferase	ICMT	116	Annotation score:
K7EQW0	K7EQW0_HUMAN	Protein-S-isoprenylcysteine O-methy... Protein-S-isoprenylcysteine O-methyltransferase	ICMT	94	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF064084 mRNA Translation: AAC16554.1 CR541671 mRNA Translation: CAG46472.1 CR541711 mRNA Translation: CAG46512.1 AL031847 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71522.1 BC028168 mRNA Translation: AAH28168.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS61.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036537.1, NM_012405.3
UniGeneⁱ	Hs.515688

Genome annotation databases

Ensemblⁱ	ENST00000343813; ENSP00000343552; ENSG00000116237
GeneIDⁱ	23463
KEGGⁱ	hsa:23463
UCSC genome browser More...UCSCⁱ	uc001amk.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O60725	Protein-S-isoprenylcysteine O-methyltransferase		HUMAN		284	UniRef100_O60725
Protein-S-isoprenylcysteine O-methyltransferase		HUMAN		94

Protein	Similar proteins		Species	Score	Length	Source
O60725	Protein-S-isoprenylcysteine O-methyltransferase		MOUSE		283	UniRef90_Q9EQK7
Protein-S-isoprenylcysteine O-methyltransferase (Fragment)		RAT		232
Protein-S-isoprenylcysteine O-methyltransferase		OTOGA		289
Protein-S-isoprenylcysteine O-methyltransferase		HUMAN		284
Protein-S-isoprenylcysteine O-methyltransferase		PANTR		284
+88

Protein	Similar proteins		Species	Score	Length	Source
O60725	Protein-S-isoprenylcysteine O-methyltransferase		MOUSE		283	UniRef50_Q9EQK7
Protein-S-isoprenylcysteine O-methyltransferase (Fragment)		RAT		232
Protein-S-isoprenylcysteine O-methyltransferase		XENLA		288
Protein-S-isoprenylcysteine O-methyltransferase		OTOGA		289
Protein-S-isoprenylcysteine O-methyltransferase		ERIEU		284
+180

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF064084 mRNA Translation: AAC16554.1 CR541671 mRNA Translation: CAG46472.1 CR541711 mRNA Translation: CAG46512.1 AL031847 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71522.1 BC028168 mRNA Translation: AAH28168.1
CCDSⁱ	CCDS61.1
RefSeqⁱ	NP_036537.1, NM_012405.3
UniGeneⁱ	Hs.515688

3D structure databases

ProteinModelPortalⁱ	O60725
SMRⁱ	O60725
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117026, 15 interactors
IntActⁱ	O60725, 15 interactors
MINTⁱ	O60725
STRINGⁱ	9606.ENSP00000343552

Chemistry databases

BindingDBⁱ	O60725
ChEMBLⁱ	CHEMBL4699

PTM databases

iPTMnetⁱ	O60725
PhosphoSitePlusⁱ	O60725

Polymorphism and mutation databases

BioMutaⁱ	ICMT

BioMutaⁱ

ICMT

Proteomic databases

EPDⁱ	O60725
PaxDbⁱ	O60725
PeptideAtlasⁱ	O60725
PRIDEⁱ	O60725
ProteomicsDBⁱ	49571

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23463
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000343813; ENSP00000343552; ENSG00000116237
GeneIDⁱ	23463
KEGGⁱ	hsa:23463
UCSCⁱ	uc001amk.4 human

Organism-specific databases

CTDⁱ	23463
DisGeNETⁱ	23463
EuPathDBⁱ	HostDB:ENSG00000116237.15
GeneCardsⁱ	ICMT
HGNCⁱ	HGNC:5350 ICMT
HPAⁱ	HPA032024 HPA032025
MIMⁱ	605851 gene
neXtProtⁱ	NX_O60725
OpenTargetsⁱ	ENSG00000116237
PharmGKBⁱ	PA29598
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2628 Eukaryota COG2020 LUCA
GeneTreeⁱ	ENSGT00390000017394
HOGENOMⁱ	HOG000213961
HOVERGENⁱ	HBG019034
InParanoidⁱ	O60725
KOⁱ	K00587
OMAⁱ	LPFIRGY
OrthoDBⁱ	EOG091G0HSB
PhylomeDBⁱ	O60725
TreeFamⁱ	TF313769

Enzyme and pathway databases

Reactomeⁱ	R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
SABIO-RKⁱ	O60725

Miscellaneous databases

GeneWikiⁱ	ICMT
GenomeRNAiⁱ	23463
Protein Ontology More...PROⁱ	PR:O60725
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116237 Expressed in 235 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_ICMT
ExpressionAtlasⁱ	O60725 baseline and differential
Genevisibleⁱ	O60725 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007269 ICMT_MeTrfase IPR025770 PPMT_MeTrfase
Pfamⁱ	View protein in Pfam PF04140 ICMT, 1 hit
PROSITEⁱ	View protein in PROSITE PS51564 SAM_ICMT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ICMT_HUMAN
Accessionⁱ	O60725Primary (citable) accession number: O60725 Secondary accession number(s): Q6FHT0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
	Last sequence update:	August 1, 1998
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Supporting data

UniProtKB - O60725 (ICMT_HUMAN)

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Protein-S-isoprenylcysteine O-methyltransferase

ICMT

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ