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Entry version 156 (13 Feb 2019)
Sequence version 1 (01 Aug 1998)
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Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene

ICMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Divalent metal cations. Probably Zn2+.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O60725

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.100)
Alternative name(s):
Isoprenylcysteine carboxylmethyltransferase
Prenylated protein carboxyl methyltransferase
Short name:
PPMT
Prenylcysteine carboxyl methyltransferase
Short name:
pcCMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ICMT
Synonyms:PCCMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000116237.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5350 ICMT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605851 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60725

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 33HelicalSequence analysisAdd BLAST17
Topological domaini34 – 41LumenalSequence analysis8
Transmembranei42 – 59HelicalSequence analysisAdd BLAST18
Topological domaini60 – 69CytoplasmicSequence analysis10
Transmembranei70 – 87HelicalSequence analysisAdd BLAST18
Topological domaini88 – 92LumenalSequence analysis5
Transmembranei93 – 112HelicalSequence analysisAdd BLAST20
Topological domaini113 – 131CytoplasmicSequence analysisAdd BLAST19
Transmembranei132 – 149HelicalSequence analysisAdd BLAST18
Topological domaini150 – 154LumenalSequence analysis5
Transmembranei155 – 174HelicalSequence analysisAdd BLAST20
Topological domaini175 – 212CytoplasmicSequence analysisAdd BLAST38
Transmembranei213 – 228HelicalSequence analysisAdd BLAST16
Topological domaini229LumenalSequence analysis1
Transmembranei230 – 244HelicalSequence analysisAdd BLAST15
Topological domaini245 – 284CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23463

Open Targets

More...
OpenTargetsi
ENSG00000116237

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29598

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4699

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ICMT

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002098941 – 284Protein-S-isoprenylcysteine O-methyltransferaseAdd BLAST284

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60725

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60725

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60725

PeptideAtlas

More...
PeptideAtlasi
O60725

PRoteomics IDEntifications database

More...
PRIDEi
O60725

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49571

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60725

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60725

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116237 Expressed in 235 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60725 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60725 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA032024
HPA032025

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117026, 18 interactors

Protein interaction database and analysis system

More...
IntActi
O60725, 15 interactors

Molecular INTeraction database

More...
MINTi
O60725

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000343552

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O60725

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60725

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60725

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2628 Eukaryota
COG2020 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017394

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000213961

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG019034

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60725

KEGG Orthology (KO)

More...
KOi
K00587

Identification of Orthologs from Complete Genome Data

More...
OMAi
LPFIRGY

Database of Orthologous Groups

More...
OrthoDBi
1479599at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60725

TreeFam database of animal gene trees

More...
TreeFami
TF313769

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007269 ICMT_MeTrfase
IPR025770 PPMT_MeTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04140 ICMT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51564 SAM_ICMT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O60725-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGCAARAPP GSEARLSLAT FLLGASVLAL PLLTRAGLQG RTGLALYVAG
60 70 80 90 100
LNALLLLLYR PPRYQIAIRA CFLGFVFGCG TLLSFSQSSW SHFGWYMCSL
110 120 130 140 150
SLFHYSEYLV TAVNNPKSLS LDSFLLNHSL EYTVAALSSW LEFTLENIFW
160 170 180 190 200
PELKQITWLS VTGLLMVVFG ECLRKAAMFT AGSNFNHVVQ NEKSDTHTLV
210 220 230 240 250
TSGVYAWFRH PSYVGWFYWS IGTQVMLCNP ICGVSYALTV WRFFRDRTEE
260 270 280
EEISLIHFFG EEYLEYKKRV PTGLPFIKGV KVDL
Length:284
Mass (Da):31,938
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC86741B13ACA611C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z750Q7Z750_HUMAN
Protein-S-isoprenylcysteine O-methy...
ICMT
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQW0K7EQW0_HUMAN
Protein-S-isoprenylcysteine O-methy...
ICMT
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF064084 mRNA Translation: AAC16554.1
CR541671 mRNA Translation: CAG46472.1
CR541711 mRNA Translation: CAG46512.1
AL031847 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71522.1
BC028168 mRNA Translation: AAH28168.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS61.1

NCBI Reference Sequences

More...
RefSeqi
NP_036537.1, NM_012405.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.515688

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343813; ENSP00000343552; ENSG00000116237

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23463

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23463

UCSC genome browser

More...
UCSCi
uc001amk.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064084 mRNA Translation: AAC16554.1
CR541671 mRNA Translation: CAG46472.1
CR541711 mRNA Translation: CAG46512.1
AL031847 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71522.1
BC028168 mRNA Translation: AAH28168.1
CCDSiCCDS61.1
RefSeqiNP_036537.1, NM_012405.3
UniGeneiHs.515688

3D structure databases

ProteinModelPortaliO60725
SMRiO60725
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117026, 18 interactors
IntActiO60725, 15 interactors
MINTiO60725
STRINGi9606.ENSP00000343552

Chemistry databases

BindingDBiO60725
ChEMBLiCHEMBL4699

PTM databases

iPTMnetiO60725
PhosphoSitePlusiO60725

Polymorphism and mutation databases

BioMutaiICMT

Proteomic databases

EPDiO60725
jPOSTiO60725
PaxDbiO60725
PeptideAtlasiO60725
PRIDEiO60725
ProteomicsDBi49571

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23463
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343813; ENSP00000343552; ENSG00000116237
GeneIDi23463
KEGGihsa:23463
UCSCiuc001amk.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23463
DisGeNETi23463
EuPathDBiHostDB:ENSG00000116237.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ICMT
HGNCiHGNC:5350 ICMT
HPAiHPA032024
HPA032025
MIMi605851 gene
neXtProtiNX_O60725
OpenTargetsiENSG00000116237
PharmGKBiPA29598

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2628 Eukaryota
COG2020 LUCA
GeneTreeiENSGT00390000017394
HOGENOMiHOG000213961
HOVERGENiHBG019034
InParanoidiO60725
KOiK00587
OMAiLPFIRGY
OrthoDBi1479599at2759
PhylomeDBiO60725
TreeFamiTF313769

Enzyme and pathway databases

ReactomeiR-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
SABIO-RKiO60725

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ICMT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23463

Protein Ontology

More...
PROi
PR:O60725

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116237 Expressed in 235 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiO60725 baseline and differential
GenevisibleiO60725 HS

Family and domain databases

InterProiView protein in InterPro
IPR007269 ICMT_MeTrfase
IPR025770 PPMT_MeTrfase
PfamiView protein in Pfam
PF04140 ICMT, 1 hit
PROSITEiView protein in PROSITE
PS51564 SAM_ICMT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICMT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60725
Secondary accession number(s): Q6FHT0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: February 13, 2019
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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